Abstract:
:The aim of the present study was to evaluate the effects of an exercise training program on lipid profile and composition of high-density lipoprotein (HDL) subfractions in systemic lupus erythematosus (SLE) patients and healthy controls. A 12-week, randomized trial was conducted. Thirty-three physically inactive SLE patients were randomly assigned into two groups: trained (SLE-TR, n = 17) and non-trained (SLE-NT, n = 16). A gender-, BMI-, and age-matched healthy control groups (C-TR, n = 11) also underwent the exercise program. Subjects were assessed at baseline (Pre) and 12 weeks after the 3-month exercise training program (Post) for lipid profile (HDL, low-density lipoprotein, very low-density lipoprotein, and total cholesterol and triglycerides levels) and composition of the HDL subfractions HDL2 and HDL3. SLE patients showed significantly lower contents of Apo A-I, phospholipid, and triglyceride in the HDL3 subfraction (p < 0.05, between-group comparisons) than healthy controls at baseline. The exercise training program did not affect any of the parameters in the SLE-TR group (p > 0.05, within-group comparisons), although there was a trend toward decreased circulating Apo B levels (p = 0.06, ES = -0.3, within-group comparison). In contrast, the same exercise training program was effective in increasing contents of cholesterol, triglyceride, and phospholipid in the HDL2 subfraction in the C-TR group (p = 0.036, ES = 2.06; p = 0.038, ES = 1.77; and p = 0.0021, ES = 2.37, respectively, within-group comparisons), whereas no changes were observed in the composition of the HDL3 subfraction. This study showed that SLE patients have a less effective response to a 12-week exercise training program than healthy individuals, with regard to lipid profile and chemical composition of HDL subfractions. These results reinforce the need for further studies to define the optimal training protocol to improve lipid profile and particularly the HDL composition in these patients (registered at clinicaltrials.gov as NCT01515163).
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Benatti FB,Miossi R,Passareli M,Nakandakare ER,Perandini L,Lima FR,Roschel H,Borba E,Bonfá E,Gualano B,de Sá Pinto ALdoi
10.1007/s00296-014-3081-4subject
Has Abstractpub_date
2015-01-01 00:00:00pages
61-9issue
1eissn
0172-8172issn
1437-160Xjournal_volume
35pub_type
杂志文章,随机对照试验abstract::We measured alpha 2-plasmin inhibitor-plasmin complexes (PI-PC) in plasma of patients with systemic lupus erythematosus (SLE) to examine the plasminogen activation in SLE. The plasma PI-PC level in 23 patients with SLE was significantly higher than that in 18 normal subjects (P less than 0.001) and the SLE patients wi...
journal_title:Rheumatology international
pub_type: 杂志文章
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journal_title:Rheumatology international
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/s00296-005-0085-0
更新日期:2006-03-01 00:00:00
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pub_type: 杂志文章
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journal_title:Rheumatology international
pub_type: 杂志文章
doi:10.1007/BF01419729
更新日期:1996-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2010-11-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章
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pub_type: 评论,信件
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pub_type: 杂志文章
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更新日期:2009-10-01 00:00:00
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journal_title:Rheumatology international
pub_type: 杂志文章
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journal_title:Rheumatology international
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Rheumatology international
pub_type: 临床试验,杂志文章
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pub_type: 临床试验,杂志文章
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journal_title:Rheumatology international
pub_type: 临床试验,杂志文章
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journal_title:Rheumatology international
pub_type: 杂志文章,meta分析
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