Serum deoxyribonuclease I and clinical activity in systemic lupus erythematosus.

Abstract:

:Serum deoxyribonuclease I (DNase I) activity in systemic lupus erythematosus (SLE) patients was shown to be lower than that of healthy laboratory personnel, rheumatoid arthritis, and scleroderma patients (P less than 0.001). The decrease in DNase I activity in SLE sera was not due to the effect of various autoantibodies or to heat labile DNase I inhibitor. A relationship between serum DNase I activity and active SLE was demonstrated. Patients with active lupus nephritis had the lowest levels of enzymatic activity.

journal_name

Rheumatol Int

authors

Chitrabamrung S,Rubin RL,Tan EM

doi

10.1007/BF00541153

subject

Has Abstract

pub_date

1981-01-01 00:00:00

pages

55-60

issue

2

eissn

0172-8172

issn

1437-160X

journal_volume

1

pub_type

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