Abstract:
:The neutrophilic granule protein proteinase 3 (PR3) is the preferred target antigen of anti-neutrophil cytoplasmic antibodies (ANCA) found in the serum of patients with Wegener's granulomatosis, a systemic small-vessel vasculitis. Due to the lack of data concerning the murine homologue of human PR3, we assessed the neutrophil marker polypeptide PR3 in mice by generating a murine-specific PR3 antibody. In contrast to humans, peripheral blood leukocytes are not the main resource of murine PR3. Interestingly, we could show that the mouse bone marrow is the main PR3 source, indicating that it is a large reservoir for functional neutrophils. This pool of neutrophils could be rapidly mobilized after injection of IL-8. The development of the new PR3 antibody provides a new tool for studying the maturation processes of the murine hematopoietic system and will also support the generation of infectious disease or vasculitis mouse models.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Relle M,Thomaidis T,Galle PR,Schwarting Adoi
10.1007/s00296-010-1672-2subject
Has Abstractpub_date
2011-08-01 00:00:00pages
1105-11issue
8eissn
0172-8172issn
1437-160Xjournal_volume
31pub_type
杂志文章abstract::In recent years, scientific efforts on the topic "gout" have focused on pathogenetic aspects. This has opened new strategies of anti-inflammatory therapy and has improved urate-lowering therapy. So far, a scientometric analysis of the topic "gout" has not been generated despite an increased need for it in times of mod...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-013-2805-1
更新日期:2013-11-01 00:00:00
abstract::Although subclinical liver disease is common in systemic lupus erythematosus (SLE), strikingly high levels of liver enzymes are rare. Our aim was to determine the cause of high levels of liver enzymes in lupus patients, particularly in patients diagnosed with toxic hepatitis. We performed a retrospective chart review ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-1237-4
更新日期:2011-01-01 00:00:00
abstract::We hypothesise that T-cell apoptosis and the percentage of T cells expressing molecules involved in apoptosis modulation (CD95, CD28) are altered at the inflammation site and in peripheral blood (PB) of children with juvenile idiopathic arthritis (JIA). Paired JIA samples of synovial fluid (SF) and PB ( n=7) and PB sa...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-002-0263-2
更新日期:2003-05-01 00:00:00
abstract::Sleep disturbances and problems are increased in ankylosing spondylitis (AS). But much is not known in a quantitative way about sleep problems and effect of treatments on AS. This study is aimed first, to investigate sleep disturbances in AS and secondly, to evaluate the effects of anti-TNF treatment on SD in AS. One ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-011-1907-x
更新日期:2012-07-01 00:00:00
abstract::A 56-year-old woman presented with changes characteristic of the reflex sympathetic dystrophy syndrome (RSDS) but also frank synovitis of the left wrist, an elevated ESR and early damage of the left carpus on radiographs, suggesting septic arthritis. A dynamic scan showed changes characteristic of RSDS. A sample of sy...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541334
更新日期:1985-01-01 00:00:00
abstract::Human parvovirus B19 (B19) rarely induces pure red cell aplasia (PRCA) in healthy hosts. Meanwhile B19 infection is often clinically similar to systemic lupus erythematosus (SLE), and several cases have been reported wherein B19 actually stimulated SLE exacerbation in an immunocompetent subject. An 82-year-old healthy...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-006-0227-z
更新日期:2007-02-01 00:00:00
abstract::Microvascular lesions are a predominant feature in systemic sclerosis (SSc) and seem to play a central pathogenic role. The presence of nailfold capillary abnormalities is useful in diagnosing SSc. Capillaroscopy, however, usually requires special equipment and may be time consuming. Dermatoscope has been presented as...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-010-1532-0
更新日期:2011-12-01 00:00:00
