当前位置： SCI文献检索 > RHEUMATOLOGY INTERNATIONAL期刊下所有文献 > The in vitro treatment with vitamin D3 is ineffective on the expression of PKC isoenzymes, but decreases further the impaired production of IL-2 in the T lymphocytes of SLE patients.

The in vitro treatment with vitamin D3 is ineffective on the expression of PKC isoenzymes, but decreases further the impaired production of IL-2 in the T lymphocytes of SLE patients.

Abstract：

:The objective of the study was to investigate the possibility whether the in vitro treatment with vitamin D3 can restore the impaired expression of protein kinase C (PKC) isoenzymes and IL-2 production in the lymphocytes of patients with systemic lupus erythematosus (SLE). Purified T lymphocytes from 14 patients with SLE and 13 healthy controls were cultured for 48 h in the presence and absence of 1 and 100 nM doses of vitamin D3. The expressions of various PKC isoenzymes were tested by Western blot analysis, and the amounts of various cytokines were detected by ELISA in the culture supernatants. Neither the low (1 nM) nor the high (100 nM) doses of vitamin D3 (1α,-25-dihydroxyvitamin) applied in vitro for 48 h were able to restore the decreased expression of PKC isoenzymes in the T cells of SLE patients. However, 100 nM of vitamin D3 significantly increased the release of IL-10, but suppressed the production of IL-2, IL-6, interferon γ and TNF α in the culture supernatants of both groups. As the low production of IL-2 is one of the main pathologic features of SLE, we recommend to avoid the use of high doses of vitamin D3 for treatment of lupus patients with vitamin D3 deficiency.

journal_name

Rheumatol Int

journal_title

Rheumatology international

authors

Czifra G,Tóth B,Kovács I,Bíró T,Griger Z,Baráth S,Tarr T,Zeher M,Sipka S

doi

10.1007/s00296-013-2751-y

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

717-20

issue

5

eissn

0172-8172

issn

1437-160X

journal_volume

34

pub_type

杂志文章

相关文献

RHEUMATOLOGY INTERNATIONAL文献大全
  • Expression of the apoptosis accelerator Bax in rheumatoid arthritis synovium.

    abstract：OBJECTIVE:The aim of this study was to analyze the expression of apoptosis-related molecules in rheumatoid arthritis (RA) synovium, with special emphasis on the apoptosis accelerator Bax. METHODS:Immunohistochemical analysis of Bax, Bcl-2, and Bcl-x(L) was performed in tissue specimens of patients with RA and compared...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-002-0255-2

    authors： Hilbers I,Hansen T,Petrow PK,Gaumann A,Bräuer R,Salzmann G,Gay RE,Kosmehl H,Kirkpatrick CJ,Gay S,Kriegsmann J

    更新日期：2003-03-01 00:00:00

  • Etanercept reduces the oxidative stress marker levels in patients with rheumatoid arthritis.

    abstract：:This study was performed to evaluate the effects of the TNF-alpha inhibitor etanercept on oxidation stress markers representing DNA damage, lipid peroxidation, and protein glycosylation. Twenty-two rheumatoid arthritis (RA) patients underwent etanercept treatment. The levels of serum total, urinary total, and urinary ...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-007-0419-1

    authors： Kageyama Y,Takahashi M,Nagafusa T,Torikai E,Nagano A

    更新日期：2008-01-01 00:00:00

  • Aceclofenac in comparison to ketoprofen in the treatment of rheumatoid arthritis.

    abstract：:The efficacy and tolerability of aceclofenac, a new non-steroidal anti-inflammatory drug (NSAID) was compared to that of ketoprofen in a multicentre, double-blind, prospective, randomized study of 3-months duration in patients with rheumatoid arthritis. One hundred and sixty-nine patients, aged between 22 and 70 years...

    journal_title：Rheumatology international

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1007/BF00302127

    authors： Martín-Mola E,Gijón-Baños J,Ansoleaga JJ

    更新日期：1995-01-01 00:00:00

  • Reproductive health counseling and contraceptive use in Mexican women with rheumatic diseases: a cross-sectional study.

