Comprehensive analysis of microRNA expression patterns in renal biopsies of lupus nephritis patients.


:MicroRNAs (miRNAs) are noncoding RNA molecules of 21-24 nt that regulate the expression of target genes in a post-transcriptional manner. Evidence indicates that miRNAs play essential roles in embryogenesis, cell differentiation, and pathogenesis of human diseases. This study describes a comparison between the miRNA profile of kidney biopsies from lupus nephritis (LN) patients and the controls, to develop further understanding of the pathogenesis of LN. Kidney biopsies were taken from five LN patients detected LN Class II and three normal controls. The miRNA microarray chip analysis identified 66 miRNAs differentially expressed in LN. The chip results were confirmed by QRT-PCR. This work indicates that miRNAs are potential diagnosis biomarkers and probable factors involved in the pathogenesis of LN.


Rheumatol Int


Dai Y,Sui W,Lan H,Yan Q,Huang H,Huang Y




Has Abstract


2009-05-01 00:00:00












  • S1P-targeted therapy for elderly rheumatoid arthritis patients with osteoporosis.

    abstract::Therapeutics targeting sphingosine-1-phosphate (S1P), a kind of lipid mediator regulating immune cell trafficking, has been emerging rapidly as a novel line of regimen for autoimmune diseases, including rheumatoid arthritis (RA). Here, we propose that S1P-targeted therapy is beneficial not only for limiting inflammati...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Kikuta J,Iwai K,Saeki Y,Ishii M

    更新日期:2011-07-01 00:00:00

  • Fibromyalgia subgroups: profiling distinct subgroups using the Fibromyalgia Impact Questionnaire. A preliminary study.

    abstract::The main goal of this project was to identify the presence of fibromyalgia (FM) subgroups using a simple and frequently used clinical tool, the Fibromyalgia Impact Questionnaire (FIQ). A total of 61 women diagnosed with FM participated in this study. FM subgroups were created by applying a hierarchical cluster analysi...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: de Souza JB,Goffaux P,Julien N,Potvin S,Charest J,Marchand S

    更新日期:2009-03-01 00:00:00

  • Investigation of the association between Rho/Rho-kinase gene polymorphisms and systemic sclerosis.

    abstract::Systemic sclerosis (SSc) is a disease characterized by inflammation, vascular abnormalities and fibrosis. The role of Rho/Rho-kinase pathway was demonstrated in the pathogenesis of fibrosis, inflammation and vascular abnormalities. This study was aimed to investigate the relation between SSc and Rho/Rho-kinase gene po...

    journal_title:Rheumatology international

    pub_type: 杂志文章,多中心研究


    authors: Pehlivan Y,Yolbas S,Cetin GY,Alibaz-Oner F,Cagatay Y,Yilmaz N,Oztuzcu S,Donmez S,Ozgen M,Koca SS,Pamuk ON,Sayarlıoglu M,Kisacik B,Direskeneli H,Demiryurek AT,Onat AM

    更新日期:2016-03-01 00:00:00

  • Significance of risk factors for osteoporosis is dependent on gender and menopause in rheumatoid arthritis.

    abstract::The aim of our study was to compare the significance of risk factors for osteoporosis according to gender and menopausal state in patients with rheumatoid arthritis (RA). Bone mineral density (dual X-ray absorptiometry), cumulative glucocorticoid dose, age, disease duration, body mass index (BMI) and parameters of dis...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Oelzner P,Schwabe A,Lehmann G,Eidner T,Franke S,Wolf G,Hein G

    更新日期:2008-09-01 00:00:00

  • Low plasma vitamin D levels in patients with familial Mediterranean fever.

    abstract::Familial Mediterranean fever (FMF) is an autosomal recessive, inherited autoinflammatory disease characterized by recurrent, self-limited attacks of fever and inflammation of serosal surfaces. There is an explosion of the data regarding inflammatory markers in FMF and clinical effects of chronic inflammation on the di...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Erten S,Altunoğlu A,Ceylan GG,Maraş Y,Koca C,Yüksel A

    更新日期:2012-12-01 00:00:00

  • Punctal plugs versus artificial tears for treating primary Sjögren's syndrome with keratoconjunctivitis SICCA: a comparative observation of their effects on visual function.

    abstract::To compare the effects of treatment with punctal plugs versus artificial tears on visual function for primary Sjögren's syndrome with dry eye. Forty-two eyes of 42 patients with primary Sjögren's syndrome were enrolled and were allocated randomly into artificial tears (AT) group and punctal plugs (PP) group. Ocular Su...

