Abstract：
:We measured alpha 2-plasmin inhibitor-plasmin complexes (PI-PC) in plasma of patients with systemic lupus erythematosus (SLE) to examine the plasminogen activation in SLE. The plasma PI-PC level in 23 patients with SLE was significantly higher than that in 18 normal subjects (P less than 0.001) and the SLE patients with nephrotic syndrome had higher plasma PI-PC levels than those without nephrotic syndrome (P less than 0.01). In addition, the plasma PI-PC level was significantly correlated with the level of plasma C3 breakdown products (iC3b/C3dg) in the patients with SLE (r = 0.53, P less than 0.01). These results suggest that plasminogen is activated in plasma of patients with SLE and that the plasminogen activation may be associated with the activation of complement in SLE.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Negoro N,Kanayama Y,Takeda T,Fujisawa M,Okamura M,Inoue Tdoi
10.1007/BF00270984subject
Has Abstractpub_date
1989-01-01 00:00:00pages
273-7issue
6eissn
0172-8172issn
1437-160Xjournal_volume
8pub_type
杂志文章abstract：:The aim was to evaluate the relative importance of the 20 functions assessed by patients to produce the Health Assessment Questionnaire's Disability Index (HAQ-DI). A systematic sample of 242 rheumatoid arthritis patients was drawn. Altogether 179 subjects returned acceptably filled questionnaire including perceived r...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1176-0
更新日期：2010-09-01 00:00:00
abstract：:Necrotic areas of rheumatoid nodules were investigated electron microscopically. PMNs in different stages of disintegration were present in all cases. Granular material, sometimes in a fiberlike orientation, and small fibrils without periodicity were detected between the collagenous fibers. It is assumed that granular...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541219
更新日期：1981-01-01 00:00:00
abstract：:The prevalence of overweight and obesity in patients with fibromyalgia is high, which makes these patients more likely to trigger metabolic changes. It is also uncertain whether the clinical manifestations of fibromyalgia alter the metabolism in these patients. This study investigates the influence of adiposity indica...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-014-2988-0
更新日期：2014-11-01 00:00:00
abstract：:IL-17 has a role in inflammation in RA, and its levels in joints correlate with disease severity. Multiple RCTs have been performed to study effects of anti-IL-17 agents. The objective of this study was to perform a systematic review and meta-analysis to analyze the efficacy and safety of anti-IL-17 agents in the mana...
journal_title：Rheumatology international
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00296-016-3480-9
更新日期：2016-08-01 00:00:00
abstract：:Cyclooxygenase-2 (COX-2) is a key regulatory enzyme in the synthesis of prostanoids associated with trauma and inflammation. Upregulation of COX-2 in human lupus T cells resists anergy and apotosis. We investigated the COX-2 gene for functional variants that may influence susceptibility, clinical outcomes and severity...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-006-0162-z
更新日期：2006-11-01 00:00:00
abstract：:Tuberculosis can affect sacroiliac joints, but only a few such cases have been reported. The onset is usually insidious, and early diagnosis requires a high index of clinical suspicion. We report herein a culture-proven case of tuberculous sacroiliitis which initially mimicked neoplastic infiltration on CT scan. ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-003-0406-0
更新日期：2004-09-01 00:00:00
abstract：:Intraocular inflammation is one of the more relevant complications of Behçet's disease (BD), which tends to respond poorly to different medications. The ocular histopathologic changes are basically identical to those occurring in other organs and consist in a necrotizing leukocytoclastic obliterative vasculitis, which...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-017-3775-5
更新日期：2018-01-01 00:00:00
abstract：:PXK was identified as a novel candidate gene for systemic lupus erythematosus (SLE) from genome-wide association studies (GWAS) in Caucasians. But a recent replication study in Hong Kong Chinese reported that PXK was not associated with SLE. The aim of this study was to determine whether PXK is associated with SLE in ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1789-3
更新日期：2012-01-01 00:00:00
