Abstract：
:MicroRNAs (miRNAs) are noncoding RNA molecules of 21-24 nt that regulate the expression of target genes in a post-transcriptional manner. Evidence indicates that miRNAs play essential roles in embryogenesis, cell differentiation, and pathogenesis of human diseases. This study describes a comparison between the miRNA profile of kidney biopsies from lupus nephritis (LN) patients and the controls, to develop further understanding of the pathogenesis of LN. Kidney biopsies were taken from five LN patients detected LN Class II and three normal controls. The miRNA microarray chip analysis identified 66 miRNAs differentially expressed in LN. The chip results were confirmed by QRT-PCR. This work indicates that miRNAs are potential diagnosis biomarkers and probable factors involved in the pathogenesis of LN.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Dai Y,Sui W,Lan H,Yan Q,Huang H,Huang Ydoi
10.1007/s00296-008-0758-6subject
Has Abstractpub_date
2009-05-01 00:00:00pages
749-54issue
7eissn
0172-8172issn
1437-160Xjournal_volume
29pub_type
杂志文章abstract：:Osteoarthritis (OA) is the most common form of arthritis, resulting in substantial disability and economic burden worldwide. While its exact pathogenesis remains elusive, both in vitro and human population-based studies have merged to support the hypothesis that TGF-β/BMP-mediated signalling pathways play a role in th...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-015-3251-z
更新日期：2015-08-01 00:00:00
abstract：:Chronic inflammation starting early in life and continuing into adulthood may predispose children with Juvenile Idiopathic Arthritis (JIA) to cardiovascular (CV) complications. To compare non-invasive CV risk markers- left ventricular mass index (LVMi), brachial artery flow mediated dilatation (FMD) and carotid artery...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04689-z
更新日期：2021-02-01 00:00:00
abstract：:Utilizing monoclonal reagents directed towards antigens of the monocyte-macrophage lineage and Ia antigens, the tissue architecture of synovial membranes obtained from patients with non-inflammatory joint diseases and patients with rheumatoid arthritis was studied. Emphasis was placed on the localization of the type I...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541597
更新日期：1983-01-01 00:00:00
abstract：:Primary Sjögren syndrome (pS) is associated with autoantibodies such as rheumatoid factor (RF) and anti-nuclear antibodies such as anti-Ro (SS-A) and/or La (SS-B). Recent developments within autoimmune diagnostics allow quantitation of RF subclasses and anti-Ro epitopes. Will this refinement by autoimmune diagnostics ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-4090-5
更新日期：2018-08-01 00:00:00
abstract：:Diffuse idiopathic skeletal hyperostosis (DISH) is difficult to distinguish from various forms of inflammatory arthritis, including psoriatic arthritis (PsA), rheumatoid arthritis, and ankylosing spondylitis. A 67-year-old Japanese male had been treated for psoriasis vulgaris for 13 years. Numbness of his right arm an...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1368-7
更新日期：2012-05-01 00:00:00
abstract：:In a Turkish League Against Rheumatism (TLAR) project, evidence-based recommendations for the management of knee osteoarthritis (OA) was developed for the first time in our country in 2012 (TLAR-2012). In accordance with developing medical knowledge and scientific evidence, recommendations were updated. The committee ...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-018-4044-y
更新日期：2018-08-01 00:00:00
abstract：BACKGROUND:There is an overall increased risk of adverse pregnancy outcomes and maternal morbidity in patients with most autoimmune rheumatic diseases (ARD); outcomes are generally improved when the pregnancy is planned and the disease is in control. OBJECTIVE:The objective of the present study was to describe the sex...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04679-1
更新日期：2021-02-01 00:00:00
abstract：:Most infectious agents, such as viruses, bacteria and parasites, can trigger autoimmunity via different mechanisms. The development of an autoimmune disorder after infection tends to occur in genetically susceptible individuals. Some parameters, such as genetic predisposition, feature of the infectious agent and somet...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-012-2451-z
更新日期：2012-11-01 00:00:00
abstract：:The efficacy and tolerability of aceclofenac (100 mg bid; n = 109), a new non-steroidal anti-inflammatory agent, was compared to that of indomethacin (50 mg bid; n = 110) in a multi-centre, 12-week, randomized, double-blind clinical trial in patients with rheumatoid arthritis. The efficacy of aceclofenac, on the basis...
