Abstract:
:The cost-effectiveness of treatments that have the potential to change the "natural history" of a chronic progressive disease has to be evaluated over the long term. Cost-effectiveness estimates have been based on the concept that, with treatment, patients will not progress to the next level(s) of disease severity or will take a longer time to progress, thus avoiding or delaying the high costs and low utility associated with more severe disease. This analysis focused on the use of Rituximab in treating patients with moderate to severe RA for whom at least one anti-TNFα blocking agent had failed. The aim of our study was to evaluate the cost-effectiveness in 32 patients with rheumatoid arthritis in therapy with a single infusion of Rituximab 1,000 mg given on days 1 and 15 of each month for 1 year. After 6 months of treatment, we observed for all 32 patients a total quality-adjusted life year (QALY) gained of 11,840 with an average of 0.37 QALY for a single patient, a treatment cost of euro 5,610 and a QALY/cost ICER (incremental cost-effectiveness ratio) of euro 15,114. After 1 year of treatment, we observed data for 28 patients with a total QALY gained of 11,480 with an average of 0.41 QALY for a single patient, a treatment cost of euro 9,690 and a QALY/cost ICER (incremental cost-effectiveness ratio) of euro 23,696. The benefit of using Rituximab is cost-effectiveness with a QALY/gained under the acceptable threshold of euro 50,000 in our observational study. These are important data for discussion from the economic point of view when we choose a biologic therapy for rheumatoid arthritis in clinical practice.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Benucci M,Saviola G,Baiardi P,Manfredi Mdoi
10.1007/s00296-010-1502-6subject
Has Abstractpub_date
2011-11-01 00:00:00pages
1465-9issue
11eissn
0172-8172issn
1437-160Xjournal_volume
31pub_type
杂志文章abstract::The Juvenile Arthritis Multidimensional Assessment Report (JAMAR) is a new parent/patient reported outcome measure that enables a thorough assessment of the disease status in children with juvenile idiopathic arthritis (JIA). We report the results of the cross-cultural adaptation and validation of the parent and patie...
journal_title:Rheumatology international
pub_type: 杂志文章,多中心研究
doi:10.1007/s00296-018-3964-x
更新日期:2018-04-01 00:00:00
abstract::A 50-year-old man presented with a complaint of low-back pain and widespread joint pain for the previous 20 years. Conventional radiography revealed wide areas of calcification in the intervertebral discs and degenerative changes in the peripheral joints. A diagnosis of ochronosis was made by the observation of bluish...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-007-0381-y
更新日期:2007-11-01 00:00:00
abstract::Smoking produces substances that activate proinflammatory, prothrombotic and vasoconstrictive mediators via posttranslational carbamylation of proteins. As a new consequence of carbamylation, induction of anti-carbamylated autoantibodies were observed in rheumatoid arthritis (RA) patients, sometimes prior to onset of ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-016-3472-9
更新日期:2016-06-01 00:00:00
abstract::The aim of this study was to evaluate whether the serum concentration of interleukin-6 (IL-6) reflects disease activity in ankylosing spondylitis (AS). A group of 271 AS patients were enrolled in the study, 261 of whom completed the entire protocol (201 males, 60 females, median age of 53 years). Serum IL-6 was measur...
