Tocilizumab treatment in Felty's syndrome.


:Felty's syndrome (FS) is a deforming disease, characterized by the triad of rheumatoid arthritis (RA), neutropenia, and splenomegaly. Currently, FS patients are treated mainly with immunosuppressants, such as methotrexate and glucocorticoids, which however are not suitable to some patients and may cause severe side effects. Here we report a clinical FS case that was treated with Tocilizumab (TCZ) successfully. The patient had symmetrical swelling and pain of multiple joints, deformity of elbow joints with obvious morning stiffness. Joint color Doppler ultrasound showed synovial hyperplasia and bone erosion of wrist and proximal interphalangeal joints and CT scan suggested splenomegaly. Further examination showed neutropenia and anemia, a high titer of anti-cyclic citrullinated peptide antibody, rheumatoid factor and anti-nuclear antibodies, positive p-ANCA, and elevated IgA and IgG. After treating with TCZ, the patient has been relieved of clinical symptoms. His spleen has recovered to normal size. The absolute neutrophil count (ANC) tended to be stable, and joint erosion did not deteriorate. We have reviewed the literatures on FS treatment with biological agents and found only a few reports using TNF-α antagonist and rituximab treating FS, but none with TCZ. So, it is the first time to report a successful FS case treated with TCZ. This case suggests that the TCZ may be a new choice for FS treatment, under the condition of closely monitoring the ANC.


Rheumatol Int


Li R,Wan Q,Chen P,Mao S,Wang Q,Li X,Yang Y,Dong L




Has Abstract


2020-07-01 00:00:00














  • Coexistence of familial Mediterranean fever and psoriasis in a patient with seronegative spondyloarthropathy.

    abstract::Familial Mediterranean fever (FMF) is a self-limited disease characterized by fever and polyserositis attacks. Arthritis caused by synovitis is either in acute monoarthritis or chronic mono-oligoarthritis form, usually affecting the lower extremities. Another potential but rare form of involvement is spondyloarthropat...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Bodur H,Seçkin U,Eser F,Ergül G,Seçkin S

    更新日期:2008-11-01 00:00:00

  • Cross-sectional correlation of single-item health literacy screening questions with established measures of health literacy in patients with rheumatoid arthritis.

    abstract::Research suggests that health literacy (HL) is associated with rheumatoid arthritis (RA) patients' functional status. Single-item health literacy screening (SILS) questionnaires may establish patients' HL; however, the wording of SILS may be misinterpreted by RA patients as a query regarding physical limitations. Desp...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Quinzanos I,Hirsh JM,Bright C,Caplan L

    更新日期:2015-09-01 00:00:00

  • Managing knee osteoarthritis with yoga or aerobic/strengthening exercise programs in older adults: a pilot randomized controlled trial.

    abstract::Although exercise is often recommended for managing osteoarthritis (OA), limited evidence-based exercise options are available for older adults with OA. This study compared the effects of Hatha yoga (HY) and aerobic/strengthening exercises (ASE) on knee OA. Randomized controlled trial with three arms design was used: ...

    journal_title:Rheumatology international

    pub_type: 杂志文章,随机对照试验


    authors: Cheung C,Wyman JF,Bronas U,McCarthy T,Rudser K,Mathiason MA

    更新日期:2017-03-01 00:00:00

  • Fibromyalgia in women with ankylosing spondylitis.

    abstract::Fibromyalgia (FM), pre-dominantly found in women, may accompany other pre-existing rheumatic diseases. The association between FM and ankylosing spondylitis (AS) is uncertain. We evaluated FM in women with AS. Eighteen women with AS were compared with 18 men with AS (controls) for age, duration of symptoms, time to di...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Aloush V,Ablin JN,Reitblat T,Caspi D,Elkayam O

    更新日期:2007-07-01 00:00:00

  • MHC2TA and FCRL3 genes are not associated with rheumatoid arthritis in Mexican patients.

    abstract::Rheumatoid arthritis (RA) is a multifactorial disease. A combination of genetic and environmental risk factors contributes to its etiology. Several genes have been reported to be associated with susceptibility to the development of RA. The MHC2TA and FCRL3 genes have been associated previously with RA in Swedish and J...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Mendoza Rincón JF,Rodríguez Elias AK,Fragoso JM,Vargas Alarcón G,Maldonado Murillo K,Rivas Jiménez ML,Barbosa Cobos RE,Jimenez Morales S,Lugo Zamudio G,Tovilla Zárate C,Ramírez Bello J

