Abstract:
:Recent data suggest that childhood and adulthood stressors may play a significant role in the development of an autoimmune disease. The present study explores the relationship between psoriatic arthritis (PsA) and positive and negative life events during childhood and adulthood in psoriatic patients. Forty-five patients with psoriatic arthritis and 101 controls (patients with skin conditions considered to be "non-psychosomatic") were enrolled in the study. All participants completed a specific questionnaire measuring traumatic life experiences [Traumatic Antecedents Questionnaire (TAQ)]. The TAQ assesses positive personal experiences (competence and safety) and negative personal experiences (neglect, separation, secrets, emotional, physical and sexual abuse, trauma witnessing, other traumas and exposure to alcohol/drugs) from early childhood to adulthood. The patients with psoriatic arthritis exhibited lower mean scores of total positive experiences during late childhood (latency) as compared to the control group. Negative experiences during four developmental periods appeared more frequently in patients with psoriatic arthritis than in the controls. The most frequently reported negative experiences were neglect, emotional abuse, physical abuse, sexual abuse, alcohol/drug abuse and other traumas. The present findings add evidence to the relationship between retrospectively reported childhood experiences and psoriatic arthritis. Furthermore, a high amount of reported emotional and physical abuse occurs in patients with psoriatic arthritis during latency and adolescence.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Simonić E,Peternel S,Stojnić-Soša L,Rončević-Gržeta I,Prpić-Massari L,Massari D,Periša D,Cabrijan L,Kaštelan Mdoi
10.1007/s00296-012-2569-zsubject
Has Abstractpub_date
2013-06-01 00:00:00pages
1587-93issue
6eissn
0172-8172issn
1437-160Xjournal_volume
33pub_type
杂志文章abstract::Methotrexate (MTX) can be toxic to patients suffering from end stage renal disease (ESRD) on hemodialysis even at low doses. This increase in toxicity is more notable in terms of bone marrow suppression in the form of pancytopenia. Many methods of elimination including dialysis itself have been proven ineffective, and...
journal_title:Rheumatology international
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pub_type: 临床试验,杂志文章
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journal_title:Rheumatology international
pub_type: 杂志文章
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journal_title:Rheumatology international
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