Abstract：
:Neopterin levels of serum and fluid were determined in 30 patients with inflammatory synovial fluids and in 30 controls with joint effusions induced by trauma or osteoarthritis. Neopterin was significantly elevated in inflammatory fluids. There was no correlation with the acute phase reactants. Neopterin levels were significantly higher in inflammatory fluids than in serum, and vice versa in non-inflammatory conditions. Our results indicate that in arthritis neopterin is produced locally in the joint by monocytes induced by T-cell activation.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Maerker-Alzer G,Diemer O,Strümper R,Rohe Mdoi
10.1007/BF00541281subject
Has Abstractpub_date
1986-01-01 00:00:00pages
151-4issue
4eissn
0172-8172issn
1437-160Xjournal_volume
6pub_type
杂志文章abstract：:Fibromyalgia (FM) is a common chronic pain syndrome with an unknown etiology. Recent years added new information to our understanding of FM pathophysiology. Researches on genetics, biogenic amines, neurotransmitters, hypothalamic-pituitary-adrenal axis hormones, oxidative stress, and mechanisms of pain modulation, cen...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-005-0078-z
更新日期：2006-05-01 00:00:00
abstract：:Interleukin-15 (IL-15) is a pleotrophic cytokine that is involved in the pathogenesis of diverse inflammatory rheumatic diseases. The aims of this study were to compare serum IL-15 levels and expression of its receptor (IL-15Rα) in Behçet's disease (BD) with those in other rheumatic diseases and to identify the relati...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2705-4
更新日期：2013-08-01 00:00:00
abstract：:Cyclooxygenase-2 (COX-2) is a key regulatory enzyme in the synthesis of prostanoids associated with trauma and inflammation. Upregulation of COX-2 in human lupus T cells resists anergy and apotosis. We investigated the COX-2 gene for functional variants that may influence susceptibility, clinical outcomes and severity...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-006-0162-z
更新日期：2006-11-01 00:00:00
abstract：:To study the clinical presentation, treatment and outcome of southern Chinese patients with Takayasu's arteritis (TA). This is a retrospective chart review study of 78 patients managed in 14 public hospitals in Hong Kong between the years 2000 and 2010. Patients were identified from the hospital registry using the ICD...
journal_title：Rheumatology international
pub_type： 杂志文章,多中心研究
doi：10.1007/s00296-018-4150-x
更新日期：2018-12-01 00:00:00
abstract：:The study objective was to examine natural variation of the patient-reported outcome measures fatigue, pain, patient global assessment (PaGl) and the Bath Ankylosing Spondylitis Functional Index (BASFI) in patients with stable axial spondyloarthropathy (ax-SpA) defined on the basis of the Bath Spondylitis Ankylosing D...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-017-3920-1
更新日期：2018-03-01 00:00:00
abstract：:In a study of synovial fluid from 110 patients with various forms of arthritis, platelets were identified in the synovial fluid of all the 50 rheumatoids, in 18 out of the 25 (72%) with osteoarthritis and in all 35 of those with other forms of inflammatory osteoarthrosis. Identification of platelets by light microscop...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00683878
更新日期：1984-01-01 00:00:00
abstract：:The aim of the study is to investigate the levels of serum interleukin-35 (IL-35) before and after treatment and its relationship with clinical parameters as well as the frequency of different subsets of CD4+ T cells in patients with systemic sclerosis (SSc) to explore the role of IL-35 in the pathogenesis of SSc. The...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-4071-8
更新日期：2018-08-01 00:00:00
abstract：:This study aims to elucidate plasma oxidant/antioxidant status in patients with rheumatoid arthritis (RA). Fasting blood samples were obtained from 24 patients with RA and 20 control subjects. Antioxidant potential (AOP) value, nonenzymatic superoxide radical scavenger activity (NSSA), and malondialdehyde (MDA) levels...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s002960050097
更新日期：1999-01-01 00:00:00
abstract：OBJECTIVES:To evaluate the prevalence and annual incidence of clinically-manifest vertebral fractures among patients with ankylosing spondylitis (AS). METHOD:Coordinated by the Ankylosing Spondylitis International Federation, a self-administered general questionnaire which included some questions on gender, age, age a...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-004-0556-8
更新日期：2006-01-01 00:00:00
abstract：:Chondrocyte structure and function under the influence of two gold-containing therapeutic agents, aurothioglucose and triethylphosphine gold, were studied in a monolayer culture system for cultivating lapine articular chondrocytes. The functional parameters investigated were chondrocyte proliferation and the incorpora...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541144
更新日期：1983-01-01 00:00:00
abstract：:Rheumatology has its roots in ancient Greece. Hippocrates and other prominent Greek (Hellenes) physicians in ancient times, Hellenistic, Roman, and Byzantine period were acute observers of disease course and of patients and were able to define many disorders. They wrote books on various aspects of medicine and these w...
