Abstract：
:To compare oxidative stress (OS) biomarkers and antioxidant capacity of plasma (ACP) between dcSSc (diffuse cutaneous systemic sclerosis) and healthy Mexicans and their possible relationship with autoantibodies, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and uric acid (UA). We included 28 dcSSc and 28 healthy individuals. Patients were grouped in early and late dcSSc and were excluded if they had infections, neoplasias, comorbidity, or antioxidant treatment. Lipoperoxidation products (malondialdehyde), protein oxidation products (carbonyls, dityrosines), ACP, CRP, ESR, and UA were investigated. Age was 47.5 ± 10 in dcSSc versus 48 ± 7 years in controls. In dcSSc, OS was higher and ACP was decreased versus controls (p < 0.001). OS was similar in early and late dcSSc. Anti-Scl-70 (anti-topoisomerase I) was associated with a higher OS (p < 0.05). Eight dcSSc patients had hyperuricemia (28.5 %). A significant correlation between UA and malondialdehyde, dityrosines and carbonyls levels (r = 0.52, r = 0.78 and r = 0.69, p < 0.01) respectively, was found in dcSSc group. A high level of ESR was present in 71 % and CRP in 40 % of dcSSc patients. Mexican dcSSc patients had elevated lipid/protein OS with respect to healthy controls. These OS biomarkers have direct correlation with UA levels. ESR and CRP were elevated in a great number of dcSSc patients. These biochemical markers suggest that dcSSc patients have a continuous stimulus for endothelial dysfunction and accelerated atherogenesis.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Cruz-Domínguez MP,Montes-Cortes DH,Olivares-Corichi IM,Vera-Lastra O,Medina G,Jara LJdoi
10.1007/s00296-013-2701-8subject
Has Abstractpub_date
2013-09-01 00:00:00pages
2261-7issue
9eissn
0172-8172issn
1437-160Xjournal_volume
33pub_type
杂志文章abstract：:Takayasu's arteritis (TA) is a rare chronic vasculitis of the aorta and its main branches. Infectious agents or autoimmunity are thought to influence the pathophysiology. Ethnic preponderance in East Asia and usually affects young Asian women suggesting a possible role of genetic factor in the etiology. We present a r...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1234-7
更新日期：2011-06-01 00:00:00
abstract：:Splenectomy may be necessary to treat systemic lupus erythematosus (SLE) patients with thrombocytopenia; however, whether performing a splenectomy on patients without SLE increases the subsequent risk of SLE remains unknown. Therefore, this study was conducted to determine the association between splenectomy and SLE. ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-015-3388-9
更新日期：2016-02-01 00:00:00
abstract：:Spondyloarthropathy refers to any joint disease of the vertebral column, but the term is mainly used for a specific group of disorders called seronegative spondyloarthropathies (SpAs). The axial skeletal involvement, peripheral and extra-articular manifestations and an association with the major histocompatibility com...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-019-04346-0
更新日期：2019-09-01 00:00:00
abstract：:The objective of this study was to search for proteomic patterns distinguishing patients with rheumatoid arthritis (RA) from healthy controls, biomarker candidates specific for early RA, and proteins reflecting disease activity, by profiling of serum proteins using magnetic bead-based (MB) separation and matrix-assist...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1407-4
更新日期：2011-08-01 00:00:00
abstract：:Radiation synovectomy (RS) is one of many therapeutic options used for recurrent joint synovitis. Our aim was to analyze the effect of the surgical synovectomy combined with yttrium 90 ((90)Y) in the treatment for recurrent joint synovitis. A surgical combined RS procedure was used on 32 knees of 30 patients. They wer...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2540-z
更新日期：2013-05-01 00:00:00
abstract：:Involvement of tendons and/or connective tissue structures in the aetiology of idiopathic carpal tunnel syndrome (CTS) has been proposed. DNA sequence variants within genes encoding structural components of the collagen fibril, the basic structural unit of connective tissue, have been shown to associate with modulatin...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-015-3385-z
更新日期：2016-03-01 00:00:00
abstract：:Rheumatoid arthritis (RA) is a multifactorial disease. A combination of genetic and environmental risk factors contributes to its etiology. Several genes have been reported to be associated with susceptibility to the development of RA. The MHC2TA and FCRL3 genes have been associated previously with RA in Swedish and J...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-015-3358-2
更新日期：2016-02-01 00:00:00
abstract：:Pancreatitis is a relatively rare but severe manifestation in systemic lupus erythematosus (SLE) patients. We report a case of a 39-year-old woman with previous SLE diagnose treated with prednisone and mycophenolate mofetil who developed an acute pancreatitis complicated by pancreatic pseudocysts within the context of...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-0964-x
