Abstract:
:We studied and characterized anti-bovine beta 2-glycoprotein I antibodies (aB beta 2-GPI) in sera from patients with antiphospholipid syndrome (APS) by ELISA. Bovine beta 2-glycoprotein I (beta 2-GPI) was purified by heparin affinity and DEAE ion-exchange chromatography, and identified on immunoblots using a monoclonal antibody against human beta 2-GPI and by amino acid sequence analysis. aB beta 2-GPI levels in the sera from 36 APS patients were measured by ELISA using purified bovine beta 2-GPI as an antigen. The mean +/- standard deviation level of aB beta 2-GPI was 17.4 +/- 22.0 units in the 58% of APS patients who were positive. There was a significant correlation (P = 0.003) between aB beta 2-GPI and anticardiolipin antibody (aCL) levels. aB beta 2-GPI from the sera of patients with APS was inhibited by bovine beta 2-GPI itself. Purified IgG from the sera of patients with APS showed that bovine beta 2-GPI was capable of acting as a cofactor for aCL. Purified bovine beta 2-GPI was useful antigen for conventional ELISA. aB beta 2-GPI may contribute to the further development of aCL analysis and to the understanding of the pathogenesis of APS.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Nomura M,Okada J,Kondo Hdoi
10.1007/BF00286762subject
Has Abstractpub_date
1995-01-01 00:00:00pages
1-8issue
1eissn
0172-8172issn
1437-160Xjournal_volume
15pub_type
杂志文章abstract::Malignant neoplasms are associated with a wide variety of paraneoplastic rheumatological syndromes. The paraneoplastic nature should be based on specific criteria. We report a series of eight cases of paraneoplastic rheumatic syndromes revealing an underlying neoplasia. Our series consists of six men and two women, wi...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-011-2252-9
更新日期:2012-06-01 00:00:00
abstract::To describe the characteristics of patients receiving belimumab, overall patterns of systemic lupus erythematosus (SLE) care, clinical outcomes, and changes in glucocorticoid dose following 6 months of therapy with belimumab, and healthcare resource utilization in belimumab users in Canadian clinical practice settings...
journal_title:Rheumatology international
pub_type: 杂志文章,多中心研究
doi:10.1007/s00296-017-3682-9
更新日期:2017-06-01 00:00:00
abstract::A 42-year-old woman presented with a 3-week history of left knee pain and swelling. She had suffered dermatitis herpetiformis for 12 years, proved by skin biopsy. She had never been on gluten-free diet. Knee pain increased with motion and her gait was antalgic. On admission, she was mainly dependent on wheelchair due ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1670-4
更新日期:2011-05-01 00:00:00
abstract::P wave dispersion (PWD) is a sign for the prediction of atrial fibrillation (AF). The aim of this study was to assess P wave dispersion and its relation with clinical and echocardiographic parameters in patients with rheumatoid arthritis (RA). Thirty RA patients (mean age 49 +/- 10 years) and 27 healthy controls (mean...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-007-0307-8
更新日期:2007-07-01 00:00:00
abstract::Here we evaluated whether 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have beneficial effects for collagen-induced arthritis (CIA). DBA/1 mice were immunized with bovine type-II collagen and administered 100 mg/kg of pravastatin interperitoneally. We measured the effects of pravastatin for CIA...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-006-0270-9
更新日期:2007-05-01 00:00:00
abstract::Therapeutic proteins, such as infliximab, have revolutionized the treatment of many diseases during the last decade and more than 80 therapeutic proteins are currently approved for clinical use. However, all exogenous proteins have the potential to cause antibody formation. In order to ensure patient safety and the ef...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-005-0085-0
更新日期:2006-03-01 00:00:00
abstract::Clinically diagnosed cases with different grades of rheumatoid arthritis (RA) were studied for (a) cryoglobulin content (b) constituents of cryoglobulins, and (c) rheumatoid factor (RF) titers in sera and cryoglobulins. Of 60 patients, 28 (46.66%) had significantly high levels of cryoglobulins and were mainly distribu...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541520
更新日期:1985-01-01 00:00:00
abstract::Although exercise is often recommended for managing osteoarthritis (OA), limited evidence-based exercise options are available for older adults with OA. This study compared the effects of Hatha yoga (HY) and aerobic/strengthening exercises (ASE) on knee OA. Randomized controlled trial with three arms design was used: ...
