Abstract:
:The objective was to investigate the effect of activin A on matrix metalloproteinase 3 (MMP-3) production and to identify the role of activin A in chondroprotection. SW1353 cells, a human chondrosarcoma cell line, were stimulated with interleukin (IL) 1alpha and tumor necrosis factor (TNF) alpha, and the concentrations of activin A, follistatin, and MMP-3 secreted into the culture media were measured by enzyme-linked immunosorbent assay (ELISA). Activin A was added to cell cultures in the presence of IL-1alpha or TNFalpha to determine its effect on the production of MMP-3 and sulfated glycosaminoglycan (sGAG) (measured by Alcian blue assay). To study the mechanism responsible for the chondroprotective effects of activin A, the production of IL-1 receptor antagonist (IL-1ra) and tissue inhibitor for metalloproteinases 1 (TIMP-1) was examined by ELISA. Addition of IL-1alpha did not affect the production of activin A by cultured SW1353 cells. IL-1alpha and activin A inhibited the production of follistatin. Stimulation of SW1353 cells with activin A suppressed IL-1alpha-induced, but not TNFalpha-induced, MMP-3 expression. Activin A had no effect on the production of sGAG, IL-1ra, or TIMP-1, although it suppressed the induction of TIMP-1 and IL-1ra by IL-1alpha. This novel finding of MMP-3 inhibition by activin A suggests a new role of activin A in cartilage remodeling. Activin A may have therapeutic potential for preventing cartilage degradation.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Chang DM,Liu SH,Lee HS,Lai JH,Chen CHdoi
10.1007/s00296-007-0350-5subject
Has Abstractpub_date
2007-09-01 00:00:00pages
1049-55issue
11eissn
0172-8172issn
1437-160Xjournal_volume
27pub_type
杂志文章abstract::The objective of the study was to determine the clinical features and treatment course in Canadian patients with dermatomyositis (DM) associated with the anti-melanoma differentiation-associated gene 5 antibody (MDA5). A retrospective chart review of consecutive patients with anti-MDA5 antibody DM from two Canadian te...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-019-04398-2
更新日期:2019-11-01 00:00:00
abstract::Intraperitoneal injection of pristane induced a clinical peripheral arthritis and/or tenosynovitis in 40% of 40 Balb/cJ/Ola mice. Hind paws were always affected first and fore paws were frequently involved. Involvement of knee joints was only apparent histologically. Some clinically unaffected animals and apparently u...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541361
更新日期:1984-01-01 00:00:00
abstract::A total of 95 patients suffering from active rheumatoid arthritis were included in this double-blind, placebo-controlled study of the immunomodulator OM-8980. Treatment was one capsule daily of OM-8980 or placebo for 6 months. A significant improvement was observed in the OM-8980 group in comparison with the placebo g...
journal_title:Rheumatology international
pub_type: 临床试验,杂志文章
doi:10.1007/BF00270248
更新日期:1989-01-01 00:00:00
abstract::To investigate the effects of TNF-alpha -308, -238 promoter polymorphisms on TNF-alpha transcription in B27 positive Chinese patients with ankylosing spondylitis (AS). The possible relationship between polymorphisms, MHC antigens, and quantitative TNF-alpha mRNA expression were evaluated. Single nucleotide polymorphis...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0671-z
更新日期:2008-12-01 00:00:00
abstract::Uveitis is an important component of many rheumatic diseases. The main causes of recurrent uveitis are seronegative spondylarthropathies and Behçet's disease. We describe a rare case of Henoch Schönlein vasculitis (HSV) along with multiple recurrences of acute anterior uveitis. In cases of skin rash and recurrent ante...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1074-5
更新日期:2010-08-01 00:00:00
abstract::The purpose of the present study was to evaluate the toxicity and tolerability of methotrexate (MTX)/gold (G; group 1) combination therapy as compared to other MTX combinations [MTX with hydroxychloroquine (HCQ; group 2), MTX with sulphasalazine (SASP; group 3) and MTX with minocycline (MNC; group 4)]. The hospital re...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/pl00006851
更新日期:1997-01-01 00:00:00
abstract::Systemic Sclerosis (SSc) is an autoimmune disease characterized by fibrosis and vasculopathy. A key feature is the presence of T cells in inflammatory lesions. To establish the differences in peripheral blood T helper (Th) subpopulations in diffuse cutaneous (dc) and limited cutaneous (lc) SSc patients, blood samples ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-2056-y
更新日期:2012-09-01 00:00:00
abstract::Behçet disease (BD) is an inflammatory disorder of unknown origin. We present here an unusual case of juvenile Behçet with hemoptysis due to large pulmonary artery aneurysms (PAA), large intra-cardiac thrombus and prolonged fever, which posed several therapeutic challenges. In this case, a 14-year-old boy was admitted...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0730-5
更新日期:2009-03-01 00:00:00
abstract::Cardiovascular disease (CVD) morbidity and mortality is highly prevalent in patients with rheumatoid arthritis (RA) with debilitating effects for the individual as well as significant healthcare impact. Current evidence demonstrates that engaging in aerobic and resistance exercise (i.e. structured physical activity) c...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-019-04483-6
更新日期:2020-03-01 00:00:00
abstract::Vasculitides associated with anti-neutrophil cytoplasmic antibodies are heterogeneous, systemic, low prevalence and high morbidity and mortality entities. They include granulomatosis with polyangiitis, microscopic polyangiitis and eosinophilic granulomatosis with polyangiitis. In Latin America, there are few descripti...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-020-04631-3
更新日期:2020-08-01 00:00:00
