Abstract：
:The distribution of tumour necrosis factor alpha (TNF alpha) in rheumatoid synovium has been investigated. Ten rheumatoid synovia were compared with seven normal synovia and a range of other tissues, using one polyclonal and six monoclonal antibodies. A common staining pattern was obtained with five reagents. Absence of staining of tissue with the other reagents may relate to binding to different epitopes. Excluding cross-reactivity with smooth muscle seen with two reagents, results with the first five reagents were as follows. Normal tissues showed either no staining or faint staining of venular endothelium. In addition skin keratinocytes and colonic mucus showed staining. Rheumatoid synovium showed staining of venules and weaker staining of mononuclear cells, both as individual cells in the deep tissue and more uniformly in areas of the lining layer. The majority of cells that stained for TNF alpha double-stained for CD68 (macrophages). These represented less than 10% of CD68-positive cells. Isolated cells staining for TNF alpha stained for CD3 (T-cells), forming less than 1% of the total T-cells. The presence of staining of venular endothelium suggests that the cytokine may be synthesised by endothelial cells or may be taken up after production by macrophages.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Wilkinson LS,Edwards JCdoi
10.1007/BF00290246subject
Has Abstractpub_date
1991-01-01 00:00:00pages
19-25issue
1eissn
0172-8172issn
1437-160Xjournal_volume
11pub_type
杂志文章abstract：:Isoform 4 of the human peptidylarginine deiminase (hPAD4) enzyme may be responsible for the citrullination of antigens in rheumatoid arthritis (RA) and has been shown to be itself the target of disease-specific autoantibodies. Here, we have tested whether the level of serum anti-hPAD4 antibodies in RA patients is stab...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1765-y
更新日期：2012-05-01 00:00:00
abstract：:Anti-Saccharomyces cerevisiae antibodies (ASCA) had been known to be specific for Crohn's disease but it has been found in many other autoimmune diseases like systemic lupus erythematosus (SLE). Furthermore, cross-reactive epitopes on β2-glycoprotein I (β2GPI) and Saccharomyces cerevisiae were found in SLE patients. T...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2431-3
更新日期：2013-03-01 00:00:00
abstract：:Sound epidemiological data are a basic requirement for decision making on the allocation of health care resources. Unfortunately, this is not the case in Estonia, where the paucity of epidemiological data has impeded health care planning for rheumatic conditions. The current paper presents the first effort to explore ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2473-6
更新日期：2013-04-01 00:00:00
abstract：:We report a case of a 39-year-old female with active systemic lupus erythematosus who complained of lethargy and weakness with a moderate renal impairment. Hypercalcemia was confirmed by laboratory examination. Her X-ray revealed significant ectopic calcinosis in subcutaneous tissue of bilateral hands, and Tc-99(m) me...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-016-3486-3
更新日期：2016-07-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to evaluate the efficacy and tolerability of long-term treatment with cyclosporin A (CsA) in patients with psoriatic arthritis (PsA). METHODS:Sixty patients with PsA were enrolled in a prospective, nonrandomised study of CsA. Patients with hypertension or hypercreatinemia were exclu...
