Abstract:
:To describe the profile of Enthesitis Related Arthritis' (ERA) patients, in the era of biologic DMARDs (bDMARDs). This retrospective cohort study included patients with ERA monitored on a 3-month schedule for at least 1 year. Their metric assessment included the disease status and damage by applying the contemporary tools clinical-Juvenile Arthritis Disease Activity Score (c-JADAS), Juvenile Spondyloarthritis Disease Activity Index (JSpADA), clinical remission (CR) on/off medication and Juvenile Arthritis Damage Index (JADI). 43 patients (males 26) were enrolled, with a mean disease onset of 10.75 years. Median lag time from diagnosis to bDMARDs was 8.5 months. Patients with sacroiliitis received earlier bDMARDs (hazard ratio, HR 3.26). 36/43 patients achieved CR on medication (median time 11 months), which was correlated with compliance (HR: 3.62). The percentage of CR in patients with or without sacroiliitis was 35% and 63% respectively (p = 0.02). Twenty patients (47%) experienced a flare following CR (75%). The median flare-free survival following CR on/off medication was 42 and 34 months, respectively. At the last evaluation, both median baseline cJADAS and JSpADA dropped to 0, 13/43 patients had a persistent disease activity, while 17/43 and 13/43 patients were in CR on/off medication, respectively. The median patient percentage of CR was 54% and no patient had a JADI > 0. Increased lag time to bDMARDs was associated with increased CR (Odds ratio: 1.48). Early administration of bDMARDs and compliance improved long-term outcome of ERA. Sacroiliitis was a negative prognostic factor with an increased need for bDMARDs and diminished rates of CR.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Deligeorgakis D,Trachana M,Pratsidou-Gertsi P,Dimopoulou D,Haidich AB,Garyfallos Adoi
10.1007/s00296-020-04581-wsubject
Has Abstractpub_date
2020-06-01 00:00:00pages
941-949issue
6eissn
0172-8172issn
1437-160Xpii
10.1007/s00296-020-04581-wjournal_volume
40pub_type
杂志文章abstract::Anti-Saccharomyces cerevisiae antibodies (ASCA) had been known to be specific for Crohn's disease but it has been found in many other autoimmune diseases like systemic lupus erythematosus (SLE). Furthermore, cross-reactive epitopes on β2-glycoprotein I (β2GPI) and Saccharomyces cerevisiae were found in SLE patients. T...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-012-2431-3
更新日期:2013-03-01 00:00:00
abstract::The aim of this study was to investigate (a) the mortality in a clinical cohort of patients with established rheumatoid arthritis in comparison with the general Dutch population over 15 years, (b) the trend in the mortality ratio during the study period, and (c) causes of death and compare these with the general popul...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-016-3638-5
更新日期:2017-04-01 00:00:00
abstract::Serotonin antagonists show impressive analgesic efficacy in rheumatoid arthritis, osteoarthritis (OA) or fibromyalgia; however, this effect is not well understood. We examined the mechanism of serotonin-induced inflammation and its antagonists in OA. Serotonin receptor subtypes and COX-2 were analysed by RT-PCR from s...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0564-1
更新日期:2008-08-01 00:00:00
abstract::Protein synthesis in all cells is readily interrupted by environmental stresses such as hyperthermia. However, stressed cells also have mechanisms which, even under conditions where normal protein synthesis is completely inhibited, allow them to synthesise a group of highly conserved proteins--the so-called heat shock...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/BF00541323
更新日期:1990-01-01 00:00:00
abstract::The minor allele of the non-synonymous single nucleotide polymorphism (SNP) +1858C>T within the PTPN22 gene has now been unequivocally confirmed as conferring susceptibility to RA in population from Europe and America, but not in population from Asia. The aim of this study was to jointly address and integrate these se...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1705-x
更新日期:2012-03-01 00:00:00
abstract::Monogenic autoinflammatory syndromes are a rare group of disorders characterized by periodic episodes of systemic inflammation of endogenous origin. Sometimes, these diseases may present with features akin to vasculitis. We conducted a literature review on such vasculitic manifestations in described monogenic autoinfl...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-017-3839-6
更新日期:2018-01-01 00:00:00
abstract::Non-tuberculous mycobacteria (NTM) are an unusual cause of osteomyelitis in immunocompetent children. Diagnosis is often difficult due to the paucity of clinical symptoms and a subtle course of the disease. NTM comprise a group of about 91 identified species of environmental mycobacteria that cause infections most fre...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-0844-4
更新日期:2009-10-01 00:00:00
abstract::Neopterin levels of serum and fluid were determined in 30 patients with inflammatory synovial fluids and in 30 controls with joint effusions induced by trauma or osteoarthritis. Neopterin was significantly elevated in inflammatory fluids. There was no correlation with the acute phase reactants. Neopterin levels were s...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541281
更新日期:1986-01-01 00:00:00
abstract::To study the clinical presentation, treatment and outcome of southern Chinese patients with Takayasu's arteritis (TA). This is a retrospective chart review study of 78 patients managed in 14 public hospitals in Hong Kong between the years 2000 and 2010. Patients were identified from the hospital registry using the ICD...
