Abstract:
:The pathway of monolignol biosynthesis involves many components interacting in a metabolic grid to regulate the supply and ratios of monolignols for lignification. The complexity of the pathway challenges any intuitive prediction of the output without mathematical modeling. Several models have been presented to quantify the metabolic flux for monolignol biosynthesis and the regulation of lignin content, composition, and structure in plant cell walls. Constraint-based models using data from transgenic plants were formulated to describe steady-state flux distribution in the pathway. Kinetic-based models using enzyme reaction and inhibition constants were developed to predict flux dynamics for monolignol biosynthesis in wood-forming cells. This review summarizes the recent progress in flux modeling and its application to lignin engineering for improved plant development and utilization.
journal_name
Curr Opin Biotechnoljournal_title
Current opinion in biotechnologyauthors
Wang JP,Matthews ML,Naik PP,Williams CM,Ducoste JJ,Sederoff RR,Chiang VLdoi
10.1016/j.copbio.2018.12.003subject
Has Abstractpub_date
2019-04-01 00:00:00pages
187-192eissn
0958-1669issn
1879-0429pii
S0958-1669(18)30066-1journal_volume
56pub_type
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