Abstract:
:The aim of this study was to explore whether the catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with susceptibility to fibromyalgia and fibromyalgia impact questionnaire (FIQ) score in fibromyalgia patients. We conducted a meta-analysis of the associations of the COMT Val158Met polymorphism with fibromyalgia risk as well as FIQ score in fibromyalgia patients. A total of 993 fibromyalgia patients and 778 controls from 10 studies on the COMT Val158Met polymorphism and 538 fibromyalgia patients from 5 studies on the COMT Val158Met polymorphism and FIQ score were included in this meta-analysis. The meta-analysis revealed an association between fibromyalgia and the COMT Met/Met + Val/Met genotype in all study subjects (odds ratio (OR) 1.635, 95 % confidence interval (CI) 1.029-2.597, p = 0.037). However, stratification by ethnicity indicated no association between the Met/Met + Val/Met genotype and fibromyalgia in the European and Turkish populations (OR 1.202, 95 % CI 0.876-1.649, p = 0.255; OR 2.132, 95 % CI 0.764-5.949, p = 0.148, respectively). Analysis using other genetic models showed no association between the COMT Val158Met polymorphism and fibromyalgia. The meta-analysis also revealed that the FIQ score was significantly higher in individuals with the COMT Met/Met genotype than in those with the Val/Val genotype [weighted mean difference (WMD) = 14.39, 95 % CI 3.316-25.48, p = 0.011] and the Val/Met genotype (WMD = 5.108, 95 % CI 2.212-4.891, p = 0.021). This meta-analysis identified an association between fibromyalgia risk and the COMT Val158Met polymorphism as well as the FIQ score in fibromyalgia patients.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Lee YH,Kim JH,Song GGdoi
10.1007/s00296-014-3075-2subject
Has Abstractpub_date
2015-01-01 00:00:00pages
159-66issue
1eissn
0172-8172issn
1437-160Xjournal_volume
35pub_type
杂志文章,meta分析abstract::Total hip arthroplasty (THA) and total knee arthroplasty (TKA) bring relief of pain and functional disability to patients with end-stage osteoarthritis, and however, the literature on their impact on patients' level of physical activity (PA) is scarce. Cross-sectional study in patients who underwent THA/TKA surgery in...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-016-3598-9
更新日期:2017-02-01 00:00:00
abstract::To describe the profile of Enthesitis Related Arthritis' (ERA) patients, in the era of biologic DMARDs (bDMARDs). This retrospective cohort study included patients with ERA monitored on a 3-month schedule for at least 1 year. Their metric assessment included the disease status and damage by applying the contemporary t...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-020-04581-w
更新日期:2020-06-01 00:00:00
abstract::CD28 is one of the main activator receptors involved in systemic lupus erythematosus (SLE) pathogenesis, and its expression and serum levels are significantly higher in patients with SLE and other autoimmune diseases than in healthy controls (HC). However, it is unknown whether this increase is associated with specifi...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1479-1
更新日期:2011-10-01 00:00:00
abstract::To determine the possible diagnostic and prognostic value of cartilage biomarkers in early-stage progressive and nonprogressive knee osteoarthritis (OA) in a population-based cohort of middle-aged subjects with chronic knee pain. Design tibiofemoral (TF) and patellofemoral (PF) radiographs were graded in 128 subjects ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-012-2463-8
更新日期:2013-04-01 00:00:00
abstract::Systemic sclerosis is a connective tissue disease, which may lead to elevated pulmonary arterial pressure due to pulmonary arterial hypertension and/or left ventricular diastolic dysfunction. Uric acid (UA) has been shown to be elevated in patients with pulmonary hypertension (PH) and heart failure. We aimed to invest...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1557-4
更新日期:2011-02-01 00:00:00
abstract::Arachnoid ossificans is a rare type of chronic arachnoiditis characterised by the presence of calcification or ossification of the dura and arachnoid. There are a few reports of these findings in relation to various disease entities, but only one case has been reported in relation to ankylosing spondylitis. We describ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-2293-0
更新日期:2013-06-01 00:00:00
abstract::Some nonsteroidal anti-inflammatory drugs (NSAIDs) used in the treatment of osteoarthritis (OA) may damage articular cartilage. This damage may be caused by suppression of proteoglycan synthesis or by altered collagen synthesis in the presence of prostaglandin E2 (PGE2) induced by interleukin-1 (IL-1). The clinical an...
