Abstract：
:Recent studies indicate that high-mobility group box protein 1 (HMGB1) contributes to the pathogenesis of diverse autoimmune disorders. It induces the production of interferon-alpha (IFN-alpha) and tumor necrosis factor alpha (TNF-alpha) in vitro. In the present study, plasma HMGB1, TNF-alpha, and IFN-alpha were determined with ELISA in 37 patients with systemic lupus erythematosus (SLE) and 39 age- and sex-matched healthy controls (HC). The possible associations of these cytokines with disease activities, autoantibodies, and certain laboratory parameters were also explored. The plasma levels of HMGB1, TNF-alpha, and IFN-alpha were increased in SLE patients compared with those of HC (P < 0.05). Moreover, the levels of HMGB1 and TNF-alpha in the active SLE patients were elevated compared with those in inactive patients and HC. Additionally, plasma HMGB1 was positively correlated with peripheral neutrophils, and plasma TNF-alpha was positively correlated with anti-Sm, ESR and CRP, while plasma IFN-alpha was inversely correlated with the age and platelet level in SLE patients. Our data indicated that increased plasma HMGB1 was associated with disease activity in SLE, which was similar to TNF-alpha. High level of plasma IFN-alpha may be related to nephritis and thrombocytopenia in SLE.
journal_name
Rheumatol Intjournal_title
Rheumatology internationalauthors
Ma CY,Jiao YL,Zhang J,Yang QR,Zhang ZF,Shen YJ,Chen ZJ,Zhao YRdoi
10.1007/s00296-010-1636-6subject
Has Abstractpub_date
2012-02-01 00:00:00pages
395-402issue
2eissn
0172-8172issn
1437-160Xjournal_volume
32pub_type
杂志文章abstract：:The occurrence of MHC class I antigens and microbial antigens derived from the triggering infection of the diseased joints in reactive arthritis (ReA) seems to set the stage for local immune activation. In this report activated lymphocytes are demonstrated by using an avidin-biotin-peroxidase complex (ABC) method comb...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00270983
更新日期：1989-01-01 00:00:00
abstract：:The objective of this study is to investigate the relationship between clinical features of ankylosing spondylitis (AS) and HLA-B27 status or its subtypes. Clinical data and blood samples were collected with patients' informed consent. Luminex liquid array combining polymerase chain reaction-sequence specific oligonuc...
journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0743-0
更新日期：2009-02-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-010-1713-x
更新日期：2012-04-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-008-0804-4
更新日期：2009-06-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2009-5
更新日期：2012-09-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-003-0406-0
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s002960000063
更新日期：2000-12-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00270454
更新日期：1988-01-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
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更新日期：2019-08-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
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更新日期：2013-03-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
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更新日期：2001-04-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3495-2
更新日期：2016-08-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF00307733
更新日期：1993-01-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-2282-3
更新日期：2012-12-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章,多中心研究
doi：10.1007/s00296-016-3499-y
更新日期：2016-07-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-016-3618-9
更新日期：2017-01-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-009-0947-y
更新日期：2009-12-01 00:00:00
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journal_title：Rheumatology international
pub_type： 临床试验,杂志文章
doi：10.1007/BF00246875
更新日期：1992-01-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0479-2
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journal_title：Rheumatology international
pub_type： 杂志文章,评审
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journal_title：Rheumatology international
pub_type： 杂志文章,评审
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journal_title：Rheumatology international
pub_type： 杂志文章,随机对照试验
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更新日期：2015-01-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/BF02274821
更新日期：1990-01-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-011-1844-8
更新日期：2012-06-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-017-3844-9
更新日期：2017-12-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-018-3986-4
更新日期：2018-06-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-012-2446-9
更新日期：2013-03-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章
doi：10.1007/s00296-007-0324-7
更新日期：2007-08-01 00:00:00
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journal_title：Rheumatology international
pub_type： 杂志文章,评审
doi：10.1007/s00296-015-3337-7
更新日期：2016-01-01 00:00:00
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journal_title：Rheumatology international
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002960100105
更新日期：2001-05-01 00:00:00
