Abstract:
:Self-assembled peptide systems have been widely studied in the context of gaining understanding of the rules that govern biomolecular processes and increasingly as new bio-inspired nanomaterials. Such materials may be designed to be highly dynamic, displaying adaptive and self-healing properties. This review focuses on recent approaches, which exploit reversible covalent and noncovalent chemistry in combination with peptide-based self-assembly. Selected examples of recent advances include sulphur and nitrogen-based reversible reactions, metal-ligand coordination and enzyme-assisted transamidation that lead to structures such as catenanes, nanofibres, β-hairpins and coiled-coil assemblies. It is demonstrated that these structures give rise to nanomaterials with emergent properties that are highly sensitive and adaptive to external conditions and may allow for in vitro evolution of novel peptide nanostructures via templating or self-recognition.
journal_name
Curr Opin Biotechnoljournal_title
Current opinion in biotechnologyauthors
Sadownik JW,Ulijn RVdoi
10.1016/j.copbio.2010.05.010subject
Has Abstractpub_date
2010-08-01 00:00:00pages
401-11issue
4eissn
0958-1669issn
1879-0429pii
S0958-1669(10)00106-0journal_volume
21pub_type
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