Abstract：
:Increased QT interval dispersion has been associated with an increased risk for ventricular arrhythmias and sudden cardiac events. We examined the QT interval dispersion in 20 North Indian children with Kawasaki disease (KD) with no coronary artery abnormalities on echocardiography compared the same with matched controls. The study population consisted of 20 children in convalescent phase of KD and 20 age and sex-matched healthy controls. Intervals were measured with the use of a digital caliper with least count of 0.01 mm by a single blinded observer. The QTc dispersion was calculated as the difference between the maximum and minimum corrected QT intervals in 12 and 8 leads (i.e. the 6 precordial leads, the shortest extremity lead, and the median of the 5 other extremity leads). Of the 480 leads obtained (12 per subject), 36 were excluded from analysis (15 because of poor T wave formation and 11 because of presence of U waves). Children with KD had significantly higher QTc dispersion in 12 lead (67.08 ± 17.72 ms compared to 47.63 ± 16.48 ms in controls P ≤ 0.001) as well as 8 lead (60.51 ± 18.54 ms compared to 42.92 ± 18.03 ms in controls P ≤ 0.001) analysis. There was no correlation between delay in IVIG therapy and QT interval dispersion. In conclusion, QT interval dispersion is significantly increased in North Indian children with KD. The dispersion is indicative of inhomogenous ventricular repolarization and may represent increased risk for developing ventricular arrhythmia in this population.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Ghelani SJ,Singh S,Manojkumar Rdoi
10.1007/s00296-009-1252-5subject
Has Abstractpub_date
2011-03-01 00:00:00pages
301-5issue
3eissn
0172-8172issn
1437-160Xjournal_volume
31pub_type
杂志文章abstract：:Biological markers of inflammation are useful for the diagnosis and monitoring of inflammatory rheumatic diseases. The present study tested, whether serum amyloid A (SAA) could be used as a marker of inflammatory disease activity in ankylosing spondylitis (AS). In 72 patients with AS, the two valuable surrogate marker...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s002960050114
更新日期：2000-01-01 00:00:00
abstract：:We aimed to determine left ventricular (LV) and right ventricular (RV) structure, function and mechanics, as well as heart rate variability (HRV), and their relationship, in patients with systemic sclerosis (SSc). The study included 41 SSc patients and 30 age-matched healthy volunteers. All the patients underwent clin...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3618-9
更新日期：2017-01-01 00:00:00
abstract：:Thrombocytosis is well described in children with Kawasaki disease (KD). We describe six children with KD who had thrombocytopenia at disease onset. This is an unusual finding and has clinical implications in the diagnosis of this condition. ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-0947-y
更新日期：2009-12-01 00:00:00
abstract：:A period of 4 weeks (w) has been recommended for rheumatoid arthritis (RA) patients as the interval between intravenous (IV) tocilizumab (TCZ, 8 mg/kg). In a previous paper, we showed the possibility that the interval between successive IV TCZ can be extended from 4 to 6 weeks in more than 60% of patients with low dis...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-4149-3
更新日期：2018-12-01 00:00:00
abstract：:Patients with rheumatoid arthritis (RA) have bone loss to various degrees at different skeletal sites. The subregional bone mineral density (BMD) of the hand and the correlation of BMD to other regional bone losses, parameters of inflammation or bone resorption was evaluated in 421 patients with RA and controls. RA pa...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0638-0
更新日期：2008-11-01 00:00:00
abstract：:It is proposed that synovial fluid biomarkers may help in differentiating the type of arthritis. The aim of study is to determine whether synovial fluid adenosine deaminase (ADA) and high-sensitivity C-reactive protein (hs-CRP) can be useful in this regard. A total of 75 patients with knee monoarthritis that were admi...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1602-3
更新日期：2012-01-01 00:00:00
abstract：:The aim was to study the association of smoking with the activity and severity of systemic lupus erythematosus (SLE) and the production of antibodies to dsDNA. The study included 223 SLE patients attending the outpatient clinics at Helsinki University Central Hospital. The history of smoking was obtained by personal i...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2889-7
更新日期：2014-03-01 00:00:00