journal_title:Rheumatology international
pub_type: 临床试验,杂志文章,评审
doi:10.1007/BF02274749
更新日期:1990-01-01 00:00:00
abstract::Knee osteoarthritis is a common disease in the elderly population worldwide. The alleviation of the symptoms associated with this disease can be achieved with physical exercise that induces a cascade of molecular and cellular processes. Of the neurotrophins, brain-derived neurotrophic factor (BDNF) appears to be the m...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-013-2786-0
更新日期:2014-06-01 00:00:00
abstract::The aim of this study was to evaluate whether cyclosporin A (CsA) influences the radiological disease progression in early rheumatoid arthritis (RA) patients in comparison with other disease-modifying drugs (DMARDs). A total of 103 early RA patients, without prior use of DMARDs, were randomized to receive CsA (3 mg/kg...
journal_title:Rheumatology international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002960050113
更新日期:2000-01-01 00:00:00
abstract::Microvascular lesions are a predominant feature in systemic sclerosis (SSc) and seem to play a central pathogenic role. The presence of nailfold capillary abnormalities is useful in diagnosing SSc. Capillaroscopy, however, usually requires special equipment and may be time consuming. Dermatoscope has been presented as...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1532-0
更新日期:2011-12-01 00:00:00
abstract::In December 2019, numerous coronavirus disease 2019 (COVID-19) cases were reported in Wuhan, China, which has since spread throughout the world. However, its impact on rheumatoid arthritis (RA) patients is unknown. Herein, we report a case of COVID-19 pneumonia in a 61-year-old female RA patient who was receiving conv...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-020-04584-7
更新日期:2020-06-01 00:00:00
abstract::We studied the relationships between physician-assessed damage, severity and activity in a large, multicentre systemic sclerosis (SSc, scleroderma) cohort. We hypothesized that there is a relationship between disease activity and severity and damage, but that severity would be more strongly related to damage. A total ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1129-7
更新日期:2010-07-01 00:00:00
abstract::Psoriatic arthritis (PsA) patients are at a higher risk of systemic inflammatory sequelae, leading to microalbuminuria, cardiovascular (CVD) and neuropsychiatric (NPD) disease. Our aim is to present the existing literature about the relationship between CVD, kidney and NPD in PsA. The literature evaluation of PsA reve...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-020-04633-1
更新日期:2020-09-01 00:00:00
abstract::The authors report an unusual case of myelodysplastic syndrome (MDS) associated with ankylosing spondylitis (AS). A 40-year-old-man with MDS presented with chronic low back pain for 6 years. Four years ago, MDS was diagnosed during routine blood analysis for the work-up of his articular complaints. His initial articul...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0735-0
更新日期:2009-04-01 00:00:00
abstract::The occurrence of MHC class I antigens and microbial antigens derived from the triggering infection of the diseased joints in reactive arthritis (ReA) seems to set the stage for local immune activation. In this report activated lymphocytes are demonstrated by using an avidin-biotin-peroxidase complex (ABC) method comb...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00270983
更新日期:1989-01-01 00:00:00
abstract::The distribution of tumour necrosis factor alpha (TNF alpha) in rheumatoid synovium has been investigated. Ten rheumatoid synovia were compared with seven normal synovia and a range of other tissues, using one polyclonal and six monoclonal antibodies. A common staining pattern was obtained with five reagents. Absence ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00290246
更新日期:1991-01-01 00:00:00
abstract::A recent genome-wide association study revealed that there is an association between serum uric acid (SUA) levels and rs2544390, a common variant in low-density lipoprotein-related protein 2 (LRP2/Megalin) gene. Two other variants of LRP2, rs2229268 and rs3755166, are also found to have associations with dyslipidemia ...
