Abstract:
:A recent genome-wide association study revealed that there is an association between serum uric acid (SUA) levels and rs2544390, a common variant in low-density lipoprotein-related protein 2 (LRP2/Megalin) gene. Two other variants of LRP2, rs2229268 and rs3755166, are also found to have associations with dyslipidemia and Alzheimer's disease, respectively, which also could have a relationship with SUA in human. Although no studies report that LRP2 transports urate, LRP2 is a multi-ligand receptor and expresses in many tissues including kidney, suggesting a direct and/or indirect relationship with gout. In the present study, we investigated the association between gout and these variants of LRP2 with 741 clinically diagnosed male gout patients and 1,302 controls. As a result, the three common LRP2 variants, rs2544390, rs2229268 and rs3755166, showed no association with gout (P = 0.76, 0.55, and 0.22, respectively). Our study is the first to reveal that an SUA-related gene LRP2 is not involved in gout susceptibility.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Nakayama A,Matsuo H,Shimizu T,Takada Y,Nakamura T,Shimizu S,Chiba T,Sakiyama M,Naito M,Morita E,Ichida K,Shinomiya Ndoi
10.1007/s00296-013-2924-8subject
Has Abstractpub_date
2014-04-01 00:00:00pages
473-6issue
4eissn
0172-8172issn
1437-160Xjournal_volume
34pub_type
杂志文章,多中心研究abstract::Splenectomy may be necessary to treat systemic lupus erythematosus (SLE) patients with thrombocytopenia; however, whether performing a splenectomy on patients without SLE increases the subsequent risk of SLE remains unknown. Therefore, this study was conducted to determine the association between splenectomy and SLE. ...
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