Abstract:
:The mononuclear phagocyte infiltrate which occupies the gout tophus has been compared with that of the subcutaneous rheumatoid nodule. In the gout tophus, macrophage migration appears to be at a relatively low level and effectively terminates once these cells have been recruited into the corona. In the nodule the evidence suggests that both macrophage and granulocyte populations continuously migrate towards, and are progressively incorporated into, the necrotic centres. These observations indicate that chemotactic activity in rheumatoid nodules is at a higher level than in gout tophi, or that the rheumatoid mononuclear phagocyte is more responsive to such stimuli.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Palmer DG,Hogg N,Denholm I,Allen CA,Highton J,Hessian PAdoi
10.1007/BF00541376subject
Has Abstractpub_date
1987-01-01 00:00:00pages
187-93issue
5eissn
0172-8172issn
1437-160Xjournal_volume
7pub_type
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