abstract：:The aim of the present study was to evaluate the effect of long-term leflunomide and methotrexate (MTX) therapy during the course of rheumatoid arthritis (RA) estimated by digital X-ray radiogrammetry (DXR) and computer-aided joint space analysis (CAJSA) as diagnostic tools for the quantification of disease-related pe...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0682-9
更新日期：2009-01-01 00:00:00
abstract：:Systemic lupus erythematosus is an autoimmune disease with protean manifestation. Arthritis is one of the most common manifestations seen in SLE. Anti-CCP Ab is a recently described autoantibody that has been claimed as a most sensitive and specific marker for the diagnosis of RA. Study was performed to see whether an...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1374-9
更新日期：2011-06-01 00:00:00
abstract：:Systemic lupus erythematosus (SLE) severity, reflecting both disease intensity and duration, is heterogeneous making it challenging to study in administrative databases where severity may confound or mediate associations with outcomes. Garris et al. developed an administrative claims-based algorithm employing claims o...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-019-04477-4
更新日期：2020-02-01 00:00:00
abstract：:Systematic reviews and meta-analyses of randomized trials have long been important synthesis tools for guiding evidence-based medicine. More recently, network meta-analyses, an extension of traditional meta-analyses enabling the comparison of multiple interventions, use new statistical methods to incorporate clinical ...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-014-2994-2
更新日期：2014-11-01 00:00:00
abstract：:Ultrasonography (US) and power Doppler sonography (PDS) was used to investigate causes of new onset of shoulder pain and sites of shoulder inflammation in 157 shoulders of 99 patients with rheumatoid arthritis (RA). US detected effusion and/or synovitis in 92/157 glenohumeral joints, subdeltoid bursitis in 56/157 shou...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0465-8
更新日期：2008-03-01 00:00:00
abstract：:A meta-analysis was done with the final data from three trials that provided the first results relating to efficacy and safety of the new sustained-release (SR) formulation of etodolac versus established nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of osteoarthritis (OA) of the knee. The studies were...
journal_title：Rheumatology international
pub_type： 杂志文章,meta分析
doi：10.1007/BF00290280
更新日期：1993-01-01 00:00:00
abstract：:The expressions of some terminal glycotopes of synovial immunoglobulins G, A, and M were analysed in relation to rheumatoid arthritis (RA) progression defined according to early and advanced radiological changes in patients' hands. The relative amounts of terminal monosaccharides were determined by lectin-immunoblotti...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1139-5
更新日期：2010-08-01 00:00:00
abstract：:A 42-year-old woman presented with a 3-week history of left knee pain and swelling. She had suffered dermatitis herpetiformis for 12 years, proved by skin biopsy. She had never been on gluten-free diet. Knee pain increased with motion and her gait was antalgic. On admission, she was mainly dependent on wheelchair due ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1670-4
更新日期：2011-05-01 00:00:00
abstract：:The objective of this study is to investigate the endothelial function in complex regional pain syndrome. A total of 21 patients with CRPS and 15 healthy controls were enrolled. The mean age of patients was 22 +/- 4.9 years and the mean duration of the disease was 5.9 +/- 2.5 months. Flow-mediated vasodilatation (FMD)...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0451-1
更新日期：2008-02-01 00:00:00
abstract：OBJECTIVE:Recent studies revealed trisomy 7 as a chromosomal abnormality in non-neoplastic disorders such as rheumatoid arthritis (RA). In the present study, we investigated the presence of trisomy 7 in the synovial fluid cells of patients with RA using fluorescence in situ hybridisation (FISH) analysis. METHODS:Synov...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-004-0477-6
更新日期：2005-10-01 00:00:00
abstract：:CCL28 is a mucosa-associated epithelial-cell-produced chemokine involved in oral defense. We assessed the level of CCL28 in saliva of primary Sjögren's syndrome (pSS) patients in comparison with healthy controls and correlated it with IgA salivary levels. We included 30 non-smoker pSS patients and 30 non-smoker health...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-014-3210-0
更新日期：2015-08-01 00:00:00
