Abstract：
:The efficient and safe delivery of therapeutic proteins is the key to commercial success and, in some cases, the demonstration of efficacy in current and future biotechnology products. Numerous delivery technologies and companies have evolved over the past year. To critically evaluate the available options, each method must be assessed in terms of how easily it can be manufactured, impact on protein quality, bioavailability, and toxicity. Recent advances in depot delivery systems have, for the most part, overcome all of these obstacles except for complex and costly manufacturing. On the other hand, pulmonary delivery usually involves efficient manufacturing, but low protein bioavailability resulting in higher doses compared with injections. Although recent advances in transdermal and oral delivery have been significant, both of these delivery routes require logarithmic increases in bioavailability to make them viable candidates for commercialization. In the next few years, protein delivery for commercial products will probably be limited to injection devices, depot systems and pulmonary administration.
journal_name
Curr Opin Biotechnoljournal_title
Current opinion in biotechnologyauthors
Cleland JL,Daugherty A,Mrsny Rdoi
10.1016/s0958-1669(00)00202-0subject
Has Abstractpub_date
2001-04-01 00:00:00pages
212-9issue
2eissn
0958-1669issn
1879-0429pii
S0958-1669(00)00202-0journal_volume
12pub_type
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