Abstract:
OBJECTIVE:The aim of this study was to measure serum oxidized low-density lipoprotein (Ox-LDL) levels in patients with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE) and to identify any association with clinical variables. METHODS:We studied 126 female patients (27 with active RA, 27 with inactive RA, 72 with SLE). One hundred fifteen age-matched healthy women (76 for RA, 39 for SLE) with no clinical or laboratory evidence of disease served as normal controls. Serum Ox-LDL levels were measured with a commercial enzyme-linked immunosorbent assay kit (Mercodia, Sweden). RESULTS:The serum Ox-LDL levels were significantly higher in patients with active RA (P<0.05) or SLE (P<0.01) than age-matched controls and significantly higher in patients with active RA than with inactive RA (P<0.01). The levels of serum total cholesterol and LDL were significantly lower in patients with RA than in age-matched controls (P<0.01). There was no correlation among serum Ox-LDL levels and inflammatory markers (erythrocyte sedimentation rate, C-reactive protein) or rheumatoid factors in patients with RA. CONCLUSIONS:Compared with healthy women, those with SLE or active RA had increased serum Ox-LDL levels, which may contribute to the increased risk of cardiovascular disease in this patient group.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Kim SH,Lee CK,Lee EY,Park SY,Cho YS,Yoo B,Moon HBdoi
10.1007/s00296-003-0358-4subject
Has Abstractpub_date
2004-07-01 00:00:00pages
230-3issue
4eissn
0172-8172issn
1437-160Xjournal_volume
24pub_type
杂志文章abstract::To evaluate the correlation between measurements of antinuclear antibodies serum levels by enzyme immunoassay (ANA-EIA), and the degree of systemic lupus erythematosus disease activity. To retest the performance of the test compared to measurement of antinuclear antibodies by immunofluorescence (ANA-IIF). Eighty-five ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-007-0324-7
更新日期:2007-08-01 00:00:00
abstract::Nailfold videocapillaroscopy was performed in 21 controls (C) and 21 patients (P) with systemic lupus erythematosus (SLE) classified according to the American College of Rheumatology, with, at least, 1 year of diagnosed disease and having low activity (MEX-SLEDAI) and sequel (SLICC) indexes at the time of the examinat...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-005-0033-z
更新日期:2006-05-01 00:00:00
abstract::To study the mechanisms of chondrocyte damage, chondrocyte cytotoxicity as shown by chromium-51 release induced by polymorphonuclear leukocytes (PMNLs) was examined. PMNLs significantly enhanced chondrocyte cytotoxicity in the presence of phorbol dibutyrate. This chondrocyte damage was abolished by the addition of cat...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00274933
更新日期:1992-01-01 00:00:00
abstract::Our aim was to evaluate fatigue and quality of life (QoL) in Moroccan patients with primary Sjögren's syndrome (PSS) and determine their correlates with disease-related parameters. Fifty-seven consecutive patients with PSS according to the American-European Consensus group (AEGG) criteria were included. Demographic, c...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-2009-5
更新日期:2012-09-01 00:00:00
abstract::Folate supplementation is widely accepted and utilized for the prevention of adverse events in juvenile idiopathic arthritis (JIA) patients who are treated with methotrexate. Despite the widespread use of folate supplementation, there is a lack of convincing evidence to support the role of folate in the enhancement of...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-013-2696-1
更新日期:2013-09-01 00:00:00
abstract::The aim of this study was to explore whether the catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with susceptibility to fibromyalgia and fibromyalgia impact questionnaire (FIQ) score in fibromyalgia patients. We conducted a meta-analysis of the associations of the COMT Val158Met polymorphism w...
