Abstract：
:Anemia is common with connective tissue disorders, but pancytopenia is rare. We report a 22-year-old female who presented with menorrhagia, seizures, anemia, leukocytosis, thrombocytopenia, pericardial effusion, positive ANA, and evidence of vasculitis on CT head scan and was diagnosed with systemic lupus erythematosus (SLE). After 7 months of remission, she was readmitted with menorrhagia and pancytopenia. Investigations revealed aplastic anemia. She survived on transfusion support for 6 weeks, during which period she received methylprednisolone and cyclophosphamide pulses, and phenytoin was omitted but to no avail. Cyclosporine (300 mg/day) was started and the aplastic anemia responded. After 4 months of therapy, the cyclosporine was gradually tapered over the next 2 months. The patient has been on 10 mg/day of prednisolone for the last 6 months. Aplastic anemia is rare in SLE and the response to immunosuppressants is variable, but here is a success story.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Singh NP,Prakash A,Garg D,Makhija A,Pathania A,Prakash N,Kubba S,Agarwal SKdoi
10.1007/s00296-003-0318-zsubject
Has Abstractpub_date
2004-01-01 00:00:00pages
40-2issue
1eissn
0172-8172issn
1437-160Xjournal_volume
24pub_type
杂志文章abstract：:Elderly often have Heberden nodes (HN) and Bouchard nodes (BN) that may affect finger dexterity. The aim of this cross-sectional study was to assess an effect of HN and BN on finger dexterity of the elderly. The nine-hole peg test was used for dexterity measurement in 200 elderly with HN and/or BN. Mean age was 68.6 +...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1196-9
更新日期：2010-02-01 00:00:00
abstract：:Patients with chronic thromboembolic pulmonary hypertension (CTEPH) have poor prognosis, and pulmonary endarterectomy (PEA) is considered the treatment of choice for this condition. We report a case and review the literature of successful PEA for CTEPH due to antiphospholipid syndrome associated with systemic lupus er...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-011-2346-4
更新日期：2013-07-01 00:00:00
abstract：:We aimed to evaluate the cost-effectiveness of certolizumab pegol (CZP), a pegylated fc-free anti-TNF, as add-on therapy to methotrexate (MTX) versus etanercept, adalimumab, or golimumab in patients with moderate-to-severe active rheumatoid arthritis (RA) not responding to the conventional synthetic disease-modifying ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-017-3736-z
更新日期：2017-09-01 00:00:00
abstract：:The group of autoimmune cutaneous connective tissue diseases (CCTD) includes systemic sclerosis, dermatomyositis (DM), lupus erythematosus (LE), and subtypes. Most CCTD patients can be assigned to one of these phenotypes or mixed forms, and transitions among the subsets exist. We present the case of a 26-year-old woma...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-003-0354-8
更新日期：2004-03-01 00:00:00
abstract：:Chlamydia trachomatis (Ct)-induced arthritis (CtIA) is characterized by persistent Ct infection, which stimulates secretion of cytokines in vitro. We therefore investigated whether CtIA patients have a unique cytokine profile in synovial fluid or serum in vivo. Because underlying Ct infection is overlooked in a high p...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-003-0393-1
更新日期：2005-01-01 00:00:00
abstract：:We studied and characterized anti-bovine beta 2-glycoprotein I antibodies (aB beta 2-GPI) in sera from patients with antiphospholipid syndrome (APS) by ELISA. Bovine beta 2-glycoprotein I (beta 2-GPI) was purified by heparin affinity and DEAE ion-exchange chromatography, and identified on immunoblots using a monoclona...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00286762
更新日期：1995-01-01 00:00:00
abstract：:PXK was identified as a novel candidate gene for systemic lupus erythematosus (SLE) from genome-wide association studies (GWAS) in Caucasians. But a recent replication study in Hong Kong Chinese reported that PXK was not associated with SLE. The aim of this study was to determine whether PXK is associated with SLE in ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1789-3
更新日期：2012-01-01 00:00:00
abstract：:Rickettsia rickettsii, a tick borne disease, is the pathogen responsible for inducing Rocky Mountain Spotted Fever (RMSF), an illness that can progress to fulminant multiorgan failure and death. We present a case where R. rickettsii, acquired on a camping trip, precipitated a flare of peripheral arthritis and episcler...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-019-04330-8
更新日期：2019-09-01 00:00:00
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journal_title：Rheumatology international
pub_type： 历史文章,杂志文章
doi：10.1007/s00296-011-2007-7
更新日期：2012-10-01 00:00:00
abstract：:Necrotic areas of rheumatoid nodules were investigated electron microscopically. PMNs in different stages of disintegration were present in all cases. Granular material, sometimes in a fiberlike orientation, and small fibrils without periodicity were detected between the collagenous fibers. It is assumed that granular...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541219
更新日期：1981-01-01 00:00:00
abstract：:The aims of this systematic review and meta-analysis were to: (1) describe the prevalence of commonly reported comorbidities in psoriatic arthritis (PsA), (2) compare the incidence and/or prevalence of comorbidities between PsA and control populations; and (3) examine the impact of comorbidities on PsA outcomes. We sy...
