Abstract:
:Serum deoxyribonuclease I (DNase I) activity in systemic lupus erythematosus (SLE) patients was shown to be lower than that of healthy laboratory personnel, rheumatoid arthritis, and scleroderma patients (P less than 0.001). The decrease in DNase I activity in SLE sera was not due to the effect of various autoantibodies or to heat labile DNase I inhibitor. A relationship between serum DNase I activity and active SLE was demonstrated. Patients with active lupus nephritis had the lowest levels of enzymatic activity.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Chitrabamrung S,Rubin RL,Tan EMdoi
10.1007/BF00541153subject
Has Abstractpub_date
1981-01-01 00:00:00pages
55-60issue
2eissn
0172-8172issn
1437-160Xjournal_volume
1pub_type
杂志文章abstract::Behçet's disease (BD) is a multi-system inflammatory disorder, in which cytokine balance is polarized to Th1. In this study, the cell surface molecule expression, Th1/Th2, inflammatory cytokine levels in blood, and synovial fluid of CD3(+) T lymphocytes in BD were investigated. The study group consisted of 10 BD, 10 a...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-012-2446-9
更新日期:2013-03-01 00:00:00
abstract::Several studies have shown a negative association between smoking and primary Sjögren's syndrome (pSS), and smoking may interfere with the immune response. The purpose of this study was to investigate if smoking affects disease activity and disease phenotype in pSS. In this cross-sectional study, consecutive pSS patie...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-019-04335-3
更新日期:2019-09-01 00:00:00
abstract::Measurement of the complement activation products C1s:C1-inh, C3bP and C5b-9 by ELISA in plasma samples from normals, rheumatoid arthritis (RA) and systemic lupus erythematosis (SLE) patients showed significantly elevated levels in the two patient groups (P less than 0.0001 for C1s:C1-inh, C3bP and C5b-9) compared to ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF02274831
更新日期:1990-01-01 00:00:00
abstract::Cardiovascular disease (CVD) morbidity and mortality is highly prevalent in patients with rheumatoid arthritis (RA) with debilitating effects for the individual as well as significant healthcare impact. Current evidence demonstrates that engaging in aerobic and resistance exercise (i.e. structured physical activity) c...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-019-04483-6
更新日期:2020-03-01 00:00:00
abstract::An imbalance in pro- and anti-inflammatory cytokines is suggested to contribute to tissue damage in rheumatoid arthritis (RA). This study was aimed at investigating profiles of cytokines in circulation and cytokines produced by mitogen-stimulated peripheral blood mononuclear cells (PBMC) in RA patients and healthy con...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-017-3774-6
更新日期:2017-10-01 00:00:00
abstract::The neutrophilic granule protein proteinase 3 (PR3) is the preferred target antigen of anti-neutrophil cytoplasmic antibodies (ANCA) found in the serum of patients with Wegener's granulomatosis, a systemic small-vessel vasculitis. Due to the lack of data concerning the murine homologue of human PR3, we assessed the ne...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1672-2
更新日期:2011-08-01 00:00:00
abstract::Several studies of rheumatoid arthritis (RA) incidence and prevalence indicate that occurrence of the disease varies significantly among different populations. We aimed to estimate the prevalence and incidence of RA in South Korea. We used Korean National Health Insurance (NHI) claims data to estimate the prevalence o...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-012-2590-2
更新日期:2013-06-01 00:00:00
abstract::To investigate whether the hypothermia induced by Adenosine 5'-Monophosphate (5'-AMP) could attenuate early stage injury in a rat acute gouty arthritis model. Ankle joint injection with monosodium urate monohydrate crystals (MSU crystals) in hypothermia rat model which was induced by 5'-AMP and then observe whether hy...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-013-2676-5
更新日期:2013-08-01 00:00:00
abstract::Osteomyelitis variolosa is an osteoarticular complication of small pox infection. We are presenting a case of osteomyelitis variolosa, who presented to us with fracture of ankle on the involved side with other orthopedic sequelae of small pox infection, which he contracted during his childhood period. We have discusse...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-2194-2