    更新日期:2016-02-01 00:00:00

  • Identification, frequency, activation and function of CD4+ CD25(high)FoxP3+ regulatory T cells in children with juvenile idiopathic arthritis.

    abstract::The aim of the study was to test the frequency of CD4+ CD25(high)FoxP3 regulatory T cells in JIA patients and to assess their activation status and functional activity. The study involved 12 children with JIA and 35 healthy control subjects. PBMC were stained with monoclonal antibodies (anti-CD25, anti-CD4, anti-CD127...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Stelmaszczyk-Emmel A,Jackowska T,Rutkowska-Sak L,Marusak-Banacka M,Wąsik M

    更新日期:2012-05-01 00:00:00

  • Sclerosis and hyperostosis of the manubrium sterni.

    abstract::Seven females and one male with almost identical sclerotic and hyperostotic changes of the manubrium sterni are reported. The clinical course was prolonged and characterized by intermittent periods of exacerbation followed by improvement. Malignancies, bacterial inflammatory processes, and Paget disease, which were fi...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Jurik AG,Møller BN,Jensen MK,Jensen JT,Graudal H

    更新日期:1986-01-01 00:00:00

  • Methotrexate for rheumatoid arthritis patients who are on hemodialysis.

    abstract::Methotrexate (MTX) can be toxic to patients suffering from end stage renal disease (ESRD) on hemodialysis even at low doses. This increase in toxicity is more notable in terms of bone marrow suppression in the form of pancytopenia. Many methods of elimination including dialysis itself have been proven ineffective, and...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审


    authors: Al-Hasani H,Roussou E

    更新日期:2011-12-01 00:00:00

  • Frequency of HLA-B27 and its alleles in patients with Reiter syndrome: comparison with the frequency in other spondyloarthropathies and a healthy control population.

    abstract::This retrospective study analyzed the HLA-B 27 alleles in a group of 20 consecutive patients with the diagnosis of Reiter syndrome (RS) followed in a tertiary referral university hospital in Brazil, during the period 1990-2006, and compared the data with that observed in other patients with spondyloarthropathies follo...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Sampaio-Barros PD,Conde RA,Donadi EA,Bonfiglioli R,Costallat LT,Samara AM,Bértolo MB

    更新日期:2008-03-01 00:00:00

  • Perforin level in CD4+ T cells from patients with systemic lupus erythematosus.

    abstract::CD4(+) T cells from patients with systemic lupus erythematosus (SLE) exhibit increased expression of various proteins contributing to defective function of CD4(+) T cells. We evaluated the transcript and protein levels of perforin (PRF1) in CD4(+) T cells from SLE patients (n = 41) and healthy individuals (n = 34). Th...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Kozłowska A,Hrycaj P,Łącki JK,Jagodziński PP

    更新日期:2010-11-01 00:00:00

  • Significance of risk factors for osteoporosis is dependent on gender and menopause in rheumatoid arthritis.

    abstract::The aim of our study was to compare the significance of risk factors for osteoporosis according to gender and menopausal state in patients with rheumatoid arthritis (RA). Bone mineral density (dual X-ray absorptiometry), cumulative glucocorticoid dose, age, disease duration, body mass index (BMI) and parameters of dis...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Oelzner P,Schwabe A,Lehmann G,Eidner T,Franke S,Wolf G,Hein G

    更新日期:2008-09-01 00:00:00

  • Relapsing polychondritis with aortic arch aneurysm and aortic arch syndrome.

    abstract::A case of relapsing polychondritis with aortic arch aneurysm and aortic arch syndrome is described. The pattern of vascular involvement supports the inclusion of relapsing polychondritis within the spectrum of systemic vasculitides. ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Giordano M,Valentini G,Sodano A

    更新日期:1984-01-01 00:00:00

  • Aplastic anemia complicating systemic lupus erythematosus: successful management with cyclosporine.

    abstract::Anemia is common with connective tissue disorders, but pancytopenia is rare. We report a 22-year-old female who presented with menorrhagia, seizures, anemia, leukocytosis, thrombocytopenia, pericardial effusion, positive ANA, and evidence of vasculitis on CT head scan and was diagnosed with systemic lupus erythematosu...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Singh NP,Prakash A,Garg D,Makhija A,Pathania A,Prakash N,Kubba S,Agarwal SK

    更新日期:2004-01-01 00:00:00

  • C4 deficiency state in antiphospholipid antibody-related recurrent preeclampsia evolving into systemic lupus erythematosus.

