Abstract：
:Alkoptunuria is an inherited autosomal recessive metabolic disorder which is caused by the lack of homogentisic acid-oxidase enzyme. It is associated with various systemic abnormalities and related to the deposition of homogentisic acid pigment in connective tissues. These pigmentary changes are termed "ochronosis". We describe two patients with ochronotic arthritis who presented with advanced degenerative changes in the lumbo-sacral spine, knee and hip. The literature, differential diagnosis and management of this rare condition are reviewed in this article.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Cetinus E,Cever I,Kural C,Erturk H,Akyildiz Mdoi
10.1007/s00296-004-0538-xsubject
Has Abstractpub_date
2005-08-01 00:00:00pages
465-8issue
6eissn
0172-8172issn
1437-160Xjournal_volume
25pub_type
杂志文章abstract：:Interleukin-15 (IL-15) is a pleotrophic cytokine that is involved in the pathogenesis of diverse inflammatory rheumatic diseases. The aims of this study were to compare serum IL-15 levels and expression of its receptor (IL-15Rα) in Behçet's disease (BD) with those in other rheumatic diseases and to identify the relati...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2705-4
更新日期：2013-08-01 00:00:00
abstract：:Low back pain is considered a problem with multiple facets for which the underlying causative factors should be determined. The aim of this study was to evaluate the relationships between depression, clinical status, and radiographic findings in a group of fifty patients with low back pain for more than 6 months. The ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s002960100133
更新日期：2001-10-01 00:00:00
abstract：:A 51-year-old man shepherd presented with mild pain and swelling of the right posterior aspect of his right elbow. In ultrasonography, the affected bursal space had swelling and effusion. Moreover, the aspiration of the affected bursa revealed an inflammatory profile. Brucella melitensis was detected in aspirated flui...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-019-04414-5
更新日期：2019-12-01 00:00:00
abstract：:A period of 4 weeks (w) has been recommended for rheumatoid arthritis (RA) patients as the interval between intravenous (IV) tocilizumab (TCZ, 8 mg/kg). In a previous paper, we showed the possibility that the interval between successive IV TCZ can be extended from 4 to 6 weeks in more than 60% of patients with low dis...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-4149-3
更新日期：2018-12-01 00:00:00
abstract：:Crystalglobulinemia is an extremely rare pathology that is associated in most cases with plasma cell dyscrasia, mainly multiple myeloma. In most cases, it may be the manifestation of incipient gammopathy or it manifests shortly after diagnosis. We report a patient with ischemic lesions of thrombotic origin in lower li...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-020-04620-6
更新日期：2020-08-01 00:00:00
abstract：:Acupuncture has been used to treat various clinical diseases in Eastern medicine. To investigate the analgesic effect of electroacupuncture (EA) pretreatment on carrageenan-induced inflammatory pain, we studied on the effect of EA parameters on an animal model of acute arthritic pain. Pretreatment with 1 mA, 10 Hz EA ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1364-y
更新日期：2011-06-01 00:00:00
abstract：:Familial Mediterranean fever is a chronic inflammatory disease characterized by periodic and self-limited episodes of fever and aseptic polyserositis. Although colchicine treatment has altered the course of the disease, it is believed that subclinical inflammation is still present, leading to endothelial dysfunction a...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-019-04457-8
更新日期：2020-01-01 00:00:00
abstract：:Clinical presentation of fibromyalgia syndrome (FMS) is heterogeneous and often involves psychological comorbidities. Clinical subgrouping of FMS patients has been proposed as a strategy to improve patients' long-term outcomes by helping identify specific treatment needs. Using the 90 Symptom Checklist Revised (SCL-90...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2199-x
更新日期：2012-11-01 00:00:00
abstract：:To study the combined effect of both genetic and environmental factors in the age of rheumatoid arthritis onset. Patients (n = 507). Shared epitope characterization was performed using Lifecodes HLA-SSO. Genotyping of protein tyrosine phosphatase non-receptor 22 (PTPN22) rs2476601 and signal transducers and activators...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2090-9
更新日期：2012-10-01 00:00:00
