Abstract:
:The authors report an unusual case of myelodysplastic syndrome (MDS) associated with ankylosing spondylitis (AS). A 40-year-old-man with MDS presented with chronic low back pain for 6 years. Four years ago, MDS was diagnosed during routine blood analysis for the work-up of his articular complaints. His initial articular complaints were attributed to extramedullary manifestations of MDS. Persistent low back pain with increasing intensity finally led the patient to seek medical attention. Radiograph of the pelvis showed bilateral asymmetric sacroiliitis. A diagnosis of AS was established on the basis of modified New York criteria. Although various autoimmune phenomena associated with MDS have been described, this is the first report of AS in the setting of MDS. Causal relationship between these two disorders is currently unknown. Increased risk of hematological diseases as well as AS in individuals with a positive HLA-B27 provides a feasible explanation for this rare observation.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Lee J,Kim H,Ahn JK,Hwang JW,Jang JH,Koh EM,Cha HSdoi
10.1007/s00296-008-0735-0subject
Has Abstractpub_date
2009-04-01 00:00:00pages
689-92issue
6eissn
0172-8172issn
1437-160Xjournal_volume
29pub_type
杂志文章abstract::In rheumatoid arthritis (RA), a disease characterized by bone loss, increased levels of serotonin have been reported. Recent studies have demonstrated a role for circulating serotonin as a regulator of osteoblastogenesis, inhibiting bone formation. Thus, we measured serum serotonin levels (SSL) in a Portuguese sample ...
journal_title:Rheumatology international
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journal_title:Rheumatology international
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pub_type: 杂志文章
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journal_title:Rheumatology international
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journal_title:Rheumatology international
pub_type: 历史文章,杂志文章
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journal_title:Rheumatology international
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journal_title:Rheumatology international
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journal_title:Rheumatology international
pub_type: 杂志文章
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journal_title:Rheumatology international
pub_type: 杂志文章,评审
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journal_title:Rheumatology international
pub_type: 杂志文章
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doi:10.1007/s00296-008-0682-9
更新日期:2009-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章,实务指引,评审
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pub_type: 杂志文章
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更新日期:2011-11-01 00:00:00
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journal_title:Rheumatology international
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journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:1989-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
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journal_title:Rheumatology international
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journal_title:Rheumatology international
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journal_title:Rheumatology international
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journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
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更新日期:2012-11-01 00:00:00
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pub_type: 杂志文章
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