journal_title：Rheumatology international
pub_type： 历史文章,杂志文章,评审
doi：10.1007/s00296-019-04261-4
更新日期：2019-06-01 00:00:00
abstract：:The aim of this study was to evaluate whether cyclosporin A (CsA) influences the radiological disease progression in early rheumatoid arthritis (RA) patients in comparison with other disease-modifying drugs (DMARDs). A total of 103 early RA patients, without prior use of DMARDs, were randomized to receive CsA (3 mg/kg...
journal_title：Rheumatology international
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002960050113
更新日期：2000-01-01 00:00:00
abstract：:CCL28 is a mucosa-associated epithelial-cell-produced chemokine involved in oral defense. We assessed the level of CCL28 in saliva of primary Sjögren's syndrome (pSS) patients in comparison with healthy controls and correlated it with IgA salivary levels. We included 30 non-smoker pSS patients and 30 non-smoker health...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-014-3210-0
更新日期：2015-08-01 00:00:00
abstract：:Arachnoid ossificans is a rare type of chronic arachnoiditis characterised by the presence of calcification or ossification of the dura and arachnoid. There are a few reports of these findings in relation to various disease entities, but only one case has been reported in relation to ankylosing spondylitis. We describ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2293-0
更新日期：2013-06-01 00:00:00
abstract：:There is no agreement among the rheumatology community in how to implement the musculoskeletal ultrasound (MSUS) technique in the Rheumatology Divisions. To test the perceived usefulness of the MSUS, under consensus indications, for referring colleagues for the clinical management of their patients with inflammatory a...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3538-8
更新日期：2016-12-01 00:00:00
abstract：:The ultrastructural localisation of class II and macrophage antigens has been sought in the intimal layer of the human synovium. The cells described as type A in early morphological studies are shown to express both class II antigens and two markers of the macrophage/monocyte lineage of cells, OKM1 and MAB 24. The mor...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00270456
更新日期：1988-01-01 00:00:00
abstract：:Analyses of the synovial tissue and fluid T lymphocytes obtained from patients with rheumatoid arthritis revealed multiple functional defects in the regulation of autologous blood B cell differentiation into cells secreting immunoglobulin. These abnormalities were not found in peripheral blood T lymphocytes from the s...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541164
更新日期：1982-01-01 00:00:00
abstract：:A 50-year-old man presented with a complaint of low-back pain and widespread joint pain for the previous 20 years. Conventional radiography revealed wide areas of calcification in the intervertebral discs and degenerative changes in the peripheral joints. A diagnosis of ochronosis was made by the observation of bluish...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-007-0381-y
更新日期：2007-11-01 00:00:00
abstract：:The case of an apparent healthy woman who developed recurrent preeclampsia with antiphospholipid antibodies and evolved towards systemic lupus erythematosus during her last pregnancy is presented. The diagnostic dilemma between lupus renal flare and toxemia is discussed. The potential role of immunological alterations...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-002-0210-2
更新日期：2002-07-01 00:00:00
abstract：OBJECTIVES:We aimed to assess the clinical significance of Krebs von den Lungen-6 (KL-6) in the diagnosis and severity of interstitial lung disease (ILD) in a French cohort of patients with systemic sclerosis (SSc). METHODS:Serum KL-6 concentrations were measured with chemiluminescent enzyme immunoassay (CLEIA) in 75 ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-3987-3
更新日期：2018-05-01 00:00:00
