Abstract：
:Adult-onset Still's disease (AOSD) is a rare disease, and large epidemiological studies of this disease are limited. Furthermore, it has been difficult to show the incidence and characteristics of severe AOSD complications due to the rarity of this disease. The aim of our study was to describe the demographics of AOSD and the incidence and characteristics of severe complications. Using a large Japanese administrative database, we identified hospitalized patients with AOSD and described the demographics. We also calculated the incidence of severe complications (i.e., macrophage activation syndrome [MAS] and disseminated intravascular coagulation [DIC]) and in-hospital mortality in AOSD patients, and then analyzed the age-controlled difference between men and women. We identified 513 patients with AOSD (mean age: 53.1 years; women 64.1 %). According to the age distribution, there was no distinct peak age. The thirties and the sixties were relatively large age groups. There were 76 patients of AOSD with MAS or DIC observed in this study. The incidence of severe complications was 14.8 %, 95 % CI [11.9, 18.2]. Women were more likely to have severe complications than men after controlling for age (odds ratio: 2.07; [1.14, 3.73]; p = 0.014). AOSD does not predominantly affect young adults in our study population. Elderly AOSD patients can be observed more than before due to global population aging. Severe complications are more likely to occur in women than in men.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Sakata N,Shimizu S,Hirano F,Fushimi Kdoi
10.1007/s00296-016-3546-8subject
Has Abstractpub_date
2016-10-01 00:00:00pages
1399-405issue
10eissn
0172-8172issn
1437-160Xpii
10.1007/s00296-016-3546-8journal_volume
36pub_type
杂志文章abstract：:Previous studies have demonstrated an increased risk of breast cancer among patients with systemic sclerosis (scleroderma). To describe the clinical characteristics of 21 patients with both systemic sclerosis and breast cancer, and compare their risk factors to female scleroderma patients without breast cancer, in a p...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0540-9
更新日期：2008-07-01 00:00:00
abstract：:TNF-α is one of the key proinflammatory cytokines in pathogenesis of rheumatoid arthritis (RA). TNF-α was also found to enhance synthesis of leptin. Leptin is mainly adipocyte-derived hormone controlling appetite and energy expenditure. It acts through inhibition of neuropeptide Y secretion. It is possible that TNF-α-...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2182-6
更新日期：2012-11-01 00:00:00
abstract：:Systemic sclerosis (SSc) is an autoimmune rheumatic disease characterised by vasculopathy, inflammation and fibrosis in multiple organs and occasionally coexists with rheumatic conditions, such as axial spondyloarthritis (axSpA). The aim of this study was to demonstrate the successful use of tofacitinib in SSc and axi...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-020-04767-2
更新日期：2021-01-12 00:00:00
abstract：:The expressions of some terminal glycotopes of synovial immunoglobulins G, A, and M were analysed in relation to rheumatoid arthritis (RA) progression defined according to early and advanced radiological changes in patients' hands. The relative amounts of terminal monosaccharides were determined by lectin-immunoblotti...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1139-5
更新日期：2010-08-01 00:00:00
abstract：:Acromegaly is a chronic endocrinopathy characterized by hypersecretion of growth hormone (GH) and consequently of insulin-like growth factor-1 (IGF-1). The arthropathy in acromegaly is the most frequent and important cause of morbidity and functional disability in acromegaly. Rheumatoid arthritis (RA) is a rarely repo...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1490-6
更新日期：2012-09-01 00:00:00
abstract：BACKGROUND:Although not validated fully, recommendations are present for diagnosis, screening and treatment modalities of patients with familial Mediterranean fever (FMF). OBJECTIVE:To review the current practices of clinicians regarding FMF and reveal their adherence to consensus guidelines. METHODS:Fifteen key poin...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04776-1
更新日期：2021-01-16 00:00:00
abstract：:Using commercially available antigens, enzyme-linked immunosorbent assays (ELISAs) were set up to demonstrate antibodies of IgG class against Sm and SS-A. Anti-Sm antibodies were demonstrated in 40% of patients with systemic lupus erythematosus (SLE), in 12% of patients with SJögren's syndrome, in 6% of patients with ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00332564
更新日期：1991-01-01 00:00:00
