Abstract：
:Articular involvement is a frequent extrahepatic manifestation of hepatitis C virus (HCV) infection. The distinction between HCV-related polyarthropathy and true RA may be very difficult, especially with recent onset RA before articular damage and erosions develop. The objective of the study is to assess the diagnostic utility of anti-CCP antibodies and compare it with that of rheumatoid factor (RF) in distinguishing between rheumatoid arthritis (RA) and HCV-related polyarthropathy. Anti-cyclic citrullinated peptide (CCP) antibodies and RF were determined in the sera of 30 patients with RA and 22 patients with HCV-related polyarthropathy. Anti-CCP antibodies were positive in 83.3% of patients with RA and in 4.5% in patients with HCV and polyarthropathy. RF was positive in 90% of RA patients and in 81.1% of HCV patients with polyarthropathy. The anti-CCP antibodies showed higher specificity for RA compared with RF (95.4 vs. 18.2%). However, the sensitivity of anti-CCP was comparable to that of RF (83.3 vs. 90%). In conclusions, anti-CCP antibodies are reliable laboratory markers to differentiate between RA and HCV-related polyarthropathy.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Ezzat WM,Raslan HM,Aly AA,Emara NA,El Menyawi MM,Edrees Adoi
10.1007/s00296-009-1225-8subject
Has Abstractpub_date
2011-01-01 00:00:00pages
65-9issue
1eissn
0172-8172issn
1437-160Xjournal_volume
31pub_type
杂志文章abstract：:Adult-onset Still's disease (AOSD) is a rare disease, and large epidemiological studies of this disease are limited. Furthermore, it has been difficult to show the incidence and characteristics of severe AOSD complications due to the rarity of this disease. The aim of our study was to describe the demographics of AOSD...
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journal_title：Rheumatology international
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pub_type： 临床试验,杂志文章
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journal_title：Rheumatology international
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pub_type： 杂志文章
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