abstract：:Systemic lupus erythematosus is an autoimmune disease with protean manifestation. Arthritis is one of the most common manifestations seen in SLE. Anti-CCP Ab is a recently described autoantibody that has been claimed as a most sensitive and specific marker for the diagnosis of RA. Study was performed to see whether an...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1374-9
更新日期：2011-06-01 00:00:00
abstract：:Systemic immune defects might reflect severely dysregulated control of chronic inflammation related to disease progression. Th17/Treg cell imbalance has been demonstrated to be involved in rheumatoid arthritis (RA) pathogenesis. Despite controversial results, a growing anti-inflammatory role in this process has been r...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2895-9
更新日期：2014-02-01 00:00:00
abstract：:Resveratrol (trans-3,4'-trihydroxystilbene), a natural phytoalexin, possesses anti-inflammatory, anti-proliferative, and immunomodulatory properties and has the potential for treating inflammatory disorders. The present study was designed to investigate the effects of resveratrol on TNF-α-induced inflammatory cytokine...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2657-0
更新日期：2013-07-01 00:00:00
abstract：:Regional migratory osteoporosis (RMO) is an idiopathic disorder characterized by severe periarticular pain, transient and migratory arthralgia, and osteoporosis. Osteoporosis in this disease may appear in the form of local regional osteoporosis and bone marrow edema or generalized osteoporosis. It occurs most commonly...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1256-1
更新日期：2011-10-01 00:00:00
abstract：:Fluoride excess primarily effects dental and skeletal tissues. leading to a condition known as endemic fluorosis. The radiological and clinical features of endemic fluorosis vary in different parts of the world. The aim of this study was to investigate the clinical and radiological features of endemic fluorosis in Tur...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s002960100132
更新日期：2001-09-01 00:00:00
abstract：:We measured alpha 2-plasmin inhibitor-plasmin complexes (PI-PC) in plasma of patients with systemic lupus erythematosus (SLE) to examine the plasminogen activation in SLE. The plasma PI-PC level in 23 patients with SLE was significantly higher than that in 18 normal subjects (P less than 0.001) and the SLE patients wi...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00270984
更新日期：1989-01-01 00:00:00
abstract：:31P Magnetic Resonance-Spectroscopy was performed at the site of tender points in the trapezius muscle of patients with primary fibromyalgia syndrome. Earlier, in vitro studies have reported changes in the high energy phosphate-metabolism in biopsies taken from tender points of fibromyalgia patients. The observed alte...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00291145
更新日期：1991-01-01 00:00:00
abstract：:Celiac disease (CD) is an autoimmune systemic disease characterized by not only gastrointestinal but also extraintestinal manifestations. The aim of our study was to do a serological screening for CD, by IgA endomysial antibodies (EmA), in patients with unexplained articular manifestations. Two hundred and eleven pati...
journal_title：Rheumatology international
pub_type： 杂志文章,多中心研究
doi：10.1007/s00296-013-2906-x
更新日期：2014-05-01 00:00:00
abstract：:Biological markers of inflammation are useful for the diagnosis and monitoring of inflammatory rheumatic diseases. The present study tested, whether serum amyloid A (SAA) could be used as a marker of inflammatory disease activity in ankylosing spondylitis (AS). In 72 patients with AS, the two valuable surrogate marker...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s002960050114
更新日期：2000-01-01 00:00:00
abstract：:Proliferation of pannus tissue cells has been investigated under in vitro conditions after labeling of joint tissues with 3H-thymidine. It was demonstrated that there is only a minimal proliferation of chondrocytes as well as of pannus tissue cells. Slight increased proliferation was observed in granulation tissue poo...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00270349
更新日期：1986-01-01 00:00:00