    abstract::The case of an apparent healthy woman who developed recurrent preeclampsia with antiphospholipid antibodies and evolved towards systemic lupus erythematosus during her last pregnancy is presented. The diagnostic dilemma between lupus renal flare and toxemia is discussed. The potential role of immunological alterations...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Queiro R,Weruaga A,Riestra JL

    更新日期:2002-07-01 00:00:00

  • Male gender results in more severe lupus nephritis.

    abstract::Gender may produce different characteristics in the manifestation of systemic lupus erythematosus (SLE). The present study investigated the influence of gender on clinical, laboratory, autoantibodies and histopathological classes of lupus nephritis (LN). As much as 81 patients diagnosed with SLE (ACR criteria) and act...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: de Carvalho JF,do Nascimento AP,Testagrossa LA,Barros RT,Bonfá E

    更新日期:2010-08-01 00:00:00

  • Damage of cultured chondrocytes by hydrogen peroxide derived from polymorphonuclear leukocytes: a possible mechanism of cartilage degradation.

    abstract::To study the mechanisms of chondrocyte damage, chondrocyte cytotoxicity as shown by chromium-51 release induced by polymorphonuclear leukocytes (PMNLs) was examined. PMNLs significantly enhanced chondrocyte cytotoxicity in the presence of phorbol dibutyrate. This chondrocyte damage was abolished by the addition of cat...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Saura R,Matsubara T,Hirohata K,Itoh H

    更新日期:1992-01-01 00:00:00

  • Application of an advanced noise reduction algorithm for imaging of hands in rheumatic diseases: evaluation of image quality compared to standard-dose images.

    abstract:OBJECTIVES:X-ray is the fundamental imaging technique in both diagnosis and follow-up of rheumatic diseases. As patients often require sequential X-rays over many years, dose reduction is of great importance. New advanced noise reduction algorithms allow for a dose reduction of up to 50%. The aim of this study was to e...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Ziegeler K,Siepmann S,Hermann S,Beck A,Lembcke A,Hamm B,Hermann KGA

    更新日期:2020-06-01 00:00:00

  • Correction to: The Italian version of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR).

    abstract::The family name of author Francesco La Torre was incorrect in the published article. The correct family name should read as La Torre F. ...

    journal_title:Rheumatology international

    pub_type: 杂志文章,已发布勘误


    authors: Consolaro A,Bovis F,Pistorio A,Cimaz R,De Benedetti F,Miniaci A,Corona F,Gerloni V,Martino S,Pastore S,Barone P,Pieropan S,Cortis E,Podda RA,Gallizzi R,Civino A,La Torre F,Rigante D,Consolini R,Maggio MC,Magni-Man

    更新日期:2018-07-01 00:00:00

  • Effects of pravastatin in murine collagen-induced arthritis.

    abstract::Here we evaluated whether 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have beneficial effects for collagen-induced arthritis (CIA). DBA/1 mice were immunized with bovine type-II collagen and administered 100 mg/kg of pravastatin interperitoneally. We measured the effects of pravastatin for CIA...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Yamagata T,Kinoshita K,Nozaki Y,Sugiyama M,Ikoma S,Funauchi M

    更新日期:2007-05-01 00:00:00

  • Sarcopenia in systemic sclerosis: the impact of nutritional, clinical, and laboratory features.

    abstract::We evaluated the presence of sarcopenia in a population of systemic sclerosis (SSc) patients, with respect to nutritional, clinical, and laboratory features. A total of 62 patients who met the ACR/EULAR 2013 classification criteria were enrolled. Sarcopenia was defined according to the Relative Skeletal Mass Index (RS...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Corallo C,Fioravanti A,Tenti S,Pecetti G,Nuti R,Giordano N

    更新日期:2019-10-01 00:00:00

  • Regional migratory osteoporosis: case report of a patient with neuropathic pain.

    abstract::Regional migratory osteoporosis (RMO) is an idiopathic disorder characterized by severe periarticular pain, transient and migratory arthralgia, and osteoporosis. Osteoporosis in this disease may appear in the form of local regional osteoporosis and bone marrow edema or generalized osteoporosis. It occurs most commonly...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Kartal E,Sahin E,Dilek B,Baydar M,Manisali M,Kosay C,Gulbahar S

    更新日期:2011-10-01 00:00:00

  • Antinuclear antibodies measured by enzyme immunoassay in patients with systemic lupus erythematosus: relation to disease activity.

    abstract::To evaluate the correlation between measurements of antinuclear antibodies serum levels by enzyme immunoassay (ANA-EIA), and the degree of systemic lupus erythematosus disease activity. To retest the performance of the test compared to measurement of antinuclear antibodies by immunofluorescence (ANA-IIF). Eighty-five ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Paz E,Adawi M,Lavi I,Mussel Y,Mader R

