当前位置： SCI文献检索 > RHEUMATOLOGY INTERNATIONAL期刊下所有文献 > Ex vivo apoptosis, CD95 and CD28 expression in T cells of children with juvenile idiopathic arthritis.

Ex vivo apoptosis, CD95 and CD28 expression in T cells of children with juvenile idiopathic arthritis.

Abstract：

:We hypothesise that T-cell apoptosis and the percentage of T cells expressing molecules involved in apoptosis modulation (CD95, CD28) are altered at the inflammation site and in peripheral blood (PB) of children with juvenile idiopathic arthritis (JIA). Paired JIA samples of synovial fluid (SF) and PB ( n=7) and PB samples from age-matched normal children ( n=23) were analysed immediately ex vivo. Apoptosis was measured by detection of phophatidylserine (PS) externalisation on T cells. CD95 or CD28 was detected by FACS, and soluble CD95 and CD95 ligand levels were detected by enzyme-linked immunosorbent assay (ELISA). In SF, the mean percentage of apoptotic T cells was somewhat higher than in PB. However, the percentages of T cells expressing CD95 and soluble CD95 levels were markedly higher in SF (CD4 cells 96+/-2%, CD8 91+/-6%, soluble CD95 6,420+/-2,571 pg/ml) than in PB (CD4 32+/-10%, CD8 36+/-9%, soluble CD95 4,296+/-2,142 pg/ml). Peripheral blood T-cell apoptosis in JIA (CD4 20+/-8%, CD8 42+/-19%) was higher than in the control group (CD4 5+/-2%, CD8 9+/-6%). Interestingly, the percentage of PB CD4 cells expressing CD28 was lower in JIA than controls. In conclusion, systemic T-cell apoptosis was higher in JIA while a substantial number of SF T cells survived locally, despite the fact that almost all cells express CD95.

journal_name

Rheumatol Int

journal_title

Rheumatology international

authors

Knipp S,Feyen O,Ndagijimana J,Niehues T

doi

10.1007/s00296-002-0263-2

subject

Has Abstract

pub_date

2003-05-01 00:00:00

pages

112-5

issue

3

eissn

0172-8172

issn

1437-160X

journal_volume

23

pub_type

杂志文章

相关文献

RHEUMATOLOGY INTERNATIONAL文献大全
  • Excessive fibrosis of supraclavicular lymph-node granulomas in a patient with progressive systemic sclerosis.

    abstract：:The case of a 29-year-old white female with a 7-year history of typical scleroderma is presented who developed excessive fibrosis of the supraclavicular lymph nodes. After 3 years of disease, firm right supraclavicular lymphadenopathy appeared, accompanied by a high fever. Biopsy revealed non-caseating granulomas and ...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/BF00301013

    authors： Andonopoulos AP,Tzanakakis G

    更新日期：1993-01-01 00:00:00

  • Diagnosis of Raynaud's phenomenon by 99mTc-pertechnetate hand perfusion scintigraphy: a pilot study.

    abstract：:We assess the usefulness of 99mTc-pertechnetate hand perfusion scintigraphy in patients with Raynaud's phenomenon (RP). The study population consisted of 18 patients with primary RP, 25 patients with secondary RP within systemic sclerosis (SSc), and ten healthy individuals. Gamma camera dynamic first-pass study during...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-016-3584-2

    authors： Pavlov-Dolijanovic S,Petrovic N,Vujasinovic Stupar N,Damjanov N,Radunovic G,Babic D,Sobic-Saranovic D,Artiko V

    更新日期：2016-12-01 00:00:00

  • Diabetic muscular infarct: an unusual cause of extremity pain and dysfunction.

    abstract：:Diabetic muscular infarct (DMI) is a rare condition, which begins with acute onset of extremity pain and swelling. Patients usually have long-standing disease and poorly controlled diabetes mellitus (DM). Thigh muscle group is the most commonly involved side, while lower leg involvement is rare. We represent herein a ...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-010-1759-9

    authors： Uçan H,Alemdaroğlu E,Yoldaş TK,Erdem Özdamar S,Akyüz M,Hatipoğlu C

    更新日期：2012-02-01 00:00:00

  • Elevated levels of nitrate in rheumatoid arthritis.