abstract：:The pathogenesis of reflex sympathetic dystrophy (RSD) is not completely understood. However, an excessive regional inflammation, sensitization of primary somatosensory afferents, and sensitization of spinal neurons are considered to have a role in the pathogenesis of RSD. The underlying pathophysiology relating the c...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-005-0009-z
更新日期：2006-03-01 00:00:00
abstract：:Accumulating evidence suggests that defects in the function of CD4(+)CD25(+) regulatory T cells (Tregs) are important in immune-mediated diseases such as rheumatoid arthritis. Here, we investigated the effects of various disease-modifying anti-rheumatic drugs (DMARDs) on Treg function. Tregs and CD4(+)CD25(-) effector...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2365-9
更新日期：2013-02-01 00:00:00
abstract：:Pure red cell aplasia (PRCA) is a disease with important relationships to autoimmune mechanisms. Although some autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus, have been associated with PRCA, until this point no studies have described the association between PRCA and primary antiphos...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1387-4
更新日期：2012-05-01 00:00:00
abstract：:The Sjögren's syndrome A antigen (SS-A) purified by affinity chromatography from human spleen was shown to contain a major polypeptide with a mol. wt. of 55 000 daltons confirmed as SS-A by its reactivity with different anti-SS-A sera on affinity columns, immunodiffusion and the Western blot. A similar reactive polype...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541183
更新日期：1984-01-01 00:00:00
abstract：:The objectives of this study are to evaluate the prevalence of radiographic hand osteoarthritis (OA) in Chuvashian community-based sample and its associations with age, sex, body mass index (BMI), smoking, and alcohol consumption. The study population was comprised of Chuvashians (443 males, age 47.4 ± 17.0 years and ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-0920-9
更新日期：2009-11-01 00:00:00
abstract：:Musculoskeletal discomfort in schoolchildren is significantly related to the weight and mode of carrying backpack to school. Prevalence and patterns of musculoskeletal discomfort among Nigerian secondary school students carrying backpack was investigated. Systematic sampling technique was used in the selection of the ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-014-2962-x
更新日期：2014-09-01 00:00:00
abstract：:The objective of this study was to determine whether levels of soluble receptors for tumor necrosis factor type I and type II (sTNF-RI and sTNF-RII) as measured in paired synovial fluids (SF) of arthritis patients are associated with clinical or laboratory parameters of local inflammation. sTNF-RI and -RII were measur...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00290299
更新日期：1993-01-01 00:00:00
abstract：:The expressions of some terminal glycotopes of synovial immunoglobulins G, A, and M were analysed in relation to rheumatoid arthritis (RA) progression defined according to early and advanced radiological changes in patients' hands. The relative amounts of terminal monosaccharides were determined by lectin-immunoblotti...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1139-5
更新日期：2010-08-01 00:00:00
abstract：:Sjögren's syndrome (SjS) and systemic lupus erythematosus (SLE) are common systemic autoimmune diseases, which impact not only patient health but also their quality of life. miRNA-146a is a microRNA that participates in the pathophysiology of SjS and SLE. In this investigation, we conducted a meta-analysis to determin...
journal_title：Rheumatology international
pub_type： 杂志文章,meta分析
doi：10.1007/s00296-017-3756-8
更新日期：2017-08-01 00:00:00
abstract：:The main objective of this study was to assess the symptoms and functional difficulties caused by rheumatoid arthritis through application of the willingness to pay (WTP) method. Structured questionnaire study was conducted among 242 RA patients. The subjects were asked to evaluate their functional capacity using visu...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1280-1
更新日期：2011-03-01 00:00:00
abstract：:Leg ulcers are a manifestation of antiphospholipid syndrome (APS), and characteristically respond poorly to treatment. Because the similar findings both clinical and pathological to pyoderma gangrenosum (PG), we treated these patients with a combination of immunosuppression (steroids, azathioprine or cyclosporine), ac...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1418-1
更新日期：2010-07-01 00:00:00
abstract：:The Juvenile Arthritis Multidimensional Assessment Report (JAMAR) is a new parent/patient-reported outcome measure that enables a thorough assessment of the disease status in children with juvenile idiopathic arthritis (JIA). We report results of the cross-cultural adaptation and validation of the parent and patient v...
