Abstract：
:Numerous studies have focused on the significance of modern marker proteins in the synovial fluid of the knee joint and in the serum both, for osteoarthritis (OA) and rheumatoid arthritis (RA). The relationship between the serum concentrations and the concentrations in the synovial fluid is still unclear. Synovial fluid and serum samples were obtained from 13 patients with advanced OA and from 8 patients with severe RA and concentrations of MMP-1, MMP-3, MMP-13, TIMP-1, COMP and MIA/CD-RAP were determined. All values were normalized against the total protein concentrations. Serum concentrations of MMP-13 in the RA-group were statistically higher than the synovial values (P<0.05). MMP-13 was the only marker protein that revealed distinct higher levels in the serum than in the synovial fluid. The study design allows only conclusions about advanced stages of RA and OA. Longitudinal investigations may provide further information about the value of MMP-13 as a potential marker to monitor the course of RA and OA.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Andereya S,Streich N,Schmidt-Rohlfing B,Mumme T,Müller-Rath R,Schneider Udoi
10.1007/s00296-005-0006-2subject
Has Abstractpub_date
2006-03-01 00:00:00pages
432-8issue
5eissn
0172-8172issn
1437-160Xjournal_volume
26pub_type
杂志文章abstract：:The aim of the study was to assess the possible association between type II collagen turnover seromarkers and disease profile in patients with axial spondyloarthritis (SpA) and psoriatic arthritis (PsA). Outpatients with axial SpA (n = 110) or PsA (n = 101) underwent clinical examination including disease activity mea...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-015-3397-8
更新日期：2016-04-01 00:00:00
abstract：:Microscopic polyangiitis (MPA) is a systemic necrotizing vasculitis affecting small vessels without necrotizing granulomatous inflammation and is commonly associated with necrotizing glomerulonephritis. Diagnosis is based on typical clinical features, the presence of antimyeloperoxidase-antineutrophil cytoplasmic anti...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-006-0127-2
更新日期：2006-08-01 00:00:00
abstract：:Rheumatoid arthritis (RA) in Thai population is significantly associated with HLA-DR4 shared epitope (SE) alleles, particularly with DRB1*0405 (P = 0.00004, OR = 3.84, 95% CI = 1.93, 7.7). In addition, tumor necrosis factor-alpha (TNF-alpha) gene -863A alleles were found to be significantly increased in 77 RA patients...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0392-8
更新日期：2007-12-01 00:00:00
abstract：:C4A and C4B levels were measured in serum from 246 normal individuals. Complement-mediated solubilisation, assayed using alkaline phosphatase anti-alkaline phosphatase immune complexes (IC), correlated with both C4A and C4B levels. However, C4A and C4B levels showed no correlation with solubilisation of bovine serum a...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00302150
更新日期：1992-01-01 00:00:00
abstract：:In Spain, the QUANTUM project has been promoted to reduce variability in clinical practice and improve the care and quality of life of people with psoriatic arthritis (PsA) by accrediting PsA units throughout the Spanish national health system. To present the results of this approach which sought to ensure an optimum ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04632-2
更新日期：2020-11-01 00:00:00
abstract：:Felty's syndrome (FS) is a deforming disease, characterized by the triad of rheumatoid arthritis (RA), neutropenia, and splenomegaly. Currently, FS patients are treated mainly with immunosuppressants, such as methotrexate and glucocorticoids, which however are not suitable to some patients and may cause severe side ef...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-020-04588-3
更新日期：2020-07-01 00:00:00
abstract：:MicroRNAs (miRNAs) are noncoding RNA molecules of 21-24 nt that regulate the expression of target genes in a post-transcriptional manner. Evidence indicates that miRNAs play essential roles in embryogenesis, cell differentiation, and pathogenesis of human diseases. This study describes a comparison between the miRNA p...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0758-6
更新日期：2009-05-01 00:00:00
abstract：:We investigated the overall frequency of anti-phospholipid syndrome (APS) occurrence in Korean patients with consecutively detected anti-phospholipid antibodies with an interval of 12 weeks (persistent aPLs). We retrospectively reviewed the results of blood tests of aPLs in 14,889 patients in whom aPL tests were perfo...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-019-04318-4
更新日期：2019-08-01 00:00:00