journal_title:Rheumatology international
pub_type: 临床试验,杂志文章
doi:10.1007/s002960050066
更新日期:1998-01-01 00:00:00
abstract::To investigate whether the hypothermia induced by Adenosine 5'-Monophosphate (5'-AMP) could attenuate early stage injury in a rat acute gouty arthritis model. Ankle joint injection with monosodium urate monohydrate crystals (MSU crystals) in hypothermia rat model which was induced by 5'-AMP and then observe whether hy...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-013-2676-5
更新日期:2013-08-01 00:00:00
abstract::Neuropathic arthropathy (NA), known as Charcot neuroarthropathy, is a chronic, degenerative arthropathy and is associated with decreased sensory innervation. Numerous causes of this arthropathy have been described. Neuropathic joint, although first described by Charcot in tabes dorsalis in 1868, has subsequently been ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1013-5
更新日期:2010-05-01 00:00:00
abstract::We studied causes of death (CoDs) between 1952 and 1991 assessed by a clinician before autopsy and then determined at autopsy by a pathologist in 369 subjects with rheumatoid arthritis (RA) and 370 subjects without RA (non-RA). We analysed clinical data for RA subjects between 1973 and 1991. In RA subjects, leading au...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0685-6
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to investigate the ear involvement, especially at extended higher frequencies than those previously studied, in patients with ankylosing spondylitis (AS). PATIENTS AND METHODS:We prospectively evaluated 45 consecutive patients with AS. All patients underwent a complete physical exam...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-007-0458-7
更新日期:2008-03-01 00:00:00
abstract::Advanced glycation endproducts (AGEs) are the products of non-enzymatic glycation and oxidation of proteins and lipids. Low-turnover tissues such as articular cartilage seem to be susceptible to the accumulation of AGEs, which might lead to cartilage degradation. Recently, a non-invasive method for measuring skin AGE ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-007-0408-4
更新日期:2007-12-01 00:00:00
abstract::The aim of this study was to compare health related quality of life (HRQoL) and assess functional and psychological status in rheumatoid arthritis (RA), fibromyalgia syndrome (FS) patients and controls (each 30 subjects). Demographic characteristics, pain and sleep disturbance by Visual Analog Scale, depression by Bec...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0551-6
更新日期:2008-07-01 00:00:00
abstract::This study was designed to determine the effects of the osteoprotegerin (OPG) on the mRNA expression of carbonic anhydrase II (CAII) and the receptor activator of NF-κB (RANK) in mouse osteoclast-like cells. Marrow cells were harvested from femora and tibiae of mouse and cultured in 6-well chamber slides. After 1 day ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-2338-4
更新日期:2012-12-01 00:00:00
abstract::We aimed to investigate the diagnostic significance of high frequency ultrasonography (USG), comparing the findings in USG, bone scintigraphy and clinical stuation. Fifty-one patients who had early symptoms of inflammatory arthritis, but not fulfilling the ACR diagnostic criteria for rheumatoid arthritis (RA) were inc...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0765-7
更新日期:2009-05-01 00:00:00
abstract::To investigate whether anti-inflammatory effects of HMG-CoA reductase inhibitor simvastatin (SMV) in rheumatoid arthritis (RA) is mediated by Toll-like receptor-2 (TLR-2) signal via inhibiting activation of RhoA, a small Rho GTPase that plays an important role in inflammatory responses. Peripheral blood monocytes from...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1510-6
更新日期:2011-11-01 00:00:00
abstract::The present cross-sectional data demonstrate cardiovascular (CV) risk in patients with rheumatoid arthritis (RA). The cross-sectional data were part of an interventional trial that included 100 patients with defined RA. Traditional CV risk parameters and risk score calculation for the German population were used to as...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-2238-7
更新日期:2012-12-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) affects women of childbearing age. To optimize fetal and maternal outcomes, effective reproductive health counseling is crucial. To analyze the effectiveness of reproductive health counseling in women with SLE and identify gaps in patient educational needs. Cross-sectional study incl...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-020-04671-9
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:Although not validated fully, recommendations are present for diagnosis, screening and treatment modalities of patients with familial Mediterranean fever (FMF). OBJECTIVE:To review the current practices of clinicians regarding FMF and reveal their adherence to consensus guidelines. METHODS:Fifteen key poin...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-020-04776-1
更新日期:2021-01-16 00:00:00
abstract::An imbalance in pro- and anti-inflammatory cytokines is suggested to contribute to tissue damage in rheumatoid arthritis (RA). This study was aimed at investigating profiles of cytokines in circulation and cytokines produced by mitogen-stimulated peripheral blood mononuclear cells (PBMC) in RA patients and healthy con...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-017-3774-6