    journal_title:Rheumatology international

    pub_type: 杂志文章,随机对照试验


    authors: Qiu W,Liu Z,Ao M,Li X,Wang W

    更新日期:2013-10-01 00:00:00

  • Ultrasonography of peripheral entheses in the diagnosis and understanding of diffuse idiopathic skeletal hyperostosis (DISH).

    abstract::The aim of this study was to investigate musculoskeletal ultrasound (MSUS) as a diagnostic modality in DISH and to explore whether it might help in elucidating its pathogenesis and events that precede the calcification/ossification process. Fifty patients with DISH and 34 patients with osteoarthritis of the lower limb...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Mader R,Novofastovski I,Iervolino S,Pavlov A,Chervinsky L,Schwartz N,Pappone N

    更新日期:2015-03-01 00:00:00

  • Prevalence and factors associated with disturbed sleep in patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis: a systematic review.

    abstract::This review explores the prevalence and factors associated with disturbed sleep for patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis in order to clarify consistent findings in this otherwise disparate research field. The association of physical, demographic and psychological factors co...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审


    authors: Leverment S,Clarke E,Wadeley A,Sengupta R

    更新日期:2017-02-01 00:00:00

  • Markers of endothelial damage and repair in Takayasu arteritis: are they associated with disease activity?

    abstract::The current clinical and laboratory parameters of Takayasu arteritis (TA) are insufficient for proper assessment of disease activity. The aims of this study were to investigate the markers of endothelial injury and repair, including circulating endothelial cell (CEC), circulating endothelial progenitor cell (CEPC) and...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Dogan S,Piskin O,Solmaz D,Akar S,Gulcu A,Yuksel F,Cakır V,Sari I,Akkoc N,Onen F

    更新日期:2014-08-01 00:00:00

  • Etodolac: efficacy in osteoarthritis and effects on chondrocyte function.

    abstract::Some nonsteroidal anti-inflammatory drugs (NSAIDs) used in the treatment of osteoarthritis (OA) may damage articular cartilage. This damage may be caused by suppression of proteoglycan synthesis or by altered collagen synthesis in the presence of prostaglandin E2 (PGE2) induced by interleukin-1 (IL-1). The clinical an...

    journal_title:Rheumatology international

    pub_type: 临床试验,杂志文章,评审


    authors: Bacon PA

    更新日期:1990-01-01 00:00:00

  • Detection of anti-bovine beta 2-glycoprotein I antibody in sera from patients with antiphospholipid syndrome.

    abstract::We studied and characterized anti-bovine beta 2-glycoprotein I antibodies (aB beta 2-GPI) in sera from patients with antiphospholipid syndrome (APS) by ELISA. Bovine beta 2-glycoprotein I (beta 2-GPI) was purified by heparin affinity and DEAE ion-exchange chromatography, and identified on immunoblots using a monoclona...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Nomura M,Okada J,Kondo H

    更新日期:1995-01-01 00:00:00

  • Activation of farnesoid X receptor attenuates liver injury in systemic lupus erythematosus.

    abstract::To investigate the expression and effect of farnesoid X receptor (FXR) on systemic lupus erythematosus (SLE) liver dysfunction and indicate its hepatoprotective role and the immunomodulatory property. mRNA and protein levels of FXR were determined on the liver specimens of SLE patients with liver injury as well as MRL...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Lian F,Wang Y,Chen J,Xu H,Yang X,Liang L,Zhan Z,Ye Y,Chen M

    更新日期:2012-06-01 00:00:00

  • Breast cancer and systemic sclerosis: a clinical description of 21 patients in a population-based cohort study.

    abstract::Previous studies have demonstrated an increased risk of breast cancer among patients with systemic sclerosis (scleroderma). To describe the clinical characteristics of 21 patients with both systemic sclerosis and breast cancer, and compare their risk factors to female scleroderma patients without breast cancer, in a p...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Lu TY,Hill CL,Pontifex EK,Roberts-Thomson PJ

    更新日期:2008-07-01 00:00:00

  • Assessment of sexual functions in female patients with ankylosing spondylitis compared with healthy controls.

    abstract::Healthy human sexuality is integral to a well-lived life. Recent studies reported that sexual problems were common in patients with ankylosing spondylitis (AS) in relation to the consequences of the illness such as pain, stiffness of the spine and depression. Twenty-three female patients with AS and 27 healthy female ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Demir SE,Rezvani A,Ok S