journal_title:Rheumatology international
pub_type: 杂志文章,多中心研究
doi:10.1007/s00296-018-4150-x
更新日期:2018-12-01 00:00:00
abstract::We describe a patient with bronchiolitis obliterans organizing pneumonia (BOOP) requiring respiratory support and treated with corticosteroids and cytoxan for presumed Wegener's granulomatosis (WG). The diagnosis of WG was based on clinical presentation and strongly positive stains for anti-neutrophilic cytoplasmic an...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s002960000095
更新日期:2001-04-01 00:00:00
abstract::Systemic Sclerosis (SSc) is an autoimmune disease characterized by fibrosis and vasculopathy. A key feature is the presence of T cells in inflammatory lesions. To establish the differences in peripheral blood T helper (Th) subpopulations in diffuse cutaneous (dc) and limited cutaneous (lc) SSc patients, blood samples ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-2056-y
更新日期:2012-09-01 00:00:00
abstract::Diabetic muscular infarct (DMI) is a rare condition, which begins with acute onset of extremity pain and swelling. Patients usually have long-standing disease and poorly controlled diabetes mellitus (DM). Thigh muscle group is the most commonly involved side, while lower leg involvement is rare. We represent herein a ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1759-9
更新日期:2012-02-01 00:00:00
abstract::The association of familial Mediterranean fever (FMF) and polyarteritis nodosa (PAN) has been well established. These patients have been reported to have an overall better prognosis than other PAN patients. Herein we report a patient with FMF and PAN who died of sepsis following a severe course of recurrent bleeding e...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-003-0424-y
更新日期:2005-01-01 00:00:00
abstract::The purpose of this study was to investigate specifically the correlation of hand functions determined by Duruoz hand index (DHI) with radiological findings and disease activity in rheumatoid arthritis (RA) patients. Forty-eight RA patients were evaluated with DHI questionnaire, disease activity score (DAS) 28 and mod...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-007-0461-z
更新日期:2008-03-01 00:00:00
abstract::Although subclinical liver disease is common in systemic lupus erythematosus (SLE), strikingly high levels of liver enzymes are rare. Our aim was to determine the cause of high levels of liver enzymes in lupus patients, particularly in patients diagnosed with toxic hepatitis. We performed a retrospective chart review ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1237-4
更新日期:2011-01-01 00:00:00
abstract::Using a sensitive and specific enzyme-linked immunosorbent assay (ELISA) assay we showed that the cryoglobulins of a patient with Lucio phenomenon contain phenolic glycolipid I antigen and a specific antibody. ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541512
更新日期:1986-01-01 00:00:00
abstract::HLA-DR antigens were determined in 111 patients with classic or definite rheumatoid arthritis. HLA-DR4 was significantly (P corr. less than 10(-6] increased in patients with rheumatoid arthritis (54%) compared with controls (23.2%). HLA-DR 5 was decreased in rheumatoid arthritis (12.6% vs 26.4% of controls); however, ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541190
更新日期:1983-01-01 00:00:00
abstract::Low back pain is considered a problem with multiple facets for which the underlying causative factors should be determined. The aim of this study was to evaluate the relationships between depression, clinical status, and radiographic findings in a group of fifty patients with low back pain for more than 6 months. The ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s002960100133
更新日期:2001-10-01 00:00:00
abstract::Our study was aimed to clarify an association between gastrointestinal (GI) amyloid-positive area and various kinds of factors including renal function in reactive amyloidosis associated with rheumatoid arthritis (RA). Twenty-five patients with an established diagnosis of reactive AA amyloidosis participated in the st...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1719-4
更新日期:2012-04-01 00:00:00
abstract::Sjögren's syndrome (SjS) and systemic lupus erythematosus (SLE) are common systemic autoimmune diseases, which impact not only patient health but also their quality of life. miRNA-146a is a microRNA that participates in the pathophysiology of SjS and SLE. In this investigation, we conducted a meta-analysis to determin...
