Anticyclic citrullinated peptide autoantibodies in systemic lupus erythematosus.

Abstract:

:Systemic lupus erythematosus is an autoimmune disease with protean manifestation. Arthritis is one of the most common manifestations seen in SLE. Anti-CCP Ab is a recently described autoantibody that has been claimed as a most sensitive and specific marker for the diagnosis of RA. Study was performed to see whether anti-CCP2 Ab is positive in lupus arthritis or not. Anti-CCP Ab, ANA, ds DNA, and APLA were estimated by ELISA. Anti-CCP2 Ab was positive in 22 cases (37.93%) of SLE. Mean value of anti-CCP (18.08±16.95 U/ml) was statistically significant (P<0.001) when compared to control (5.07±U/ml). A total of 44 (75.86%) patients with SLE had arthritis. In 29 (50.00%) cases, arthritis resembled RA along with classical features of SLE, while 15 cases (25.86%) had nonspecific lupus arthritis. In 13 cases (44.82%) of RA type lupus arthritis, anti-CCP2 Ab was positive, while only three (20%) nonspecific lupus arthritis cases had elevated anti-CCP. In 14 (24.13) patients with SLE, there was no arthritis, but in this group also (6/14) 42.85% cases had elevated anti-CCP. A total of 11 (50%) patients with duration less than 1 year had more anti-CCP 2 positivity when compared to disease duration between 1 and 3 years (27.27%) and disease duration more than 3 years (22.72%), but specifically, it was not significant. Our study concludes that anti-CCP2 is not a specific antibody for RA, but it is present in autoimmune diseases.

journal_name

Rheumatol Int

authors

Singh U,Singh S,Singh NK,Verma PK,Singh S

doi

10.1007/s00296-010-1374-9

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

765-7

issue

6

eissn

0172-8172

issn

1437-160X

journal_volume

31

pub_type

杂志文章
  • Crystalglobulinemia manifested as acute renal failure and thrombotic vasculopathy.

    abstract::Crystalglobulinemia is an extremely rare pathology that is associated in most cases with plasma cell dyscrasia, mainly multiple myeloma. In most cases, it may be the manifestation of incipient gammopathy or it manifests shortly after diagnosis. We report a patient with ischemic lesions of thrombotic origin in lower li...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审

    doi:10.1007/s00296-020-04620-6

    authors: Gómez-Lechón Quirós L,Acosta De La Vega ME,Compán Fernández O,Pastor Navarro S,Montilla Morales C,Moyano Bueno D,Martín Centellas J,Santos-Briz Terrón A,Hidalgo Calleja C

    更新日期:2020-08-01 00:00:00

  • Temporomandibular disorders in ankylosing spondylitis: a cross-sectional, monocentric study.

    abstract::There are contradictory results in the relevant literature about the relationship between objective determinants of craniocervical posture and temporomandibular disorder (TMD), whereas no study has worked on ankylosing spondylitis (AS) and TMD relationship. We conducted this study to test the predictors of TMD in AS p...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-020-04563-y

    authors: Bilgin E,Bilgin E,Özdemir O,Kalyoncu U

    更新日期:2020-06-01 00:00:00

  • Brucellosis as a rare cause of olecranon bursitis: case-based review.

    abstract::A 51-year-old man shepherd presented with mild pain and swelling of the right posterior aspect of his right elbow. In ultrasonography, the affected bursal space had swelling and effusion. Moreover, the aspiration of the affected bursa revealed an inflammatory profile. Brucella melitensis was detected in aspirated flui...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审

    doi:10.1007/s00296-019-04414-5

    authors: Esmaeilnejad-Ganji SM,Roushan MRH,Ebrahimpour S,Babazadeh A

    更新日期:2019-12-01 00:00:00

  • Calcaneus bone mineral density in Japanese women with rheumatoid arthritis.

