Abstract：
:Activation of opioid receptors on peripheral sensory nerve terminals by opioid peptides that are produced and released from immune cells can result in inhibition of inflammatory pain. This study tests the hypothesis that postoperative pain is attenuated endogenously through a local sympathetic neurotransmitter-activated release of opioids in patients undergoing knee surgery. We examined the expression of opioid peptides and adrenergic receptors in cells infiltrating inflamed synovial tissue and we hypothesized that intra-articular (i.a.) administration of the adrenergic receptor antagonist labetalol will increase postoperative analgesic consumption and/or pain intensity in these patients. In a double-blind, randomized manner, 75 patients undergoing therapeutic knee arthroscopy received i.a. placebo (20 ml saline) or labetalol (2.5 or 5 mg in 20 ml saline) at the end of surgery. Postoperative pain intensity was assessed by visual analog and verbal rating scales at rest and on exertion, and by the consumption of morphine via patient-controlled analgesia. Synovial biopsies were taken during the operation for double-immunofluorescence confocal microscopy studies. Alpha(1)- and beta(2)-adrenergic receptors were co-expressed in opioid peptide-containing cells. No significant difference was seen in pain scores, but patients receiving 2.5 mg labetalol requested significantly higher amounts of morphine. These findings are consistent with the notion that surgical stress induces sympathetically activated release of endogenous opioids from inflammatory cells and subsequent analgesia via activation of peripheral opioid receptors.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Kager I,Mousa SA,Sieper J,Stein C,Pipam W,Likar Rdoi
10.1007/s00296-010-1489-zsubject
Has Abstractpub_date
2011-10-01 00:00:00pages
1299-306issue
10eissn
0172-8172issn
1437-160Xjournal_volume
31pub_type
杂志文章,随机对照试验abstract：:Acupuncture has been used to treat various clinical diseases in Eastern medicine. To investigate the analgesic effect of electroacupuncture (EA) pretreatment on carrageenan-induced inflammatory pain, we studied on the effect of EA parameters on an animal model of acute arthritic pain. Pretreatment with 1 mA, 10 Hz EA ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1364-y
更新日期：2011-06-01 00:00:00
abstract：:Women in reproductive age with rheumatic diseases (RD) are especially vulnerable for depression and anxiety which negatively impacts the pregnancy, birth, and RD. The purpose of this study is to describe the frequency of anxiety and depression symptoms employing the Hospital Anxiety and Depression Scale (HADS) in wome...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04591-8
更新日期：2020-09-01 00:00:00
abstract：:We examined the intracellular mechanisms of substance P induced oxyradical production in rheumatoid synovial cells by the luminol-dependent chemiluminescence method. After stimulation with substance P (30 microM), single synovial A (macrophage-like) or B (fibroblast-like) cells released oxyradicals such as superoxide ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF01419729
更新日期：1996-01-01 00:00:00
abstract：:We measured alpha 2-plasmin inhibitor-plasmin complexes (PI-PC) in plasma of patients with systemic lupus erythematosus (SLE) to examine the plasminogen activation in SLE. The plasma PI-PC level in 23 patients with SLE was significantly higher than that in 18 normal subjects (P less than 0.001) and the SLE patients wi...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00270984
更新日期：1989-01-01 00:00:00
abstract：:Necrotic areas of rheumatoid nodules were investigated electron microscopically. PMNs in different stages of disintegration were present in all cases. Granular material, sometimes in a fiberlike orientation, and small fibrils without periodicity were detected between the collagenous fibers. It is assumed that granular...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541219
更新日期：1981-01-01 00:00:00
abstract：:A recent genome-wide association study revealed that there is an association between serum uric acid (SUA) levels and rs2544390, a common variant in low-density lipoprotein-related protein 2 (LRP2/Megalin) gene. Two other variants of LRP2, rs2229268 and rs3755166, are also found to have associations with dyslipidemia ...