journal_title:Rheumatology international
pub_type: 杂志文章,meta分析
doi:10.1007/s00296-014-3075-2
更新日期:2015-01-01 00:00:00
abstract::Fibromyalgia (FM), pre-dominantly found in women, may accompany other pre-existing rheumatic diseases. The association between FM and ankylosing spondylitis (AS) is uncertain. We evaluated FM in women with AS. Eighteen women with AS were compared with 18 men with AS (controls) for age, duration of symptoms, time to di...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-007-0344-3
更新日期:2007-07-01 00:00:00
abstract::This study examines whether or not MBD4 polymorphism is a marker for rheumatoid arthritis (RA) susceptibility or severity for Chinese patients in Taiwan. This study included 193 patients with RA, while 190 unrelated healthy individuals living in Central Taiwan served as controls. The relationship between MBD4 polymorp...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1545-8
更新日期:2012-01-01 00:00:00
abstract::We aimed to determine left ventricular (LV) and right ventricular (RV) structure, function and mechanics, as well as heart rate variability (HRV), and their relationship, in patients with systemic sclerosis (SSc). The study included 41 SSc patients and 30 age-matched healthy volunteers. All the patients underwent clin...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-016-3618-9
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the prevalence and annual incidence of clinically-manifest vertebral fractures among patients with ankylosing spondylitis (AS). METHOD:Coordinated by the Ankylosing Spondylitis International Federation, a self-administered general questionnaire which included some questions on gender, age, age a...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-004-0556-8
更新日期:2006-01-01 00:00:00
abstract::In a prospective study 222 sera from 56 patients with systemic lupus erythematosus (SLE) were tested for antibodies to poly(A), poly dAT and histones using enzyme-linked immunosorbent assay (ELISA). Patients with active disease had significantly more often antibodies to poly(A), poly dAT and histones than patients wit...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541200
更新日期:1984-01-01 00:00:00
abstract::Radiation synovectomy (RS) is one of many therapeutic options used for recurrent joint synovitis. Our aim was to analyze the effect of the surgical synovectomy combined with yttrium 90 ((90)Y) in the treatment for recurrent joint synovitis. A surgical combined RS procedure was used on 32 knees of 30 patients. They wer...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-012-2540-z
更新日期:2013-05-01 00:00:00
abstract::Several studies of rheumatoid arthritis (RA) incidence and prevalence indicate that occurrence of the disease varies significantly among different populations. We aimed to estimate the prevalence and incidence of RA in South Korea. We used Korean National Health Insurance (NHI) claims data to estimate the prevalence o...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-012-2590-2
更新日期:2013-06-01 00:00:00
abstract::This study evaluates prospectively whether baseline scores [Health Assessment Questionnaire (HAQ) and SF-36] can predict clinical and radiographic evolution in a cohort of early rheumatoid arthritis (RA) during a 3-year follow-up. Forty consecutive early RA patients were followed for 3 years, while receiving standardi...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-2261-8
更新日期:2012-12-01 00:00:00
abstract::Hand osteoarthritis (OA) is a common degenerative joint disorder leading to substantial pain and disability. The most severe subtype is erosive hand OA characterized by an abrupt onset, local inflammation, subchondral erosions and worse outcomes than non-erosive disease. Biomarkers of hand OA could help to diagnose th...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-017-3864-5
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:The aim was to evaluate the efficacy and safety of multiple infusions with achimeric, anti-tumor necrosis factor (TNF)alpha monoclonal antibody (infliximab) in patients with psoriatic arthritis (PsA) and psoriasis vulgaris. METHODS:Over 22 weeks, nine patients with both active psoriasis and PsA received five...
journal_title:Rheumatology international
pub_type: 临床试验,杂志文章
doi:10.1007/s00296-002-0246-3
更新日期:2002-11-01 00:00:00
abstract::Gender may produce different characteristics in the manifestation of systemic lupus erythematosus (SLE). The present study investigated the influence of gender on clinical, laboratory, autoantibodies and histopathological classes of lupus nephritis (LN). As much as 81 patients diagnosed with SLE (ACR criteria) and act...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1151-9
更新日期:2010-08-01 00:00:00
abstract::A meta-analysis was done with the final data from three trials that provided the first results relating to efficacy and safety of the new sustained-release (SR) formulation of etodolac versus established nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of osteoarthritis (OA) of the knee. The studies were...