更新日期：2010-03-01 00:00:00
abstract：:Adult-onset Still's disease (AOSD) is a rare disease, and large epidemiological studies of this disease are limited. Furthermore, it has been difficult to show the incidence and characteristics of severe AOSD complications due to the rarity of this disease. The aim of our study was to describe the demographics of AOSD...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3546-8
更新日期：2016-10-01 00:00:00
abstract：:This review explores the prevalence and factors associated with disturbed sleep for patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis in order to clarify consistent findings in this otherwise disparate research field. The association of physical, demographic and psychological factors co...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-016-3589-x
更新日期：2017-02-01 00:00:00
abstract：:Dermatomyositis (DM) is a rare inflammatory disorder affecting the muscle and skin. DM patients can present with spontaneous muscle hemorrhage, a potentially fatal complication. The best practice for management of hemorrhagic myositis in these patients remains unclear. Here we discuss the case of a patient who present...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-019-04501-7
更新日期：2020-02-01 00:00:00
abstract：:E-selectin and intercellular adhesion molecule (ICAM)-1 are crucial to the inflammatory response in chronic inflammatory arthritis. Soluble (s) levels of these molecules in sera and synovial fluid (SF) correlate with some clinical parameters and synovial tissue expression of the same molecules in rheumatoid arthritis....
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-002-0212-0
更新日期：2002-09-01 00:00:00
abstract：:The clinical use of pulsed electromagnetic fields (PEMF) in osteoarticular pathology is widely extended, although the mechanisms involved are unknown. The aim of this study was to evaluate the action of a new protocol of treatment with PEMF on liquid medium cultures of fibroblast-like cells derivates of mononuclear pe...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1488-0
更新日期：2011-10-01 00:00:00
abstract：:The Juvenile Arthritis Multidimensional Assessment Report (JAMAR) is a new parent/patient-reported outcome measure that enables a thorough assessment of the disease status in children with juvenile idiopathic arthritis (JIA). We report the results of the cross-cultural adaptation and validation of the parent and patie...
journal_title：Rheumatology international
pub_type： 杂志文章,多中心研究
doi：10.1007/s00296-018-3977-5
更新日期：2018-04-01 00:00:00
abstract：:Currently, many studies have focused on the possibility of using mean platelet volume (MPV) as a biomarker for disease activity in patients with systemic lupus erythematosus (SLE). To derive a more accurate estimation, a meta-analysis was conducted. Embase, PubMed, The Cochrane Library database and several Chinese dat...
journal_title：Rheumatology international
pub_type： 杂志文章,meta分析
doi：10.1007/s00296-018-4065-6
更新日期：2018-09-01 00:00:00
abstract：:The objective of the study was to determine the clinical features and treatment course in Canadian patients with dermatomyositis (DM) associated with the anti-melanoma differentiation-associated gene 5 antibody (MDA5). A retrospective chart review of consecutive patients with anti-MDA5 antibody DM from two Canadian te...
journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-019-04398-2
更新日期：2019-11-01 00:00:00
abstract：:A 42-year-old woman presented with a 3-week history of left knee pain and swelling. She had suffered dermatitis herpetiformis for 12 years, proved by skin biopsy. She had never been on gluten-free diet. Knee pain increased with motion and her gait was antalgic. On admission, she was mainly dependent on wheelchair due ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1670-4
更新日期：2011-05-01 00:00:00
abstract：:Dissemination of research studies is important for research ideas to be transformed from initial abstracts to full publications. Analyses of the scientific impact and publication record of the Canadian Rheumatology Association (CRA) Annual meeting have not been previously described. This study determines the publicati...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-017-3701-x
更新日期：2017-06-01 00:00:00
abstract：:We have examined the way in which products of cultured human blood mononuclear cells activate human articular chondrocytes. Conditioned medium from mononuclear cells enhanced the production of prostaglandin E by cultured human chondrocytes and also stimulated fibrinolytic activity in these cultures. These two effects ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00541204
更新日期：1984-01-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to evaluate the efficacy and tolerability of long-term treatment with cyclosporin A (CsA) in patients with psoriatic arthritis (PsA). METHODS:Sixty patients with PsA were enrolled in a prospective, nonrandomised study of CsA. Patients with hypertension or hypercreatinemia were exclu...
