Comparative aspects of murine proteinase 3.


:The neutrophilic granule protein proteinase 3 (PR3) is the preferred target antigen of anti-neutrophil cytoplasmic antibodies (ANCA) found in the serum of patients with Wegener's granulomatosis, a systemic small-vessel vasculitis. Due to the lack of data concerning the murine homologue of human PR3, we assessed the neutrophil marker polypeptide PR3 in mice by generating a murine-specific PR3 antibody. In contrast to humans, peripheral blood leukocytes are not the main resource of murine PR3. Interestingly, we could show that the mouse bone marrow is the main PR3 source, indicating that it is a large reservoir for functional neutrophils. This pool of neutrophils could be rapidly mobilized after injection of IL-8. The development of the new PR3 antibody provides a new tool for studying the maturation processes of the murine hematopoietic system and will also support the generation of infectious disease or vasculitis mouse models.


Rheumatol Int


Relle M,Thomaidis T,Galle PR,Schwarting A




Has Abstract


2011-08-01 00:00:00












  • Punctal plugs versus artificial tears for treating primary Sjögren's syndrome with keratoconjunctivitis SICCA: a comparative observation of their effects on visual function.

    abstract::To compare the effects of treatment with punctal plugs versus artificial tears on visual function for primary Sjögren's syndrome with dry eye. Forty-two eyes of 42 patients with primary Sjögren's syndrome were enrolled and were allocated randomly into artificial tears (AT) group and punctal plugs (PP) group. Ocular Su...

    journal_title:Rheumatology international

    pub_type: 杂志文章,随机对照试验


    authors: Qiu W,Liu Z,Ao M,Li X,Wang W

    更新日期:2013-10-01 00:00:00

  • Iloprost infusion does not reduce oxidative stress in systemic sclerosis.

    abstract::Systemic sclerosis is a connective tissue disease in which oxidative stress represents an important player among the complex pathogenetic mechanisms of the disease. Iloprost, an analogue of natural prostacyclin, is used in systemic sclerosis for the treatment of severe Raynaud's phenomenon and ischemic ulcers. There i...

    journal_title:Rheumatology international

    pub_type: 临床试验,杂志文章


    authors: Volpe A,Biasi D,Caramaschi P,Bambara LM,Carletto A,Degan M,Minuz P

    更新日期:2008-02-01 00:00:00

  • Schistosoma mansoni infection: an immune complex disease presenting with polyarthritis.

    abstract::Schistosomiasis or bilharzia is a parasitic disease found in tropical countries. Most infections are subclinical but may progress to chronic form characterized most frequently by the presence of liver involvement and portal hypertension. We report a patient that presented chronic polyarthritis with positive rheumatoid...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Lapa AT,Appenzeller S,Bértolo MB

    更新日期:2013-05-01 00:00:00

  • Coexistence of familial Mediterranean fever and psoriasis in a patient with seronegative spondyloarthropathy.

    abstract::Familial Mediterranean fever (FMF) is a self-limited disease characterized by fever and polyserositis attacks. Arthritis caused by synovitis is either in acute monoarthritis or chronic mono-oligoarthritis form, usually affecting the lower extremities. Another potential but rare form of involvement is spondyloarthropat...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Bodur H,Seçkin U,Eser F,Ergül G,Seçkin S

    更新日期:2008-11-01 00:00:00

  • C4 deficiency state in antiphospholipid antibody-related recurrent preeclampsia evolving into systemic lupus erythematosus.

    abstract::The case of an apparent healthy woman who developed recurrent preeclampsia with antiphospholipid antibodies and evolved towards systemic lupus erythematosus during her last pregnancy is presented. The diagnostic dilemma between lupus renal flare and toxemia is discussed. The potential role of immunological alterations...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Queiro R,Weruaga A,Riestra JL

    更新日期:2002-07-01 00:00:00

  • Intracranial manifestations in SAPHO syndrome: the first case report in literature.

    abstract::A 41-year-old woman with SAPHO syndrome presented with numbness of her left arm followed by a generalized seizure. Computed tomography and magnetic resonance imaging of the brain revealed a small ring enhancing lesion in the right parietal lobe with adjacent meningeal thickening and enhancement. Surgical removal and h...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Abul-Kasim K,Nilsson T,Turesson C

    更新日期:2012-06-01 00:00:00

  • Mechanisms of oxyradical production in substance P stimulated rheumatoid synovial cells.

    abstract::We examined the intracellular mechanisms of substance P induced oxyradical production in rheumatoid synovial cells by the luminol-dependent chemiluminescence method. After stimulation with substance P (30 microM), single synovial A (macrophage-like) or B (fibroblast-like) cells released oxyradicals such as superoxide ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Tanabe T,Otani H,Mishima K,Ogawa R,Inagaki C