    abstract：:Nitric oxide (NO) is a free radical that plays important roles in many physiological and pathological processes. Evidence suggests that NO participates in the pathogenesis of inflammatory reactions in many autoimmune and inflammatory diseases such as rheumatoid arthritis (RA). The purpose of this study was to evaluate...

    journal_title：Rheumatology international

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s002960100105

    authors： Onur O,Akinci AS,Akbiyik F,Unsal I

    更新日期：2001-05-01 00:00:00

  • The use of 'alternative treatments' by patients with rheumatoid arthritis.

    abstract：:In a study of 199 patients with rheumatoid arthritis, 68% were found to have tried 'alternative treatments'. Some treatments (acupuncture and faith healing) gave subjective benefit in nearly half those who tried them and were considered to be better than others (such as copper bracelets). No adverse reactions were rep...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/BF00541593

    authors： Struthers GR,Scott DL,Scott DG

    更新日期：1983-01-01 00:00:00

  • Anti-annexin II antibody is associated with thrombosis and/or pregnancy morbidity in antiphospholipid syndrome and systemic lupus erythematosus with thrombosis.

    abstract：:This study investigated the prevalence of antibody against annexin II (A2) in patients with antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). It also explored the role of this antibody in thrombosis. Purified recombinant A2 was used in ELISA to measure the levels of IgG anti-A2 antibody in 101 AP...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-010-1379-4

    authors： Ao W,Zheng H,Chen XW,Shen Y,Yang CD

    更新日期：2011-07-01 00:00:00

  • Brucellosis as a rare cause of olecranon bursitis: case-based review.

    abstract：:A 51-year-old man shepherd presented with mild pain and swelling of the right posterior aspect of his right elbow. In ultrasonography, the affected bursal space had swelling and effusion. Moreover, the aspiration of the affected bursa revealed an inflammatory profile. Brucella melitensis was detected in aspirated flui...

    journal_title：Rheumatology international

    pub_type： 杂志文章,评审

    doi：10.1007/s00296-019-04414-5

    authors： Esmaeilnejad-Ganji SM,Roushan MRH,Ebrahimpour S,Babazadeh A

    更新日期：2019-12-01 00:00:00

  • Endemic fluorosis in Turkish patients: relationship with knee osteoarthritis.

    abstract：:Fluoride excess primarily effects dental and skeletal tissues. leading to a condition known as endemic fluorosis. The radiological and clinical features of endemic fluorosis vary in different parts of the world. The aim of this study was to investigate the clinical and radiological features of endemic fluorosis in Tur...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s002960100132

    authors： Savas S,Cetin M,Akdoğan M,Heybeli N

    更新日期：2001-09-01 00:00:00

  • Chitotriosidase as a marker of disease activity in sarcoidosis.

    abstract：:Sarcoidosis is a chronic granulomatous inflammation. The clinical spectrum in childhood is heterogeneous. Angiotensin converting enzyme activity is used as a marker for disease activity. Human chitotriosidase is produced in macrophages. In this study, serum chitotriosidase levels were significantly higher in active sa...

    journal_title：Rheumatology international

    pub_type： 信件

    doi：10.1007/s00296-007-0318-5

    authors： Brunner J,Scholl-Bürgi S,Prelog M,Zimmerhackl LB

    更新日期：2007-10-01 00:00:00

  • Early arthritis clinic is effective for rheumatoid and psoriatic arthritides.

    abstract：INTRODUCTION:Early arthritis clinics (EACs) have been well established since 1980s. Most of the data for their effectiveness comes from rheumatoid arthritis (RA) management and is largely limited to process outcomes. There is little evidence that such clinics improve clinical outcomes particularly for psoriatic arthrit...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-019-04253-4

    authors： Nisar MK

    更新日期：2019-04-01 00:00:00

  • Color Doppler imaging of ocular hemodynamic changes in patients with rheumatoid arthritis unrelated to disease activity.