journal_title:Rheumatology international
pub_type: 杂志文章,meta分析
doi:10.1007/BF00290280
更新日期:1993-01-01 00:00:00
abstract::Although arthroscopic surgery (AS) for knee osteoarthritis has been widely employed, scientific evidence is lacking. The purpose of this study was to investigate temporal changes in synovial fluid levels of biochemical markers associated with cartilage metabolism following AS. Twenty-five knees of 24 patients with med...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-012-2374-8
更新日期:2013-01-01 00:00:00
abstract::Cardiovascular disease (CVD) morbidity and mortality is highly prevalent in patients with rheumatoid arthritis (RA) with debilitating effects for the individual as well as significant healthcare impact. Current evidence demonstrates that engaging in aerobic and resistance exercise (i.e. structured physical activity) c...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-019-04483-6
更新日期:2020-03-01 00:00:00
abstract::We report a case of reversible sensorineural hearing loss due to hydroxychloroquine (HQ) treatment. The patient was a 34-year-old woman with 1 year of rheumatoid arthritis (RA). She developed reversible hearing loss after 5 months of HQ treatment. Sensorineural deafness has previously been reported with chloroquine tr...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s002960000054
更新日期:2000-01-01 00:00:00
abstract::The clinical use of pulsed electromagnetic fields (PEMF) in osteoarticular pathology is widely extended, although the mechanisms involved are unknown. The aim of this study was to evaluate the action of a new protocol of treatment with PEMF on liquid medium cultures of fibroblast-like cells derivates of mononuclear pe...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1488-0
更新日期:2011-10-01 00:00:00
abstract::In chronic diseases such as rheumatoid arthritis and osteoarthritis, the progression of the disease is characterized by stress oxidative, inflammation, and elevated levels of cholesterol. In mevalonate kinase deficiency, an auto-inflammatory disease, the correlation between inflammation and cholesterol levels is oppos...
journal_title:Rheumatology international
pub_type: 评论,信件
doi:10.1007/s00296-012-2436-y
更新日期:2013-09-01 00:00:00
abstract::The aim of this study was to investigate (a) the mortality in a clinical cohort of patients with established rheumatoid arthritis in comparison with the general Dutch population over 15 years, (b) the trend in the mortality ratio during the study period, and (c) causes of death and compare these with the general popul...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-016-3638-5
更新日期:2017-04-01 00:00:00
abstract::The current study was to investigate the quantity and quality of researches in the field of ankylosing spondylitis, and to reveal the characteristics of worldwide productivity on this disease. This was a bibliometric study on ankylosing spondylitis using Web of Science. The numbers of papers, citations, research outpu...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-019-04308-6
更新日期:2019-06-01 00:00:00
abstract::IgM, IgG and IgA class antibodies against Yersinia, Salmonella, Campylobacter and Borrelia were determined by enzyme-linked immunosorbent assay (ELISA) in a group of 340 unselected patients with a recent inflammatory joint disease. The control group consisted of 340 and 100 healthy blood donors using Borrelia-ELISA an...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF02274884
更新日期:1991-01-01 00:00:00
abstract::The purpose of this study was to compare quality of life health identifiers in patients with and without osteoarthritis (OA) while controlling for the potentially confounding variables of gender, age, race, education, and income. Data were obtained for comparison from the Behavioral Risk Factor Surveillance System (BR...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-006-0269-2
更新日期:2007-02-01 00:00:00
abstract::MicroRNAs (miRNAs) are noncoding RNA molecules of 21-24 nt that regulate the expression of target genes in a post-transcriptional manner. Evidence indicates that miRNAs play essential roles in embryogenesis, cell differentiation, and pathogenesis of human diseases. This study describes a comparison between the miRNA p...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0758-6
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:The present study was performed to localize the articular deposition of monosodium urate (MSU) crystal in joints. We compare the detection efficiencies of dual-energy CT (DECT) and ultrasound scans. METHODS:Analyses by DECT and ultrasound were performed with 184 bilateral joints of the lower limbs of 54 cons...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-018-3994-4
更新日期:2018-05-01 00:00:00
abstract::31P Magnetic Resonance-Spectroscopy was performed at the site of tender points in the trapezius muscle of patients with primary fibromyalgia syndrome. Earlier, in vitro studies have reported changes in the high energy phosphate-metabolism in biopsies taken from tender points of fibromyalgia patients. The observed alte...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00291145
更新日期:1991-01-01 00:00:00