    更新日期:1996-01-01 00:00:00

  • Prevalence of comorbidities in Mexican mestizo patients with rheumatoid arthritis.

    abstract::Patients with rheumatoid arthritis (RA) have a high risk for comorbid conditions which increase mortality, hospital admissions, costs of care and inability. To evaluate the prevalence of comorbidities in Mexican mestizo patients with RA and determine the associated risk factors. Cross-sectional study in which RA patie...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Galarza-Delgado DA,Azpiri-Lopez JR,Colunga-Pedraza IJ,Cárdenas-de la Garza JA,Vera-Pineda R,Wah-Suárez M,Arvizu-Rivera RI,Martínez-Moreno A,Ramos-Cázares RE,Torres-Quintanilla FJ,Valdovinos-Bañuelos A,Esquivel-Valerio JA,Garza-El

    更新日期:2017-09-01 00:00:00

  • Investigation of the association between Rho/Rho-kinase gene polymorphisms and systemic sclerosis.

    abstract::Systemic sclerosis (SSc) is a disease characterized by inflammation, vascular abnormalities and fibrosis. The role of Rho/Rho-kinase pathway was demonstrated in the pathogenesis of fibrosis, inflammation and vascular abnormalities. This study was aimed to investigate the relation between SSc and Rho/Rho-kinase gene po...

    journal_title:Rheumatology international

    pub_type: 杂志文章,多中心研究


    authors: Pehlivan Y,Yolbas S,Cetin GY,Alibaz-Oner F,Cagatay Y,Yilmaz N,Oztuzcu S,Donmez S,Ozgen M,Koca SS,Pamuk ON,Sayarlıoglu M,Kisacik B,Direskeneli H,Demiryurek AT,Onat AM

    更新日期:2016-03-01 00:00:00

  • Relative importance of the functional abilities comprising Health Assessment Questionnaire Disability Index among rheumatoid arthritis patients.

    abstract::The aim was to evaluate the relative importance of the 20 functions assessed by patients to produce the Health Assessment Questionnaire's Disability Index (HAQ-DI). A systematic sample of 242 rheumatoid arthritis patients was drawn. Altogether 179 subjects returned acceptably filled questionnaire including perceived r...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Tuominen R,Möttönen T,Suominen C,Vahlberg T,Tuominen S

    更新日期:2010-09-01 00:00:00

  • Rheumatoid factor isotype and Ro epitope distribution in primary Sjögren syndrome and rheumatoid arthritis with keratoconjunctivitis sicca.

    abstract::Primary Sjögren syndrome (pS) is associated with autoantibodies such as rheumatoid factor (RF) and anti-nuclear antibodies such as anti-Ro (SS-A) and/or La (SS-B). Recent developments within autoimmune diagnostics allow quantitation of RF subclasses and anti-Ro epitopes. Will this refinement by autoimmune diagnostics ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Meek B,Kelder JC,Claessen AME,van Houte AJ,Ter Borg EJ

    更新日期:2018-08-01 00:00:00

  • Association study of CD154 polymorphisms and serum CD154 level with systemic lupus erythematous in Chinese population.

    abstract::The aim of this study was to investigate the association of three polymorphisms of CD154 with risk of SLE in Chinese population. The study population comprised 770 Chinese individuals, including 350 SLE patients and 420 healthy controls. The gene polymorphism was measured using Snapshot SNP genotyping assays and confi...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Xiang Y,Guo J,Peng YF,Huang HT,Lan Y,Wei YS

    更新日期:2017-08-01 00:00:00

  • Is psychological distress intrinsic to fibromyalgia syndrome? Cross-sectional analysis in two clinical presentations.

    abstract::Clinical presentation of fibromyalgia syndrome (FMS) is heterogeneous and often involves psychological comorbidities. Clinical subgrouping of FMS patients has been proposed as a strategy to improve patients' long-term outcomes by helping identify specific treatment needs. Using the 90 Symptom Checklist Revised (SCL-90...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Salgueiro M,Aira Z,Buesa I,Bilbao J,Azkue JJ

    更新日期:2012-11-01 00:00:00

  • Coexistence of osteopoikilosis with reactive arthritis: a case report.

    abstract::Osteopoikilosis, a form of osteosclerotic disorders, is a rare bone dysplasia with typical radiologic findings. The pathology, which sometimes requires attention in differential diagnosis due to its radiologic appearance, has been reported previously with other diseases. In this report, a case diagnosed with both reac...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Mesci E