journal_title：Rheumatology international
pub_type： 临床试验,杂志文章
doi：10.1007/s00296-001-0166-7
更新日期：2002-04-01 00:00:00
abstract：:PADI4 that catalyzes the conversion of peptidylarginine to citrulline is associated with rheumatoid arthritis in some populations. The current study investigated the expressions of PADI4 in synovial fluid of RA (n = 73), osteoarthritis (OA, n = 96) and ankylosing spondylitis (AS, n = 32) using ELISA and western blotti...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-0870-2
更新日期：2009-10-01 00:00:00
abstract：:Fluoride excess primarily effects dental and skeletal tissues. leading to a condition known as endemic fluorosis. The radiological and clinical features of endemic fluorosis vary in different parts of the world. The aim of this study was to investigate the clinical and radiological features of endemic fluorosis in Tur...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s002960100132
更新日期：2001-09-01 00:00:00
abstract：:The group of autoimmune cutaneous connective tissue diseases (CCTD) includes systemic sclerosis, dermatomyositis (DM), lupus erythematosus (LE), and subtypes. Most CCTD patients can be assigned to one of these phenotypes or mixed forms, and transitions among the subsets exist. We present the case of a 26-year-old woma...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-003-0354-8
更新日期：2004-03-01 00:00:00
abstract：:Evidence is limited on the association between hyperuricaemia and mortality in children and adolescents. This study was to investigate this association in the paediatric population. The study included children and adolescents who had undergone serum uric acid (SUA) measurement at the Chang Gung Memorial Hospital betwe...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2808-y
更新日期：2013-11-01 00:00:00
abstract：:Clinically diagnosed cases with different grades of rheumatoid arthritis (RA) were studied for (a) cryoglobulin content (b) constituents of cryoglobulins, and (c) rheumatoid factor (RF) titers in sera and cryoglobulins. Of 60 patients, 28 (46.66%) had significantly high levels of cryoglobulins and were mainly distribu...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541520
更新日期：1985-01-01 00:00:00
abstract：:Sjogren's syndrome (SS) is a systemic autoimmune disease characterized by xerophthalmia, xerostomia and extraglandular manifestations. Anemia, leukopenia, thrombocytopenia and lymphoproliferative disorders, including lymphoma are well-known extraglandular, hematological complications of SS. We report here a rare case ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1395-4
更新日期：2012-05-01 00:00:00
abstract：:Gender may produce different characteristics in the manifestation of systemic lupus erythematosus (SLE). The present study investigated the influence of gender on clinical, laboratory, autoantibodies and histopathological classes of lupus nephritis (LN). As much as 81 patients diagnosed with SLE (ACR criteria) and act...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1151-9
更新日期：2010-08-01 00:00:00
abstract：:Addison's disease is an autoimmune process. However, Addison's disease associated with connective tissue diseases (CTD) is only occasionally reported. Here, we report six cases of Addison's disease secondary to a variety of CTD, which include systemic lupus erythematosus, Takayasu arteritis, systemic sclerosis, ankylo...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0749-7
更新日期：2009-04-01 00:00:00
abstract：:To develop a semi-automated method to quantify inflammation in sacroiliac (SI) joints by measuring bone marrow edema (BME) on MRI. The SCAISS was designed as an image-processing software. Validation followed: (1) three readers evaluated SI images of 23 patients with axial SpA and various levels of BME severity with th...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-4104-3
更新日期：2018-10-01 00:00:00
abstract：:The objective of this study is to investigate the clinical markers of life-threatening Pneumocystis pneumonia (PCP) in patients with collagen vascular diseases (CVD). The patients who contracted Pneumocystis jeroveccii were retrospectively selected from our medical charts and conditions related to the patients' death ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-0857-z
更新日期：2009-09-01 00:00:00
abstract：:We describe a patient with bronchiolitis obliterans organizing pneumonia (BOOP) requiring respiratory support and treated with corticosteroids and cytoxan for presumed Wegener's granulomatosis (WG). The diagnosis of WG was based on clinical presentation and strongly positive stains for anti-neutrophilic cytoplasmic an...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s002960000095
更新日期：2001-04-01 00:00:00
abstract：:A 51-year-old man shepherd presented with mild pain and swelling of the right posterior aspect of his right elbow. In ultrasonography, the affected bursal space had swelling and effusion. Moreover, the aspiration of the affected bursa revealed an inflammatory profile. Brucella melitensis was detected in aspirated flui...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-019-04414-5
更新日期：2019-12-01 00:00:00
abstract：:Sphingolipids are components of the plasma membrane whose metabolic manipulation is of interest as a potential therapeutic approach in a number of diseases. Sphingosine kinase 1 (SphK1), the major kinase that phosphorylates sphingosine to sphingosine-1-phosphate (S1P), was previously shown by our group and others to m...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2493-2
更新日期：2013-10-01 00:00:00
abstract：:A meta-analysis was done with the final data from three trials that provided the first results relating to efficacy and safety of the new sustained-release (SR) formulation of etodolac versus established nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of osteoarthritis (OA) of the knee. The studies were...