    abstract：BACKGROUND:There is an overall increased risk of adverse pregnancy outcomes and maternal morbidity in patients with most autoimmune rheumatic diseases (ARD); outcomes are generally improved when the pregnancy is planned and the disease is in control. OBJECTIVE:The objective of the present study was to describe the sex...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-020-04679-1

    authors： Skinner-Taylor CM,Perez-Barbosa L,Barriga-Maldonado ES,Cardenas-de la Garza JA,Diaz-Angulo JE,Figueroa-Parra G,Riega-Torres J,Galarza-Delgado DA

    更新日期：2021-02-01 00:00:00

  • Adrenocorticotropic hormone: an effective "natural" biologic therapy for acute gout?

    abstract：:Treatment of acute gout consists of non-steroidal anti-inflammatory drugs (NSAIDs), colchicine and steroids. However, the typical patient with gout has multiple comorbidities such as cardiovascular disease, hypertension, renal dysfunction or diabetes/metabolic syndrome that represent contraindications to these therape...

    journal_title：Rheumatology international

    pub_type： 杂志文章,评审

    doi：10.1007/s00296-020-04659-5

    authors： Daoussis D,Bogdanos DP,Dimitroulas T,Sakkas L,Andonopoulos AP

    更新日期：2020-12-01 00:00:00

  • One-year direct costs of biological therapy in rheumatoid arthritis and its predictive factors: data from the Moroccan RBSMR registry.

    abstract：:The aim of the study was to estimate the annual direct costs of biological therapies in rheumatoid arthritis (RA), and to establish possible factors associated with those costs. The main data source was the Moroccan registry of biological therapies in rheumatic diseases (RBSMR Registry). We included patients with avai...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-020-04762-7

    authors： Fellous S,Rkain H,Ahid S,Abouqal R,Tahiri L,Hmamouchi I,Achemlal L,El Bouchti I,El Maghraoui A,Ghozlani I,Hassikou H,Harzy T,Ichchou L,Mkinsi O,Niamane R,Bahiri R,Allali F

    更新日期：2021-01-02 00:00:00

  • Posterior tibial tendon dysfunction and MR imaging in rheumatoid arthritis.

    abstract：:We present the case of a patient with long-standing rheumatoid arthritis and an acute onset of total dysfunction of the posterior tibial tendon. On MRI, a rupture of the tendon was apparent. Intraoperatively, however, massive tenosynovitis with stricture of the tendon was identified as the cause of posterior tibial te...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-002-0183-1

    authors： Hasler P,Hintermann B,Meier M

    更新日期：2002-05-01 00:00:00

  • Sense of coherence and self-sacrificing defense style as predictors of psychological distress and quality of life in rheumatoid arthritis: a 5-year prospective study.

    abstract：:Individual differences in adjustment during a disease's course determine psychological response and outcome. This study aimed to investigate prospectively whether coping with health stressors and self-sacrificing defense style could predict psychological adjustment and health-related quality of life (HRQoL) in patient...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-014-3134-8

    authors： Goulia P,Voulgari PV,Tsifetaki N,Andreoulakis E,Drosos AA,Carvalho AF,Hyphantis T

    更新日期：2015-04-01 00:00:00

  • Hypothermia induced by adenosine 5'-monophosphate attenuates early stage injury in an acute gouty arthritis rat model.

    abstract：:To investigate whether the hypothermia induced by Adenosine 5'-Monophosphate (5'-AMP) could attenuate early stage injury in a rat acute gouty arthritis model. Ankle joint injection with monosodium urate monohydrate crystals (MSU crystals) in hypothermia rat model which was induced by 5'-AMP and then observe whether hy...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-013-2676-5

    authors： Miao Z,Guo W,Lu S,Lv W,Li C,Wang Y,Zhao S,Yan S,Tao Z,Wang Y

    更新日期：2013-08-01 00:00:00

  • A study on the association of autoantibodies, chemokine, and its receptor with disease activity in systemic lupus erythematosus in North Indian population.

    abstract：:Systemic lupus erythematosus (SLE) is a chronic and complex autoimmune disease characterized by the production of autoantibodies against a spectrum of nuclear antigens. RANTES and its receptor CCR5 have been associated with the pathogenesis of SLE. The objective of this study is to analyze autoantibodies (DNA/RNA), al...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-013-2812-2

    authors： Bidyalaxmi Devi L,Bhatnagar A,Wanchu A,Sharma A

    更新日期：2013-11-01 00:00:00

  • ESSDAI activity index of the SJÖGRENSER cohort: analysis and comparison with other European cohorts.

