Abstract:
:Systemic immune defects might reflect severely dysregulated control of chronic inflammation related to disease progression. Th17/Treg cell imbalance has been demonstrated to be involved in rheumatoid arthritis (RA) pathogenesis. Despite controversial results, a growing anti-inflammatory role in this process has been recently attributed to Th1 responses. The aim of the study was to estimate the extent of Th1/Th17/Treg imbalance in peripheral blood (PB) of patients with short- and long-term RA in relation to cytokine milieu and its reversal after therapy with methotrexate and/or TNF inhibitors, respectively. Patients with different duration of RA (median 6 vs. 120 months) in the active phase of RA were enrolled in this study. We performed flow cytometric analysis of PB Th1, Th17, and Treg populations together with estimation of serum cytokine concentrations using cytometric bead array. Disease activity was calculated on the basis of clinical and biochemical indices of inflammation (DAS28, ESR, CRP). All parameters were measured and correlated with each other before and after 6 months therapy. Elevated levels of circulating Th17 cells and IL-6 were found in all active patients, of which Th17 cells were down-regulated by the treatment. Significantly reduced Th1 and functional CTLA-4+ Treg cell frequencies as well as Th1 cytokines observed only in progressive RA seemed to be irreversible. Although therapy induced clinical improvement in almost all patients, those with advanced RA remained with signs of inflammation. Our report demonstrates that both the extent of systemic immune abnormalities and their restoration are dependent on duration of the active RA.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Kosmaczewska A,Swierkot J,Ciszak L,Szteblich A,Chrobak A,Karabon L,Partyka A,Szechinski J,Wiland P,Frydecka Idoi
10.1007/s00296-013-2895-9subject
Has Abstractpub_date
2014-02-01 00:00:00pages
243-53issue
2eissn
0172-8172issn
1437-160Xjournal_volume
34pub_type
杂志文章abstract::A total of 300 consecutive patients referred to a tertiary-care center and fulfilling the American Rheumatism Association criteria for definite-classical rheumatoid arthritis, (with a mean disease-duration of 10.3 +/- 9 years) were studied by structured interview and medical record review. The type of onset (rapid or ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00270365
更新日期:1987-01-01 00:00:00
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journal_title:Rheumatology international
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journal_title:Rheumatology international
pub_type: 临床试验,杂志文章
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journal_title:Rheumatology international
pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,多中心研究
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journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:1991-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541200
更新日期:1984-01-01 00:00:00
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pub_type: 杂志文章,多中心研究
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journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:1984-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:2016-12-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:2005-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2008-08-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 历史文章,杂志文章
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更新日期:2010-09-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2011-11-01 00:00:00
abstract::Previous studies showed a link between systemic lupus erythematosus (SLE) and Epstein-Barr virus (EBV) infection. We sought to determine the features of serologic response to EBV in SLE patients and whether this response differs from those of systemic sclerosis (SSc) and primary antiphospholipid syndrome (PAPS) patien...
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pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:2012-08-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541245
更新日期:1982-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541361
更新日期:1984-01-01 00:00:00
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pub_type: 杂志文章
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