journal_title：Rheumatology international
pub_type： 杂志文章,多中心研究
doi：10.1007/s00296-013-2924-8
更新日期：2014-04-01 00:00:00
abstract：:We describe a typical case of a patient with remitting seronegative symmetrical synovitis and pitting edema (RS(3)PE) syndrome. He underwent a successful clinical course monitored by serologic variables and radiographic methods. Serum levels of interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), matrix me...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1142-x
更新日期：2010-11-01 00:00:00
abstract：:The efficacy of balneotherapy in fibromyalgia syndrome (FS) has been well demonstrated, while controlled studies using mud packs are lacking. We performed a randomized clinical trial to evaluate the effects and the tolerability of mud-bath treatment in FS patients, who are poor responders to pharmacological therapy. E...
journal_title：Rheumatology international
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00296-007-0358-x
更新日期：2007-10-01 00:00:00
abstract：:Osteomyelitis variolosa is an osteoarticular complication of small pox infection. We are presenting a case of osteomyelitis variolosa, who presented to us with fracture of ankle on the involved side with other orthopedic sequelae of small pox infection, which he contracted during his childhood period. We have discusse...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2194-2
更新日期：2012-11-01 00:00:00
abstract：:The purpose of this study was to determine the effects of an oral preparation containing hyaluronic acid on osteoarthritic knee joint pain and function as well as changes in inflammatory cytokines, bradykinin, and leptin. We also used heavy water to determine the turnover rates of glycosaminoglycans in synovial fluid....
journal_title：Rheumatology international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00296-014-3047-6
更新日期：2015-01-01 00:00:00
abstract：:Autoantibodies have been detected in systemic sclerosis patients, and typical clinical features regarding organ involvement by each autoantibody have been reported. To reveal differences in exercise intolerance in patients with either anti-topoisomerase-I or anti-centromere antibodies, 53 systemic sclerosis patients w...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2541-y
更新日期：2013-11-01 00:00:00
abstract：:This study was designed to investigate the association of oral ulceration and oral health factors, together with psycho-social well-being in Behçet's disease (BD), and to clarify the importance of psycho-social support of patients in the overall management of BD. The study comprised of a cohort of 146 BD patients (mea...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-4117-y
更新日期：2018-10-01 00:00:00
abstract：:The family name of author Francesco La Torre was incorrect in the published article. The correct family name should read as La Torre F. ...
journal_title：Rheumatology international
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00296-018-4042-0
更新日期：2018-07-01 00:00:00
abstract：:Histoplasmosis is an important cause of morbidity in endemic areas of the USA. Infection is often asymptomatic but can cause a broad spectrum of pathology. Less commonly, histoplasmosis can present with a wide-range of rheumatologic manifestations. The aim of this review is to provide a synopsis of the rheumatologic m...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-013-2816-y
更新日期：2013-12-01 00:00:00
abstract：:The FRAX tool that calculates the 10-year probability of having a fracture has recently been validated for Belgium. Little is known about the perception and knowledge that GPs have about this tool in their daily practice. A survey has been conducted as part of a screening campaign for various diseases. The primary obj...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2461-x
更新日期：2013-04-01 00:00:00
abstract：:Severe vaso-occlusive retinopathy is a relatively rare form of retinopathy in systemic lupus erythematosus (SLE). We report two patients with severe vaso-occlusive retinopathy in SLE who were treated with intravitreal bevacizumab (IVB). (Patient 1) A 35-year-old woman presented with left visual loss and was diagnosed ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2139-9
更新日期：2013-01-01 00:00:00
abstract：:Systemic immune defects might reflect severely dysregulated control of chronic inflammation related to disease progression. Th17/Treg cell imbalance has been demonstrated to be involved in rheumatoid arthritis (RA) pathogenesis. Despite controversial results, a growing anti-inflammatory role in this process has been r...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2895-9
更新日期：2014-02-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to investigate the adequacy of the following criteria for the classification of juvenile-onset spondyloarthropathies (JSpA): European Spondyloarthropathy Study Group criteria (ESSGCr) and Amor criteria (ACr) (proposed for adult SpA), Garmisch-Partenkirchen (G-PCr), seronegative enthe...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-004-0460-2
