Abstract：
:Interleukin-15 (IL-15) is a pleotrophic cytokine that is involved in the pathogenesis of diverse inflammatory rheumatic diseases. The aims of this study were to compare serum IL-15 levels and expression of its receptor (IL-15Rα) in Behçet's disease (BD) with those in other rheumatic diseases and to identify the relationship between serum IL-15 levels and various clinical parameters in BD. One hundred fifty-eight subjects consisting of 40 BD, 38 systemic lupus erythematosus (SLE), 40 rheumatoid arthritis (RA), and 40 healthy controls were enrolled. Serum IL-15 levels were measured using an enzyme-linked immunosorbent assay. The proportion of IL-15Rα expression on each leukocyte subset was measured by flow cytometry. Erythrocyte sediment rate (ESR) and C-reactive protein (CRP) were measured for each enrolled subject. The clinical activity index of BD was assessed for BD patients. Serum IL-15 levels in BD patients are significantly higher than those of healthy controls, SLE, and RA patients (p < 0.001, p < 0.001, and p < 0.001, respectively). Serum IL-15 levels in BD were closely related to ESR (r = 0.405, p = 0.027), but not to CRP or the clinical activity index of BD (p > 0.05 for both). Additionally, there was no difference in serum IL-15 levels between active and inactive disease states in BD (p > 0.05). The proportion of IL-15Rα expression on total leukocytes was much lower for all rheumatic diseases, including BD, than in healthy controls (p < 0.01 for SLE, p < 0.01 for RA, and p < 0.05 for BD). IL-15 and IL-15Rα system may be involved in the inflammatory process and pathogenesis of BD.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Choe JY,Lee H,Kim SG,Kim MJ,Park SH,Kim SKdoi
10.1007/s00296-013-2705-4subject
Has Abstractpub_date
2013-08-01 00:00:00pages
2109-15issue
8eissn
0172-8172issn
1437-160Xjournal_volume
33pub_type
杂志文章abstract：:We report a case of reversible sensorineural hearing loss due to hydroxychloroquine (HQ) treatment. The patient was a 34-year-old woman with 1 year of rheumatoid arthritis (RA). She developed reversible hearing loss after 5 months of HQ treatment. Sensorineural deafness has previously been reported with chloroquine tr...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s002960000054
更新日期：2000-01-01 00:00:00
abstract：:The distribution of tumour necrosis factor alpha (TNF alpha) in rheumatoid synovium has been investigated. Ten rheumatoid synovia were compared with seven normal synovia and a range of other tissues, using one polyclonal and six monoclonal antibodies. A common staining pattern was obtained with five reagents. Absence ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00290246
更新日期：1991-01-01 00:00:00
abstract：:Sarcoidosis is a chronic, multisystemic, non-caseating granulomatous disease of unknown etiology. Nasopharyngeal involvement is very rare in sarcoidosis. The objective of this report was to evaluate a rare involvement of sarcoidosis. This report includes a case of nasopharyngeal sarcoidosis. A 51-year-old female with ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-1866-2
更新日期：2012-05-01 00:00:00
abstract：:The objectives of this study are to evaluate the prevalence of radiographic hand osteoarthritis (OA) in Chuvashian community-based sample and its associations with age, sex, body mass index (BMI), smoking, and alcohol consumption. The study population was comprised of Chuvashians (443 males, age 47.4 ± 17.0 years and ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-0920-9
更新日期：2009-11-01 00:00:00
abstract：:Meigs' syndrome represents a triad of pleural effusion, ascites, and an ovarian tumor, usually benign, occurring together. We describe here a case of Meigs' syndrome in a patient with systemic sclerosis, the first such report to our knowledge, in systemic sclerosis. A 53-year-old woman with systemic sclerosis presente...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2437-x
更新日期：2013-10-01 00:00:00
abstract：:Non-tuberculous mycobacteria (NTM) are an unusual cause of osteomyelitis in immunocompetent children. Diagnosis is often difficult due to the paucity of clinical symptoms and a subtle course of the disease. NTM comprise a group of about 91 identified species of environmental mycobacteria that cause infections most fre...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-0844-4
更新日期：2009-10-01 00:00:00
abstract：:The thiol status of patients with rheumatoid arthritis is significantly different from that of controls. Plasma thiol levels are lower, albumin thiol reactivity is altered and intracellular thiol levels measured after hemoglobin precipitation are increased. These variations correlate with other indices of disease seve...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541162
更新日期：1982-01-01 00:00:00