abstract：:Postural changes are sometimes a risk factor for low back pain. Abnormal posture creates a strain on ligaments and muscles that indirectly affects the curvature of the lumbar spine. This study was planned to investigate the relationship between the angles of the lower lumbar spine and spinal mobility in acute and chro...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-002-0268-x
更新日期：2003-07-01 00:00:00
abstract：:Spondyloarthropathy refers to any joint disease of the vertebral column, but the term is mainly used for a specific group of disorders called seronegative spondyloarthropathies (SpAs). The axial skeletal involvement, peripheral and extra-articular manifestations and an association with the major histocompatibility com...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-019-04346-0
更新日期：2019-09-01 00:00:00
abstract：:We examined the agreement between self-reported osteoporosis and bone mineral density (BMD) results through dual-energy x-ray absorptiometry (DXA) using data from a national representative sample taken from the US communities. Six-year data from the continuous National Health and Nutrition Examination Survey 2005-2006...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3573-5
更新日期：2016-12-01 00:00:00
abstract：:Systemic lupus erythematosus (SLE) affects women of childbearing age. To optimize fetal and maternal outcomes, effective reproductive health counseling is crucial. To analyze the effectiveness of reproductive health counseling in women with SLE and identify gaps in patient educational needs. Cross-sectional study incl...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04671-9
更新日期：2021-02-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to investigate the relationships among bone mineral densities (BMD) in the calcaneus and leg activity of daily living (L-ADL) in rheumatoid arthritis (RA) patients. METHODS:We measured and compared calcaneus BMD using single X-ray absorptiometry and lumbar spine and femoral neck BM...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-003-0421-1
更新日期：2005-04-01 00:00:00
abstract：AIM:The aim of this study was to assess the efficacy of long-term azathioprine and steroids for treatment of severe nephritis in children with Henoch-Schönlein purpura (HSP). METHODS:Analysis of case records of children with HSP followed up for a mean duration of 4.7 years (range 6 months-6.5 years) was performed. All...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-002-0208-9
更新日期：2002-08-01 00:00:00
abstract：:The objective of the study was to evaluate synovial tissue receptor activator of nuclear factor-κβ ligand (RANKL) and osteoprotegerin (OPG) as biomarkers of disease activity, progressive joint damage, and therapeutic response, during cytokine blockade in rheumatoid arthritis (RA). Patients with active RA entered a ran...
journal_title：Rheumatology international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00296-009-1191-1
更新日期：2010-11-01 00:00:00
abstract：:In December 2019, numerous coronavirus disease 2019 (COVID-19) cases were reported in Wuhan, China, which has since spread throughout the world. However, its impact on rheumatoid arthritis (RA) patients is unknown. Herein, we report a case of COVID-19 pneumonia in a 61-year-old female RA patient who was receiving conv...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04584-7
更新日期：2020-06-01 00:00:00
abstract：:Antibodies to citrullinated proteins and rheumatoid factor (RF) are widely used in patients with rheumatoid arthritis (RA) and the antibodies to citrullinated proteins appear to be the most specific markers of the disease. The objective was to compare the diagnostic performance of the anti-cyclic citrullinated peptide...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-0980-x
更新日期：2010-02-01 00:00:00
abstract：:To determine the forms and characteristics of rheumatic diseases whose initial presentation mimics septic arthritis. Retrospective study of 398 patients hospitalized between 1979 and 2005 for arthritis diagnosed and treated as septic. In 10 cases, initial presentation of a rheumatic disease was highly suggestive of se...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2364-x
更新日期：2013-08-01 00:00:00
abstract：:Macrophage activation syndrome (MAS) is a clinical syndrome caused by an excessive proliferation of T lymphocytes and well-differentiated macrophages; an entity distinct from malignant histiocytosis. Although rheumatologic conditions are the common cause of MAS, a wide range of infections are also seen to cause MAS. W...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1033-1
更新日期：2010-06-01 00:00:00
abstract：:The assessment of skin fibrosis is vital for the diagnosis and monitoring of treatment in the systemic sclerosis (SSc)-a severe autoimmune disease. The elastography is a technique of skin fibrosis assessment through the evaluation of skin strain. We compared the efficacy of the shear wave elastography (SWE) and common...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04539-y