    abstract：:We aimed to investigate how orbital blood flow rates in patients with rheumatoid arthritis (RA) are affected by the active and remission phase of the disease. This prospective study included a total of 56 patients with RA (study group) and 24 control individuals (control group). All RA patients were divided into two g...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-019-04275-y

    authors： Unal O,Can ME,Ozcan A,Ozcan ME,Erten S,Cagil N

    更新日期：2019-06-01 00:00:00

  • Pristane-induced arthritis in Balb/c mice. I. Clinical and histological features of the arthropathy.

    abstract：:Intraperitoneal injection of pristane induced a clinical peripheral arthritis and/or tenosynovitis in 40% of 40 Balb/cJ/Ola mice. Hind paws were always affected first and fore paws were frequently involved. Involvement of knee joints was only apparent histologically. Some clinically unaffected animals and apparently u...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/BF00541361

    authors： Hopkins SJ,Freemont AJ,Jayson MI

    更新日期：1984-01-01 00:00:00

  • Vasculitis and vasculitis-like manifestations in monogenic autoinflammatory syndromes.

    abstract：:Monogenic autoinflammatory syndromes are a rare group of disorders characterized by periodic episodes of systemic inflammation of endogenous origin. Sometimes, these diseases may present with features akin to vasculitis. We conducted a literature review on such vasculitic manifestations in described monogenic autoinfl...

    journal_title：Rheumatology international

    pub_type： 杂志文章,评审

    doi：10.1007/s00296-017-3839-6

    authors： Jain A,Misra DP,Sharma A,Wakhlu A,Agarwal V,Negi VS

    更新日期：2018-01-01 00:00:00

  • The effect of different treatment time of millimeter wave on chondrocyte apoptosis, caspase-3, caspase-8, and MMP-13 expression in rabbit surgically induced model of knee osteoarthritis.

    abstract：:The aim of this study is to observe the effect of different treatment time of millimeter wave (MMW) on chondrocyte apoptosis, caspase-3, caspase-8, and matrix metalloproteinase-13 (MMP-13) in rabbit knee osteoarthritis induced by anterior cruciate ligament transection (ACLT). Thirty-two New Zealand White rabbits were ...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-011-2080-y

    authors： Xia L,Luo QL,Lin HD,Zhang JL,Guo H,He CQ

    更新日期：2012-09-01 00:00:00

  • Prevalence and risk factors of anxiety and depression in patients with systemic lupus erythematosus in Southwest China.

    abstract：:Systemic lupus erythematosus (SLE) patients have high risk for anxiety and depression. We aimed to investigate the prevalence and risk factors of anxiety and depression in SLE patients in Southwest China. Participants were recruited by convenience sampling from Rheumatic Outpatient Clinic of West China Hospital Sichua...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-016-3559-3

    authors： Xie X,Wu D,Chen H

    更新日期：2016-12-01 00:00:00

  • Topographical analysis of structural lesions between dominant and non-dominant hands in erosive osteoarthritis.

    abstract：KEY MESSAGES:No difference between both hands was observed for clinical and radiographical presentations in EHOA patients. A bilateral and symmetrical relationship was found between hand joints. HIGHLIGHTS:EHOA have symmetrical distribution and specific association in structural lesions. This study aims to analyse the...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-020-04784-1

    authors： Allado E,Wittoek R,Albuisson E,Ferrero S,Chenuel B,Chary-Valckenaere I,Roux C,Loeuille D

    更新日期：2021-01-27 00:00:00

  • Coexistence of osteopoikilosis with reactive arthritis: a case report.

    abstract：:Osteopoikilosis, a form of osteosclerotic disorders, is a rare bone dysplasia with typical radiologic findings. The pathology, which sometimes requires attention in differential diagnosis due to its radiologic appearance, has been reported previously with other diseases. In this report, a case diagnosed with both reac...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-005-0037-8

    authors： Mesci E

    更新日期：2006-05-01 00:00:00

  • Efficacy of EMLA cream phonophoresis comparison with ultrasound therapy on myofascial pain syndrome of the trapezius: a single-blind, randomized clinical study.

