RNA nanostructures and scaffolds for biotechnology applications.


:RNA plays important roles in the regulation of gene expressions and other cellular functions. It functions as both as an informational carrier and a nanomachine due to its complementary base-pairing ability and complexed three-dimensional structure. Several nanostructures have been designed and constructed by exploiting these natural RNA properties. In this review, we will introduce the design principles of RNA nanostructures and their biotechnology applications as molecular scaffolds. RNA-based molecular scaffolds can control the accumulation and interaction of target proteins at nanometer-scale to regulate the function of bacterial and mammalian cells. Combining useful property of RNA as a nano-material and a molecular scaffold may provide us powerful tools in biological research, bioengineering, and future medicine.


Curr Opin Biotechnol


Ohno H,Akamine S,Saito H




Has Abstract


2019-08-01 00:00:00












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  • Engineering solventogenic clostridia.

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    journal_title:Current opinion in biotechnology

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    authors: Papoutsakis ET

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  • Stem cell niche engineering through droplet microfluidics.

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    pub_type: 杂志文章,评审


    authors: Allazetta S,Lutolf MP

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  • Genetically encoded tools for RNA imaging in living cells.

    abstract::RNA imaging probes help us investigate how transport and dynamics of RNA contribute to subcellular RNA localization or regulation of gene expression. Out of the plethora of strategies that have been developed to image RNA in living cells, genetically encoded probes are interesting because they can be produced by the c...

    journal_title:Current opinion in biotechnology

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    authors: Rath AK,Rentmeister A

    更新日期:2015-02-01 00:00:00

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    journal_title:Current opinion in biotechnology

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    authors: Liu Y,Nielsen J

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  • Omics data input for metabolic modeling.

    abstract::Recent advancements in high-throughput large-scale analytical methods to sequence genomes of organisms, and to quantify gene expression, proteins, lipids and metabolites have changed the paradigm of metabolic modeling. The cost of data generation and analysis has decreased significantly, which has allowed exponential ...

    journal_title:Current opinion in biotechnology

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    authors: Rai A,Saito K

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  • Biological hydrogen production by dark fermentation: challenges and prospects towards scaled-up production.

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    authors: RenNanqi,GuoWanqian,LiuBingfeng,CaoGuangli,DingJie

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    pub_type: 杂志文章,评审


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  • Cranberry components for the therapy of infectious disease.

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    pub_type: 杂志文章,评审


    authors: Hsu CC,Dorrestein PC

    更新日期:2015-02-01 00:00:00

  • Protein processing within the secretory pathway.

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    pub_type: 杂志文章,评审


    authors: Rehemtulla A,Kaufman RJ

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  • Protein fragment complementation strategies for biochemical network mapping.

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    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Radzikowski JL,Schramke H,Heinemann M

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  • Stable-isotope probing of DNA: insights into the function of uncultivated microorganisms from isotopically labeled metagenomes.

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    pub_type: 杂志文章,评审


    authors: Friedrich MW

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  • Towards real-time monitoring of therapeutic protein quality in mammalian cell processes.

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    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Pais DA,Carrondo MJ,Alves PM,Teixeira AP

    更新日期:2014-12-01 00:00:00

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    pub_type: 杂志文章


    authors: Lee TD,Shively JE

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  • The evolution of IncP catabolic plasmids.

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    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Dennis JJ

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    pub_type: 杂志文章,评审


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  • Advances in quantitative proteomics via stable isotope tagging and mass spectrometry.

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    pub_type: 杂志文章,评审


    authors: Tao WA,Aebersold R

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  • Human-on-chip for therapy development and fundamental science.

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    pub_type: 杂志文章,评审


    authors: Luni C,Serena E,Elvassore N

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  • Biological approaches for controlling shellfish-associated pathogens.

    abstract::As the consumption of seafood and shellfish increases around the world, so is the incidence of associated outbreaks of illness. Various postharvest treatments are effective at killing seafood-associated bacteria, but most of these treatments also kill the mollusks. Because consumer preferences for raw live shellfish p...

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    pub_type: 杂志文章


    authors: Friedrich B,Fritsch J,Lenz O

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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


    authors: Stoloff DH,Wanunu M

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    pub_type: 杂志文章,评审


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    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Fotiadis D

    更新日期:2012-08-01 00:00:00

  • Decaying signals: will understanding bacterial-plant communications lead to control of soft rot?

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    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Charkowski AO

    更新日期:2009-04-01 00:00:00

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    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Carrillo-Carrion C,Carril M,Parak WJ

    更新日期:2017-08-01 00:00:00

  • The flux and impact of wastewater infrastructure microorganisms on human and ecosystem health.

    abstract::Wastewater infrastructure is designed, in part, to remove microorganisms. However, many microorganisms are able to colonize infrastructure and resist treatment, resulting in an enormous flux of microorganisms to urban adjacent waters. These urban-associated microorganisms are discharged through three primary routes 1)...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Newton RJ,McClary JS

    更新日期:2019-06-01 00:00:00

  • Customised nucleic acid libraries for enhanced aptamer selection and performance.

    abstract::Aptamers are short single-stranded oligo(deoxy)nucleotides that are selected to bind to target molecules with high affinity and specificity. Because of their sophisticated characteristics and versatile applicability, aptamers are thought to become universal molecular probes in biotechnological and therapeutic applicat...

    journal_title:Current opinion in biotechnology

    pub_type: 杂志文章,评审


    authors: Pfeiffer F,Rosenthal M,Siegl J,Ewers J,Mayer G

    更新日期:2017-12-01 00:00:00