Ankylosing spondylitis in a patient with myelodysplastic syndrome: an association with HLA-B27 or coincidence?

Abstract:

:The authors report an unusual case of myelodysplastic syndrome (MDS) associated with ankylosing spondylitis (AS). A 40-year-old-man with MDS presented with chronic low back pain for 6 years. Four years ago, MDS was diagnosed during routine blood analysis for the work-up of his articular complaints. His initial articular complaints were attributed to extramedullary manifestations of MDS. Persistent low back pain with increasing intensity finally led the patient to seek medical attention. Radiograph of the pelvis showed bilateral asymmetric sacroiliitis. A diagnosis of AS was established on the basis of modified New York criteria. Although various autoimmune phenomena associated with MDS have been described, this is the first report of AS in the setting of MDS. Causal relationship between these two disorders is currently unknown. Increased risk of hematological diseases as well as AS in individuals with a positive HLA-B27 provides a feasible explanation for this rare observation.

journal_name

Rheumatol Int

authors

Lee J,Kim H,Ahn JK,Hwang JW,Jang JH,Koh EM,Cha HS

doi

10.1007/s00296-008-0735-0

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

689-92

issue

6

eissn

0172-8172

issn

1437-160X

journal_volume

29

pub_type

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