    abstract：:The aim of this study is to investigate whether eutectic mixture of local anesthetics (EMLA) cream phonophoresis superior to conventional US over the trigger points (TPs) in terms of improvements of pain, range of motion and disability in myofascial pain syndrome (MPS). Fifty patients (42 female, 8 male) diagnosed wit...

    journal_title：Rheumatology international

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00296-013-2881-2

    authors： Ustun N,Arslan F,Mansuroglu A,Inanoglu D,Yagız AE,Guler H,Turhanoglu AD

    更新日期：2014-04-01 00:00:00

  • Anti-phospholipid antibody syndrome occurrence in patients with persistent anti-phospholipid antibodies.

    abstract：:We investigated the overall frequency of anti-phospholipid syndrome (APS) occurrence in Korean patients with consecutively detected anti-phospholipid antibodies with an interval of 12 weeks (persistent aPLs). We retrospectively reviewed the results of blood tests of aPLs in 14,889 patients in whom aPL tests were perfo...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-019-04318-4

    authors： Choi H,Ahn SS,Song JJ,Park YB,Song J,Lee SW

    更新日期：2019-08-01 00:00:00

  • Plasminogen activator inhibitor-1 as a link between pathological fibrinolysis and arthritis of Behçet's disease.

    abstract：:Behçet's disease (BD) commonly presents with articular manifestations and thrombotic vasculopathy. Arthritis of BD characteristically demonstrates a recurrent and nondestructive course. The pathobiological basis of the thrombotic vasculopathy and protective factors against cartilage destruction in arthritis of BD have...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-003-0324-1

    authors： Oztürk MA,Ertenli I,Kiraz S,C Haznedaroğlu I,Celik I,Kirazli S,Calgüneri M

    更新日期：2004-03-01 00:00:00

  • The comparison of ultrasonographic and scintigraphic findings of early arthritis in revealing rheumatoid arthritis according to criteria of American College of Rheumatology.

    abstract：:We aimed to investigate the diagnostic significance of high frequency ultrasonography (USG), comparing the findings in USG, bone scintigraphy and clinical stuation. Fifty-one patients who had early symptoms of inflammatory arthritis, but not fulfilling the ACR diagnostic criteria for rheumatoid arthritis (RA) were inc...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-008-0765-7

    authors： Ozgul A,Yasar E,Arslan N,Balaban B,Taskaynatan MA,Tezel K,Baklaci K,Ozgüven MA,Kalyon TA

    更新日期：2009-05-01 00:00:00

  • Aplastic anemia complicating systemic lupus erythematosus: successful management with cyclosporine.

    abstract：:Anemia is common with connective tissue disorders, but pancytopenia is rare. We report a 22-year-old female who presented with menorrhagia, seizures, anemia, leukocytosis, thrombocytopenia, pericardial effusion, positive ANA, and evidence of vasculitis on CT head scan and was diagnosed with systemic lupus erythematosu...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-003-0318-z

    authors： Singh NP,Prakash A,Garg D,Makhija A,Pathania A,Prakash N,Kubba S,Agarwal SK

    更新日期：2004-01-01 00:00:00

  • Paleopathological interpretations of hypermobility syndrome in the art from ancient America.

    abstract：:Paleopathological representations of hypermobility syndrome were assumed in pre-Columbian artifacts from different ancient civilizations from America. Anthropomorphic sculptures from several museums and galleries visited on site or thru Internet show the human figure in contorted positions. These positions are only po...

    journal_title：Rheumatology international

    pub_type： 历史文章,杂志文章

    doi：10.1007/s00296-011-2007-7

    authors： Checa A

    更新日期：2012-10-01 00:00:00

  • Serum levels of interleukin 1-beta, tumor necrosis factor-alpha, soluble interleukin 2 receptor and soluble CD8 in seronegative spondylarthropathies.