journal_title：Rheumatology international
pub_type：
doi：10.1007/s00296-020-04775-2
更新日期：2021-02-01 00:00:00
abstract：:The purpose of this study was to investigate specifically the correlation of hand functions determined by Duruoz hand index (DHI) with radiological findings and disease activity in rheumatoid arthritis (RA) patients. Forty-eight RA patients were evaluated with DHI questionnaire, disease activity score (DAS) 28 and mod...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0461-z
更新日期：2008-03-01 00:00:00
abstract：:We sought to determine the prevalence of additional connective tissue diseases (CTDs) in patients with idiopathic inflammatory myopathies (IIM), and to study the muscle biopsy patterns in various clinico-serologic subsets of myositis. We undertook a retrospective cohort study of 648 patients with a histological diagno...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-019-04411-8
更新日期：2019-10-01 00:00:00
abstract：:Hand osteoarthritis (OA) is a common degenerative joint disorder leading to substantial pain and disability. The most severe subtype is erosive hand OA characterized by an abrupt onset, local inflammation, subchondral erosions and worse outcomes than non-erosive disease. Biomarkers of hand OA could help to diagnose th...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-017-3864-5
更新日期：2018-05-01 00:00:00
abstract：:Severe acute respiratory syndrome coranovirus-2 (SARS-CoV-2) infection has become an important health-care issue worldwide. The coronavirus disease 2019 (COVID-19) has also raised concerns among patients with inflammatory rheumatic conditions and their treating physicians. There are emerging data regarding the potenti...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-020-04635-z
更新日期：2020-10-01 00:00:00
abstract：:We evaluated the frequency of secondary amyloidosis, associated clinical features, and outcomes in ankylosing spondylitis (AS) patients diagnosed in the last decade. The medical records of AS patients diagnosed at single academic medical center were reviewed for clinical evidence of amyloidosis. During routine follow-...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2646-3
更新日期：2013-07-01 00:00:00
abstract：:Fibromyalgia is a multi-factorial illness primarily characterised by widespread chronic pain and fatigue, with several symptoms and associated conditions. Due to a lack of clinical awareness and an absence of objective diagnostic measures, fibromyalgia patients often engage with online health information. The aim is t...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-019-04265-0
更新日期：2019-04-01 00:00:00
abstract：:Uveitis is an important component of many rheumatic diseases. The main causes of recurrent uveitis are seronegative spondylarthropathies and Behçet's disease. We describe a rare case of Henoch Schönlein vasculitis (HSV) along with multiple recurrences of acute anterior uveitis. In cases of skin rash and recurrent ante...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1074-5
更新日期：2010-08-01 00:00:00
abstract：:Sjogren's syndrome (SS) is a systemic autoimmune disease characterized by xerophthalmia, xerostomia and extraglandular manifestations. Anemia, leukopenia, thrombocytopenia and lymphoproliferative disorders, including lymphoma are well-known extraglandular, hematological complications of SS. We report here a rare case ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1395-4
更新日期：2012-05-01 00:00:00
abstract：:Interleukin-6 (IL-6) was detected at low levels in plasma [0.014 +/- 0.006 ng/ml (mean +/- SEM] and in high amounts in synovial fluid [SF; 2.6 +/- 2.2 ng/ml (mean +/- SEM)] of patients with rheumatoid arthritis. No correlation of IL-6 levels in plasma or SF with the ESR (n = 15) or with histological parameters of acut...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00307733
更新日期：1993-01-01 00:00:00