abstract::We studied the relationships between physician-assessed damage, severity and activity in a large, multicentre systemic sclerosis (SSc, scleroderma) cohort. We hypothesized that there is a relationship between disease activity and severity and damage, but that severity would be more strongly related to damage. A total ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1129-7
更新日期:2010-07-01 00:00:00
abstract::The objectives of the study were to evaluate the prevalence of antinuclear antibodies (ANA) in patients with fibromyalgia (FM) and the probability of the development of clinically overt connective tissue diseases. Four hundred and fifty FM patients were compared to 129 healthy matched blood donors. ANA testing was per...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-007-0413-7
更新日期:2007-09-01 00:00:00
abstract::The aim was to evaluate the relative importance of the 20 functions assessed by patients to produce the Health Assessment Questionnaire's Disability Index (HAQ-DI). A systematic sample of 242 rheumatoid arthritis patients was drawn. Altogether 179 subjects returned acceptably filled questionnaire including perceived r...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1176-0
更新日期:2010-09-01 00:00:00
abstract::A 42-year-old woman presented with a 3-week history of left knee pain and swelling. She had suffered dermatitis herpetiformis for 12 years, proved by skin biopsy. She had never been on gluten-free diet. Knee pain increased with motion and her gait was antalgic. On admission, she was mainly dependent on wheelchair due ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1670-4
更新日期:2011-05-01 00:00:00
abstract::The role of free radicals in fibromyalgia is controversial. In this study, 85 female patients with primary fibromyalgia and 80 age-, height-, and weight-matched healthy women were evaluated for oxidant/antioxidant balance. Malondialdehyde is a toxic metabolite of lipid peroxidation used as a marker of free radical dam...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-003-0427-8
更新日期:2005-04-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-005-0085-0
更新日期:2006-03-01 00:00:00
abstract:INTRODUCTION:Early arthritis clinics (EACs) have been well established since 1980s. Most of the data for their effectiveness comes from rheumatoid arthritis (RA) management and is largely limited to process outcomes. There is little evidence that such clinics improve clinical outcomes particularly for psoriatic arthrit...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-019-04253-4
更新日期:2019-04-01 00:00:00
abstract::The capillaroscopic pattern in paraneoplastic Raynaud's phenomenon (RP) has not been investigated systematically and is not well-defined. Here, we present three case reports of patients with paraneoplastic rheumatic conditions, manifested with severe secondary RP with emphasis upon capillaroscopic findings. The first ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1715-8
更新日期:2013-06-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541162
更新日期:1982-01-01 00:00:00
abstract::Several chronic inflammatory disorders, such as rheumatoid arthritis and systemic lupus erythematosus, are associated with an increased risk of coronary artery disease (CAD) as a result of accelerated atherosclerosis. However, the data on CAD risk of polymyalgia rheumatica (PMR), one of the most common chronic inflamm...
journal_title:Rheumatology international
pub_type: 杂志文章,meta分析,评审
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更新日期:2017-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0570-3
更新日期:2008-08-01 00:00:00
abstract::Osteoporosis has become an increasingly recognized complication among patients with chronic liver disease (CLD). The aim of the present study was to assess the prevalence and risk factors of osteoporosis in patients with CLD (primary biliary cirrhosis and chronic viral hepatitis B or C patients) in comparison with a g...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1071-8
更新日期:2010-05-01 00:00:00
abstract::Arachnoid ossificans is a rare type of chronic arachnoiditis characterised by the presence of calcification or ossification of the dura and arachnoid. There are a few reports of these findings in relation to various disease entities, but only one case has been reported in relation to ankylosing spondylitis. We describ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-2293-0
更新日期:2013-06-01 00:00:00
abstract::P wave dispersion (PWD) is a sign for the prediction of atrial fibrillation (AF). The aim of this study was to assess P wave dispersion and its relation with clinical and echocardiographic parameters in patients with rheumatoid arthritis (RA). Thirty RA patients (mean age 49 +/- 10 years) and 27 healthy controls (mean...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-007-0307-8
更新日期:2007-07-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-012-2365-9
更新日期:2013-02-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0739-9
更新日期:2009-04-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-014-3046-7
更新日期:2014-12-01 00:00:00
abstract::Clinical presentation of fibromyalgia syndrome (FMS) is heterogeneous and often involves psychological comorbidities. Clinical subgrouping of FMS patients has been proposed as a strategy to improve patients' long-term outcomes by helping identify specific treatment needs. Using the 90 Symptom Checklist Revised (SCL-90...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-2199-x
更新日期:2012-11-01 00:00:00
abstract::Neurocognitive dysfunction and brain injury on magnetic resonance imaging (MRI) are common in patients with systemic lupus erythematosus (SLE) and are associated with increased morbidity and mortality. However, brain MRI is expensive, is restricted by payers, and requires high expertise. Neurocognitive assessment is a...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-018-4080-7
更新日期:2018-08-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1256-1
更新日期:2011-10-01 00:00:00