Abstract:
OBJECTIVE:The aim of this study was to measure serum oxidized low-density lipoprotein (Ox-LDL) levels in patients with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE) and to identify any association with clinical variables. METHODS:We studied 126 female patients (27 with active RA, 27 with inactive RA, 72 with SLE). One hundred fifteen age-matched healthy women (76 for RA, 39 for SLE) with no clinical or laboratory evidence of disease served as normal controls. Serum Ox-LDL levels were measured with a commercial enzyme-linked immunosorbent assay kit (Mercodia, Sweden). RESULTS:The serum Ox-LDL levels were significantly higher in patients with active RA (P<0.05) or SLE (P<0.01) than age-matched controls and significantly higher in patients with active RA than with inactive RA (P<0.01). The levels of serum total cholesterol and LDL were significantly lower in patients with RA than in age-matched controls (P<0.01). There was no correlation among serum Ox-LDL levels and inflammatory markers (erythrocyte sedimentation rate, C-reactive protein) or rheumatoid factors in patients with RA. CONCLUSIONS:Compared with healthy women, those with SLE or active RA had increased serum Ox-LDL levels, which may contribute to the increased risk of cardiovascular disease in this patient group.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Kim SH,Lee CK,Lee EY,Park SY,Cho YS,Yoo B,Moon HBdoi
10.1007/s00296-003-0358-4subject
Has Abstractpub_date
2004-07-01 00:00:00pages
230-3issue
4eissn
0172-8172issn
1437-160Xjournal_volume
24pub_type
杂志文章abstract::IL-17 has a role in inflammation in RA, and its levels in joints correlate with disease severity. Multiple RCTs have been performed to study effects of anti-IL-17 agents. The objective of this study was to perform a systematic review and meta-analysis to analyze the efficacy and safety of anti-IL-17 agents in the mana...
journal_title:Rheumatology international
pub_type: 杂志文章,meta分析,评审
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journal_title:Rheumatology international
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Rheumatology international
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pub_type: 杂志文章,随机对照试验
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journal_title:Rheumatology international
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pub_type: 杂志文章,评审
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更新日期:2014-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00296-009-0899-2
更新日期:2009-07-01 00:00:00
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pub_type: 杂志文章,多中心研究
doi:10.1007/s00296-013-2906-x
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pub_type: 杂志文章
doi:10.1007/s00296-011-2124-3
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,meta分析
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pub_type: 临床试验,杂志文章
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journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:2007-07-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-007-0324-7
更新日期:2007-08-01 00:00:00
abstract::The aim of this study was to evaluate systemic sclerosis (SSc) hospitalizations through a retrospective population-based study analyzing administrative data during 2001-2012 in Sardinia, an Italian region with universal Health System coverage. Data on hospital discharge records with ICD-9-CM code for SSc (710.1) were ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-015-3330-1
更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-03-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:2016-02-01 00:00:00
abstract::The aim of this study was to assess the changes in the characteristics of rheumatoid arthritis information on the Internet over a 15-year period and the positioning of Web sites posted by universities, hospitals, and medical associations. We replicated the methods of a 2001 study assessing rheumatoid arthritis informa...
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pub_type: 杂志文章
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更新日期:2016-09-01 00:00:00