journal_title:Rheumatology international
pub_type: 杂志文章,多中心研究
doi:10.1007/s00296-013-2924-8
更新日期:2014-04-01 00:00:00
abstract::The aim of this study was to investigate the association of three polymorphisms of CD154 with risk of SLE in Chinese population. The study population comprised 770 Chinese individuals, including 350 SLE patients and 420 healthy controls. The gene polymorphism was measured using Snapshot SNP genotyping assays and confi...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-017-3745-y
更新日期:2017-08-01 00:00:00
abstract::Immunofluorescence on polymorphonuclear cells (PMN) of patients with Felty syndrome (FS) revealed increased amounts of IgG, IgA, and IgM bound to the PMN surface compared with PMN of patients with rheumatoid arthritis alone. A positive correlation was found between the score for surface-bound immunoglobulins on FS-PMN...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541352
更新日期:1985-01-01 00:00:00
abstract::Behçet's syndrome (BS) is a chronic (auto)-inflammatory disorder characterized by different clusters of symptoms, including mucocutaneous and ocular involvements. Interleukin-1 inhibitors anakinra (ANA), canakinumab (CAN), and gevokizumab (GEV) represent a promising therapeutic alternative in BS. To date, evidence on ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-019-04259-y
更新日期:2019-06-01 00:00:00
abstract::The objective of the study is to assess the disease course and associated healthcare costs in a cohort of established rheumatoid arthritis (RA) patients in Turkey. The study cohort consisted of 75 RA patients from our outpatient clinic who took part in a previous multicenter study assessing RA-related healthcare costs...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-020-04574-9
更新日期:2020-07-01 00:00:00
abstract::To establish whether a cadaver model can serve as an effective surrogate for the detection of tendon damage characteristic of rheumatoid arthritis (RA). In addition, we evaluated intraobserver and interobserver agreement in the grading of RA-like tendon tears shown by US, as well as the concordance between the US find...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-016-3460-0
更新日期:2016-06-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a chronic systemic disorder characterized by the development through angiogenesis, which is dependent on endothelial cell activation, migration and proliferation and CCL21 plays an important role in this pathology. Currently, CCL21 gene polymorphism studies on rheumatoid arthritis are scar...
journal_title:Rheumatology international
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00296-017-3784-4
更新日期:2017-10-01 00:00:00
abstract::This prospective study aimed to determine the patient acceptable symptom state (PASS) cut-off for the patient reported outcome measure shoulder pain and disability index (SPADI), and evaluate predictors of PASS achievement following standard shoulder care. Patients with shoulder pain, referred for shoulder ultrasound ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-019-04486-3
更新日期:2020-04-01 00:00:00
abstract::Heart rate variability (HRV) is a useful tool for the detection of sympathetic-parasympathetic balance in the autonomic nervous system. Autonomic nervous system involvement in patients with rheumatoid arthritis (RA) has rarely been studied and has shown conflicting results. Our purpose was to determine if HRV showed c...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-003-0357-5
更新日期:2004-07-01 00:00:00
abstract::Sleep disturbances and problems are increased in ankylosing spondylitis (AS). But much is not known in a quantitative way about sleep problems and effect of treatments on AS. This study is aimed first, to investigate sleep disturbances in AS and secondly, to evaluate the effects of anti-TNF treatment on SD in AS. One ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-1907-x
更新日期:2012-07-01 00:00:00
abstract::Adult-onset Still's disease (AOSD) is a systemic inflammatory disease in which a variety of thrombotic events may occur. However, to our knowledge, portal vein thrombosis (PVT), a potential cause of gastrointestinal bleeding, has not been described in the English literature. A previously well 47-year-old man diagnosed...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-009-0894-7
更新日期:2009-10-01 00:00:00
abstract::Systemic sclerosis (SSc) is a generalized disorder characterized by fibrosis and vascular obliteration in the skin, lung, gastrointestinal tract, and kidney. One of its two subsets is a stable, limited cutaneous group (lSSc). Pulmonary involvement in scleroderma is common, and several types of pulmonary disorders are ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-002-0230-y
更新日期:2002-09-01 00:00:00
abstract::Omentin is an adipokine that reportedly protects against cardiometabolic risk. We investigated the relationships between omentin concentrations and subclinical cardiovascular disease in rheumatoid arthritis (RA). Omentin concentrations were measured in 213 (104 black; 109 white) RA patients. Relationships of omentin l...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-016-3541-0
更新日期:2017-01-01 00:00:00
abstract::Pancreatitis is uncommon in systemic lupus erythematosus (SLE) and is rarely reported in children, possibly being related to macrophage activation syndrome (MAS). The incidence of MAS in children with lupus pancreatitis is unknown, as is their prognosis. In this case-based review, we report a pediatric patient with SL...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-019-04388-4
更新日期:2020-05-01 00:00:00