abstract：:Healthy human sexuality is integral to a well-lived life. Recent studies reported that sexual problems were common in patients with ankylosing spondylitis (AS) in relation to the consequences of the illness such as pain, stiffness of the spine and depression. Twenty-three female patients with AS and 27 healthy female ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2340-x
更新日期：2013-01-01 00:00:00
abstract：:Monocyte interleukin-1 (IL-1) production in vitro was studied in 49 patients with rheumatoid arthritis (RA) and 31 controls. Twenty-six of the RA patients were studied prospectively for up to 12 months after beginning chrysotherapy. About half of the patients (group 1) exhibited pretreatment levels of monocyte IL-1 se...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF02274840
更新日期：1990-01-01 00:00:00
abstract：:The aim of the study was to compare the diagnostic efficacy of the visual assessment of diffusion-weighted imaging (DWI) and dynamic contrast-enhanced (DCE) sequences compared to the STIR sequence in the diagnostics of active sacroiliitis in the course of axial spondyloarthritis (axSpA). The study group consisted of 4...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-019-04373-x
更新日期：2019-09-01 00:00:00
abstract：:Several studies have shown a negative association between smoking and primary Sjögren's syndrome (pSS), and smoking may interfere with the immune response. The purpose of this study was to investigate if smoking affects disease activity and disease phenotype in pSS. In this cross-sectional study, consecutive pSS patie...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-019-04335-3
更新日期：2019-09-01 00:00:00
abstract：:The aim of the study is to determine the prevalence of and factors associated with major depression among those with Fibromyalgia Syndrome (FMS) in a Canadian representative sample. The study was a secondary analysis of a large, nationally representative sample from the Canadian Community Health Survey. The full sampl...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1713-x
更新日期：2012-04-01 00:00:00
abstract：:The clinical use of pulsed electromagnetic fields (PEMF) in osteoarticular pathology is widely extended, although the mechanisms involved are unknown. The aim of this study was to evaluate the action of a new protocol of treatment with PEMF on liquid medium cultures of fibroblast-like cells derivates of mononuclear pe...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1488-0
更新日期：2011-10-01 00:00:00
abstract：:A 44-year-old man with intermittent asymmetric migratory oligoarthritis lasting the recent decade was admitted to our hospital. Considerable specific biomarkers for rheumatoid arthritis such as anti-agalactosyl IgG antibody are all negative. He was diagnosed as palindromic rheumatism (PR). Although hand X-rays showed ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0654-0
更新日期：2008-11-01 00:00:00
abstract：:We have examined the way in which products of cultured human blood mononuclear cells activate human articular chondrocytes. Conditioned medium from mononuclear cells enhanced the production of prostaglandin E by cultured human chondrocytes and also stimulated fibrinolytic activity in these cultures. These two effects ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541204
更新日期：1984-01-01 00:00:00
abstract：:The objective of this study was to translate and evaluate the psychometric properties of the Thai version of the Rheumatoid Arthritis Disease Activity Index (RADAI) in patients with rheumatoid arthritis (RA). We translated and modified the original RADAI into the Thai version. A total of 116 Thai patients with RA were...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2749-5
更新日期：2013-10-01 00:00:00
abstract：:Patients with rheumatoid arthritis (RA) have bone loss to various degrees at different skeletal sites. The subregional bone mineral density (BMD) of the hand and the correlation of BMD to other regional bone losses, parameters of inflammation or bone resorption was evaluated in 421 patients with RA and controls. RA pa...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0638-0
更新日期：2008-11-01 00:00:00
abstract：:Pancreatitis is a relatively rare but severe manifestation in systemic lupus erythematosus (SLE) patients. We report a case of a 39-year-old woman with previous SLE diagnose treated with prednisone and mycophenolate mofetil who developed an acute pancreatitis complicated by pancreatic pseudocysts within the context of...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-0964-x
更新日期：2010-03-01 00:00:00
abstract：:Thrombotic microangiopathy (TMA)/thrombotic thrombocytopenic purpura (TTP) is a rare but potentially lethal condition requiring rapid recognition, diagnosis, and initiation of therapy. We experienced a case of a 61-year-old woman with primary Sjögren's syndrome (pSS) complicated with severe renal TMA/TTP following IgM...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1569-0