    更新日期:2013-01-01 00:00:00

  • Interleukin 1 activity in the synovial fluid of patients with rheumatoid arthritis.

    abstract::The synovial fluids (SF) of patients with rheumatoid arthritis (RA) were investigated for their effects on thymocytes of C3H/HeJ mice. Of the 20 SF tested, 17 (85%) showed an augmentation of the phytohaemagglutinin (PHA) induced thymocyte stimulation. Out of 16 SF of patients with osteoarthrosis, such an activity was ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Fontana A,Hengartner H,Weber E,Fehr K,Grob PJ,Cohen G

    更新日期:1982-01-01 00:00:00

  • Lack of association between mean platelet volume and disease activity in systemic lupus erythematosus patients: a systematic review and meta-analysis.

    abstract::Currently, many studies have focused on the possibility of using mean platelet volume (MPV) as a biomarker for disease activity in patients with systemic lupus erythematosus (SLE). To derive a more accurate estimation, a meta-analysis was conducted. Embase, PubMed, The Cochrane Library database and several Chinese dat...

    journal_title:Rheumatology international

    pub_type: 杂志文章,meta分析


    authors: Zhao CN,Mao YM,Wang P,Guan SY,Sam NB,Li XM,Wang DG,Pan HF

    更新日期:2018-09-01 00:00:00

  • Association of TNF-alpha -308 G/A polymorphism with responsiveness to TNF-alpha-blockers in rheumatoid arthritis: a meta-analysis.

    abstract::Tumor necrosis factor (TNF) antagonists are among the most effective therapies for rheumatoid arthritis (RA), yet not all patients show a response. Using meta-analysis, this present study was designed to investigate whether or not the TNF-alpha promoter -308 A/G polymorphism is associated with responsiveness to anti-T...

    journal_title:Rheumatology international

    pub_type: 杂志文章,meta分析


    authors: Lee YH,Rho YH,Choi SJ,Ji JD,Song GG

    更新日期:2006-12-01 00:00:00

  • Disease course and healthcare costs of a cohort of rheumatoid arthritis patients from Turkey.

    abstract::The objective of the study is to assess the disease course and associated healthcare costs in a cohort of established rheumatoid arthritis (RA) patients in Turkey. The study cohort consisted of 75 RA patients from our outpatient clinic who took part in a previous multicenter study assessing RA-related healthcare costs...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Ayan G,Esatoglu SN,Hatemi G,Hamuryudan V

    更新日期:2020-07-01 00:00:00

  • Determination of inflammation of reflex sympathetic dystrophy at early stages with Tc-99m HIG scintigraphy: preliminary results.

    abstract::The pathogenesis of reflex sympathetic dystrophy (RSD) is not completely understood. However, an excessive regional inflammation, sensitization of primary somatosensory afferents, and sensitization of spinal neurons are considered to have a role in the pathogenesis of RSD. The underlying pathophysiology relating the c...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Okudan B,Celik C

    更新日期:2006-03-01 00:00:00

  • Synovial fluid levels of E-selectin and intercellular adhesion molecule-1: relationship to joint inflammation in children with chronic arthritis.

    abstract::E-selectin and intercellular adhesion molecule (ICAM)-1 are crucial to the inflammatory response in chronic inflammatory arthritis. Soluble (s) levels of these molecules in sera and synovial fluid (SF) correlate with some clinical parameters and synovial tissue expression of the same molecules in rheumatoid arthritis....

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Bloom BJ,Nelson SM,Alario AJ,Miller LC,Schaller JG

    更新日期:2002-09-01 00:00:00

  • Activated T lymphocytes, rheumatoid factor and erythrocyte sedimentation rate assays in rheumatoid arthritis.

    abstract::Activated T lymphocytes (Ia+ T-cells) in peripheral blood are associated with immune stimulation. We found the percentages of these cells significantly increased in 95% of rheumatoid arthritis (RA) patients. Our studies showed no relation between the percentages of these cells in peripheral blood and concurrent erythr...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Bartfeld H,Dham C

    更新日期:1988-01-01 00:00:00

  • Development of a bedside pain assessment kit for the classification of patients with osteoarthritis.

