Abstract:
:Rheumatoid arthritis (RA) is a multifactorial disease. A combination of genetic and environmental risk factors contributes to its etiology. Several genes have been reported to be associated with susceptibility to the development of RA. The MHC2TA and FCRL3 genes have been associated previously with RA in Swedish and Japanese populations, respectively. In two recent reports, we show an association between FCRL3 and juvenile rheumatoid arthritis (JRA), and MHC2TA and acute coronary syndrome (ACS) in Mexican population. We assessed the association between three single nucleotide polymorphisms (SNPs) of the MHC2TA (-168G/A; rs3087456, and +16G/C; rs4774) and FCRL3 (-169T/C; rs7528684) genes and rheumatoid arthritis in Mexican population through a genotyping method using allelic discrimination assays with TaqMan probes. Our case-control study included 249 patients with RA and 314 controls. We found no evidence of an association between the MHC2TA -168G/A and +1614G/C or FCRL3 -169T/C polymorphisms and RA in this Mexican population. In this cohort of Mexican patients with RA, we observed no association between the MHC2TA or FCRL3 genes and this autoimmune disease.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Mendoza Rincón JF,Rodríguez Elias AK,Fragoso JM,Vargas Alarcón G,Maldonado Murillo K,Rivas Jiménez ML,Barbosa Cobos RE,Jimenez Morales S,Lugo Zamudio G,Tovilla Zárate C,Ramírez Bello Jdoi
10.1007/s00296-015-3358-2subject
Has Abstractpub_date
2016-02-01 00:00:00pages
249-54issue
2eissn
0172-8172issn
1437-160Xpii
10.1007/s00296-015-3358-2journal_volume
36pub_type
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