abstract：:Takayasu arteritis (TA) is a chronic, inflammatory large vessel vasculitis that affects aorta and its main branches. We aimed to evaluate the incidence and prevalence of TA in the northwestern part of Turkey. We retrospectively evaluated 23 TA patients followed by our clinic. Clinical features, treatments and response...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-016-3445-z
更新日期：2016-07-01 00:00:00
abstract：:Methotrexate (MTX) can be toxic to patients suffering from end stage renal disease (ESRD) on hemodialysis even at low doses. This increase in toxicity is more notable in terms of bone marrow suppression in the form of pancytopenia. Many methods of elimination including dialysis itself have been proven ineffective, and...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-011-2041-5
更新日期：2011-12-01 00:00:00
abstract：:Behçet's disease (BD) is a chronic multi-system disorder commonly seen in Mediterranean, middle east and far eastern populations. In this report, we describe a case of a 55-year-old male with Behçet's disease who presented with a low back pain and sciatica. Imaging studies showed that he had a destruction of the third...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-014-3077-0
更新日期：2015-02-01 00:00:00
abstract：:The aim of this study was to investigate (a) the mortality in a clinical cohort of patients with established rheumatoid arthritis in comparison with the general Dutch population over 15 years, (b) the trend in the mortality ratio during the study period, and (c) causes of death and compare these with the general popul...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3638-5
更新日期：2017-04-01 00:00:00
abstract：OBJECTIVES:To evaluate the prevalence and annual incidence of clinically-manifest vertebral fractures among patients with ankylosing spondylitis (AS). METHOD:Coordinated by the Ankylosing Spondylitis International Federation, a self-administered general questionnaire which included some questions on gender, age, age a...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-004-0556-8
更新日期：2006-01-01 00:00:00
abstract：:Pancreatitis is a relatively rare but severe manifestation in systemic lupus erythematosus (SLE) patients. We report a case of a 39-year-old woman with previous SLE diagnose treated with prednisone and mycophenolate mofetil who developed an acute pancreatitis complicated by pancreatic pseudocysts within the context of...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-0964-x
更新日期：2010-03-01 00:00:00
abstract：:TNF-α is one of the key proinflammatory cytokines in pathogenesis of rheumatoid arthritis (RA). TNF-α was also found to enhance synthesis of leptin. Leptin is mainly adipocyte-derived hormone controlling appetite and energy expenditure. It acts through inhibition of neuropeptide Y secretion. It is possible that TNF-α-...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2182-6
更新日期：2012-11-01 00:00:00
abstract：:The aim of the study was to analyze the concentrations of sTNFR1 and sTNFR2 in both plasma and synovial fluid of patients with primary knee osteoarthritis (OA) and to determine their relationship to self-reported pain, stiffness and physical function. Twenty-seven patients with knee OA and 19 healthy subjects were enr...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-014-3016-0
更新日期：2014-12-01 00:00:00
abstract：:This retrospective medical chart review aimed to provide a current, real-world overview of biologic usage in patients with rheumatoid arthritis (RA) in Germany, Spain, and the UK, and estimate clinical and healthcare utilization outcomes associated with early versus late treatment. Adults (≥18 years) with a confirmed ...
journal_title：Rheumatology international
pub_type： 杂志文章,多中心研究
doi：10.1007/s00296-015-3312-3
更新日期：2015-11-01 00:00:00
abstract：:The aim was to further characterize the SKG model of rheumatoid arthritis (RA) and its potential for studying intervention treatments, with special focus on bone targeting therapies. Three individual studies were conducted, using a total of 71 SKG mice, comparing arthritis induction with mannan versus zymosan A, femal...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2500-7
更新日期：2013-05-01 00:00:00
abstract：:Fluoride excess primarily effects dental and skeletal tissues. leading to a condition known as endemic fluorosis. The radiological and clinical features of endemic fluorosis vary in different parts of the world. The aim of this study was to investigate the clinical and radiological features of endemic fluorosis in Tur...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s002960100132
更新日期：2001-09-01 00:00:00
abstract：:The objective of the study was to evaluate synovial tissue receptor activator of nuclear factor-κβ ligand (RANKL) and osteoprotegerin (OPG) as biomarkers of disease activity, progressive joint damage, and therapeutic response, during cytokine blockade in rheumatoid arthritis (RA). Patients with active RA entered a ran...
