Engineering carbon fixation with artificial protein organelles.

Abstract:

:Based on projections for global population growth, current techniques for improving agricultural yields will not be able to address future demands for major food crops. Improving photosynthetic efficiency by engineering carbon fixation has been identified as one of the most important approaches for increasing agricultural output. Recent studies indicate that introducing cyanobacterial-like carbon concentrating mechanisms (CCMs) into plant chloroplasts represents a promising strategy for enhancing plant photosynthesis. Here, we give a general outline for transferring CCMs to plants. The proposed trajectory includes introducing bicarbonate transporters and CO2-fixing organelles into plant chloroplasts as well as minimizing stromal carbonic anhydrase (CA) activity. We focus on different approaches for constructing compartments that co-localize the CO2-fixing enzyme d-ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) and CA, aimed at increasing RuBisCO turnover and decreasing wasteful photorespiration. We consider strategies based on cyanobacterial carboxysomes and on other protein-based compartments, specifically encapsulin nanocompartments. Finally, recent advances in expressing catalytic and structural carboxysomal components in plants will be highlighted.

journal_name

Curr Opin Biotechnol

authors

Giessen TW,Silver PA

doi

10.1016/j.copbio.2017.01.004

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

42-50

eissn

0958-1669

issn

1879-0429

pii

S0958-1669(16)30280-4

journal_volume

46

pub_type

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