更新日期：2005-08-01 00:00:00
abstract：:Systemic lupus erythematosus (SLE) is a severe complex rheumatic disease, but good estimate of its prevalence and risk factors is lacking in China. The aim of the study was to explore the prevalence of SLE and risk factors in rural areas of Anhui Province of China. Eleven counties were randomly selected in Anhui Provi...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2902-1
更新日期：2014-03-01 00:00:00
abstract：:There are contradictory results in the relevant literature about the relationship between objective determinants of craniocervical posture and temporomandibular disorder (TMD), whereas no study has worked on ankylosing spondylitis (AS) and TMD relationship. We conducted this study to test the predictors of TMD in AS p...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04563-y
更新日期：2020-06-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0722-5
更新日期：2009-03-01 00:00:00
abstract：:Fibromyalgia is a multi-factorial illness primarily characterised by widespread chronic pain and fatigue, with several symptoms and associated conditions. Due to a lack of clinical awareness and an absence of objective diagnostic measures, fibromyalgia patients often engage with online health information. The aim is t...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-019-04265-0
更新日期：2019-04-01 00:00:00
abstract：:A period of 4 weeks (w) has been recommended for rheumatoid arthritis (RA) patients as the interval between intravenous (IV) tocilizumab (TCZ, 8 mg/kg). In a previous paper, we showed the possibility that the interval between successive IV TCZ can be extended from 4 to 6 weeks in more than 60% of patients with low dis...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-4149-3
更新日期：2018-12-01 00:00:00
abstract：:Schistosomiasis or bilharzia is a parasitic disease found in tropical countries. Most infections are subclinical but may progress to chronic form characterized most frequently by the presence of liver involvement and portal hypertension. We report a patient that presented chronic polyarthritis with positive rheumatoid...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1562-7
更新日期：2013-05-01 00:00:00
abstract：:A meta-analysis was done with the final data from three trials that provided the first results relating to efficacy and safety of the new sustained-release (SR) formulation of etodolac versus established nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of osteoarthritis (OA) of the knee. The studies were...
journal_title：Rheumatology international
pub_type： 杂志文章,meta分析
doi：10.1007/BF00290280
更新日期：1993-01-01 00:00:00
abstract：:With better understanding of the pathogenesis of AIDS and the advent of anti-retroviral medications, patients with HIV are living longer and the probability that they will suffer musculoskeletal complications are increasing. There is a vast array of musculoskeletal impairments including rheumatologic, infectious, and ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-005-0043-x
更新日期：2006-05-01 00:00:00
abstract：OBJECTIVES:To identify recommendations on the diagnosis and management of rheumatoid arthritis (RA) supported by low recommendation grades, to study the causes of this low grading, and to propose solutions. METHODS:A group of six rheumatologists, with extensive experience in the development of systematic reviews, revi...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04724-z
更新日期：2021-01-01 00:00:00
abstract：:Acromegaly is a chronic endocrinopathy characterized by hypersecretion of growth hormone (GH) and consequently of insulin-like growth factor-1 (IGF-1). The arthropathy in acromegaly is the most frequent and important cause of morbidity and functional disability in acromegaly. Rheumatoid arthritis (RA) is a rarely repo...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1490-6
更新日期：2012-09-01 00:00:00
abstract：:The purpose of this study was to detect the frequency of inflammatory cervical spine changes and characteristic features such as resorption in rheumatoid arthritis (RA) with arthritis mutilans (AM) hand deformity. The series included 23 patients with AM hand deformity who fulfilled the 1987 American Rheumatism Associa...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s002960100114
更新日期：2001-08-01 00:00:00
abstract：:Wells' syndrome is a multifaceted dermatosis with a wide morphological spectrum, ranging from characteristic cellulitis-like erythema and papula to an unusual presentation of vesicles and pustules. The most important elements for diagnosis are erythemal plaques and histological picture of eosinophilic infiltration of ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-1809-y
更新日期：2012-04-01 00:00:00
