Comparison of phenotype expression by mononuclear phagocytes within subcutaneous gouty tophi and rheumatoid nodules.

Abstract:

:The mononuclear phagocyte infiltrate which occupies the gout tophus has been compared with that of the subcutaneous rheumatoid nodule. In the gout tophus, macrophage migration appears to be at a relatively low level and effectively terminates once these cells have been recruited into the corona. In the nodule the evidence suggests that both macrophage and granulocyte populations continuously migrate towards, and are progressively incorporated into, the necrotic centres. These observations indicate that chemotactic activity in rheumatoid nodules is at a higher level than in gout tophi, or that the rheumatoid mononuclear phagocyte is more responsive to such stimuli.

journal_name

Rheumatol Int

authors

Palmer DG,Hogg N,Denholm I,Allen CA,Highton J,Hessian PA

doi

10.1007/BF00541376

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

187-93

issue

5

eissn

0172-8172

issn

1437-160X

journal_volume

7

pub_type

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