Abstract：
:Systemic sclerosis is a connective tissue disease in which oxidative stress represents an important player among the complex pathogenetic mechanisms of the disease. Iloprost, an analogue of natural prostacyclin, is used in systemic sclerosis for the treatment of severe Raynaud's phenomenon and ischemic ulcers. There is a clear evidence that iloprost attenuates oxidative damage induced by ischemia-reperfusion phenomena. The aim of this study is to evaluate the effect of iloprost on oxidative status in ten patients with systemic sclerosis by measuring urinary levels of 8-isoprostaglandin-F(2alpha), a member of F(2)-isoprostanes. We found that systemic sclerosis patients cyclically treated with iloprost showed increased urinary level of 8-isoprostaglandin-F(2alpha )in comparison with healthy subjects; urinary 8-isoprostaglandin-F(2alpha) did not diminish soon after the iloprost infusion as well as 3, 15 and 30 days after the drug administration. Unlike experimental studies, in vivo the strong vasodilator effect of iloprost infusion did not reduce oxidative status.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Volpe A,Biasi D,Caramaschi P,Bambara LM,Carletto A,Degan M,Minuz Pdoi
10.1007/s00296-007-0443-1subject
Has Abstractpub_date
2008-02-01 00:00:00pages
335-7issue
4eissn
0172-8172issn
1437-160Xjournal_volume
28pub_type
临床试验,杂志文章abstract：:The objective of this study was to search for proteomic patterns distinguishing patients with rheumatoid arthritis (RA) from healthy controls, biomarker candidates specific for early RA, and proteins reflecting disease activity, by profiling of serum proteins using magnetic bead-based (MB) separation and matrix-assist...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1407-4
更新日期：2011-08-01 00:00:00
abstract：:The objective of this study is to investigate the relationship between clinical features of ankylosing spondylitis (AS) and HLA-B27 status or its subtypes. Clinical data and blood samples were collected with patients' informed consent. Luminex liquid array combining polymerase chain reaction-sequence specific oligonuc...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0743-0
更新日期：2009-02-01 00:00:00
abstract：OBJECTIVES:To evaluate the prevalence and annual incidence of clinically-manifest vertebral fractures among patients with ankylosing spondylitis (AS). METHOD:Coordinated by the Ankylosing Spondylitis International Federation, a self-administered general questionnaire which included some questions on gender, age, age a...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-004-0556-8
更新日期：2006-01-01 00:00:00
abstract：:IgM, IgG and IgA class antibodies against Yersinia, Salmonella, Campylobacter and Borrelia were determined by enzyme-linked immunosorbent assay (ELISA) in a group of 340 unselected patients with a recent inflammatory joint disease. The control group consisted of 340 and 100 healthy blood donors using Borrelia-ELISA an...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF02274884
更新日期：1991-01-01 00:00:00
abstract：:An abnormal immune response towards the Epstein-Barr virus (EBV) has been documented in patients with rheumatoid arthritis (RA). To investigate whether these findings are due to the transformation event caused by EBV, RA blood mononuclear cells and monocyte-enriched preparations were incubated with two different EBV s...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00271873
更新日期：1989-01-01 00:00:00
abstract：:Gender may produce different characteristics in the manifestation of systemic lupus erythematosus (SLE). The present study investigated the influence of gender on clinical, laboratory, autoantibodies and histopathological classes of lupus nephritis (LN). As much as 81 patients diagnosed with SLE (ACR criteria) and act...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1151-9
更新日期：2010-08-01 00:00:00
abstract：:Nitric oxide (NO) is a free radical that plays important roles in many physiological and pathological processes. Evidence suggests that NO participates in the pathogenesis of inflammatory reactions in many autoimmune and inflammatory diseases such as rheumatoid arthritis (RA). The purpose of this study was to evaluate...