更新日期:2012-11-01 00:00:00
abstract::This retrospective study analyzed the HLA-B 27 alleles in a group of 20 consecutive patients with the diagnosis of Reiter syndrome (RS) followed in a tertiary referral university hospital in Brazil, during the period 1990-2006, and compared the data with that observed in other patients with spondyloarthropathies follo...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-007-0441-3
更新日期:2008-03-01 00:00:00
abstract::Crystalglobulinemia is an extremely rare pathology that is associated in most cases with plasma cell dyscrasia, mainly multiple myeloma. In most cases, it may be the manifestation of incipient gammopathy or it manifests shortly after diagnosis. We report a patient with ischemic lesions of thrombotic origin in lower li...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-020-04620-6
更新日期:2020-08-01 00:00:00
abstract::To investigate changes in the risk for serious infections (SIs) over time in Japanese rheumatoid arthritis (RA) patients treated with tumor necrosis factor inhibitors (TNFIs). This prospective cohort study included Japanese RA patients who began treatment with a TNFI from 2005 to 2007 (2005 group, n = 716, 634.2 patie...
journal_title:Rheumatology international
pub_type: 杂志文章,多中心研究
doi:10.1007/s00296-014-3045-8
更新日期:2014-12-01 00:00:00
abstract::Fibromyalgia (FM) is a common chronic pain syndrome with an unknown etiology. Recent years added new information to our understanding of FM pathophysiology. Researches on genetics, biogenic amines, neurotransmitters, hypothalamic-pituitary-adrenal axis hormones, oxidative stress, and mechanisms of pain modulation, cen...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-005-0078-z
更新日期:2006-05-01 00:00:00
abstract::The current study aimed to define evidence-based admission criteria of pediatric Henoch-Schonlein purpura (HSP). In addition, we aimed to better characterize epidemiological and clinical features of pediatric HSP in Israel. We performed a retrospective cohort study of all children with HSP admitted during a 15 years p...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-014-2971-9
更新日期:2014-11-01 00:00:00
abstract::Our aim was to investigate the relationship between the DNA methylation status of glucocorticoid receptor (GR) gene promoter and mRNA expression level of GRα gene of peripheral blood mononuclear cells (PBMCs) in patients with systemic lupus erythematosus (SLE). Fifteen newly emerging SLE patients and fifteen healthy c...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-015-3266-5
更新日期:2015-08-01 00:00:00
abstract::The aim was to further characterize the SKG model of rheumatoid arthritis (RA) and its potential for studying intervention treatments, with special focus on bone targeting therapies. Three individual studies were conducted, using a total of 71 SKG mice, comparing arthritis induction with mannan versus zymosan A, femal...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-012-2500-7
更新日期:2013-05-01 00:00:00
abstract::With better understanding of the pathogenesis of AIDS and the advent of anti-retroviral medications, patients with HIV are living longer and the probability that they will suffer musculoskeletal complications are increasing. There is a vast array of musculoskeletal impairments including rheumatologic, infectious, and ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-005-0043-x
更新日期:2006-05-01 00:00:00
abstract::Patients with rheumatoid arthritis (RA) have bone loss to various degrees at different skeletal sites. The subregional bone mineral density (BMD) of the hand and the correlation of BMD to other regional bone losses, parameters of inflammation or bone resorption was evaluated in 421 patients with RA and controls. RA pa...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0638-0
更新日期:2008-11-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a multifactorial disease. A combination of genetic and environmental risk factors contributes to its etiology. Several genes have been reported to be associated with susceptibility to the development of RA. The MHC2TA and FCRL3 genes have been associated previously with RA in Swedish and J...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-015-3358-2
更新日期:2016-02-01 00:00:00
