Abstract:
:Sjögren's syndrome (SjS) and systemic lupus erythematosus (SLE) are common systemic autoimmune diseases, which impact not only patient health but also their quality of life. miRNA-146a is a microRNA that participates in the pathophysiology of SjS and SLE. In this investigation, we conducted a meta-analysis to determine the relationship of miR-146a to primary SjS (PSS) and to SLE. The following databases were interrogated; Pubmed, Cochrane Central Register of Controlled Trials, WANFANG, Chinese National Knowledge Infrastructure, and WEIPU. Standard mean difference with 95% confidence intervals (CI) were used to study the relationship between miRNA-146a expression and thee diseases by random-effects model. A total of six studies, with 158 cases and 124 controls were included for the meta-analysis. The meta-analysis shows that miRNA-146a expression is associated with the risk of PSS (MD = 6.32, p = 0.005). No relationship between miR-146a expression and SLE was identified (MD = -0.86, p = 0.26). SLE subgroup analysis (peripheral blood mononuclear cells and serum) confirmed this result. The risk for PSS is related to miR-146a expression, while miRNA-146a expression is not related to SLE. As such, miRNA-146a may serve as a novel biomarker for the diagnosis of PSS, but not SLE.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Sun HY,Lv AK,Yao Hdoi
10.1007/s00296-017-3756-8subject
Has Abstractpub_date
2017-08-01 00:00:00pages
1311-1316issue
8eissn
0172-8172issn
1437-160Xpii
10.1007/s00296-017-3756-8journal_volume
37pub_type
杂志文章,meta分析abstract::Fluoride excess primarily effects dental and skeletal tissues. leading to a condition known as endemic fluorosis. The radiological and clinical features of endemic fluorosis vary in different parts of the world. The aim of this study was to investigate the clinical and radiological features of endemic fluorosis in Tur...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s002960100132
更新日期:2001-09-01 00:00:00
abstract::We aimed to determine left ventricular (LV) and right ventricular (RV) structure, function and mechanics, as well as heart rate variability (HRV), and their relationship, in patients with systemic sclerosis (SSc). The study included 41 SSc patients and 30 age-matched healthy volunteers. All the patients underwent clin...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-016-3618-9
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abstract::Biological treatments aiming to neutralize TNF-alpha (tumour necrosis factor alpha) (infliximab, adalimumab and etanercept) are increasingly used to treat rheumatoid arthritis (RA). Although increased frequency has not been observed in randomized clinical trials with TNF-alpha antagonist agents, postmarketing surveill...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-006-0165-9
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541219
更新日期:1981-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章,随机对照试验
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abstract::Wegener granulomatosis (WG) is a necrotizing granulomatous vasculitis that predominantly affects airways and kidneys. But central nervous system involvement (7-11%) is an uncommon. Massive ICH may occur in the course of WG, and this serious condition is related with high risk of mortality. Therefore, the new treatment...
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pub_type: 杂志文章
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-005-0085-0
更新日期:2006-03-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章,实务指引,评审
doi:10.1007/s00296-011-2126-1
更新日期:2012-05-01 00:00:00
abstract::Monocyte interleukin-1 (IL-1) production in vitro was studied in 49 patients with rheumatoid arthritis (RA) and 31 controls. Twenty-six of the RA patients were studied prospectively for up to 12 months after beginning chrysotherapy. About half of the patients (group 1) exhibited pretreatment levels of monocyte IL-1 se...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF02274840
更新日期:1990-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1395-4
更新日期:2012-05-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1329-1
更新日期:2010-11-01 00:00:00
abstract::A 42-year-old woman presented with a 3-week history of left knee pain and swelling. She had suffered dermatitis herpetiformis for 12 years, proved by skin biopsy. She had never been on gluten-free diet. Knee pain increased with motion and her gait was antalgic. On admission, she was mainly dependent on wheelchair due ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1670-4
更新日期:2011-05-01 00:00:00
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journal_title:Rheumatology international
pub_type: 历史文章,杂志文章,评审
doi:10.1007/s00296-019-04261-4
更新日期:2019-06-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1614-z
更新日期:2011-07-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1759-9
更新日期:2012-02-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-019-04396-4
更新日期:2019-10-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1634-8
更新日期:2011-07-01 00:00:00
abstract::The Juvenile Arthritis Multidimensional Assessment Report (JAMAR) is a new parent/patient reported outcome measure that enables a thorough assessment of the disease status in children with juvenile idiopathic arthritis (JIA). We report the results of the cross-cultural adaptation and validation of the parent and patie...
journal_title:Rheumatology international
pub_type: 杂志文章,多中心研究
doi:10.1007/s00296-018-3964-x
更新日期:2018-04-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:2021-01-02 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章,多中心研究
doi:10.1007/s00296-017-3682-9
更新日期:2017-06-01 00:00:00
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journal_title:Rheumatology international
pub_type: 临床试验,杂志文章
doi:10.1007/BF00246875
更新日期:1992-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-019-04275-y
更新日期:2019-06-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/BF00271870
更新日期:1989-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-007-0333-6
更新日期:2007-09-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00290330
更新日期:1993-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-016-3537-9
更新日期:2016-10-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-0870-2
更新日期:2009-10-01 00:00:00
abstract::The Juvenile Arthritis Multidimensional Assessment Report (JAMAR) is a new parent/patient-reported outcome measure that enables a thorough assessment of the disease status in children with juvenile idiopathic arthritis (JIA). We report the results of the cross-cultural adaptation and validation of the parent and patie...
journal_title:Rheumatology international
pub_type: 杂志文章,多中心研究
doi:10.1007/s00296-018-3957-9
更新日期:2018-04-01 00:00:00
abstract::The aim of this study was to investigate the prevalence, predictors and radiological findings of primary Sjögren's syndrome (pSS)-associated lung involvement. This retrospective cohort study included 123 patients with demographic, clinical, laboratory and radiological data who were diagnosed with pSS. Lung involvement...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1152-8
更新日期:2010-08-01 00:00:00