    abstract:OBJECTIVES:The aim of this study was to investigate the relationships among bone mineral densities (BMD) in the calcaneus and leg activity of daily living (L-ADL) in rheumatoid arthritis (RA) patients. METHODS:We measured and compared calcaneus BMD using single X-ray absorptiometry and lumbar spine and femoral neck BM...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-003-0421-1

    authors: Doi S,Kushida K,Miyamoto S,Sekioka Y,Suzuki M,Inoue T,Nagano A

    更新日期:2005-04-01 00:00:00

  • Repeat etanercept administration restores clinical response of patients with rheumatoid arthritis.

    abstract::We determined whether repeated treatment with the tumor necrosis factor-α (TNF-α) antagonist etanercept can be effective after an initial clinical response to this drug is lost. We describe three female patients with active, refractory rheumatoid arthritis who were administered with a second course of etanercept after...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-011-2124-3

    authors: Wakabayashi H,Sudo A,Nishioka Y,Hasegawa M,Minami Y,Nishioka K

    更新日期:2012-11-01 00:00:00

  • Individuals with fibromyalgia and depression: findings from a nationally representative Canadian survey.

    abstract::The aim of the study is to determine the prevalence of and factors associated with major depression among those with Fibromyalgia Syndrome (FMS) in a Canadian representative sample. The study was a secondary analysis of a large, nationally representative sample from the Canadian Community Health Survey. The full sampl...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-010-1713-x

    authors: Fuller-Thomson E,Nimigon-Young J,Brennenstuhl S

    更新日期:2012-04-01 00:00:00

  • Pituitary involvement in patients with granulomatosis with polyangiitis: case series and literature review.

    abstract::GPA with pituitary involvement is a rare condition which is prone to be misdiagnosed. The aim of this study was to summarize clinical features of pituitary involvement in GPA and facilitate early diagnosis. Twelve GPA patients were retrospectively analyzed at a single hospital between 2000 and 2017. A literature revie...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审

    doi:10.1007/s00296-019-04338-0

    authors: Gu Y,Sun X,Peng M,Zhang T,Shi J,Mao J

    更新日期:2019-08-01 00:00:00

  • Leg ulcers in the antiphospholipid syndrome may be considered as a form of pyoderma gangrenosum and they respond favorably to treatment with immunosuppression and anticoagulation.

    abstract::Leg ulcers are a manifestation of antiphospholipid syndrome (APS), and characteristically respond poorly to treatment. Because the similar findings both clinical and pathological to pyoderma gangrenosum (PG), we treated these patients with a combination of immunosuppression (steroids, azathioprine or cyclosporine), ac...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-010-1418-1

    authors: Cañas CA,Durán CE,Bravo JC,Castaño DE,Tobón GJ

    更新日期:2010-07-01 00:00:00

  • Ultrasound-guided retro-calcaneal bursa corticosteroid injection for refractory Achilles tendinitis in patients with seronegative spondyloarthropathy: efficacy and follow-up study.

    abstract::Ultrasound (US)-guided corticosteroid injection has been shown to be safe and effective for varied causes of plantar fasciitis; however, its use for Achilles tendinitis is controversial. We studied the efficacy and changes in US findings at Achilles enthesitis after corticosteroid injection in patients with spondyloar...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-016-3440-4

    authors: Srivastava P,Aggarwal A

    更新日期:2016-06-01 00:00:00

  • Demonstration of specific antibodies against infliximab induced during treatment of a patient with ankylosing spondylitis.

    abstract::Therapeutic proteins, such as infliximab, have revolutionized the treatment of many diseases during the last decade and more than 80 therapeutic proteins are currently approved for clinical use. However, all exogenous proteins have the potential to cause antibody formation. In order to ensure patient safety and the ef...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-005-0085-0

    authors: Aybay C,Ozel S,Aybay C

    更新日期:2006-03-01 00:00:00

  • Low plasma vitamin D levels in patients with familial Mediterranean fever.

    abstract::Familial Mediterranean fever (FMF) is an autosomal recessive, inherited autoinflammatory disease characterized by recurrent, self-limited attacks of fever and inflammation of serosal surfaces. There is an explosion of the data regarding inflammatory markers in FMF and clinical effects of chronic inflammation on the di...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-011-2281-4

    authors: Erten S,Altunoğlu A,Ceylan GG,Maraş Y,Koca C,Yüksel A

    更新日期:2012-12-01 00:00:00

  • Factors associated with the accuracy of self-reported osteoporosis in the community.