journal_title：Rheumatology international
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002960100105
更新日期：2001-05-01 00:00:00
abstract：:Malignant neoplasms are associated with a wide variety of paraneoplastic rheumatological syndromes. The paraneoplastic nature should be based on specific criteria. We report a series of eight cases of paraneoplastic rheumatic syndromes revealing an underlying neoplasia. Our series consists of six men and two women, wi...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-011-2252-9
更新日期：2012-06-01 00:00:00
abstract：:The role of free radicals in fibromyalgia is controversial. In this study, 85 female patients with primary fibromyalgia and 80 age-, height-, and weight-matched healthy women were evaluated for oxidant/antioxidant balance. Malondialdehyde is a toxic metabolite of lipid peroxidation used as a marker of free radical dam...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-003-0427-8
更新日期：2005-04-01 00:00:00
abstract：:The objective was to investigate the effect of activin A on matrix metalloproteinase 3 (MMP-3) production and to identify the role of activin A in chondroprotection. SW1353 cells, a human chondrosarcoma cell line, were stimulated with interleukin (IL) 1alpha and tumor necrosis factor (TNF) alpha, and the concentration...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0350-5
更新日期：2007-09-01 00:00:00
abstract：:The purpose of the present study was to evaluate the toxicity and tolerability of methotrexate (MTX)/gold (G; group 1) combination therapy as compared to other MTX combinations [MTX with hydroxychloroquine (HCQ; group 2), MTX with sulphasalazine (SASP; group 3) and MTX with minocycline (MNC; group 4)]. The hospital re...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/pl00006851
更新日期：1997-01-01 00:00:00
abstract：:There is no agreement among the rheumatology community in how to implement the musculoskeletal ultrasound (MSUS) technique in the Rheumatology Divisions. To test the perceived usefulness of the MSUS, under consensus indications, for referring colleagues for the clinical management of their patients with inflammatory a...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3538-8
更新日期：2016-12-01 00:00:00
abstract：:A critical analysis has been performed of reports published on the incidence of gastro-intestinal (GI) side-effects found in arthritic patients being treated with non-steroid anti-inflammatory (NSAI) drugs. The results show the following: 1. The incidence of GI ulceration (as revealed by gastroscopy) and haemorrhage i...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541263
更新日期：1982-01-01 00:00:00
abstract：:Hand osteoarthritis (OA) is a common degenerative joint disorder leading to substantial pain and disability. The most severe subtype is erosive hand OA characterized by an abrupt onset, local inflammation, subchondral erosions and worse outcomes than non-erosive disease. Biomarkers of hand OA could help to diagnose th...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-017-3864-5
更新日期：2018-05-01 00:00:00
abstract：:Therapeutic proteins, such as infliximab, have revolutionized the treatment of many diseases during the last decade and more than 80 therapeutic proteins are currently approved for clinical use. However, all exogenous proteins have the potential to cause antibody formation. In order to ensure patient safety and the ef...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-005-0085-0
更新日期：2006-03-01 00:00:00
abstract：:The main objective of this study was to assess the symptoms and functional difficulties caused by rheumatoid arthritis through application of the willingness to pay (WTP) method. Structured questionnaire study was conducted among 242 RA patients. The subjects were asked to evaluate their functional capacity using visu...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1280-1
更新日期：2011-03-01 00:00:00
abstract：:Tribal differences are demonstrated in the presentation of lupus in Omani Gulf Arabs (OGA) and Omani Arabs of Persian descent (OAP), both groups resident in and indigenous to the Sultanate of Oman. The OAP have a lower risk of joint complications, skin rash, and dsDNA antibodies than OGA (beta coefficient and 95% conf...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-001-0151-1
更新日期：2002-01-01 00:00:00
abstract：:As has been shown by a number of working groups, primary fibromyalgia syndrome does not represent a single clinical entity. It is possible to distinguish between a subgroup with high pain sensitivity and no associated psychiatric condition, a second and a third subgroup characterized by depression associated with fibr...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-007-0403-9
更新日期：2007-09-01 00:00:00