    更新日期:2007-08-01 00:00:00

  • Paleopathological interpretations of hypermobility syndrome in the art from ancient America.

    abstract::Paleopathological representations of hypermobility syndrome were assumed in pre-Columbian artifacts from different ancient civilizations from America. Anthropomorphic sculptures from several museums and galleries visited on site or thru Internet show the human figure in contorted positions. These positions are only po...

    journal_title:Rheumatology international

    pub_type: 历史文章,杂志文章


    authors: Checa A

    更新日期:2012-10-01 00:00:00

  • Regulatory T cells in Behçet's disease: is there a correlation with disease activity? Does regulatory T cell type matter?

    abstract::The aim of this study was to investigate the percentage of regulatory T cells and the correlation with clinical activity in Behçet's disease. Forty Behçet's disease (BD) patients, 18 males and 22 females, were included in the study. The patients were diagnosed according to the published BD criteria. Twenty age- and se...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Gündüz E,Teke HU,Bilge NS,Cansu DU,Bal C,Korkmaz C,Gülbaş Z

    更新日期:2013-12-01 00:00:00

  • Macrophage activation syndrome in children with systemic juvenile idiopathic arthritis and systemic lupus erythematosus.

    abstract::Macrophage activation syndrome (MAS) is a hyper-inflammatory disorder secondary to a rheumatic disease such as systemic juvenile idiopathic arthritis (SJIA) and systemic lupus erythematosus (SLE). We aimed to present the characteristics of our pediatric MAS patients. Clinical features, laboratory parameters, treatment...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Aytaç S,Batu ED,Ünal Ş,Bilginer Y,Çetin M,Tuncer M,Gümrük F,Özen S

    更新日期:2016-10-01 00:00:00

  • Ultrastructural characterisation of macrophages (type A cells) in the synovial lining.

    abstract::The ultrastructural localisation of class II and macrophage antigens has been sought in the intimal layer of the human synovium. The cells described as type A in early morphological studies are shown to express both class II antigens and two markers of the macrophage/monocyte lineage of cells, OKM1 and MAB 24. The mor...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Mapp PI,Revell PA

    更新日期:1988-01-01 00:00:00

  • Thrombocytopenia as a presenting feature of Kawasaki disease: a case series from North India.

    abstract::Thrombocytosis is well described in children with Kawasaki disease (KD). We describe six children with KD who had thrombocytopenia at disease onset. This is an unusual finding and has clinical implications in the diagnosis of this condition. ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Singh S,Gupta D,Suri D,Kumar RM,Ahluwalia J,Das R,Varma N

    更新日期:2009-12-01 00:00:00

  • Measurement properties of Portuguese-Brazil Western Ontario and McMaster Universities osteoarthritis index (WOMAC) for the assessment of knee complaints in Brazilian adults: ELSA-Brasil Musculoskeletal cohort.

    abstract::Information on measurement properties of translated versions of the Western Ontario and McMaster Universities (WOMAC) osteoarthritis index is still limited. This study investigated the internal consistency, test-retest reliability/agreement, construct validity, and floor and ceiling effects of Portuguese-Brazil WOMAC ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Lage PTS,Machado LAC,Barreto SM,de Figueiredo RC,Telles RW

    更新日期:2020-02-01 00:00:00

  • Serum serotonin levels and bone in rheumatoid arthritis patients.

    abstract::In rheumatoid arthritis (RA), a disease characterized by bone loss, increased levels of serotonin have been reported. Recent studies have demonstrated a role for circulating serotonin as a regulator of osteoblastogenesis, inhibiting bone formation. Thus, we measured serum serotonin levels (SSL) in a Portuguese sample ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Bernardes M,Vieira T,Lucas R,Pereira J,Costa L,Simões-Ventura F,Martins MJ

    更新日期:2017-11-01 00:00:00

  • Hydroxychloroquine ototoxicity in a patient with rheumatoid arthritis.

    abstract::We report a case of reversible sensorineural hearing loss due to hydroxychloroquine (HQ) treatment. The patient was a 34-year-old woman with 1 year of rheumatoid arthritis (RA). She developed reversible hearing loss after 5 months of HQ treatment. Sensorineural deafness has previously been reported with chloroquine tr...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Seçkin U,Ozoran K,Ikinciogullari A,Borman P,Bostan EE

    更新日期:2000-01-01 00:00:00