Phantom cytomegalovirus infection in vasculitis patients: what it means and what to do.

Abstract:

:We report our experience and hypothesis on the diagnosis and treatment of patients with vasculitis who are simultaneously diagnosed with serum-positive cytomegalovirus (CMV) immunoglobulin (Ig)M antibodies and negative CMV DNA polymerase chain reaction (PCR). It remains unknown how to treat this kind of "phantom" CMV infection. In a patient diagnosed with Henoch-Schönlein vasculitis, CMV IgM titers were increased while angiitis and renal function deteriorated. Empiric treatment of phantom CMV infection with ganciclovir in this CMV IgM-positive and PCR-negative patient resulted in complete vasculitis remission, serum CMV antibody seroconversion, and renal function improvement. These results imply something more than coincidence.

journal_name

Rheumatol Int

authors

Katsanos KH,Kostoula A,Katopodis KP,Siamopoulos KC

doi

10.1007/s00296-004-0522-5

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

631-2

issue

8

eissn

0172-8172

issn

1437-160X

journal_volume

25

pub_type

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