journal_title:Rheumatology international
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00296-016-3620-2
更新日期:2017-03-01 00:00:00
abstract::Agalactosyl IgG [Gal(0)] was first discovered in patients with rheumatoid arthritis (RA). However, the proportion of this glycoform is also raised in tuberculosis and leprosy. This has helped reinforce the suggestion that RA may be triggered by a mycobacterium-like slow bacterial infection. On the other hand, arthriti...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00262090
更新日期:1995-01-01 00:00:00
abstract::Wells' syndrome is a multifaceted dermatosis with a wide morphological spectrum, ranging from characteristic cellulitis-like erythema and papula to an unusual presentation of vesicles and pustules. The most important elements for diagnosis are erythemal plaques and histological picture of eosinophilic infiltration of ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-1809-y
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:The present study was performed to localize the articular deposition of monosodium urate (MSU) crystal in joints. We compare the detection efficiencies of dual-energy CT (DECT) and ultrasound scans. METHODS:Analyses by DECT and ultrasound were performed with 184 bilateral joints of the lower limbs of 54 cons...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-018-3994-4
更新日期:2018-05-01 00:00:00
abstract::Pancreatitis is a relatively rare but severe manifestation in systemic lupus erythematosus (SLE) patients. We report a case of a 39-year-old woman with previous SLE diagnose treated with prednisone and mycophenolate mofetil who developed an acute pancreatitis complicated by pancreatic pseudocysts within the context of...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-0964-x
更新日期:2010-03-01 00:00:00
abstract::The Fc receptor-like (FCRL) molecules have recently been shown to contribute to the pathogenesis of certain autoimmune disorders. In this study, we investigated the expression levels of FCRL1, 2 and 4 in blood mononuclear cells from rheumatoid arthritis patients using real-time PCR. The mRNA of these molecules was det...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-016-3495-2
更新日期:2016-08-01 00:00:00
abstract::Alkoptunuria is an inherited autosomal recessive metabolic disorder which is caused by the lack of homogentisic acid-oxidase enzyme. It is associated with various systemic abnormalities and related to the deposition of homogentisic acid pigment in connective tissues. These pigmentary changes are termed "ochronosis". W...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-004-0538-x
更新日期:2005-08-01 00:00:00
abstract::Rheumatoid arthritis (RA) in Thai population is significantly associated with HLA-DR4 shared epitope (SE) alleles, particularly with DRB1*0405 (P = 0.00004, OR = 3.84, 95% CI = 1.93, 7.7). In addition, tumor necrosis factor-alpha (TNF-alpha) gene -863A alleles were found to be significantly increased in 77 RA patients...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-007-0392-8
更新日期:2007-12-01 00:00:00
abstract::The Juvenile Arthritis Multidimensional Assessment Report (JAMAR) is a new parent/patient reported outcome measure that enables a thorough assessment of the disease status in children with juvenile idiopathic arthritis (JIA). We report the results of the cross-cultural adaptation and validation of the parent and patie...
journal_title:Rheumatology international
pub_type: 杂志文章,多中心研究
doi:10.1007/s00296-018-3964-x
更新日期:2018-04-01 00:00:00
abstract::Non-tuberculous mycobacteria (NTM) are an unusual cause of osteomyelitis in immunocompetent children. Diagnosis is often difficult due to the paucity of clinical symptoms and a subtle course of the disease. NTM comprise a group of about 91 identified species of environmental mycobacteria that cause infections most fre...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-0844-4
更新日期:2009-10-01 00:00:00
abstract::The objective of this study was to search for proteomic patterns distinguishing patients with rheumatoid arthritis (RA) from healthy controls, biomarker candidates specific for early RA, and proteins reflecting disease activity, by profiling of serum proteins using magnetic bead-based (MB) separation and matrix-assist...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1407-4
更新日期:2011-08-01 00:00:00
abstract::A meta-analysis was done with the final data from three trials that provided the first results relating to efficacy and safety of the new sustained-release (SR) formulation of etodolac versus established nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of osteoarthritis (OA) of the knee. The studies were...
