Abstract:
:We report a case of sudden onset of late infection after TKA inflamed by anti-TNFalpha therapy, Infliximab, in a 54-year-old woman with RA. Infliximab therapy was started 3 years and 8 months after TKAs as a result of multiple arthritides showing high inflammation of RA. One week after the third administration of Infliximab, the patient suffered sudden knee pain and infectious clinical symptoms, and bacteria (MSSA) were detected by joint effusion culture. She was successfully treated by open debridement with antibiotics-loaded calcium phosphate bone paste and cement and the prostheses were retained. Early diagnosis and operative treatment might be the key to controlling infected TKA without removing the implant. This present case might indicate a serious risk of immunosuppressive effects caused by Infliximab.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Yurube T,Takahi K,Owaki H,Fuji T,Kurosaka M,Doita Mdoi
10.1007/s00296-009-0948-xsubject
Has Abstractpub_date
2010-01-01 00:00:00pages
405-8issue
3eissn
0172-8172issn
1437-160Xjournal_volume
30pub_type
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