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Long-term response after 6-year treatment with anakinra and onset of focal bone erosion in neonatal-onset multisystem inflammatory disease (NOMID/CINCA).

Abstract：

:The exact elucidation of skeletal and cartilagineous involvement in neonatal-onset multisystem inflammatory disease (NOMID) is still poorly known, and there are few data providing the long-term response to treatment with the available interleukin-1 inhibitors. We present here a 13-year-old boy with NOMID treated with anakinra and low-dose methylprednisolone since he was 7 years old for an overall period of 6 years. Every clinical manifestation was highly responsive to interleukin-1 blockade, with the exception of his bone abnormalities. At the comparison of radiography and magnetic resonance imaging of his knees made respectively at 7 and 13 years, we noticed a bone erosion on the posterior surface of the patella combined with the progression of distal femoral overgrowth and endosteal thinning of both meta-epiphyses. This report must encourage clinicians in a precocious institution of interleukin-1 antagonists to thwart the occurrence of irreversible bone changes.

journal_name

Rheumatol Int

journal_title

Rheumatology international

authors

Rigante D,Leone A,Marrocco R,Laino ME,Stabile A

doi

10.1007/s00296-010-1787-5

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

1661-4

issue

12

eissn

0172-8172

issn

1437-160X

journal_volume

31

pub_type

杂志文章

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