journal_title:Rheumatology international
pub_type: 杂志文章,meta分析
doi:10.1007/BF00290280
更新日期:1993-01-01 00:00:00
abstract::Sphingolipids are components of the plasma membrane whose metabolic manipulation is of interest as a potential therapeutic approach in a number of diseases. Sphingosine kinase 1 (SphK1), the major kinase that phosphorylates sphingosine to sphingosine-1-phosphate (S1P), was previously shown by our group and others to m...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-012-2493-2
更新日期:2013-10-01 00:00:00
abstract::We examined the intracellular mechanisms of substance P induced oxyradical production in rheumatoid synovial cells by the luminol-dependent chemiluminescence method. After stimulation with substance P (30 microM), single synovial A (macrophage-like) or B (fibroblast-like) cells released oxyradicals such as superoxide ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF01419729
更新日期:1996-01-01 00:00:00
abstract::The aim of this study was to analyze the change of serum chemokins levels of CXCL16, CX3CL1/Fractalkine, and CXCL10/interferon-gamma inducible protein-10 (IP-10) with rheumatoid arthritis (RA), by infliximab treatment. The effects of infliximab treatment were studied in 23 patients with RA, over a period of 30 weeks. ...
journal_title:Rheumatology international
pub_type: 临床试验,杂志文章
doi:10.1007/s00296-006-0241-1
更新日期:2007-03-01 00:00:00
abstract::Parenchymal neuro-Behçet disease (NBD) is a serious clinic condition with a sub-acute or chronic disease course that results in incapability through pyramidal tract involvement. Though well-known consequences can deter a patient's life, both urinary symptoms and sexual dysfunction are underestimated complications of N...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-017-3858-3
更新日期:2018-01-01 00:00:00
abstract::To evaluate serum levels of IL6 in patients with Kawasaki disease and compare it with CRP, and to assess the role of these biomarkers in predicting coronary changes and resistance to the first-line therapy of this disease in a subset of Indian population. A single centre prospective observational study was conducted a...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-019-04375-9
更新日期:2019-10-01 00:00:00
abstract::Celiac disease (CD) is an autoimmune systemic disease characterized by not only gastrointestinal but also extraintestinal manifestations. The aim of our study was to do a serological screening for CD, by IgA endomysial antibodies (EmA), in patients with unexplained articular manifestations. Two hundred and eleven pati...
journal_title:Rheumatology international
pub_type: 杂志文章,多中心研究
doi:10.1007/s00296-013-2906-x
更新日期:2014-05-01 00:00:00
abstract::We evaluated the presence of sarcopenia in a population of systemic sclerosis (SSc) patients, with respect to nutritional, clinical, and laboratory features. A total of 62 patients who met the ACR/EULAR 2013 classification criteria were enrolled. Sarcopenia was defined according to the Relative Skeletal Mass Index (RS...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-019-04401-w
更新日期:2019-10-01 00:00:00
abstract::Healthy human sexuality is integral to a well-lived life. Recent studies reported that sexual problems were common in patients with ankylosing spondylitis (AS) in relation to the consequences of the illness such as pain, stiffness of the spine and depression. Twenty-three female patients with AS and 27 healthy female ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-2340-x
更新日期:2013-01-01 00:00:00
abstract::Several studies have shown a negative association between smoking and primary Sjögren's syndrome (pSS), and smoking may interfere with the immune response. The purpose of this study was to investigate if smoking affects disease activity and disease phenotype in pSS. In this cross-sectional study, consecutive pSS patie...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-019-04335-3
更新日期:2019-09-01 00:00:00
abstract::The case of a 29-year-old white female with a 7-year history of typical scleroderma is presented who developed excessive fibrosis of the supraclavicular lymph nodes. After 3 years of disease, firm right supraclavicular lymphadenopathy appeared, accompanied by a high fever. Biopsy revealed non-caseating granulomas and ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00301013
更新日期:1993-01-01 00:00:00
abstract::Osteoarthritis (OA) has a strong genetic component, and experimental evidence suggests the involvement of the Wnt pathway in its pathogenesis. Hence, we explored the association of common single nucleotide polymorphisms (SNPs) related to the Wnt pathway with hip and knee OA. Seventy-eight SNPs were analyzed in 606 pat...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-013-2821-1
更新日期:2013-11-01 00:00:00