更新日期：2020-05-01 00:00:00
abstract：:Most infectious agents, such as viruses, bacteria and parasites, can trigger autoimmunity via different mechanisms. The development of an autoimmune disorder after infection tends to occur in genetically susceptible individuals. Some parameters, such as genetic predisposition, feature of the infectious agent and somet...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-012-2451-z
更新日期：2012-11-01 00:00:00
abstract：:Polyarteritis nodosa (PAN) is a rare systemic vasculitis affecting multiple organs. Current standard treatment includes the use of glucocorticoids and cyclophosphamide. Unfortunately, some patients do not respond to this treatment and other therapeutic options are needed. We present a case of a young male with refract...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-018-4210-2
更新日期：2019-02-01 00:00:00
abstract：:Osteoarthritis (OA) has a strong genetic component, and experimental evidence suggests the involvement of the Wnt pathway in its pathogenesis. Hence, we explored the association of common single nucleotide polymorphisms (SNPs) related to the Wnt pathway with hip and knee OA. Seventy-eight SNPs were analyzed in 606 pat...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2821-1
更新日期：2013-11-01 00:00:00
abstract：:Isoform 4 of the human peptidylarginine deiminase (hPAD4) enzyme may be responsible for the citrullination of antigens in rheumatoid arthritis (RA) and has been shown to be itself the target of disease-specific autoantibodies. Here, we have tested whether the level of serum anti-hPAD4 antibodies in RA patients is stab...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1765-y
更新日期：2012-05-01 00:00:00
abstract：:We present a rare case of retinoid-induced sclerotic changes of lumbar spine and femur demonstrated by dual energy x-ray absorptiometrie (DEXA). The patient had flowing ossification along thoracic spine resembling diffuse idiopathic skeletal hyperostosis (DISH), but there was no ligament calcification in the lumbar sp...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-003-0391-3
更新日期：2004-09-01 00:00:00
abstract：:Psoriatic arthritis (PsA) patients are at a higher risk of systemic inflammatory sequelae, leading to microalbuminuria, cardiovascular (CVD) and neuropsychiatric (NPD) disease. Our aim is to present the existing literature about the relationship between CVD, kidney and NPD in PsA. The literature evaluation of PsA reve...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-020-04633-1
更新日期：2020-09-01 00:00:00
abstract：:The aim of this study was to investigate the frequency of patients with rheumatoid arthritis (RA) who have inflammatory back pain (IBP) and meet the existing classification criteria for ankylosing spondylitis (AS) and spondyloarthritis (SpA). We included 167 patients fulfilling the ACR 1987 revised criteria for RA. Af...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2553-7
更新日期：2013-05-01 00:00:00
abstract：:Diagnostic accuracy of anti-DNase I antibodies measurement in a differentiation between SLE and other autoimmune rheumatic diseases was evaluated. The share of anti-DNase I and actin in the DNase I activity decrease in SLE was established. Serum samples were obtained from 54 patients with verified SLE, 52 control pati...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3437-z
更新日期：2016-04-01 00:00:00
abstract：:Numerous studies have focused on the significance of modern marker proteins in the synovial fluid of the knee joint and in the serum both, for osteoarthritis (OA) and rheumatoid arthritis (RA). The relationship between the serum concentrations and the concentrations in the synovial fluid is still unclear. Synovial flu...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-005-0006-2
更新日期：2006-03-01 00:00:00
abstract：:To describe the profile of Enthesitis Related Arthritis' (ERA) patients, in the era of biologic DMARDs (bDMARDs). This retrospective cohort study included patients with ERA monitored on a 3-month schedule for at least 1 year. Their metric assessment included the disease status and damage by applying the contemporary t...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04581-w
更新日期：2020-06-01 00:00:00
abstract：:CD4(+) T cells from patients with systemic lupus erythematosus (SLE) exhibit increased expression of various proteins contributing to defective function of CD4(+) T cells. We evaluated the transcript and protein levels of perforin (PRF1) in CD4(+) T cells from SLE patients (n = 41) and healthy individuals (n = 34). Th...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1329-1
更新日期：2010-11-01 00:00:00