journal_title：Rheumatology international
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00290375
更新日期：1996-01-01 00:00:00
abstract：:Although arthroscopic surgery (AS) for knee osteoarthritis has been widely employed, scientific evidence is lacking. The purpose of this study was to investigate temporal changes in synovial fluid levels of biochemical markers associated with cartilage metabolism following AS. Twenty-five knees of 24 patients with med...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2374-8
更新日期：2013-01-01 00:00:00
abstract：:The aim of this study was to compare health related quality of life (HRQoL) and assess functional and psychological status in rheumatoid arthritis (RA), fibromyalgia syndrome (FS) patients and controls (each 30 subjects). Demographic characteristics, pain and sleep disturbance by Visual Analog Scale, depression by Bec...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0551-6
更新日期：2008-07-01 00:00:00
abstract：:Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily involving the spine and sacroiliac joint and rarely the kidneys. This study aimed to define the clinical and histological features and biology of renal disease in AS. We reviewed the medical records of 681 patients diagnosed with AS from November ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2624-9
更新日期：2013-07-01 00:00:00
abstract：:In recent years, scientific efforts on the topic "gout" have focused on pathogenetic aspects. This has opened new strategies of anti-inflammatory therapy and has improved urate-lowering therapy. So far, a scientometric analysis of the topic "gout" has not been generated despite an increased need for it in times of mod...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2805-1
更新日期：2013-11-01 00:00:00
abstract：:Kynurenic acid is an antagonist of ionotropic glutamate receptors. It has been found that glutamate antagonists inhibit proliferation of different human tumor cells. Since the hyperplasia of synovial fibroblasts is one of the most striking features of inflammatory arthritis, the main goals of this study were detection...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-005-0057-4
更新日期：2006-03-01 00:00:00
abstract：:The Australian/Canadian Osteoarthritis Hand Index (AUSCAN) is a patient self-reported 15-item questionnaire measuring the severity of hand osteoarthritis symptoms in the respect of pain, stiffness, and function. In this study, we developed a Korean version of the AUSCAN Index (K-AUSCAN) and confirmed its reliability, ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2227-x
更新日期：2012-11-01 00:00:00
abstract：:The minor allele of the non-synonymous single nucleotide polymorphism (SNP) +1858C>T within the PTPN22 gene has now been unequivocally confirmed as conferring susceptibility to RA in population from Europe and America, but not in population from Asia. The aim of this study was to jointly address and integrate these se...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1705-x
更新日期：2012-03-01 00:00:00
abstract：:To investigate the efficacy of etanercept and MTX (methotrexate) combination therapy in Chinese patients with ankylosing spondylitis hip joint lesion, the possible courses and maintenance protocol, altogether 97 ankylosing spondylitis patients fulfilling the modified New York criteria with hip joint lesion were enroll...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-1844-8
更新日期：2012-06-01 00:00:00
abstract：:Healthy human sexuality is integral to a well-lived life. Recent studies reported that sexual problems were common in patients with ankylosing spondylitis (AS) in relation to the consequences of the illness such as pain, stiffness of the spine and depression. Twenty-three female patients with AS and 27 healthy female ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2340-x
更新日期：2013-01-01 00:00:00
abstract：:Diagnostic accuracy of anti-DNase I antibodies measurement in a differentiation between SLE and other autoimmune rheumatic diseases was evaluated. The share of anti-DNase I and actin in the DNase I activity decrease in SLE was established. Serum samples were obtained from 54 patients with verified SLE, 52 control pati...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3437-z
更新日期：2016-04-01 00:00:00