journal_title:Rheumatology international
pub_type: 杂志文章,meta分析
doi:10.1007/s00296-017-3756-8
更新日期:2017-08-01 00:00:00
abstract::The aim of this study was to compare health related quality of life (HRQoL) and assess functional and psychological status in rheumatoid arthritis (RA), fibromyalgia syndrome (FS) patients and controls (each 30 subjects). Demographic characteristics, pain and sleep disturbance by Visual Analog Scale, depression by Bec...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0551-6
更新日期:2008-07-01 00:00:00
abstract::The aim of the study was the thermovisual comparison of mean temperature of hand surface changes after local cryotherapy with vapors of nitrogen (-160°C) and cold air (-30°C). Forty-seven patients with rheumatoid arthritis (39 women and 8 men; average age 56.2 ± 10.5 years) were included in the study. They had the app...
journal_title:Rheumatology international
pub_type: 临床试验,杂志文章
doi:10.1007/s00296-011-2078-5
更新日期:2012-10-01 00:00:00
abstract::Chronic inflammatory syndromes such as rheumatoid arthritis (RA) are associated with high frequencies of CD4+CD28- T cells. The number of these cells is genetically determined and may also be a consequence of chronic exposure to tumor necrosis factor-alpha (TNFalpha). The aim of this study was to examine whether the r...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-003-0374-4
更新日期:2004-11-01 00:00:00
abstract::The purpose of this study was to demonstrate the direct effects of celecoxib, one of the selective cyclo-oxygenase (COX)-2 inhibitors, on nitric oxide (NO) and prostaglandinE2 (PGE2) synthesis in cultured osteoarthritic chondrocyte comparing with those of indomethacin. Articular chondrocytes were isolated from rat ost...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-006-0107-6
更新日期:2006-09-01 00:00:00
abstract::To study the combined effect of both genetic and environmental factors in the age of rheumatoid arthritis onset. Patients (n = 507). Shared epitope characterization was performed using Lifecodes HLA-SSO. Genotyping of protein tyrosine phosphatase non-receptor 22 (PTPN22) rs2476601 and signal transducers and activators...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-2090-9
更新日期:2012-10-01 00:00:00
abstract::Autoimmune diseases (AID) are caused by the loss of immunological tolerance against self-antigens. The deoxyribonuclease I (DNASE1) gene seems to participate in the genetic susceptibility of some AID. In fact, two mutations were reported among systemic lupus erythematosus (SLE) patients from Japan and Spain (the 172 A...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-0917-4
更新日期:2009-11-01 00:00:00
abstract::The fibromyalgia syndrome (FMS) is a chronic, widespread pain disorder of unknown etiology. It has been suggest that familial component, environmental factors, endocrine and neurotransmitter alterations, and psychological factors may contribute to the development of FMS. The role of melatonin in FMS is unclear. Some s...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-2315-y
更新日期:2013-06-01 00:00:00
abstract::Individual differences in adjustment during a disease's course determine psychological response and outcome. This study aimed to investigate prospectively whether coping with health stressors and self-sacrificing defense style could predict psychological adjustment and health-related quality of life (HRQoL) in patient...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-014-3134-8
更新日期:2015-04-01 00:00:00
abstract::Acute pseudogout of the neck, also known as the crowned dens syndrome, is a rare cause of neck pain characterised by crystalline deposition in periodontoid articular tissues. It is typified clinically by severe cervical pain and stiffness, often in conjunction with pyrexia and raised inflammatory markers. As such, it ...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-009-1145-7
更新日期:2011-01-01 00:00:00
abstract::Life expectancy in autoimmune rheumatic diseases (ARDs) remains lower compared to the general population, due to various comoborbidities. Cardiovascular disease (CVD) represents the main contributor to premature mortality. Conventional and biologic disease-modifying antirheumatic drugs (DMARDs) have considerably impro...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-018-4004-6
更新日期:2018-06-01 00:00:00