abstract::Behçet's disease (BD) is a multi-system inflammatory disorder, in which cytokine balance is polarized to Th1. In this study, the cell surface molecule expression, Th1/Th2, inflammatory cytokine levels in blood, and synovial fluid of CD3(+) T lymphocytes in BD were investigated. The study group consisted of 10 BD, 10 a...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-012-2446-9
更新日期:2013-03-01 00:00:00
abstract::The mononuclear phagocyte infiltrate which occupies the gout tophus has been compared with that of the subcutaneous rheumatoid nodule. In the gout tophus, macrophage migration appears to be at a relatively low level and effectively terminates once these cells have been recruited into the corona. In the nodule the evid...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541376
更新日期:1987-01-01 00:00:00
abstract::A previously healthy 40-year-old woman presented as unstable angina. She had a family history of stroke as the only cardiovascular risk factor. Her blood pressure on admission was 150/90 mmHg. Laboratory study showed absolutely all negative markers of inflammation, autoimmune disorders, or atherosclerosis. Coronary an...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-008-0739-9
更新日期:2009-04-01 00:00:00
abstract::Intercellular adhesion molecule-1 (ICAM-1) is a membrane-bound molecule primarily involved in cell-cell adhesive interactions of the immune system. It is a cytokine-induced glycoprotein involved in the recruitment of cells into tissues undergoing inflammatory responses. The levels of soluble ICAM-1 were measured in se...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-001-0159-6
更新日期:2002-01-01 00:00:00
abstract::We present a 10-year-old girl who had been diagnosed with juvenile idiopathic arthritis 5 years before and who experienced a flare of arthritis affecting one knee while she was off medication for almost 3 years. Seronegative Lyme arthritis had to be diagnosed based on the detection of Borrelia burgdorferi DNA in synov...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-007-0333-6
更新日期:2007-09-01 00:00:00
abstract::The objective was to investigate the effect of activin A on matrix metalloproteinase 3 (MMP-3) production and to identify the role of activin A in chondroprotection. SW1353 cells, a human chondrosarcoma cell line, were stimulated with interleukin (IL) 1alpha and tumor necrosis factor (TNF) alpha, and the concentration...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-007-0350-5
更新日期:2007-09-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) affects women of childbearing age. To optimize fetal and maternal outcomes, effective reproductive health counseling is crucial. To analyze the effectiveness of reproductive health counseling in women with SLE and identify gaps in patient educational needs. Cross-sectional study incl...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-020-04671-9
更新日期:2021-02-01 00:00:00
abstract::Pancreatitis is a relatively rare but severe manifestation in systemic lupus erythematosus (SLE) patients. We report a case of a 39-year-old woman with previous SLE diagnose treated with prednisone and mycophenolate mofetil who developed an acute pancreatitis complicated by pancreatic pseudocysts within the context of...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-0964-x
更新日期:2010-03-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a systemic autoimmune disease that causes joint pain, inflammation, and loss of function. Disease pathogenesis involves activation and proliferation of autoreactive pro-inflammatory effector T cells. While the details of RA onset and progression remain controversial, dendritic cell (DC) nu...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-017-3671-z
更新日期:2017-07-01 00:00:00
abstract::We report a case of an association of four autoimmune diseases in a 15-year-old girl and we discuss the etiopathogenic of this association and difficulties of treatment. ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-009-0988-2
更新日期:2010-04-01 00:00:00
abstract::Previous studies have shown that fibromyalgia syndrome (FMS) is associated with low level of physical activity and exercise, which may lead to an increased risk of osteoporosis. However, studies of bone mineral density (BMD) in fibromyalgia have shown conflicting results. Thus, we conducted a systematic review and met...