abstract：:Osteoarthritis (OA) is the most common form of arthritis, resulting in substantial disability and economic burden worldwide. While its exact pathogenesis remains elusive, both in vitro and human population-based studies have merged to support the hypothesis that TGF-β/BMP-mediated signalling pathways play a role in th...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-015-3251-z
更新日期：2015-08-01 00:00:00
abstract：:We describe the case of a 59 year old man with systemic sclerosis and superficial siderosis of the central nervous system characterized by progressive worsening of walking with signs of pyramidal liberation associated with cerebellar ataxia and bilateral hypoacusia. Ferritin and oligoclonal bands were found on lumbar ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0523-x
更新日期：2008-06-01 00:00:00
abstract：:The mechanisms of male idiopathic osteoporosis are little known. We evaluated bone mineral loss by dual-energy X-ray absorptiometry and determined its cortical or trabecular nature in a cohort of men with idiopathic osteoporosis with fractures. Thirty-nine men (mean age 60 ± 13 years), with negative investigations for...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2076-7
更新日期：2012-10-01 00:00:00
abstract：:While carpal tunnel syndrome (CTS) is the most common entrapment neuropathy presented at rheumatologic consultation, its ulcerative variant is rarely described. We report of a case of severe bilateral medial nerve palsy, presented to us for diagnosis of chronic digital ulcers which had been suspected to be rheumatolog...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1229-4
更新日期：2011-05-01 00:00:00
abstract：:Increased QT interval dispersion has been associated with an increased risk for ventricular arrhythmias and sudden cardiac events. We examined the QT interval dispersion in 20 North Indian children with Kawasaki disease (KD) with no coronary artery abnormalities on echocardiography compared the same with matched contr...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1252-5
更新日期：2011-03-01 00:00:00
abstract：:We present a 10-year-old girl who had been diagnosed with juvenile idiopathic arthritis 5 years before and who experienced a flare of arthritis affecting one knee while she was off medication for almost 3 years. Seronegative Lyme arthritis had to be diagnosed based on the detection of Borrelia burgdorferi DNA in synov...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0333-6
更新日期：2007-09-01 00:00:00
abstract：:The Assessment of SpondyloArthritis international Society Health Index (ASAS HI) is an inclusive questionnaire, able to describe the total impairments and restrictions due to axial spondyloarthritis (axSpA). Considering the relationship between ASAS HI and the Ankylosing Spondylitis Disease Activity Score (ASDAS)-CRP,...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3642-9
更新日期：2017-05-01 00:00:00
abstract：KEY MESSAGES:There is a relative lack of confidence among GPs in the assessment and management of IBP vs. mechanical back pain. A simple screening tool for SpA, applicable in primary care urgently needs to be developed. It is reasonable for patients with symptoms suggestive of inflammatory back pain to be referred to s...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-4058-5
更新日期：2018-10-01 00:00:00
abstract：:The aims of this systematic review and meta-analysis were to: (1) describe the prevalence of commonly reported comorbidities in psoriatic arthritis (PsA), (2) compare the incidence and/or prevalence of comorbidities between PsA and control populations; and (3) examine the impact of comorbidities on PsA outcomes. We sy...
journal_title：Rheumatology international
pub_type：
doi：10.1007/s00296-020-04775-2
更新日期：2021-02-01 00:00:00
abstract：:We examined the intracellular mechanisms of substance P induced oxyradical production in rheumatoid synovial cells by the luminol-dependent chemiluminescence method. After stimulation with substance P (30 microM), single synovial A (macrophage-like) or B (fibroblast-like) cells released oxyradicals such as superoxide ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF01419729
更新日期：1996-01-01 00:00:00
abstract：:Catalase (CAT) and peroxisome proliferator activated receptor-gamma2 (PPARgamma2) are important regulators of oxidative stress and inflammation, and may contribute to the development of rheumatoid arthritis (RA). We investigated the association between CAT and PPARgamma2 genotypes and risk and severity of RA using 474...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-005-0013-3
更新日期：2006-03-01 00:00:00
abstract：:Omentin is an adipokine that reportedly protects against cardiometabolic risk. We investigated the relationships between omentin concentrations and subclinical cardiovascular disease in rheumatoid arthritis (RA). Omentin concentrations were measured in 213 (104 black; 109 white) RA patients. Relationships of omentin l...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3541-0
更新日期：2017-01-01 00:00:00