abstract：:The aim of this study was to analyze the longitudinal practice patterns of prophylaxis of glucocorticoid-induced osteoporosis in patients with polymyalgia rheumatica (PMR). Patients diagnosed with PMR were collected retrospectively in two rheumatology departments. In addition to demographic and diagnostic criteria, th...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-014-3014-2
更新日期：2014-10-01 00:00:00
abstract：:Systematic reviews and meta-analyses of randomized trials have long been important synthesis tools for guiding evidence-based medicine. More recently, network meta-analyses, an extension of traditional meta-analyses enabling the comparison of multiple interventions, use new statistical methods to incorporate clinical ...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-014-2994-2
更新日期：2014-11-01 00:00:00
abstract：:Reduction in jaw opening is a neglected symptom of giant cell arteritis (GCA) in clinical practice and in the scientific literature. We describe the case of a 71-year-old woman with GCA who was misdiagnosed as occipital neuritis and craniomandibular dysfunction because of headaches in the occipital region and reductio...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1690-0
更新日期：2011-11-01 00:00:00
abstract：:We report on a 69-year-old woman who presented with myalgia, hearing impairment, fever, night sweats, weight loss, muscular weakness, paresthesia, hypesthesia, and hypalgesia. Sural nerve biopsy showed demyelinative and axonal polyneuropathy due to necrotizing vasculitis with fibrinoid necrosis. A positive test for an...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s002960000063
更新日期：2000-12-01 00:00:00
abstract：:Sarcoidosis is a chronic granulomatous inflammation. The clinical spectrum in childhood is heterogeneous. Angiotensin converting enzyme activity is used as a marker for disease activity. Human chitotriosidase is produced in macrophages. In this study, serum chitotriosidase levels were significantly higher in active sa...
journal_title：Rheumatology international
pub_type： 信件
doi：10.1007/s00296-007-0318-5
更新日期：2007-10-01 00:00:00
abstract：:The aim of the study is to determine the prevalence of and factors associated with major depression among those with Fibromyalgia Syndrome (FMS) in a Canadian representative sample. The study was a secondary analysis of a large, nationally representative sample from the Canadian Community Health Survey. The full sampl...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1713-x
更新日期：2012-04-01 00:00:00
abstract：:Spondyloarthropathy refers to any joint disease of the vertebral column, but the term is mainly used for a specific group of disorders called seronegative spondyloarthropathies (SpAs). The axial skeletal involvement, peripheral and extra-articular manifestations and an association with the major histocompatibility com...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-019-04346-0
更新日期：2019-09-01 00:00:00
abstract：:The fibromyalgia syndrome (FMS) is a chronic, widespread pain disorder of unknown etiology. It has been suggest that familial component, environmental factors, endocrine and neurotransmitter alterations, and psychological factors may contribute to the development of FMS. The role of melatonin in FMS is unclear. Some s...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2315-y
更新日期：2013-06-01 00:00:00
abstract：:The aim of this study was to evaluate the total antioxidant status (TAS), total oxidative status (TOS) and oxidative stress index (OSI) in patients with postmenopausal osteoporosis. We also investigate the relation between bone mineral density and oxidative/antioxidative parameters. Thirty-nine patients with osteoporo...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0452-0
更新日期：2008-02-01 00:00:00
abstract：:The objective of this study is to investigate the relationship between clinical features of ankylosing spondylitis (AS) and HLA-B27 status or its subtypes. Clinical data and blood samples were collected with patients' informed consent. Luminex liquid array combining polymerase chain reaction-sequence specific oligonuc...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0743-0
更新日期：2009-02-01 00:00:00
abstract：:C4A and C4B levels were measured in serum from 246 normal individuals. Complement-mediated solubilisation, assayed using alkaline phosphatase anti-alkaline phosphatase immune complexes (IC), correlated with both C4A and C4B levels. However, C4A and C4B levels showed no correlation with solubilisation of bovine serum a...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00302150
更新日期：1992-01-01 00:00:00
