Abstract:
:The present cross-sectional data demonstrate cardiovascular (CV) risk in patients with rheumatoid arthritis (RA). The cross-sectional data were part of an interventional trial that included 100 patients with defined RA. Traditional CV risk parameters and risk score calculation for the German population were used to assess the CV risk profile in the collective given. Proatherogenic lipid profile characterised by increased total cholesterol (≥ 5.2 mmol/l) and LDL cholesterol (≥ 3.5 mmol/l) levels was measured in 85 and 66%, respectively, of the study population. Elevated concentrations of homocysteine (≥ 10 μmol/l) were reached by 67%. The prevalence of patients at high CV risk was 12% and increased up to 42% after using a multiplication factor of 1.5. No association was seen between the CV risk SCORE and DAS 28 or disease duration. RA patients in this study showed a proatherogenic risk profile with regard to the CV risk factors evaluated. The calculation of a 10-year risk using German risk charts might have led to an overall underestimation of the mean CV risk. Cardiovascular co-morbidity in RA patients must be seen as a major prevention and treatment target and should be monitored adequately.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Willers J,Hahn Adoi
10.1007/s00296-011-2238-7subject
Has Abstractpub_date
2012-12-01 00:00:00pages
3741-9issue
12eissn
0172-8172issn
1437-160Xjournal_volume
32pub_type
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journal_title:Rheumatology international
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journal_title:Rheumatology international
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journal_title:Rheumatology international
pub_type: 临床试验,杂志文章
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journal_title:Rheumatology international
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journal_title:Rheumatology international
pub_type: 杂志文章
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journal_title:Rheumatology international
pub_type: 杂志文章
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journal_title:Rheumatology international
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2007-10-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s00296-018-4026-0
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
doi:10.1007/s00296-015-3266-5
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1715-8
更新日期:2013-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:1993-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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