abstract：:The objective of this study is to investigate the relationship between clinical features of ankylosing spondylitis (AS) and HLA-B27 status or its subtypes. Clinical data and blood samples were collected with patients' informed consent. Luminex liquid array combining polymerase chain reaction-sequence specific oligonuc...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0743-0
更新日期：2009-02-01 00:00:00
abstract：:The aim of this study was to compare clinical symptoms, perceived health status, health resource use and psychosocial features in fibromyalgia (FM) patients at different health care levels. A total of 315 participants were recruited from primary care (PC) (n=101) and rheumatology settings (RS) (n=214). Subjects comple...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0818-y
更新日期：2009-08-01 00:00:00
abstract：:Primary Sjögren syndrome (pS) is associated with autoantibodies such as rheumatoid factor (RF) and anti-nuclear antibodies such as anti-Ro (SS-A) and/or La (SS-B). Recent developments within autoimmune diagnostics allow quantitation of RF subclasses and anti-Ro epitopes. Will this refinement by autoimmune diagnostics ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-4090-5
更新日期：2018-08-01 00:00:00
abstract：:The aim of the study was to compare the diagnostic efficacy of the visual assessment of diffusion-weighted imaging (DWI) and dynamic contrast-enhanced (DCE) sequences compared to the STIR sequence in the diagnostics of active sacroiliitis in the course of axial spondyloarthritis (axSpA). The study group consisted of 4...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-019-04373-x
更新日期：2019-09-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to evaluate the efficacy and tolerability of long-term treatment with cyclosporin A (CsA) in patients with psoriatic arthritis (PsA). METHODS:Sixty patients with PsA were enrolled in a prospective, nonrandomised study of CsA. Patients with hypertension or hypercreatinemia were exclu...
journal_title：Rheumatology international
pub_type： 临床试验,杂志文章
doi：10.1007/s00296-001-0166-7
更新日期：2002-04-01 00:00:00
abstract：:Clinically diagnosed cases with different grades of rheumatoid arthritis (RA) were studied for (a) cryoglobulin content (b) constituents of cryoglobulins, and (c) rheumatoid factor (RF) titers in sera and cryoglobulins. Of 60 patients, 28 (46.66%) had significantly high levels of cryoglobulins and were mainly distribu...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541520
更新日期：1985-01-01 00:00:00
abstract：OBJECTIVE:To describe the prevalence of and evaluate the factors associated with fatigue patients with psoriatic arthritis (PsA) in an Asian population. METHODS:We used baseline data from a registry of patients with PsA attending an outpatient clinic of a tertiary hospital in Singapore. Demographic data and disease ch...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04678-2
更新日期：2020-11-01 00:00:00
abstract：:Antibodies to DNA are quite specific for systemic lupus erythematosus (SLE) and occur in the majority of SLE patients. Therefore, their detection is an important diagnostic aid to the clinician. Detection of anti-dsDNA may precede the diagnosis of SLE by more than a year. Fluctuations in the level of anti-dsDNA in an ...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/BF00304496
更新日期：1991-01-01 00:00:00
abstract：:Patients with rheumatoid arthritis (RA) have bone loss to various degrees at different skeletal sites. The subregional bone mineral density (BMD) of the hand and the correlation of BMD to other regional bone losses, parameters of inflammation or bone resorption was evaluated in 421 patients with RA and controls. RA pa...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0638-0
更新日期：2008-11-01 00:00:00
abstract：:We present a 10-year-old girl who had been diagnosed with juvenile idiopathic arthritis 5 years before and who experienced a flare of arthritis affecting one knee while she was off medication for almost 3 years. Seronegative Lyme arthritis had to be diagnosed based on the detection of Borrelia burgdorferi DNA in synov...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0333-6
更新日期：2007-09-01 00:00:00
abstract：:Behçet disease (BD) is an inflammatory disorder of unknown origin. We present here an unusual case of juvenile Behçet with hemoptysis due to large pulmonary artery aneurysms (PAA), large intra-cardiac thrombus and prolonged fever, which posed several therapeutic challenges. In this case, a 14-year-old boy was admitted...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0730-5
更新日期：2009-03-01 00:00:00