journal_title：Rheumatology international
pub_type： 杂志文章,meta分析
doi：10.1007/BF00290280
更新日期：1993-01-01 00:00:00
abstract：:The aim of this study was to assess the changes in the characteristics of rheumatoid arthritis information on the Internet over a 15-year period and the positioning of Web sites posted by universities, hospitals, and medical associations. We replicated the methods of a 2001 study assessing rheumatoid arthritis informa...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3507-2
更新日期：2016-09-01 00:00:00
abstract：:Establishing prevention and therapeutic strategies for osteoarthritis (OA) is necessary to minimize functional disability and the impact of the disease on society. The aim of this study was to determine the effects of an exercise therapy protocol on inflammatory markers, perception of pain, and physical performance in...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-014-3148-2
更新日期：2015-03-01 00:00:00
abstract：:To define the relationship between serum anti-cyclic citrullinated peptide antibodies (anti-CCP) and disease activity, and to construct a new disease activity index by using anti-CCP in rheumatoid arthritis (RA). One hundred and five RA patients were included. Disease activity based on DAS28-ESR and serum anti-CCP was...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2282-3
更新日期：2012-12-01 00:00:00
abstract：:Uveitis may represent an opportunity to diagnose spondyloarthropathies (SpA) earlier and influence treatment decisions. We describe the percentage of acute anterior uveitis (AAU) in a diverse group of SpA patients seen at one academic setting and compare demographic and clinical characteristics according to the presen...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-019-04386-6
更新日期：2019-09-01 00:00:00
abstract：:The results from previous studies on association of IL-6 -174 G/C and -572 G/C polymorphisms with the risk of systemic lupus erythematosus (SLE) remained inconsistent. Therefore, a meta-analysis was performed to assess the association between these two polymorphisms and SLE susceptibility. A literature-based search wa...
journal_title：Rheumatology international
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00296-013-2855-4
更新日期：2014-02-01 00:00:00
abstract：:A 50-year-old man presented with a complaint of low-back pain and widespread joint pain for the previous 20 years. Conventional radiography revealed wide areas of calcification in the intervertebral discs and degenerative changes in the peripheral joints. A diagnosis of ochronosis was made by the observation of bluish...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-007-0381-y
更新日期：2007-11-01 00:00:00
abstract：:The aim of this study was to compare the efficacy of sodium hyaluronate (SH) injection with the most common treatment methods, intraarticular steroid injection and physical therapy modalities in patients with adhesive capsulitis (AC). A total of 95 shoulders of 90 patients were included in the study and were randomize...
journal_title：Rheumatology international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00296-005-0022-2
更新日期：2006-04-01 00:00:00
abstract：:Adult-onset Still's disease (AOSD) is a systemic inflammatory disease in which a variety of thrombotic events may occur. However, to our knowledge, portal vein thrombosis (PVT), a potential cause of gastrointestinal bleeding, has not been described in the English literature. A previously well 47-year-old man diagnosed...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-009-0894-7
更新日期：2009-10-01 00:00:00
abstract：:To investigate the effects of TNF-alpha -308, -238 promoter polymorphisms on TNF-alpha transcription in B27 positive Chinese patients with ankylosing spondylitis (AS). The possible relationship between polymorphisms, MHC antigens, and quantitative TNF-alpha mRNA expression were evaluated. Single nucleotide polymorphis...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0671-z
更新日期：2008-12-01 00:00:00
abstract：:To translate and culturally adapt the Mayo Elbow Performance Score (MEPS), a widely used instrument for evaluating disability associated with elbow injuries, into Turkish (MEPS-T) and to determine psychometric properties of the translated version. The MEPS was translated into Turkish using published methodological gui...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-014-3201-1
更新日期：2015-06-01 00:00:00
abstract：:Echocardiographic examination and 24-h electrocardiographic Holter monitoring were carried out on 35 patients with nodular rheumatoid arthritis (RA) and 35 with non-nodular RA, who were matched with the nodular RA group regarding age, sex and BSA. A further 35 patients with osteoarthrosis and spondyloarthrosis matched...
journal_title：Rheumatology international
pub_type： 临床试验,杂志文章
doi：10.1007/s002960050079
更新日期：1999-01-01 00:00:00