    abstract::There are no standardized bedside assessments for subtyping patients with osteoarthritis (OA) based on pain mechanisms. Thus, we developed a bedside sensory testing kit (BSTK) to classify OA patients based on sensory profiles potentially indicative of pain mechanism. After usability and informal reliability testing (n...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Osgood E,Trudeau JJ,Eaton TA,Jensen MP,Gammaitoni A,Simon LS,Katz N

    更新日期:2015-06-01 00:00:00

  • The function of myeloid dendritic cells in rheumatoid arthritis.

    abstract::Rheumatoid arthritis (RA) is a systemic autoimmune disease that causes joint pain, inflammation, and loss of function. Disease pathogenesis involves activation and proliferation of autoreactive pro-inflammatory effector T cells. While the details of RA onset and progression remain controversial, dendritic cell (DC) nu...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审


    authors: Yu MB,Langridge WHR

    更新日期:2017-07-01 00:00:00

  • Heart rate variability in patients with rheumatoid arthritis.

    abstract::Heart rate variability (HRV) is a useful tool for the detection of sympathetic-parasympathetic balance in the autonomic nervous system. Autonomic nervous system involvement in patients with rheumatoid arthritis (RA) has rarely been studied and has shown conflicting results. Our purpose was to determine if HRV showed c...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Evrengül H,Dursunoglu D,Cobankara V,Polat B,Seleci D,Kabukçu S,Kaftan A,Semiz E,Kilic M

    更新日期:2004-07-01 00:00:00

  • Lumbar lordosis in acute and chronic low back pain patients.

    abstract::Postural changes are sometimes a risk factor for low back pain. Abnormal posture creates a strain on ligaments and muscles that indirectly affects the curvature of the lumbar spine. This study was planned to investigate the relationship between the angles of the lower lumbar spine and spinal mobility in acute and chro...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Evcik D,Yücel A

    更新日期:2003-07-01 00:00:00

  • Causes of death in patients with rheumatoid arthritis autopsied during a 40-year period.

    abstract::We studied causes of death (CoDs) between 1952 and 1991 assessed by a clinician before autopsy and then determined at autopsy by a pathologist in 369 subjects with rheumatoid arthritis (RA) and 370 subjects without RA (non-RA). We analysed clinical data for RA subjects between 1973 and 1991. In RA subjects, leading au...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Koivuniemi R,Paimela L,Suomalainen R,Piirainen H,Karesoja M,Helve T,Leirisalo-Repo M

    更新日期:2008-10-01 00:00:00

  • The effect of coffee, tea, and caffeine consumption on serum uric acid and the risk of hyperuricemia in Korean Multi-Rural Communities Cohort.

    abstract::Caffeine, a commonly consumed food constituent, is known to exert beneficial physiological effects in humans. There is a lack of comprehensive population data for the effects of caffeine intake on urate metabolism. Therefore, the aim of this study was to determine whether coffee, tea, and caffeine intake influences se...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Bae J,Park PS,Chun BY,Choi BY,Kim MK,Shin MH,Lee YH,Shin DH,Kim SK

    更新日期:2015-02-01 00:00:00

  • The prevalence of rheumatoid arthritis in Estonia: an estimate based on rheumatology patients' database.

    abstract::Sound epidemiological data are a basic requirement for decision making on the allocation of health care resources. Unfortunately, this is not the case in Estonia, where the paucity of epidemiological data has impeded health care planning for rheumatic conditions. The current paper presents the first effort to explore ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Otsa K,Tammaru M,Vorobjov S,Esko M,Pärsik E,Lang K

    更新日期:2013-04-01 00:00:00

  • Disseminated multiple ostial stenoses in a young woman presenting as unstable angina.

    abstract::A previously healthy 40-year-old woman presented as unstable angina. She had a family history of stroke as the only cardiovascular risk factor. Her blood pressure on admission was 150/90 mmHg. Laboratory study showed absolutely all negative markers of inflammation, autoimmune disorders, or atherosclerosis. Coronary an...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Lee SH,Chae JK,Lim ST,Ko JK

    更新日期:2009-04-01 00:00:00

  • Prevalence and incidence of rheumatoid arthritis in South Korea.

    abstract::Several studies of rheumatoid arthritis (RA) incidence and prevalence indicate that occurrence of the disease varies significantly among different populations. We aimed to estimate the prevalence and incidence of RA in South Korea. We used Korean National Health Insurance (NHI) claims data to estimate the prevalence o...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Sung YK,Cho SK,Choi CB,Bae SC

    更新日期:2013-06-01 00:00:00