更新日期:2017-10-01 00:00:00
abstract::Anaemia of chronic disease (ACD) is a common extra-articular manifestation of rheumatoid arthritis (RA). Tumour necrosis factor alpha (TNF alpha) plays an important role in the development of ACD. The objective of the present study was to assess inhibition of in vitro colony-forming unit erythrocyte (CFUe) and blast-f...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00300811
更新日期:1994-01-01 00:00:00
abstract::The aim of the study was to assess the possible association between type II collagen turnover seromarkers and disease profile in patients with axial spondyloarthritis (SpA) and psoriatic arthritis (PsA). Outpatients with axial SpA (n = 110) or PsA (n = 101) underwent clinical examination including disease activity mea...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-015-3397-8
更新日期:2016-04-01 00:00:00
abstract::This review explores the prevalence and factors associated with disturbed sleep for patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis in order to clarify consistent findings in this otherwise disparate research field. The association of physical, demographic and psychological factors co...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-016-3589-x
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:The present study was performed to localize the articular deposition of monosodium urate (MSU) crystal in joints. We compare the detection efficiencies of dual-energy CT (DECT) and ultrasound scans. METHODS:Analyses by DECT and ultrasound were performed with 184 bilateral joints of the lower limbs of 54 cons...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-018-3994-4
更新日期:2018-05-01 00:00:00
abstract::The case of an apparent healthy woman who developed recurrent preeclampsia with antiphospholipid antibodies and evolved towards systemic lupus erythematosus during her last pregnancy is presented. The diagnostic dilemma between lupus renal flare and toxemia is discussed. The potential role of immunological alterations...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-002-0210-2
更新日期:2002-07-01 00:00:00
abstract::Histoplasmosis is an important cause of morbidity in endemic areas of the USA. Infection is often asymptomatic but can cause a broad spectrum of pathology. Less commonly, histoplasmosis can present with a wide-range of rheumatologic manifestations. The aim of this review is to provide a synopsis of the rheumatologic m...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-013-2816-y
更新日期:2013-12-01 00:00:00
abstract::Tuberculosis can affect sacroiliac joints, but only a few such cases have been reported. The onset is usually insidious, and early diagnosis requires a high index of clinical suspicion. We report herein a culture-proven case of tuberculous sacroiliitis which initially mimicked neoplastic infiltration on CT scan. ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-003-0406-0
更新日期:2004-09-01 00:00:00
abstract::The aim of this study is to observe the effect of different treatment time of millimeter wave (MMW) on chondrocyte apoptosis, caspase-3, caspase-8, and matrix metalloproteinase-13 (MMP-13) in rabbit knee osteoarthritis induced by anterior cruciate ligament transection (ACLT). Thirty-two New Zealand White rabbits were ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-2080-y
更新日期:2012-09-01 00:00:00
abstract::Macrophagic myofascitis (MMF) is an unusual inflammatory myopathy characterized by muscle infiltration by macrophages and lymphocytes. Here, we describe a case of MMF which is associated with rheumatoid arthritis. A 53-year-old Japanese rheumatoid arthritis (RA) patient presented with focal tenderness of lower extremi...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1015-3
更新日期:2010-05-01 00:00:00
abstract::The aim of this study was to evaluate whether cyclosporin A (CsA) influences the radiological disease progression in early rheumatoid arthritis (RA) patients in comparison with other disease-modifying drugs (DMARDs). A total of 103 early RA patients, without prior use of DMARDs, were randomized to receive CsA (3 mg/kg...
journal_title:Rheumatology international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002960050113
更新日期:2000-01-01 00:00:00
abstract::To evaluate the efficacy and safety of infliximab biosimilar CT-P13 in patients with active Takayasu arteritis (TAK). In this single-center open-label trial, patients with active TAK received CT-P13 at a starting dose of 5 mg/kg at weeks 0, 2, 6, and then every 8 weeks up to week 46. They were followed up until week 5...
journal_title:Rheumatology international
pub_type: 临床试验,杂志文章
doi:10.1007/s00296-018-4159-1
更新日期:2018-12-01 00:00:00
abstract::PXK was identified as a novel candidate gene for systemic lupus erythematosus (SLE) from genome-wide association studies (GWAS) in Caucasians. But a recent replication study in Hong Kong Chinese reported that PXK was not associated with SLE. The aim of this study was to determine whether PXK is associated with SLE in ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1789-3
更新日期:2012-01-01 00:00:00
abstract::The objective of this study was to report 11 cases of propylthiouracil (PTU)-induced autoimmune syndromes. We describe the clinical presentation, course, and outcome of 11 patients and compare clinical features between PTU-induced lupus and PTU-induced vasculitis. Of our 11 patients, 7 patients had vasculitis and 4 pa...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1675-z
更新日期:2012-03-01 00:00:00