    abstract：:The objective of the study was to assess the ESSDAI index characteristics in the SJÖGRENSER cohort (Spanish Rheumatology Association's registry of patients with Primary Sjögren Syndrome [PSS]). SJÖGRENSER is a prospective multicentric study on a cohort of Spanish patients with PSS who meet the 2002 American-European c...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-019-04285-w

    authors： Rosas J,Sánchez-Piedra C,Fernández-Castro M,Andreu JL,Martínez-Taboada V,Olivé A,SJÖGRENSER Group, part of the Spanish Society of Rheumatology Systemic Autoimmune Diseases Study Group (EASSER).

    更新日期：2019-06-01 00:00:00

  • Cardiovascular risk in patients with rheumatoid arthritis: assessment of several traditional risk parameters and a German risk score model.

    abstract：:The present cross-sectional data demonstrate cardiovascular (CV) risk in patients with rheumatoid arthritis (RA). The cross-sectional data were part of an interventional trial that included 100 patients with defined RA. Traditional CV risk parameters and risk score calculation for the German population were used to as...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-011-2238-7

    authors： Willers J,Hahn A

    更新日期：2012-12-01 00:00:00

  • Incidence of infection other than tuberculosis in patients with autoimmune rheumatic diseases treated with bDMARDs: a real-time clinical experience from India.

    abstract：:Biologic disease-modifying anti-rheumatic drugs (bDMARD) have transformed the treatment paradigm of chronic autoimmune rheumatic diseases (ARDs), but they are often associated with adverse drug reactions. The present study evaluated the frequency, characteristics and type of infections, other than tuberculosis (TB), i...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-019-04245-4

    authors： Chandrashekara S,Shobha V,Rao V,Desai A,Jois R,Dharmanand BG,Kumar S,Kumar P,Dharmapalaiah C,Mahendranath KM,Prasad S,Daware MA,Singh Y,Karjigi U,Nagaraj S,Anupama KR

    更新日期：2019-03-01 00:00:00

  • Paleopathological interpretations of hypermobility syndrome in the art from ancient America.

    abstract：:Paleopathological representations of hypermobility syndrome were assumed in pre-Columbian artifacts from different ancient civilizations from America. Anthropomorphic sculptures from several museums and galleries visited on site or thru Internet show the human figure in contorted positions. These positions are only po...

    journal_title：Rheumatology international

    pub_type： 历史文章,杂志文章

    doi：10.1007/s00296-011-2007-7

    authors： Checa A

    更新日期：2012-10-01 00:00:00

  • Associations of cigarette smoking with disease phenotype and type I interferon expression in primary Sjögren's syndrome.

    abstract：:Several studies have shown a negative association between smoking and primary Sjögren's syndrome (pSS), and smoking may interfere with the immune response. The purpose of this study was to investigate if smoking affects disease activity and disease phenotype in pSS. In this cross-sectional study, consecutive pSS patie...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-019-04335-3

    authors： Olsson P,Bodewes ILA,Nilsson AM,Turesson C,Jacobsson LTH,Theander E,Versnel MA,Mandl T

    更新日期：2019-09-01 00:00:00

  • Demographic and clinical features of gout patients in Turkey: a multicenter study.

    abstract：:Gout results from multifactor interactions between gender, age, genetic and environmental factors. Environmental factors underlying gout and precipitating factors triggering acute attacks might vary in different populations with different lifestyles. In this study, we aimed to collect data regarding the demographic an...

    journal_title：Rheumatology international

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00296-012-2442-0

    authors： Öztürk MA,Kaya A,Şenel S,Dönmez S,Balkarlı A,Çobankara V,Erhan Ç,Sayarlıoğlu M,Ugan Y,Tunç ŞE,Pehlivan Y,Kısacık B,Tufan A,Onat AM,Tezcan E,Yıldırım Çetin G,Pamuk ON

    更新日期：2013-04-01 00:00:00

  • Biomarkers of hand osteoarthritis.