    更新日期:2006-05-01 00:00:00

  • Performance of subjects with knee osteoarthritis during walking: differential parameters.

    abstract::The effect of knee OA on kinetic and kinematic parameters during walking and standing is still controversial. Stability and energy consumption have not been well investigated in patients with OA. This research investigated the parameters distinguishing between the healthy subjects and patients with OA performance. It ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Esrafilian A,Karimi MT,Amiri P,Fatoye F

    更新日期:2013-07-01 00:00:00

  • HLA-B27 spondyloarthritis and spotted fever rickettsiosis: case-based review.

    abstract::Rickettsia rickettsii, a tick borne disease, is the pathogen responsible for inducing Rocky Mountain Spotted Fever (RMSF), an illness that can progress to fulminant multiorgan failure and death. We present a case where R. rickettsii, acquired on a camping trip, precipitated a flare of peripheral arthritis and episcler...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审


    authors: Redford AH,Trost JR,Sibbitt WL Jr,Fangtham M,Emil NS,Singh S,Bankhurst AD

    更新日期:2019-09-01 00:00:00

  • Anxiety and depression in reproductive age women with rheumatic diseases.

    abstract::Women in reproductive age with rheumatic diseases (RD) are especially vulnerable for depression and anxiety which negatively impacts the pregnancy, birth, and RD. The purpose of this study is to describe the frequency of anxiety and depression symptoms employing the Hospital Anxiety and Depression Scale (HADS) in wome...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Skinner-Taylor CM,Perez-Barbosa L,Corral-Trujillo ME,Perez-Onofre I,Barriga-Maldonado ES,Cardenas-de la Garza JA,Riega-Torres J,Galarza-Delgado DA

    更新日期:2020-09-01 00:00:00

  • Platelets in the synovial fluid of patients with rheumatoid arthritis.

    abstract::In a study of synovial fluid from 110 patients with various forms of arthritis, platelets were identified in the synovial fluid of all the 50 rheumatoids, in 18 out of the 25 (72%) with osteoarthritis and in all 35 of those with other forms of inflammatory osteoarthrosis. Identification of platelets by light microscop...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Farr M,Wainwright A,Salmon M,Hollywell CA,Bacon PA

    更新日期:1984-01-01 00:00:00

  • Etodolac: efficacy in osteoarthritis and effects on chondrocyte function.

    abstract::Some nonsteroidal anti-inflammatory drugs (NSAIDs) used in the treatment of osteoarthritis (OA) may damage articular cartilage. This damage may be caused by suppression of proteoglycan synthesis or by altered collagen synthesis in the presence of prostaglandin E2 (PGE2) induced by interleukin-1 (IL-1). The clinical an...

    journal_title:Rheumatology international

    pub_type: 临床试验,杂志文章,评审


    authors: Bacon PA

    更新日期:1990-01-01 00:00:00

  • A comparative evaluation of health related quality of life and depression in patients with fibromyalgia syndrome and rheumatoid arthritis.

    abstract::The aim of this study was to compare health related quality of life (HRQoL) and assess functional and psychological status in rheumatoid arthritis (RA), fibromyalgia syndrome (FS) patients and controls (each 30 subjects). Demographic characteristics, pain and sleep disturbance by Visual Analog Scale, depression by Bec...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Tander B,Cengiz K,Alayli G,Ilhanli I,Canbaz S,Canturk F

    更新日期:2008-07-01 00:00:00

  • Acute pseudogout of the neck--the crowned dens syndrome: 2 case reports and review of the literature.

    abstract::Acute pseudogout of the neck, also known as the crowned dens syndrome, is a rare cause of neck pain characterised by crystalline deposition in periodontoid articular tissues. It is typified clinically by severe cervical pain and stiffness, often in conjunction with pyrexia and raised inflammatory markers. As such, it ...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审


    authors: Siau K,Lee M,Laversuch CJ

    更新日期:2011-01-01 00:00:00

  • The epidemiology of Takayasu arteritis: a hospital-based study from northwestern part of Turkey.

    abstract::Takayasu arteritis (TA) is a chronic, inflammatory large vessel vasculitis that affects aorta and its main branches. We aimed to evaluate the incidence and prevalence of TA in the northwestern part of Turkey. We retrospectively evaluated 23 TA patients followed by our clinic. Clinical features, treatments and response...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审


    authors: Saritas F,Donmez S,Direskeneli H,Pamuk ON

    更新日期:2016-07-01 00:00:00

  • Carbamylated vimentin represents a relevant autoantigen in Latin American (Cuban) rheumatoid arthritis patients.

