Abstract：
:This study was performed to evaluate the effects of the TNF-alpha inhibitor etanercept on oxidation stress markers representing DNA damage, lipid peroxidation, and protein glycosylation. Twenty-two rheumatoid arthritis (RA) patients underwent etanercept treatment. The levels of serum total, urinary total, and urinary free pentosidine, which is an advanced glycation end-product (AGE), of urinary N(epsilon)-hexanoyl lysine (N(epsilon)-HEL), and of 8-hydroxy-deoxy guanosine (8-OHdG) were measured at baseline and at 3 and 6 months after the initial treatment with etanercept. Serum total and urinary total pentosidine levels were reduced at 6 months after the initial treatment with etanercept, and urinary free pentosidine levels were reduced at 3 and 6 months. Urinary N(epsilon)-HEL levels were also reduced at 3 and 6 months, and urinary 8-OHdG levels were reduced at 6 months. Serum total and urinary total pentosidine levels in RA patients correlated with the number of swelling joints and tender joints, and urinary total pentosidine levels correlated with the Disease Activity Score using 28 joints (DAS28). This study demonstrated that etanercept acts as a regulator against pentosidine formation, oxidative DNA damage, and lipid peroxidation in RA patients.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Kageyama Y,Takahashi M,Nagafusa T,Torikai E,Nagano Adoi
10.1007/s00296-007-0419-1subject
Has Abstractpub_date
2008-01-01 00:00:00pages
245-51issue
3eissn
0172-8172issn
1437-160Xjournal_volume
28pub_type
杂志文章abstract：:Knee osteoarthritis is a common disease in the elderly population worldwide. The alleviation of the symptoms associated with this disease can be achieved with physical exercise that induces a cascade of molecular and cellular processes. Of the neurotrophins, brain-derived neurotrophic factor (BDNF) appears to be the m...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-013-2786-0
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journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-013-2771-7
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journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-006-0152-1
更新日期：2006-10-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-001-0159-6
更新日期：2002-01-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1703-z
更新日期：2011-09-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-006-0107-6
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-006-0227-z
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-1844-8
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pub_type： 杂志文章
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0350-5
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pub_type： 杂志文章
doi：10.1007/s00296-002-0194-y
更新日期：2002-06-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-015-3238-9
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-014-3016-0
更新日期：2014-12-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章,meta分析
doi：10.1007/s00296-013-2806-0
更新日期：2013-11-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1672-2
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1418-1
更新日期：2010-07-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-0844-4
更新日期：2009-10-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0685-6
更新日期：2008-10-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-005-0034-y
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0344-3
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541593
更新日期：1983-01-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
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更新日期：2018-06-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-4117-y
更新日期：2018-10-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-020-04635-z
更新日期：2020-10-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
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更新日期：2019-12-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1148-4
更新日期：2010-08-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-4133-y
更新日期：2019-02-01 00:00:00
abstract：:Biological markers of inflammation are useful for the diagnosis and monitoring of inflammatory rheumatic diseases. The present study tested, whether serum amyloid A (SAA) could be used as a marker of inflammatory disease activity in ankylosing spondylitis (AS). In 72 patients with AS, the two valuable surrogate marker...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s002960050114
更新日期：2000-01-01 00:00:00
abstract：:Our study was aimed to clarify an association between gastrointestinal (GI) amyloid-positive area and various kinds of factors including renal function in reactive amyloidosis associated with rheumatoid arthritis (RA). Twenty-five patients with an established diagnosis of reactive AA amyloidosis participated in the st...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1719-4
更新日期：2012-04-01 00:00:00
