Abstract：
:The Peptidyl arginine deiminase, type IV (PADI4) gene has been suggested to have an association with rheumatoid arthritis (RA) in several populations. But its role in Chinese RA is not clarified. We investigated five single-nucleotide polymorphisms (SNPs) of PADI4 as PADI4-89 (rs11203366), PADI4-90 (rs11203367), PADI4-92 (rs874881) PADI4-94 (rs2240340), and PADI4-104 (rs1748033) in Chinese Han population. A total of 378 unrelated RA patients and 204 healthy controls were genotyped for the five SNPs. Individual allele, genotype and haplotype frequencies were compared between patients and controls. No significant differences in the frequency of PADI4 alleles, genotypes and haplotypes were observed between the patients and controls except PADI4-92. These data indicated that PADI4 polymorphisms were unlikely to play an important role in the susceptibility to RA in Chinese Han population.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Chen R,Wei Y,Cai Q,Duan S,Ren D,Shen J,He D,Fang M,Lv K,Cheng N,Sun Sdoi
10.1007/s00296-010-1519-xsubject
Has Abstractpub_date
2011-12-01 00:00:00pages
1631-4issue
12eissn
0172-8172issn
1437-160Xjournal_volume
31pub_type
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journal_title：Rheumatology international
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journal_title：Rheumatology international
pub_type： 临床试验,杂志文章
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journal_title：Rheumatology international
pub_type： 杂志文章
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journal_title：Rheumatology international
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journal_title：Rheumatology international
pub_type： 临床试验,杂志文章
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journal_title：Rheumatology international
pub_type： 杂志文章,meta分析
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pub_type： 杂志文章
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pub_type： 杂志文章,多中心研究
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Rheumatology international
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章,多中心研究
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pub_type： 杂志文章
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journal_title：Rheumatology international
pub_type： 杂志文章
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更新日期：2011-11-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Rheumatology international
pub_type： 杂志文章
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pub_type： 杂志文章
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