    abstract：:Seronegative spondylarthropathies are disorders with the same predisposing antigen, namely HLA B27, a class I molecule of the HLA system. The mechanisms of the different diseases are unknown, and there is no proof of immune system participation. We have investigated patients with spondylarthropathies in order to searc...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/BF00390264

    authors： Toussirot E,Lafforgue P,Boucraut J,Despieds P,Schiano A,Bernard D,Acquaviva PC

    更新日期：1994-01-01 00:00:00

  • Longitudinal practice patterns of prophylaxis of glucocorticoid-induced osteoporosis in patients with polymyalgia rheumatica.

    abstract：:The aim of this study was to analyze the longitudinal practice patterns of prophylaxis of glucocorticoid-induced osteoporosis in patients with polymyalgia rheumatica (PMR). Patients diagnosed with PMR were collected retrospectively in two rheumatology departments. In addition to demographic and diagnostic criteria, th...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-014-3014-2

    authors： Naranjo A,López R,García-Magallón B,Cáceres L,Francisco F,Jiménez-Palop M,Ojeda-Bruno S

    更新日期：2014-10-01 00:00:00

  • Anti-DNase I antibodies in systemic lupus erythematosus: diagnostic value and share in the enzyme inhibition.

    abstract：:Diagnostic accuracy of anti-DNase I antibodies measurement in a differentiation between SLE and other autoimmune rheumatic diseases was evaluated. The share of anti-DNase I and actin in the DNase I activity decrease in SLE was established. Serum samples were obtained from 54 patients with verified SLE, 52 control pati...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-016-3437-z

    authors： Trofimenko AS,Gontar IP,Zborovsky AB,Paramonova OV

    更新日期：2016-04-01 00:00:00

  • Resolutive pulmonary endarterectomy in a non-compliant patient with systemic lupus erythematosus and antiphospholipid syndrome.

    abstract：:Patients with chronic thromboembolic pulmonary hypertension (CTEPH) have poor prognosis, and pulmonary endarterectomy (PEA) is considered the treatment of choice for this condition. We report a case and review the literature of successful PEA for CTEPH due to antiphospholipid syndrome associated with systemic lupus er...

    journal_title：Rheumatology international

    pub_type： 杂志文章,评审

    doi：10.1007/s00296-011-2346-4

    authors： Kuzenko A,Sciascia S,Silvestro E,Badiu I,Morsolini M,Rovere ME,Bertero MT

    更新日期：2013-07-01 00:00:00

  • Successful treatment of nephrotic syndrome due to FMF amyloidosis with azathioprine: report of three Turkish cases.

    abstract：:Secondary amyloidosis is a well-known complication of certain familial Mediterranean fever (FMF). We presented three Turkish patients with FMF and biopsy proven amyloidosis. These patients were treated with colchicine 1.5 mg/day. They have experienced five to six peritonitis attacks with fever within 1 year. On admiss...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-006-0188-2

    authors： Sayarlioglu H,Erkoc R,Sayarlioglu M,Dogan E,Soyoral Y

    更新日期：2006-12-01 00:00:00

  • OPG inhibits gene expression of RANK and CAII in mouse osteoclast-like cell.

    abstract：:This study was designed to determine the effects of the osteoprotegerin (OPG) on the mRNA expression of carbonic anhydrase II (CAII) and the receptor activator of NF-κB (RANK) in mouse osteoclast-like cells. Marrow cells were harvested from femora and tibiae of mouse and cultured in 6-well chamber slides. After 1 day ...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-011-2338-4

    authors： Chen J,He JQ,Zhen SY,Huang LQ

    更新日期：2012-12-01 00:00:00

  • Atypical Kawasaki disease with remarkable paucity of signs and symptoms.

    abstract：:We report on a 7-month-old infant with Kawasaki disease (KD) whose only manifestations were high-grade fever of 7 days duration, "non-toxic look" and "extreme irritability", thereby not meeting the criteria for the classical or the atypical form of the disease. The diagnosis was confirmed by the demonstration of a sol...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-009-0899-2

    authors： Thapa R,Chakrabartty S

    更新日期：2009-07-01 00:00:00