abstract::We have examined the way in which products of cultured human blood mononuclear cells activate human articular chondrocytes. Conditioned medium from mononuclear cells enhanced the production of prostaglandin E by cultured human chondrocytes and also stimulated fibrinolytic activity in these cultures. These two effects ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541204
更新日期:1984-01-01 00:00:00
abstract::Biological treatments aiming to neutralize TNF-alpha (tumour necrosis factor alpha) (infliximab, adalimumab and etanercept) are increasingly used to treat rheumatoid arthritis (RA). Although increased frequency has not been observed in randomized clinical trials with TNF-alpha antagonist agents, postmarketing surveill...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-006-0165-9
更新日期:2006-11-01 00:00:00
abstract::Necrotic areas of rheumatoid nodules were investigated electron microscopically. PMNs in different stages of disintegration were present in all cases. Granular material, sometimes in a fiberlike orientation, and small fibrils without periodicity were detected between the collagenous fibers. It is assumed that granular...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541219
更新日期:1981-01-01 00:00:00
abstract::Total hip arthroplasty (THA) and total knee arthroplasty (TKA) bring relief of pain and functional disability to patients with end-stage osteoarthritis, and however, the literature on their impact on patients' level of physical activity (PA) is scarce. Cross-sectional study in patients who underwent THA/TKA surgery in...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-016-3598-9
更新日期:2017-02-01 00:00:00
abstract::Information on measurement properties of translated versions of the Western Ontario and McMaster Universities (WOMAC) osteoarthritis index is still limited. This study investigated the internal consistency, test-retest reliability/agreement, construct validity, and floor and ceiling effects of Portuguese-Brazil WOMAC ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-019-04496-1
更新日期:2020-02-01 00:00:00
abstract::Wegener granulomatosis (WG) is a necrotizing granulomatous vasculitis that predominantly affects airways and kidneys. But central nervous system involvement (7-11%) is an uncommon. Massive ICH may occur in the course of WG, and this serious condition is related with high risk of mortality. Therefore, the new treatment...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-1954-3
更新日期:2012-06-01 00:00:00
abstract::We examined the agreement between self-reported osteoporosis and bone mineral density (BMD) results through dual-energy x-ray absorptiometry (DXA) using data from a national representative sample taken from the US communities. Six-year data from the continuous National Health and Nutrition Examination Survey 2005-2006...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-016-3573-5
更新日期:2016-12-01 00:00:00
abstract::The purpose of this study was to investigate specifically the correlation of hand functions determined by Duruoz hand index (DHI) with radiological findings and disease activity in rheumatoid arthritis (RA) patients. Forty-eight RA patients were evaluated with DHI questionnaire, disease activity score (DAS) 28 and mod...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-007-0461-z
更新日期:2008-03-01 00:00:00
abstract::Polyarteritis nodosa (PAN) is a rare systemic vasculitis affecting multiple organs. Current standard treatment includes the use of glucocorticoids and cyclophosphamide. Unfortunately, some patients do not respond to this treatment and other therapeutic options are needed. We present a case of a young male with refract...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-018-4210-2
更新日期:2019-02-01 00:00:00
abstract::We have investigated the prevalence of dry mouth among patients with autoimmune diseases other than Sjögren's syndrome. One hundred and forty-four patients, excluding patients with primary Sjögren's syndrome, were enrolled in this study. The volume of saliva secreted was measured with the screening technique for estim...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-012-2611-1
更新日期:2013-12-01 00:00:00
abstract::The aim of this study was to evaluate whether the serum concentration of interleukin-6 (IL-6) reflects disease activity in ankylosing spondylitis (AS). A group of 271 AS patients were enrolled in the study, 261 of whom completed the entire protocol (201 males, 60 females, median age of 53 years). Serum IL-6 was measur...
journal_title:Rheumatology international
pub_type: 临床试验,杂志文章
doi:10.1007/s002960050066
更新日期:1998-01-01 00:00:00