    abstract::We examined the agreement between self-reported osteoporosis and bone mineral density (BMD) results through dual-energy x-ray absorptiometry (DXA) using data from a national representative sample taken from the US communities. Six-year data from the continuous National Health and Nutrition Examination Survey 2005-2006...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-016-3573-5

    authors: Cunningham TD,DeShields SC

    更新日期:2016-12-01 00:00:00

  • Thrombocytopenia as a presenting feature of Kawasaki disease: a case series from North India.

    abstract::Thrombocytosis is well described in children with Kawasaki disease (KD). We describe six children with KD who had thrombocytopenia at disease onset. This is an unusual finding and has clinical implications in the diagnosis of this condition. ...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-009-0947-y

    authors: Singh S,Gupta D,Suri D,Kumar RM,Ahluwalia J,Das R,Varma N

    更新日期:2009-12-01 00:00:00

  • Monitoring of therapeutic efficacy in a patient with RS₃PE syndrome by serologic variables and radiographic methods.

    abstract::We describe a typical case of a patient with remitting seronegative symmetrical synovitis and pitting edema (RS(3)PE) syndrome. He underwent a successful clinical course monitored by serologic variables and radiographic methods. Serum levels of interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), matrix me...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-009-1142-x

    authors: Kawashiri SY,Nakano M,Kawakami A,Eguchi K

    更新日期:2010-11-01 00:00:00

  • Tribal and geographical variations of lupus in the Sultanate of Oman: a hospital-based study.

    abstract::Tribal differences are demonstrated in the presentation of lupus in Omani Gulf Arabs (OGA) and Omani Arabs of Persian descent (OAP), both groups resident in and indigenous to the Sultanate of Oman. The OAP have a lower risk of joint complications, skin rash, and dsDNA antibodies than OGA (beta coefficient and 95% conf...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-001-0151-1

    authors: Al Maini MH,El-Ageb el-N,Al-Shukaily AK,Al-Wahaibi S,Richens ER

    更新日期:2002-01-01 00:00:00

  • Exercise capacity in relation to autoantibodies in systemic sclerosis patients.

    abstract::Autoantibodies have been detected in systemic sclerosis patients, and typical clinical features regarding organ involvement by each autoantibody have been reported. To reveal differences in exercise intolerance in patients with either anti-topoisomerase-I or anti-centromere antibodies, 53 systemic sclerosis patients w...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-012-2541-y

    authors: Someya F,Mugii N,Yahata T,Nakagawa T

    更新日期:2013-11-01 00:00:00

  • Adherence to best practice consensus guidelines for familial Mediterranean fever: a modified Delphi study among paediatric rheumatologists in Turkey.

    abstract:BACKGROUND:Although not validated fully, recommendations are present for diagnosis, screening and treatment modalities of patients with familial Mediterranean fever (FMF). OBJECTIVE:To review the current practices of clinicians regarding FMF and reveal their adherence to consensus guidelines. METHODS:Fifteen key poin...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-020-04776-1

    authors: Kavrul Kayaalp G,Sozeri B,Sönmez HE,Demir F,Cakan M,Oztürk K,Karadag SG,Otar Yener G,Ozdel S,Baglan E,Celikel E,Sahin N,Gezgin Yildirim D,Eker Omeroglu R,Aktay Ayaz N,PeRA-Research Group.