abstract：:In a study of synovial fluid from 110 patients with various forms of arthritis, platelets were identified in the synovial fluid of all the 50 rheumatoids, in 18 out of the 25 (72%) with osteoarthritis and in all 35 of those with other forms of inflammatory osteoarthrosis. Identification of platelets by light microscop...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00683878
更新日期：1984-01-01 00:00:00
abstract：:Uveitis is an important component of many rheumatic diseases. The main causes of recurrent uveitis are seronegative spondylarthropathies and Behçet's disease. We describe a rare case of Henoch Schönlein vasculitis (HSV) along with multiple recurrences of acute anterior uveitis. In cases of skin rash and recurrent ante...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1074-5
更新日期：2010-08-01 00:00:00
abstract：:The aim of this study was to investigate the association of three polymorphisms of CD154 with risk of SLE in Chinese population. The study population comprised 770 Chinese individuals, including 350 SLE patients and 420 healthy controls. The gene polymorphism was measured using Snapshot SNP genotyping assays and confi...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-017-3745-y
更新日期：2017-08-01 00:00:00
abstract：:The FRAX tool that calculates the 10-year probability of having a fracture has recently been validated for Belgium. Little is known about the perception and knowledge that GPs have about this tool in their daily practice. A survey has been conducted as part of a screening campaign for various diseases. The primary obj...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2461-x
更新日期：2013-04-01 00:00:00
abstract：:To determine the forms and characteristics of rheumatic diseases whose initial presentation mimics septic arthritis. Retrospective study of 398 patients hospitalized between 1979 and 2005 for arthritis diagnosed and treated as septic. In 10 cases, initial presentation of a rheumatic disease was highly suggestive of se...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2364-x
更新日期：2013-08-01 00:00:00
abstract：:Echocardiographic examination and 24-h electrocardiographic Holter monitoring were carried out on 35 patients with nodular rheumatoid arthritis (RA) and 35 with non-nodular RA, who were matched with the nodular RA group regarding age, sex and BSA. A further 35 patients with osteoarthrosis and spondyloarthrosis matched...
journal_title：Rheumatology international
pub_type： 临床试验,杂志文章
doi：10.1007/s002960050079
更新日期：1999-01-01 00:00:00
abstract：:Acute pseudogout of the neck, also known as the crowned dens syndrome, is a rare cause of neck pain characterised by crystalline deposition in periodontoid articular tissues. It is typified clinically by severe cervical pain and stiffness, often in conjunction with pyrexia and raised inflammatory markers. As such, it ...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-009-1145-7
更新日期：2011-01-01 00:00:00
abstract：KEY MESSAGES:No difference between both hands was observed for clinical and radiographical presentations in EHOA patients. A bilateral and symmetrical relationship was found between hand joints. HIGHLIGHTS:EHOA have symmetrical distribution and specific association in structural lesions. This study aims to analyse the...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04784-1
更新日期：2021-01-27 00:00:00
abstract：:To investigate the effects of TNF-alpha -308, -238 promoter polymorphisms on TNF-alpha transcription in B27 positive Chinese patients with ankylosing spondylitis (AS). The possible relationship between polymorphisms, MHC antigens, and quantitative TNF-alpha mRNA expression were evaluated. Single nucleotide polymorphis...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0671-z
更新日期：2008-12-01 00:00:00
abstract：:The minor allele of the non-synonymous single nucleotide polymorphism (SNP) +1858C>T within the PTPN22 gene has now been unequivocally confirmed as conferring susceptibility to RA in population from Europe and America, but not in population from Asia. The aim of this study was to jointly address and integrate these se...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1705-x
更新日期：2012-03-01 00:00:00
abstract：:Takayasu's arteritis (TA) is a rare chronic vasculitis of the aorta and its main branches. Infectious agents or autoimmunity are thought to influence the pathophysiology. Ethnic preponderance in East Asia and usually affects young Asian women suggesting a possible role of genetic factor in the etiology. We present a r...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1234-7
更新日期：2011-06-01 00:00:00
abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease that causes joint pain, inflammation, and loss of function. Disease pathogenesis involves activation and proliferation of autoreactive pro-inflammatory effector T cells. While the details of RA onset and progression remain controversial, dendritic cell (DC) nu...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-017-3671-z