journal_title：Rheumatology international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00296-009-1191-1
更新日期：2010-11-01 00:00:00
abstract：:Rickettsia rickettsii, a tick borne disease, is the pathogen responsible for inducing Rocky Mountain Spotted Fever (RMSF), an illness that can progress to fulminant multiorgan failure and death. We present a case where R. rickettsii, acquired on a camping trip, precipitated a flare of peripheral arthritis and episcler...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-019-04330-8
更新日期：2019-09-01 00:00:00
abstract：:The purpose of this study was to compare quality of life health identifiers in patients with and without osteoarthritis (OA) while controlling for the potentially confounding variables of gender, age, race, education, and income. Data were obtained for comparison from the Behavioral Risk Factor Surveillance System (BR...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-006-0269-2
更新日期：2007-02-01 00:00:00
abstract：:Agalactosyl IgG [Gal(0)] was first discovered in patients with rheumatoid arthritis (RA). However, the proportion of this glycoform is also raised in tuberculosis and leprosy. This has helped reinforce the suggestion that RA may be triggered by a mycobacterium-like slow bacterial infection. On the other hand, arthriti...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00262090
更新日期：1995-01-01 00:00:00
abstract：:We have prepared antibody/3H-dsDNA immune complexes and have used three independent radioimmunoassays to quantitate their interaction with complement; the solution phase C1q assay, the Raji cell assay, and a complement-based red blood cell adherence assay (RBC-CF). Our results indicate that although there is reasonabl...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541220
更新日期：1981-01-01 00:00:00
abstract：:We report on a 7-month-old infant with Kawasaki disease (KD) whose only manifestations were high-grade fever of 7 days duration, "non-toxic look" and "extreme irritability", thereby not meeting the criteria for the classical or the atypical form of the disease. The diagnosis was confirmed by the demonstration of a sol...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-0899-2
更新日期：2009-07-01 00:00:00
abstract：:Low molecular weight IgM (LMW IgM) is the monomeric subunit of the naturally occurring pentameric IgM. It is not seen in health but has been previously observed in systemic lupus erythematosus (SLE) particularly in those patients with active disease and may reflect an adverse prognostic finding. We have therefore stud...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF02274821
更新日期：1990-01-01 00:00:00
abstract：:The authors report an unusual case of myelodysplastic syndrome (MDS) associated with ankylosing spondylitis (AS). A 40-year-old-man with MDS presented with chronic low back pain for 6 years. Four years ago, MDS was diagnosed during routine blood analysis for the work-up of his articular complaints. His initial articul...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0735-0
更新日期：2009-04-01 00:00:00
abstract：:The objective was to investigate the effect of activin A on matrix metalloproteinase 3 (MMP-3) production and to identify the role of activin A in chondroprotection. SW1353 cells, a human chondrosarcoma cell line, were stimulated with interleukin (IL) 1alpha and tumor necrosis factor (TNF) alpha, and the concentration...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0350-5
更新日期：2007-09-01 00:00:00
abstract：:A previously healthy 40-year-old woman presented as unstable angina. She had a family history of stroke as the only cardiovascular risk factor. Her blood pressure on admission was 150/90 mmHg. Laboratory study showed absolutely all negative markers of inflammation, autoimmune disorders, or atherosclerosis. Coronary an...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0739-9
更新日期：2009-04-01 00:00:00
abstract：:The assessment of skin fibrosis is vital for the diagnosis and monitoring of treatment in the systemic sclerosis (SSc)-a severe autoimmune disease. The elastography is a technique of skin fibrosis assessment through the evaluation of skin strain. We compared the efficacy of the shear wave elastography (SWE) and common...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04539-y
更新日期：2020-05-01 00:00:00