journal_title:Rheumatology international
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00296-016-3625-x
更新日期:2017-04-01 00:00:00
abstract::Interleukin-15 (IL-15) is a pleotrophic cytokine that is involved in the pathogenesis of diverse inflammatory rheumatic diseases. The aims of this study were to compare serum IL-15 levels and expression of its receptor (IL-15Rα) in Behçet's disease (BD) with those in other rheumatic diseases and to identify the relati...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-013-2705-4
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVES:We aimed to assess the clinical significance of Krebs von den Lungen-6 (KL-6) in the diagnosis and severity of interstitial lung disease (ILD) in a French cohort of patients with systemic sclerosis (SSc). METHODS:Serum KL-6 concentrations were measured with chemiluminescent enzyme immunoassay (CLEIA) in 75 ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-018-3987-3
更新日期:2018-05-01 00:00:00
abstract::IgM, IgG and IgA class antibodies against Yersinia, Salmonella, Campylobacter and Borrelia were determined by enzyme-linked immunosorbent assay (ELISA) in a group of 340 unselected patients with a recent inflammatory joint disease. The control group consisted of 340 and 100 healthy blood donors using Borrelia-ELISA an...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF02274884
更新日期:1991-01-01 00:00:00
abstract::The objective of this study is to investigate the endothelial function in complex regional pain syndrome. A total of 21 patients with CRPS and 15 healthy controls were enrolled. The mean age of patients was 22 +/- 4.9 years and the mean duration of the disease was 5.9 +/- 2.5 months. Flow-mediated vasodilatation (FMD)...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-007-0451-1
更新日期:2008-02-01 00:00:00
abstract::As has been shown by a number of working groups, primary fibromyalgia syndrome does not represent a single clinical entity. It is possible to distinguish between a subgroup with high pain sensitivity and no associated psychiatric condition, a second and a third subgroup characterized by depression associated with fibr...
journal_title:Rheumatology international
pub_type: 杂志文章,评审
doi:10.1007/s00296-007-0403-9
更新日期:2007-09-01 00:00:00
abstract::With better understanding of the pathogenesis of AIDS and the advent of anti-retroviral medications, patients with HIV are living longer and the probability that they will suffer musculoskeletal complications are increasing. There is a vast array of musculoskeletal impairments including rheumatologic, infectious, and ...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-005-0043-x
更新日期:2006-05-01 00:00:00
abstract::Here we evaluated whether 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have beneficial effects for collagen-induced arthritis (CIA). DBA/1 mice were immunized with bovine type-II collagen and administered 100 mg/kg of pravastatin interperitoneally. We measured the effects of pravastatin for CIA...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-006-0270-9
更新日期:2007-05-01 00:00:00
abstract::The aim of this study was to investigate the percentage of regulatory T cells and the correlation with clinical activity in Behçet's disease. Forty Behçet's disease (BD) patients, 18 males and 22 females, were included in the study. The patients were diagnosed according to the published BD criteria. Twenty age- and se...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-013-2835-8
更新日期:2013-12-01 00:00:00
abstract::Axial spondyloarthritis (axSpA) is a chronic inflammatory rheumatic disease affecting predominantly sacroiliac joints and axial skeleton. axSpA progression being irregular and hardly predictable, identifying functional decline is particularly important in patient with axSpA to allow delivery of timely and targeted int...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-019-04396-4
更新日期:2019-10-01 00:00:00
abstract::Serum deoxyribonuclease I (DNase I) activity in systemic lupus erythematosus (SLE) patients was shown to be lower than that of healthy laboratory personnel, rheumatoid arthritis, and scleroderma patients (P less than 0.001). The decrease in DNase I activity in SLE sera was not due to the effect of various autoantibodi...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00541153
更新日期:1981-01-01 00:00:00
abstract::Proliferation of pannus tissue cells has been investigated under in vitro conditions after labeling of joint tissues with 3H-thymidine. It was demonstrated that there is only a minimal proliferation of chondrocytes as well as of pannus tissue cells. Slight increased proliferation was observed in granulation tissue poo...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF00270349
更新日期:1986-01-01 00:00:00
abstract::Sixty-six hospitalized patients with systemic lupus erythematosus (SLE) were enrolled into this study. The test for anti-mitochondrial antibodies (AMAs) was performed and biochemical parameters were determined. AMAs were detected in 15 of the 66 patients with SLE. Meanwhile, we compared enzymatic levels in AMA-positiv...
journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-005-0034-y
更新日期:2006-06-01 00:00:00