journal_title：Rheumatology international
pub_type： 临床试验,杂志文章
doi：10.1007/s00296-001-0166-7
更新日期：2002-04-01 00:00:00
abstract：:We studied the relationships between physician-assessed damage, severity and activity in a large, multicentre systemic sclerosis (SSc, scleroderma) cohort. We hypothesized that there is a relationship between disease activity and severity and damage, but that severity would be more strongly related to damage. A total ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-1129-7
更新日期：2010-07-01 00:00:00
abstract：:Cyclooxygenase-2 (COX-2) is a key regulatory enzyme in the synthesis of prostanoids associated with trauma and inflammation. Upregulation of COX-2 in human lupus T cells resists anergy and apotosis. We investigated the COX-2 gene for functional variants that may influence susceptibility, clinical outcomes and severity...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-006-0162-z
更新日期：2006-11-01 00:00:00
abstract：:This study was performed to identify the role of cholinergic stimulation on changes of intracellular calcium concentrations as intracellular messenger of neuroimmune interaction. Incubation of PBMC with acetylcholine (ACh) leads to Ca(2+) oscillations in healthy controls. PBMC from rheumatoid arthritis (RA) patients e...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0723-4
更新日期：2009-03-01 00:00:00
abstract：OBJECTIVE:The prevalence of dermatophytic infections in rheumatoid arthritis is unknown. This study investigated the prevalence of dermatophytosis in patients with rheumatoid arthritis and the relationship between sulfasalazine, low-dose methotrexate and steroid therapy. METHODS:We examined 53 consecutive patients wit...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-002-0238-3
更新日期：2003-01-01 00:00:00
abstract：:Sarcoidosis is a chronic, multisystemic, non-caseating granulomatous disease of unknown etiology. Nasopharyngeal involvement is very rare in sarcoidosis. The objective of this report was to evaluate a rare involvement of sarcoidosis. This report includes a case of nasopharyngeal sarcoidosis. A 51-year-old female with ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-1866-2
更新日期：2012-05-01 00:00:00
abstract：:A 44-year-old man with intermittent asymmetric migratory oligoarthritis lasting the recent decade was admitted to our hospital. Considerable specific biomarkers for rheumatoid arthritis such as anti-agalactosyl IgG antibody are all negative. He was diagnosed as palindromic rheumatism (PR). Although hand X-rays showed ...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0654-0
更新日期：2008-11-01 00:00:00
abstract：:Acute leukemia is uncommonly seen with rheumatoid arthritis during or following treatment with low-dose methotrexate, a safe and effective treatment for the arthritic condition. We describe here a 68-year-old woman with rheumatoid arthritis who developed acute erythroleukemia during low-dose methotrexate therapy (tota...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-004-0502-9
更新日期：2005-05-01 00:00:00
abstract：:Abnormal manifestations of central nervous system in system lupus erythematosus (SLE) patients are mainly caused by primary neuropsychiatric SLE (NP-SLE). We reported a new onset SLE patient who had secondary neuropsychiatric manifestations caused by Epstein-Barr virus (EBV) encephalitis. Although EBV has an uncertain...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-1877-z
更新日期：2012-08-01 00:00:00
abstract：:Kawasaki disease is an acute self-limited systemic vasculitis common in childhood. Intravenous immunoglobulin (IVIG) is an effective treatment, and it reduces the incidence of cardiac complications. Egami score has been validated to identify IVIG non-responder patients in Japanese population, and it has shown high sen...
journal_title：Rheumatology international
pub_type： 杂志文章,多中心研究
doi：10.1007/s00296-016-3499-y
更新日期：2016-07-01 00:00:00
abstract：:Fatigue has a large impact on quality of life and is still unmanageable for many patients. Study aims were describe (1) the prevalence and pattern of fatigue over time in patients with early rheumatoid arthritis under a treat-to-target strategy and (2) identify predictive factors for worsening and recovering of fatigu...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-4102-5
更新日期：2018-09-01 00:00:00
