Abstract：
:Biotechnology applications require engineering complex multi-genic traits. The lack of knowledge on the genetic basis of complex phenotypes restricts our ability to rationally engineer them. However, complex phenotypes can be engineered at the systems level, utilizing directed evolution strategies that drive whole biological systems toward desired phenotypes without requiring prior knowledge of the genetic basis of the targeted trait. Recent developments in the synthetic biology field accelerates the directed evolution cycle, facilitating engineering of increasingly complex traits in biological systems. In this review, we summarize some of the most recent advances in directed evolution and synthetic biology that allows engineering of complex traits in microbial systems. Then, we discuss applications that can be achieved through engineering at the systems level.
journal_name
Curr Opin Biotechnoljournal_title
Current opinion in biotechnologyauthors
Bassalo MC,Liu R,Gill RTdoi
10.1016/j.copbio.2016.03.016subject
Has Abstractpub_date
2016-06-01 00:00:00pages
126-133eissn
0958-1669issn
1879-0429pii
S0958-1669(16)30072-6journal_volume
39pub_type
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journal_title：Current opinion in biotechnology
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journal_title：Current opinion in biotechnology
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journal_title：Current opinion in biotechnology
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journal_title：Current opinion in biotechnology
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journal_title：Current opinion in biotechnology
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journal_title：Current opinion in biotechnology
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journal_title：Current opinion in biotechnology
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journal_title：Current opinion in biotechnology
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journal_title：Current opinion in biotechnology
pub_type： 杂志文章,评审
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journal_title：Current opinion in biotechnology
pub_type： 杂志文章,评审
doi：10.1016/j.copbio.2007.07.008
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journal_title：Current opinion in biotechnology
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journal_title：Current opinion in biotechnology
pub_type： 杂志文章,评审
doi：10.1016/j.copbio.2020.03.002
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journal_title：Current opinion in biotechnology
pub_type： 杂志文章,评审
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journal_title：Current opinion in biotechnology
pub_type： 杂志文章,评审
doi：10.1016/j.copbio.2017.03.026
更新日期：2017-12-01 00:00:00
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journal_title：Current opinion in biotechnology
pub_type： 杂志文章,评审
doi：10.1016/j.copbio.2003.11.002
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journal_title：Current opinion in biotechnology
pub_type： 杂志文章
doi：10.1016/j.copbio.2010.05.010
更新日期：2010-08-01 00:00:00
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journal_title：Current opinion in biotechnology
pub_type： 杂志文章,评审
doi：10.1016/0958-1669(92)90167-h
更新日期：1992-08-01 00:00:00
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journal_title：Current opinion in biotechnology
pub_type： 杂志文章,评审
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journal_title：Current opinion in biotechnology
pub_type： 杂志文章,评审
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journal_title：Current opinion in biotechnology
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journal_title：Current opinion in biotechnology
pub_type： 杂志文章,评审
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journal_title：Current opinion in biotechnology
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journal_title：Current opinion in biotechnology
pub_type： 杂志文章,评审
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journal_title：Current opinion in biotechnology
pub_type： 杂志文章,评审
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journal_title：Current opinion in biotechnology
pub_type： 杂志文章,评审
doi：10.1016/j.copbio.2012.08.004
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journal_title：Current opinion in biotechnology
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journal_title：Current opinion in biotechnology
pub_type： 杂志文章,评审
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更新日期：2020-12-01 00:00:00
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journal_title：Current opinion in biotechnology
pub_type： 杂志文章,评审
doi：10.1016/0958-1669(94)90061-2
更新日期：1994-10-01 00:00:00