更新日期：2017-07-01 00:00:00
abstract：:The aim was to evaluate the relative importance of the 20 functions assessed by patients to produce the Health Assessment Questionnaire's Disability Index (HAQ-DI). A systematic sample of 242 rheumatoid arthritis patients was drawn. Altogether 179 subjects returned acceptably filled questionnaire including perceived r...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1176-0
更新日期：2010-09-01 00:00:00
abstract：:3-Aminobenzamide is an inhibitor of poly-(ADP-ribosyl)ation. In concentrations from 3 to 10 mM it reduced the collagenase activity in culture supernatants of interleukin-1 beta-stimulated rabbit synovial fibroblasts. 3-Aminobenzoate, not an inhibiter of poly(ADP-ribosyl)ation, had no effect on collagenase activity at ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00301776
更新日期：1995-01-01 00:00:00
abstract：:IgM, IgG and IgA class antibodies against Yersinia, Salmonella, Campylobacter and Borrelia were determined by enzyme-linked immunosorbent assay (ELISA) in a group of 340 unselected patients with a recent inflammatory joint disease. The control group consisted of 340 and 100 healthy blood donors using Borrelia-ELISA an...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF02274884
更新日期：1991-01-01 00:00:00
abstract：:Chondrocyte structure and function under the influence of two gold-containing therapeutic agents, aurothioglucose and triethylphosphine gold, were studied in a monolayer culture system for cultivating lapine articular chondrocytes. The functional parameters investigated were chondrocyte proliferation and the incorpora...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541144
更新日期：1983-01-01 00:00:00
abstract：:The aim of this study was to investigate the prevalence, predictors and radiological findings of primary Sjögren's syndrome (pSS)-associated lung involvement. This retrospective cohort study included 123 patients with demographic, clinical, laboratory and radiological data who were diagnosed with pSS. Lung involvement...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1152-8
更新日期：2010-08-01 00:00:00
abstract：:Reported here is a 19-year-old female patient with familial Mediterranean fever who was seen for altered mental status and seizures. She was eventually diagnosed to have posterior reversible leukoencephalopathy syndrome. Although a variety of conditions have been reported in association with this syndrome, to our best...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1388-3
更新日期：2012-06-01 00:00:00
abstract：:Therapeutic proteins, such as infliximab, have revolutionized the treatment of many diseases during the last decade and more than 80 therapeutic proteins are currently approved for clinical use. However, all exogenous proteins have the potential to cause antibody formation. In order to ensure patient safety and the ef...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-005-0085-0
更新日期：2006-03-01 00:00:00
abstract：:Cyclooxygenase-2 (COX-2) is a key regulatory enzyme in the synthesis of prostanoids associated with trauma and inflammation. Upregulation of COX-2 in human lupus T cells resists anergy and apotosis. We investigated the COX-2 gene for functional variants that may influence susceptibility, clinical outcomes and severity...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-006-0162-z
更新日期：2006-11-01 00:00:00
abstract：:A 50-year-old man presented with a complaint of low-back pain and widespread joint pain for the previous 20 years. Conventional radiography revealed wide areas of calcification in the intervertebral discs and degenerative changes in the peripheral joints. A diagnosis of ochronosis was made by the observation of bluish...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-007-0381-y
更新日期：2007-11-01 00:00:00
abstract：:The purpose of this study was to detect the frequency of inflammatory cervical spine changes and characteristic features such as resorption in rheumatoid arthritis (RA) with arthritis mutilans (AM) hand deformity. The series included 23 patients with AM hand deformity who fulfilled the 1987 American Rheumatism Associa...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s002960100114
更新日期：2001-08-01 00:00:00
abstract：:In a Turkish League Against Rheumatism (TLAR) project, evidence-based recommendations for the management of knee osteoarthritis (OA) was developed for the first time in our country in 2012 (TLAR-2012). In accordance with developing medical knowledge and scientific evidence, recommendations were updated. The committee ...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-018-4044-y
更新日期：2018-08-01 00:00:00