    abstract：:Hand osteoarthritis (OA) is a common degenerative joint disorder leading to substantial pain and disability. The most severe subtype is erosive hand OA characterized by an abrupt onset, local inflammation, subchondral erosions and worse outcomes than non-erosive disease. Biomarkers of hand OA could help to diagnose th...

    journal_title：Rheumatology international

    pub_type： 杂志文章,评审

    doi：10.1007/s00296-017-3864-5

    authors： Lennerová T,Pavelka K,Šenolt L

    更新日期：2018-05-01 00:00:00

  • Mortality in patients with rheumatoid arthritis: a 15-year prospective cohort study.

    abstract：:The aim of this study was to investigate (a) the mortality in a clinical cohort of patients with established rheumatoid arthritis in comparison with the general Dutch population over 15 years, (b) the trend in the mortality ratio during the study period, and (c) causes of death and compare these with the general popul...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-016-3638-5

    authors： van den Hoek J,Boshuizen HC,Roorda LD,Tijhuis GJ,Nurmohamed MT,van den Bos GA,Dekker J

    更新日期：2017-04-01 00:00:00

  • Effectiveness of ultrasound treatment applied with exercise therapy on patients with ankylosing spondylitis: a double-blind, randomized, placebo-controlled trial.

    abstract：:The aim of our study was to evaluate effectiveness of ultrasound treatment applied with exercise therapy in patients with ankylosing spondylitis. Fifty-two patients, who were diagnosed according to modified New York criteria, were aged 25-60, and have spine pain, were randomly assigned to two groups. Ultrasound (US) a...

    journal_title：Rheumatology international

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00296-016-3441-3

    authors： Şilte Karamanlioğlu D,Aktas I,Ozkan FU,Kaysin M,Girgin N

    更新日期：2016-05-01 00:00:00

  • Associations between CCL21 gene polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis.

    abstract：:Rheumatoid arthritis (RA) is a chronic systemic disorder characterized by the development through angiogenesis, which is dependent on endothelial cell activation, migration and proliferation and CCL21 plays an important role in this pathology. Currently, CCL21 gene polymorphism studies on rheumatoid arthritis are scar...

    journal_title：Rheumatology international

    pub_type： 杂志文章,meta分析,评审

    doi：10.1007/s00296-017-3784-4

    authors： Li G,Zhao J,Li B,Ma J,Zhao Q,Wang X,Lv Z,Li K,Du Z,Ma X,Liu J

    更新日期：2017-10-01 00:00:00

  • Resolutive pulmonary endarterectomy in a non-compliant patient with systemic lupus erythematosus and antiphospholipid syndrome.

    abstract：:Patients with chronic thromboembolic pulmonary hypertension (CTEPH) have poor prognosis, and pulmonary endarterectomy (PEA) is considered the treatment of choice for this condition. We report a case and review the literature of successful PEA for CTEPH due to antiphospholipid syndrome associated with systemic lupus er...

    journal_title：Rheumatology international

    pub_type： 杂志文章,评审

    doi：10.1007/s00296-011-2346-4

    authors： Kuzenko A,Sciascia S,Silvestro E,Badiu I,Morsolini M,Rovere ME,Bertero MT

    更新日期：2013-07-01 00:00:00

  • Endothelial cells are the major source of sICAM-1 in rheumatoid synovial tissue.

    abstract：:The objective of this research was to investigate the cellular source of soluble ICAM-1 (siCAM-1) from rheumatoid synovial tissue (RS) and its relation to sICAM-1 in synovial fluid (SF) and serum, and to study the expression of ICAM-1 in isolated cells of RS. sICAM-1 was determined by using the enzyme-linked immunosor...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/pl00006846

    authors： Krenn V,Schedel J,Döring A,Huppertz HI,Gohlke F,Tony HP,Vollmers HP,Müller-Hermelink HK

    更新日期：1997-01-01 00:00:00

  • Sclerosis and hyperostosis of the manubrium sterni.