abstract：:The Australian/Canadian Osteoarthritis Hand Index (AUSCAN) is a patient self-reported 15-item questionnaire measuring the severity of hand osteoarthritis symptoms in the respect of pain, stiffness, and function. In this study, we developed a Korean version of the AUSCAN Index (K-AUSCAN) and confirmed its reliability, ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2227-x
更新日期：2012-11-01 00:00:00
abstract：:Advanced glycation endproducts (AGEs) are the products of non-enzymatic glycation and oxidation of proteins and lipids. Low-turnover tissues such as articular cartilage seem to be susceptible to the accumulation of AGEs, which might lead to cartilage degradation. Recently, a non-invasive method for measuring skin AGE ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0408-4
更新日期：2007-12-01 00:00:00
abstract：:The objective of this research was to investigate the cellular source of soluble ICAM-1 (siCAM-1) from rheumatoid synovial tissue (RS) and its relation to sICAM-1 in synovial fluid (SF) and serum, and to study the expression of ICAM-1 in isolated cells of RS. sICAM-1 was determined by using the enzyme-linked immunosor...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/pl00006846
更新日期：1997-01-01 00:00:00
abstract：:Fatigue has a large impact on quality of life and is still unmanageable for many patients. Study aims were describe (1) the prevalence and pattern of fatigue over time in patients with early rheumatoid arthritis under a treat-to-target strategy and (2) identify predictive factors for worsening and recovering of fatigu...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-4102-5
更新日期：2018-09-01 00:00:00
abstract：:To study the combined effect of both genetic and environmental factors in the age of rheumatoid arthritis onset. Patients (n = 507). Shared epitope characterization was performed using Lifecodes HLA-SSO. Genotyping of protein tyrosine phosphatase non-receptor 22 (PTPN22) rs2476601 and signal transducers and activators...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2090-9
更新日期：2012-10-01 00:00:00
abstract：OBJECTIVES:To identify recommendations on the diagnosis and management of rheumatoid arthritis (RA) supported by low recommendation grades, to study the causes of this low grading, and to propose solutions. METHODS:A group of six rheumatologists, with extensive experience in the development of systematic reviews, revi...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-020-04724-z
更新日期：2021-01-01 00:00:00
abstract：:This study investigated the prevalence of antibody against annexin II (A2) in patients with antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). It also explored the role of this antibody in thrombosis. Purified recombinant A2 was used in ELISA to measure the levels of IgG anti-A2 antibody in 101 AP...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1379-4
更新日期：2011-07-01 00:00:00
abstract：:Systemic sclerosis is a connective tissue disease, which may lead to elevated pulmonary arterial pressure due to pulmonary arterial hypertension and/or left ventricular diastolic dysfunction. Uric acid (UA) has been shown to be elevated in patients with pulmonary hypertension (PH) and heart failure. We aimed to invest...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1557-4
更新日期：2011-02-01 00:00:00
abstract：:To determine the "hand anatomic index" (HAI--a quantitative measure of hand deformity) in systemic sclerosis (scleroderma) and to compare it with the other measures of hand deformity and functional impairment. The HAI (measure of open hand span minus closed hand span/lateral height of hand) was determined in 30 patien...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-005-0058-3
更新日期：2006-03-01 00:00:00
abstract：:The aim of this study was to compare the efficacy of sodium hyaluronate (SH) injection with the most common treatment methods, intraarticular steroid injection and physical therapy modalities in patients with adhesive capsulitis (AC). A total of 95 shoulders of 90 patients were included in the study and were randomize...
journal_title：Rheumatology international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00296-005-0022-2
更新日期：2006-04-01 00:00:00
