Trade-offs between gene expression, growth and phenotypic diversity in microbial populations.

Abstract:

:Bacterial cells have a limited number of resources that can be allocated for gene expression. The intracellular competition for these resources has an impact on the cell physiology. Bacteria have evolved mechanisms to optimize resource allocation in a variety of scenarios, showing a trade-off between the resources used to maximise growth (e.g. ribosome synthesis) and the rest of cellular functions. Limitations in gene expression also play a role in generating phenotypic diversity, which is advantageous in fluctuating environments, at the expenses of decreasing growth rates. Our current understanding of these trade-offs can be exploited for biotechnological applications benefiting from the selective manipulation of the allocation of resources.

journal_name

Curr Opin Biotechnol

authors

Kim J,Darlington A,Salvador M,Utrilla J,Jiménez JI

doi

10.1016/j.copbio.2019.08.004

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

29-37

eissn

0958-1669

issn

1879-0429

pii

S0958-1669(19)30058-8

journal_volume

62

pub_type

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