    更新日期:2021-01-16 00:00:00

  • Long-term follow-up of 89 patients with giant cell arteritis: a retrospective observational study on disease characteristics, flares and organ damage.

    abstract::The objective of the study is to investigate the clinical characteristics and long-term prognosis including flares and organ damage in patients with giant cell arteritis (GCA) from a tertiary referral centre and compare these features in different subgroups. In this retrospective observational study, patients with GCA...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-020-04730-1

    authors: Ince B,Artan S,Yalcinkaya Y,Artim-Esen B,Gul A,Ocal L,Inanc M

    更新日期:2021-02-01 00:00:00

  • Mononuclear cells recovered from inflammatory synovial membrane using fine-needle biopsy.

    abstract::A simple technique for fine-needle aspiration biopsy from the synovial membrane of arthritis knee joints preceded by lavage of the joint cavity is described. The procedure was atraumatic, well accepted, and could be performed on outpatients. Cells originating from the synovial membrane were obtained in 12 of 17 knees ...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/BF00272430

    authors: Geborek P,Sandberg M,Wollheim FA

    更新日期:1988-01-01 00:00:00

  • Anti-PAD4 autoantibodies in rheumatoid arthritis: levels in serum over time and impact on PAD4 activity as measured with a small synthetic substrate.

    abstract::Isoform 4 of the human peptidylarginine deiminase (hPAD4) enzyme may be responsible for the citrullination of antigens in rheumatoid arthritis (RA) and has been shown to be itself the target of disease-specific autoantibodies. Here, we have tested whether the level of serum anti-hPAD4 antibodies in RA patients is stab...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-010-1765-y

    authors: Pollmann S,Stensland M,Halvorsen EH,Sollid LM,Kvien TK,Fleckenstein B,Molberg O

    更新日期:2012-05-01 00:00:00

  • Incidence of infection other than tuberculosis in patients with autoimmune rheumatic diseases treated with bDMARDs: a real-time clinical experience from India.

    abstract::Biologic disease-modifying anti-rheumatic drugs (bDMARD) have transformed the treatment paradigm of chronic autoimmune rheumatic diseases (ARDs), but they are often associated with adverse drug reactions. The present study evaluated the frequency, characteristics and type of infections, other than tuberculosis (TB), i...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-019-04245-4

    authors: Chandrashekara S,Shobha V,Rao V,Desai A,Jois R,Dharmanand BG,Kumar S,Kumar P,Dharmapalaiah C,Mahendranath KM,Prasad S,Daware MA,Singh Y,Karjigi U,Nagaraj S,Anupama KR

    更新日期:2019-03-01 00:00:00

  • Standards of care and quality indicators for multidisciplinary care models for psoriatic arthritis in Spain.

    abstract::To define and give priority to standards of care and quality indicators of multidisciplinary care for patients with psoriatic arthritis (PsA). A systematic literature review on PsA standards of care and quality indicators was performed. An expert panel of rheumatologists and dermatologists who provide multidisciplinar...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-018-3986-4

    authors: Gratacós J,Luelmo J,Rodríguez J,Notario J,Marco TN,de la Cueva P,Busquets MP,Font MG,Joven B,Rivera R,Vega JLA,Álvarez AJC,Parera RS,Carrascosa JCR,Martínez FJR,Sánchez JP,Olmos CF,Pujol C,Galindez E,Barrio SP,Ara

    更新日期:2018-06-01 00:00:00

  • Elevated levels of nitrate in rheumatoid arthritis.

    abstract::Nitric oxide (NO) is a free radical that plays important roles in many physiological and pathological processes. Evidence suggests that NO participates in the pathogenesis of inflammatory reactions in many autoimmune and inflammatory diseases such as rheumatoid arthritis (RA). The purpose of this study was to evaluate...

    journal_title:Rheumatology international

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s002960100105

    authors: Onur O,Akinci AS,Akbiyik F,Unsal I

    更新日期:2001-05-01 00:00:00

  • Patients who underwent total hip or knee arthroplasty are more physically active than the general Dutch population.

    abstract::Total hip arthroplasty (THA) and total knee arthroplasty (TKA) bring relief of pain and functional disability to patients with end-stage osteoarthritis, and however, the literature on their impact on patients' level of physical activity (PA) is scarce. Cross-sectional study in patients who underwent THA/TKA surgery in...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-016-3598-9

    authors: Meessen JM,Peter WF,Wolterbeek R,Cannegieter SC,Tilbury C,Bénard MR,van der Linden HM,Onstenk R,Tordoir R,Vehmeijer SB,Verdegaal SH,Vermeulen HM,Nelissen RG,Vliet Vlieland TP