    abstract：:Seven females and one male with almost identical sclerotic and hyperostotic changes of the manubrium sterni are reported. The clinical course was prolonged and characterized by intermittent periods of exacerbation followed by improvement. Malignancies, bacterial inflammatory processes, and Paget disease, which were fi...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/BF00541284

    authors： Jurik AG,Møller BN,Jensen MK,Jensen JT,Graudal H

    更新日期：1986-01-01 00:00:00

  • Balneotherapy in rheumatic diseases--an overview of novel and known aspects.

    abstract：:Balneotherapeutic applications to treat rheumatic diseases have a long-term tradition and are based on established scientific principles, and the majority of rheumatic diseases most frequently include balneotherapy. However, as other therapeutic strategies, balneological interventions require scientific proof of their...

    journal_title：Rheumatology international

    pub_type： 杂志文章,评审

    doi：10.1007/s00296-005-0019-x

    authors： Lange U,Müller-Ladner U,Schmidt KL

    更新日期：2006-04-01 00:00:00

  • Anterior uveitis in patients with spondyloarthropathies in a single US academic center: a retrospective study.

    abstract：:Uveitis may represent an opportunity to diagnose spondyloarthropathies (SpA) earlier and influence treatment decisions. We describe the percentage of acute anterior uveitis (AAU) in a diverse group of SpA patients seen at one academic setting and compare demographic and clinical characteristics according to the presen...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-019-04386-6

    authors： Gevorgyan O,Riad M,Sarran RD,Merrill PT,Block JA,Castrejon I

    更新日期：2019-09-01 00:00:00

  • Elevated levels of nitrate in rheumatoid arthritis.

    abstract：:Nitric oxide (NO) is a free radical that plays important roles in many physiological and pathological processes. Evidence suggests that NO participates in the pathogenesis of inflammatory reactions in many autoimmune and inflammatory diseases such as rheumatoid arthritis (RA). The purpose of this study was to evaluate...

    journal_title：Rheumatology international

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s002960100105

    authors： Onur O,Akinci AS,Akbiyik F,Unsal I

    更新日期：2001-05-01 00:00:00

  • Osteoarthritis and the impact on quality of life health indicators.

    abstract：:The purpose of this study was to compare quality of life health identifiers in patients with and without osteoarthritis (OA) while controlling for the potentially confounding variables of gender, age, race, education, and income. Data were obtained for comparison from the Behavioral Risk Factor Surveillance System (BR...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-006-0269-2

    authors： Cook C,Pietrobon R,Hegedus E

    更新日期：2007-02-01 00:00:00

  • Seronegative Lyme arthritis.

    abstract：:We present a 10-year-old girl who had been diagnosed with juvenile idiopathic arthritis 5 years before and who experienced a flare of arthritis affecting one knee while she was off medication for almost 3 years. Seronegative Lyme arthritis had to be diagnosed based on the detection of Borrelia burgdorferi DNA in synov...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-007-0333-6

    authors： Holl-Wieden A,Suerbaum S,Girschick HJ

    更新日期：2007-09-01 00:00:00

  • Contralateral electroacupuncture pretreatment suppresses carrageenan-induced inflammatory pain via the opioid-mu receptor.

    abstract：:Acupuncture has been used to treat various clinical diseases in Eastern medicine. To investigate the analgesic effect of electroacupuncture (EA) pretreatment on carrageenan-induced inflammatory pain, we studied on the effect of EA parameters on an animal model of acute arthritic pain. Pretreatment with 1 mA, 10 Hz EA ...

    journal_title：Rheumatology international

    pub_type： 杂志文章

    doi：10.1007/s00296-010-1364-y

    authors： Yang EJ,Koo ST,Kim YS,Lee JE,Hwang HS,Lee MS,Choi SM

    更新日期：2011-06-01 00:00:00

  • Toxic epidermal necrolysis in a child with lupus-associated pancreatitis.

    abstract：:Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening dermatological conditions that are characterized by mucosal erosions, epidermal detachments and erosions. The most common causes of SJS and TEN are drugs; other causes such as systemic lupus erythematosus (SLE), vaccinations and i...

    journal_title：Rheumatology international

    pub_type： 杂志文章,评审

    doi：10.1007/s00296-017-3677-6

    authors： Marija S,Ivana B,Nina R,Dragan N,Zlatko B,Branislav J,Jelena P,Dusica S

    更新日期：2017-07-01 00:00:00