Inhibition of the induction of collagenase by interleukin-1 beta in cultured rabbit synovial fibroblasts after treatment with the poly(ADP-ribose)-polymerase inhibitor 3-aminobenzamide.

Abstract:

:3-Aminobenzamide is an inhibitor of poly-(ADP-ribosyl)ation. In concentrations from 3 to 10 mM it reduced the collagenase activity in culture supernatants of interleukin-1 beta-stimulated rabbit synovial fibroblasts. 3-Aminobenzoate, not an inhibiter of poly(ADP-ribosyl)ation, had no effect on collagenase activity at a concentration of 10 mM. We concluded that poly(ADP-ribosyl)ation plays a role in the induction of the expression of collagenase and that 3-aminobenzamide can inhibit this process.

journal_name

Rheumatol Int

authors

Ehrlich W,Huser H,Kröger H

doi

10.1007/BF00301776

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

171-2

issue

4

eissn

0172-8172

issn

1437-160X

journal_volume

15

pub_type

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