    更新日期:2017-02-01 00:00:00

  • Profile of gastrointestinal involvement in patients with systemic sclerosis.

    abstract::Systemic sclerosis (SSc) is a chronic autoimmune connective tissue disease. Of the numerous organ manifestations, involvement of the upper and lower gastrointestinal tract (GIT) appears to be the most frequent with regard to the clinical symptoms. However, as the frequency and clinical relevance of GI involvement in p...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-011-1988-6

    authors: Schmeiser T,Saar P,Jin D,Noethe M,Müller A,Soydan N,Hardt PD,Jaeger C,Distler O,Roeb E,Bretzel RG,Müller-Ladner U

    更新日期:2012-08-01 00:00:00

  • Massive intracerebral hemorrhage associated with Wegener granulomatosis.

    abstract::Wegener granulomatosis (WG) is a necrotizing granulomatous vasculitis that predominantly affects airways and kidneys. But central nervous system involvement (7-11%) is an uncommon. Massive ICH may occur in the course of WG, and this serious condition is related with high risk of mortality. Therefore, the new treatment...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-011-1954-3

    authors: Ceri M,Ortabozkoyun L,Unverdi S,Kirac M,Duranay M

    更新日期:2012-06-01 00:00:00

  • Frequency and role of low molecular weight IgM in systemic lupus erythematosus. Study of patients from different ethnic origins.

    abstract::Low molecular weight IgM (LMW IgM) is the monomeric subunit of the naturally occurring pentameric IgM. It is not seen in health but has been previously observed in systemic lupus erythematosus (SLE) particularly in those patients with active disease and may reflect an adverse prognostic finding. We have therefore stud...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/BF02274821

    authors: Roberts-Thomson PJ,Shepherd K,Bradley J,Boey ML

    更新日期:1990-01-01 00:00:00

  • Interference of cartilage surface with interaction of granulocyte elastase with alpha 1-proteinase inhibitor. An in vitro model of enzyme inhibition in the joint space.

    abstract::Synovial fluids of patients suffering from rheumatoid arthritis contain elevated levels of granulocyte (PMN) elastase in complex with alpha 1-proteinase inhibitor (alpha 1-PI), whereas free-elastase activity is usually not detectable. This absence of free enzymatic activity in joint effusions has cast some doubt on th...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/BF00270466

    authors: Burkhardt H,Kasten M,Rauls S,Rehkopf E

    更新日期:1987-01-01 00:00:00

  • A portable dermatoscope for easy, rapid examination of periungual nailfold capillary changes in patients with systemic sclerosis.

    abstract::Microvascular lesions are a predominant feature in systemic sclerosis (SSc) and seem to play a central pathogenic role. The presence of nailfold capillary abnormalities is useful in diagnosing SSc. Capillaroscopy, however, usually requires special equipment and may be time consuming. Dermatoscope has been presented as...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-010-1532-0

    authors: Muroi E,Hara T,Yanaba K,Ogawa F,Yoshizaki A,Takenaka M,Shimizu K,Sato S

    更新日期:2011-12-01 00:00:00

  • Resveratrol inhibits TNF-α-induced IL-1β, MMP-3 production in human rheumatoid arthritis fibroblast-like synoviocytes via modulation of PI3kinase/Akt pathway.

    abstract::Resveratrol (trans-3,4'-trihydroxystilbene), a natural phytoalexin, possesses anti-inflammatory, anti-proliferative, and immunomodulatory properties and has the potential for treating inflammatory disorders. The present study was designed to investigate the effects of resveratrol on TNF-α-induced inflammatory cytokine...

    journal_title:Rheumatology international

    pub_type: 杂志文章

    doi:10.1007/s00296-012-2657-0

    authors: Tian J,Chen JW,Gao JS,Li L,Xie X

    更新日期:2013-07-01 00:00:00