更新日期：2013-01-01 00:00:00
abstract：:The study includes a case report and a literature review. The main objective of this study is to present a case of spondylodiscitis due to a fungal pathogen, Blastoschizomyces capitatus and to review the published literature on this emergent fungus in etiology of spondylodiscitis, and osteomyelitis. Osteoarticular inv...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-009-0928-1
更新日期：2009-08-01 00:00:00
abstract：:Familial Mediterranean fever (FMF) is a self-limited disease characterized by fever and polyserositis attacks. Arthritis caused by synovitis is either in acute monoarthritis or chronic mono-oligoarthritis form, usually affecting the lower extremities. Another potential but rare form of involvement is spondyloarthropat...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0616-6
更新日期：2008-11-01 00:00:00
abstract：:Biological markers of inflammation are useful for the diagnosis and monitoring of inflammatory rheumatic diseases. The present study tested, whether serum amyloid A (SAA) could be used as a marker of inflammatory disease activity in ankylosing spondylitis (AS). In 72 patients with AS, the two valuable surrogate marker...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s002960050114
更新日期：2000-01-01 00:00:00
abstract：:Ultrasound (US)-guided corticosteroid injection has been shown to be safe and effective for varied causes of plantar fasciitis; however, its use for Achilles tendinitis is controversial. We studied the efficacy and changes in US findings at Achilles enthesitis after corticosteroid injection in patients with spondyloar...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3440-4
更新日期：2016-06-01 00:00:00
abstract：:The efficacy and tolerability of aceclofenac (100 mg bid; n = 109), a new non-steroidal anti-inflammatory agent, was compared to that of indomethacin (50 mg bid; n = 110) in a multi-centre, 12-week, randomized, double-blind clinical trial in patients with rheumatoid arthritis. The efficacy of aceclofenac, on the basis...
journal_title：Rheumatology international
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00290375
更新日期：1996-01-01 00:00:00
abstract：:Fibromyalgia (FM) is the most common chronic pain syndrome encountered in medical practice, affecting females more than males, and the estimated prevalence of FM in Egypt is 1.3 %. The aim was to translate and adapt the Fibromyalgia Impact Questionnaire (FIQ) into Arabic and assess reliability and validity. The Arabic...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2779-z
更新日期：2013-10-01 00:00:00
abstract：:Using different monoclonal antibodies, we performed an immunofluorescent technique on labial salivary glands in order to investigate the immunological phenomena involved in Sjögren's syndrome (SS). An aberrant expression of HLA-DR molecules was detected on cytoplasm of epithelial labial salivary cells in 9 out of 19 (...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00262708
更新日期：1995-01-01 00:00:00
abstract：:Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis associated with BRAFV600E mutations in more than 50% of cases and presenting with 95% with skeletal lesions. However, cutaneous, pulmonary, large vessels and central nervous system involvement can also occur. We report a case of a 25-year-old wo...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-020-04627-z
更新日期：2020-09-01 00:00:00
abstract：:Folate supplementation is widely accepted and utilized for the prevention of adverse events in juvenile idiopathic arthritis (JIA) patients who are treated with methotrexate. Despite the widespread use of folate supplementation, there is a lack of convincing evidence to support the role of folate in the enhancement of...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2696-1
更新日期：2013-09-01 00:00:00
abstract：:Fatigue has a large impact on quality of life and is still unmanageable for many patients. Study aims were describe (1) the prevalence and pattern of fatigue over time in patients with early rheumatoid arthritis under a treat-to-target strategy and (2) identify predictive factors for worsening and recovering of fatigu...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-4102-5
更新日期：2018-09-01 00:00:00
abstract：:The aim of our study was to evaluate effectiveness of ultrasound treatment applied with exercise therapy in patients with ankylosing spondylitis. Fifty-two patients, who were diagnosed according to modified New York criteria, were aged 25-60, and have spine pain, were randomly assigned to two groups. Ultrasound (US) a...
journal_title：Rheumatology international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00296-016-3441-3
更新日期：2016-05-01 00:00:00
