Abstract:
:Strain-specificity of probiotic effects has been a cornerstone principle of probiotic science for decades. Certainly, some important mechanisms are present in only a few probiotic strains. But scientific advances now reveal commonalities among members of certain taxonomic groups of probiotic microbes. Some clinical benefits likely derive from these shared mechanisms, suggesting that sub-species-specific, species-specific or genus-specific probiotic effects exist. Human trials are necessary to confirm specific health benefits. However, a strain that has not been tested in human efficacy trials may meet the minimum definition of the term 'probiotic' if it is a member of a well-studied probiotic species expressing underlying core mechanisms and it is delivered at an effective dose.
journal_name
Curr Opin Biotechnoljournal_title
Current opinion in biotechnologyauthors
Sanders ME,Benson A,Lebeer S,Merenstein DJ,Klaenhammer TRdoi
10.1016/j.copbio.2017.09.007subject
Has Abstractpub_date
2018-02-01 00:00:00pages
207-216eissn
0958-1669issn
1879-0429pii
S0958-1669(17)30148-9journal_volume
49pub_type
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