journal_title：Rheumatology international
pub_type： 杂志文章,多中心研究
doi：10.1007/s00296-018-3969-5
更新日期：2018-04-01 00:00:00
abstract：:Fatigue has a large impact on quality of life and is still unmanageable for many patients. Study aims were describe (1) the prevalence and pattern of fatigue over time in patients with early rheumatoid arthritis under a treat-to-target strategy and (2) identify predictive factors for worsening and recovering of fatigu...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-4102-5
更新日期：2018-09-01 00:00:00
abstract：:Statistical analysis plays a critical role in data interpretation in all fields and particularly so for clinical data where important treatment decisions are made. We provide here an in-depth and illustrative analysis to examine patterns and radiographic scores in an early disease rheumatoid arthritis cohort over a 3-...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2879-9
更新日期：2014-02-01 00:00:00
abstract：:Several molecular epidemiological studies have been conducted in recent years to evaluate a possible association between the interferon regulatory factor 5 (IRF5) rs2004640 polymorphism and rheumatoid arthritis risk in diverse populations. However, the results remain conflicting rather than conclusive. Our aim was to ...
journal_title：Rheumatology international
pub_type： 杂志文章,meta分析
doi：10.1007/s00296-013-2806-0
更新日期：2013-11-01 00:00:00
abstract：:Severe vaso-occlusive retinopathy is a relatively rare form of retinopathy in systemic lupus erythematosus (SLE). We report two patients with severe vaso-occlusive retinopathy in SLE who were treated with intravitreal bevacizumab (IVB). (Patient 1) A 35-year-old woman presented with left visual loss and was diagnosed ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2139-9
更新日期：2013-01-01 00:00:00
abstract：:The objective of the study was to determine whether cartilage expression of the bone regulating molecules receptor activator of nuclear factor κB ligand (RANKL) and osteoprotegerin (OPG) varies between the different grades of osteoarthritis (OA). Cartilage samples were obtained from 30 patients undergoing total hip/kn...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1733-6
更新日期：2012-02-01 00:00:00
abstract：:Osteopoikilosis, a form of osteosclerotic disorders, is a rare bone dysplasia with typical radiologic findings. The pathology, which sometimes requires attention in differential diagnosis due to its radiologic appearance, has been reported previously with other diseases. In this report, a case diagnosed with both reac...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-005-0037-8
更新日期：2006-05-01 00:00:00
abstract：:Uveitis is an important component of many rheumatic diseases. The main causes of recurrent uveitis are seronegative spondylarthropathies and Behçet's disease. We describe a rare case of Henoch Schönlein vasculitis (HSV) along with multiple recurrences of acute anterior uveitis. In cases of skin rash and recurrent ante...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1074-5
更新日期：2010-08-01 00:00:00
abstract：:To date, numerous genetic and epigenetic studies have been performed and provided a crucial step forward in our understanding of the pathogenesis of rheumatic diseases. However, most of the recent advances in the treatment of rheumatic diseases including biological therapies are not based on or even discrepant from th...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-018-4026-0
更新日期：2018-08-01 00:00:00
abstract：:Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis associated with BRAFV600E mutations in more than 50% of cases and presenting with 95% with skeletal lesions. However, cutaneous, pulmonary, large vessels and central nervous system involvement can also occur. We report a case of a 25-year-old wo...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-020-04627-z
更新日期：2020-09-01 00:00:00