    abstract::Smoking produces substances that activate proinflammatory, prothrombotic and vasoconstrictive mediators via posttranslational carbamylation of proteins. As a new consequence of carbamylation, induction of anti-carbamylated autoantibodies were observed in rheumatoid arthritis (RA) patients, sometimes prior to onset of ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Martínez G,Gómez JA,Bang H,Martínez-Gamboa L,Roggenbuck D,Burmester GR,Torres B,Prada D,Feist E

    更新日期:2016-06-01 00:00:00

  • Backpack-related musculoskeletal symptoms among Nigerian secondary school students.

    abstract::Musculoskeletal discomfort in schoolchildren is significantly related to the weight and mode of carrying backpack to school. Prevalence and patterns of musculoskeletal discomfort among Nigerian secondary school students carrying backpack was investigated. Systematic sampling technique was used in the selection of the ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Hamzat TK,Abdulkareem TA,Akinyinka OO,Fatoye FA

    更新日期:2014-09-01 00:00:00

  • Neuropathic arthropathy progressing with multiple joint involvement in the upper extremity due to syringomyelia and type I Arnold-Chiari malformation.

    abstract::Neuropathic arthropathy (NA), known as Charcot neuroarthropathy, is a chronic, degenerative arthropathy and is associated with decreased sensory innervation. Numerous causes of this arthropathy have been described. Neuropathic joint, although first described by Charcot in tabes dorsalis in 1868, has subsequently been ...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Nacir B,Arslan Cebeci S,Cetinkaya E,Karagoz A,Erdem HR

    更新日期:2010-05-01 00:00:00

  • Cutaneous leukocytoclastic vasculitis with cervical tuberculous lymphadenitis: a case report and literature review.

    abstract::Cutaneous leukocytoclastic vasculitis (CLV) is a small-vessel vasculitis localized to the skin. Many possible causes exist for this pathological condition, including drugs, infection, collagen vascular disease, and malignancy. However, Mycobacterium tuberculosis is rarely reported to be associated with CLV. Here, we r...

    journal_title:Rheumatology international

    pub_type: 杂志文章,评审


    authors: Kim HM,Park YB,Maeng HY,Lee SK

    更新日期:2006-10-01 00:00:00

  • Mitochondrial DNA haplogroups modulate the radiographic progression of Spanish patients with osteoarthritis.

    abstract::Not all patients with osteoarthritis (OA) show the same disease progression, as some of them remain relatively stable over time, while others progress to severe structural deterioration of the joint. In this sense, the main goal of both genetic and protein biomarkers in OA is to predict not only the risk of OA at an e...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Soto-Hermida A,Fernández-Moreno M,Pértega-Díaz S,Oreiro N,Fernández-López C,Blanco FJ,Rego-Pérez I

    更新日期:2015-02-01 00:00:00

  • Anterior uveitis in patients with spondyloarthropathies in a single US academic center: a retrospective study.

    abstract::Uveitis may represent an opportunity to diagnose spondyloarthropathies (SpA) earlier and influence treatment decisions. We describe the percentage of acute anterior uveitis (AAU) in a diverse group of SpA patients seen at one academic setting and compare demographic and clinical characteristics according to the presen...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Gevorgyan O,Riad M,Sarran RD,Merrill PT,Block JA,Castrejon I

    更新日期:2019-09-01 00:00:00

  • Efficacy of EMLA cream phonophoresis comparison with ultrasound therapy on myofascial pain syndrome of the trapezius: a single-blind, randomized clinical study.

    abstract::The aim of this study is to investigate whether eutectic mixture of local anesthetics (EMLA) cream phonophoresis superior to conventional US over the trigger points (TPs) in terms of improvements of pain, range of motion and disability in myofascial pain syndrome (MPS). Fifty patients (42 female, 8 male) diagnosed wit...

    journal_title:Rheumatology international

    pub_type: 杂志文章,随机对照试验


    authors: Ustun N,Arslan F,Mansuroglu A,Inanoglu D,Yagız AE,Guler H,Turhanoglu AD

    更新日期:2014-04-01 00:00:00

  • Abdominal aortic aneurysm causing lumbar vertebral erosion in Behçet's disease presenting by low back pain.

    abstract::Behçet's disease (BD) is a chronic multi-system disorder commonly seen in Mediterranean, middle east and far eastern populations. In this report, we describe a case of a 55-year-old male with Behçet's disease who presented with a low back pain and sciatica. Imaging studies showed that he had a destruction of the third...

    journal_title:Rheumatology international

    pub_type: 杂志文章


    authors: Örücü M,Keleş D,Peker E,Çakıcı M,Shimbori N,Erden İ,Yazıcıoğlu L,Sonel Tur B

    更新日期:2015-02-01 00:00:00